PubRank

Junichi Takagi

Author PubWeight™ 73.59‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature 2004 5.87
2 Conformational regulation of integrin structure and function. Annu Rev Biophys Biomol Struct 2001 3.74
3 Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nat Struct Biol 2002 2.56
4 A specific interface between integrin transmembrane helices and affinity for ligand. PLoS Biol 2004 2.26
5 Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins. Structure 2002 2.00
6 Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand. Proc Natl Acad Sci U S A 2003 1.93
7 Crystal structure of autotaxin and insight into GPCR activation by lipid mediators. Nat Struct Mol Biol 2011 1.87
8 Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 2007 1.87
9 Ligand-binding specificities of laminin-binding integrins: a comprehensive survey of laminin-integrin interactions using recombinant alpha3beta1, alpha6beta1, alpha7beta1 and alpha6beta4 integrins. Matrix Biol 2006 1.82
10 The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol 2007 1.81
11 Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering. Proc Natl Acad Sci U S A 2005 1.73
12 Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Sci Transl Med 2014 1.67
13 Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain. J Biol Chem 2004 1.60
14 Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides. J Biol Chem 2003 1.56
15 Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor. J Cell Biol 2012 1.52
16 Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring. Proc Natl Acad Sci U S A 2004 1.49
17 Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor. Proc Natl Acad Sci U S A 2009 1.45
18 Potentiation of the ligand-binding activity of integrin alpha3beta1 via association with tetraspanin CD151. Proc Natl Acad Sci U S A 2005 1.44
19 Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation. Proc Natl Acad Sci U S A 2004 1.36
20 Structural basis for semaphorin signalling through the plexin receptor. Nature 2010 1.33
21 Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds. Proc Natl Acad Sci U S A 2002 1.18
22 Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus. J Leukoc Biol 2008 1.13
23 The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7. J Biol Chem 2004 1.13
24 Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation. Thromb Haemost 2006 1.12
25 Molecular basis of the recognition of nephronectin by integrin alpha8beta1. J Biol Chem 2009 1.09
26 Structural basis for specific recognition of reelin by its receptors. Structure 2010 1.08
27 A rapid screening method for cell lines producing singly-tagged recombinant proteins using the "TARGET tag" system. J Proteomics 2010 1.06
28 Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors. Proc Natl Acad Sci U S A 2007 1.06
29 Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling. Proc Natl Acad Sci U S A 2012 1.05
30 alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity. J Biol Chem 2006 1.03
31 Schwann cell myelination requires integration of laminin activities. J Cell Sci 2012 1.00
32 Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography. EMBO J 2006 0.95
33 Key interactions in integrin ectodomain responsible for global conformational change detected by elastic network normal-mode analysis. Biophys J 2008 0.94
34 Fibronectin peptides derived from two distinct regions stimulate adipocyte differentiation by preventing fibronectin matrix assembly. Biochemistry 2002 0.93
35 Novel affinity tag system using structurally defined antibody-tag interaction: application to single-step protein purification. Protein Sci 2008 0.92
36 Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin. Cell Rep 2012 0.92
37 Three-dimensional architecture of virus-packed tubule. J Electron Microsc (Tokyo) 2007 0.90
38 High affinity ligand binding by integrins does not involve head separation. J Biol Chem 2003 0.87
39 The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides. Proc Natl Acad Sci U S A 2002 0.87
40 Functional importance of covalent homodimer of reelin protein linked via its central region. J Biol Chem 2011 0.84
41 A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration. Nat Commun 2013 0.84
42 Detection of endogenous LRP6 expressed on human cells by monoclonal antibodies specific for the native conformation. J Immunol Methods 2009 0.83
43 Laminin-121--recombinant expression and interactions with integrins. Matrix Biol 2010 0.83
44 Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1. Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 0.82
45 Comparison of the envelope architecture of E. coli using two methods: CEMOVIS and cryo-electron tomography. J Electron Microsc (Tokyo) 2010 0.81
46 Structure of the F-spondin reeler domain reveals a unique beta-sandwich fold with a deformable disulfide-bonded loop. Acta Crystallogr D Biol Crystallogr 2008 0.81
47 A murine monoclonal antibody that binds N-terminal extracellular segment of human protease-activated receptor-4. Hybridoma (Larchmt) 2008 0.80
48 Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 0.80
49 Structural basis for variant-specific neuroligin-binding by α-neurexin. PLoS One 2011 0.79
50 Crystallization and preliminary crystallographic analysis of human LR11 Vps10p domain. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.78
51 A multipurpose fusion tag derived from an unstructured and hyperacidic region of the amyloid precursor protein. Protein Sci 2013 0.78
52 Duplication (22)(q11.22-q11.23) without coloboma and cleft lip or palate. Pediatr Int 2003 0.75
53 [New era of structural analysis of proteins by electron microscopy-application to a dynamic structural analysis of integrin cell adhesion receptor-]. Seikagaku 2005 0.75
54 Co-occurrence of Down syndrome and Treacher-Collins syndrome. Pediatr Int 2002 0.75
55 [Multiple discontinuous exosites for von Willebrand factor of ADAMTS13]. Seikagaku 2010 0.75
56 [Transient signalling complex formed by axon guidance cue semaphorin]. Seikagaku 2011 0.75
57 Tilt-angle measurement of a sample stage using a capacitive liquid-based inclinometer. J Electron Microsc (Tokyo) 2012 0.75