Published in J Biol Chem on April 27, 2004
Structural basis of integrin regulation and signaling. Annu Rev Immunol (2007) 8.60
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature (2004) 5.87
Integrin structures and conformational signaling. Curr Opin Cell Biol (2006) 2.03
Integrin inside-out signaling and the immunological synapse. Curr Opin Cell Biol (2011) 1.89
Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. PLoS Pathog (2009) 1.82
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering. Proc Natl Acad Sci U S A (2005) 1.73
Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate. PLoS Comput Biol (2009) 1.69
How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation. J Cell Biol (2006) 1.60
Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor. J Cell Biol (2012) 1.52
Antibodies causing thrombocytopenia in patients treated with RGD-mimetic platelet inhibitors recognize ligand-specific conformers of αIIb/β3 integrin. Blood (2012) 1.46
Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domain. J Biol Chem (2005) 1.38
Complete integrin headpiece opening in eight steps. J Cell Biol (2013) 1.37
Tests of the extension and deadbolt models of integrin activation. J Biol Chem (2007) 1.28
Catch-bond mechanism of force-enhanced adhesion: counterintuitive, elusive, but ... widespread? Cell Host Microbe (2008) 1.26
The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7. J Biol Chem (2004) 1.13
Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion. J Cell Biol (2012) 1.13
Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy. J Biol Chem (2011) 1.07
Cyclic mechanical reinforcement of integrin-ligand interactions. Mol Cell (2013) 1.05
Modulation of integrin activation by an entropic spring in the {beta}-knee. J Biol Chem (2010) 1.05
Reconstruction of integrin activation. Blood (2011) 1.04
α(V)β(3) integrin crystal structures and their functional implications. Biochemistry (2012) 1.02
Integrin activation dynamics between the RGD-binding site and the headpiece hinge. J Biol Chem (2009) 1.01
Selective targeting of TGF-β activation to treat fibroinflammatory airway disease. Sci Transl Med (2014) 1.00
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation. J Biol Chem (2008) 1.00
Three-dimensional reconstruction of intact human integrin αIIbβ3: new implications for activation-dependent ligand binding. Blood (2013) 0.96
Metal ion and ligand binding of integrin α5β1. Proc Natl Acad Sci U S A (2014) 0.96
How natalizumab binds and antagonizes α4 integrins. J Biol Chem (2013) 0.95
The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins. EMBO J (2014) 0.91
Relating conformation to function in integrin α5β1. Proc Natl Acad Sci U S A (2016) 0.88
Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli. PLoS Pathog (2015) 0.83
Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function. Elife (2016) 0.79
Conformational equilibria and intrinsic affinities define integrin activation. EMBO J (2017) 0.78
Allosteric modulation of beta1 integrin function induces lung tissue repair. Adv Pharmacol Sci (2012) 0.78
Epitope mapping for monoclonal antibody reveals the activation mechanism for αVβ3 integrin. PLoS One (2013) 0.77
Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling. J Immunol (2014) 0.75
Structural basis of integrin regulation and signaling. Annu Rev Immunol (2007) 8.60
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science (2006) 7.84
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell (2002) 7.03
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92
Negative Staining and Image Classification - Powerful Tools in Modern Electron Microscopy. Biol Proced Online (2004) 6.14
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature (2004) 5.87
Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science (2003) 5.58
Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature (2005) 5.44
Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature (2002) 5.32
Multiple associated proteins regulate proteasome structure and function. Mol Cell (2002) 4.97
The genome of M. acetivorans reveals extensive metabolic and physiological diversity. Genome Res (2002) 4.58
Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature (2004) 4.48
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell (2012) 4.29
Transcellular diapedesis is initiated by invasive podosomes. Immunity (2007) 4.06
Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor. Science (2009) 3.85
Conformational regulation of integrin structure and function. Annu Rev Biophys Biomol Struct (2001) 3.74
A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol (2004) 3.66
Structure of the human transferrin receptor-transferrin complex. Cell (2004) 3.64
Integrin avidity regulation: are changes in affinity and conformation underemphasized? Curr Opin Cell Biol (2003) 3.59
Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Mol Cell (2008) 3.54
Latent TGF-β structure and activation. Nature (2011) 3.42
Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell (2010) 3.33
RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell (2004) 3.27
Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity (2006) 3.11
Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J (2003) 2.99
Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature (2004) 2.94
Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol (2002) 2.92
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol Cell (2005) 2.82
Integrin activation and structural rearrangement. Immunol Rev (2002) 2.60
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nat Struct Biol (2002) 2.56
Implications of the aquaporin-4 structure on array formation and cell adhesion. J Mol Biol (2005) 2.50
Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions. Neuron (2004) 2.49
Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell (2007) 2.48
Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation. Cell (2005) 2.47
Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics. Structure (2004) 2.35
Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other. Immunity (2003) 2.34
Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell (2012) 2.34
A specific interface between integrin transmembrane helices and affinity for ligand. PLoS Biol (2004) 2.26
A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell (2009) 2.24
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat Struct Mol Biol (2011) 2.23
Structure and different conformational states of native AMPA receptor complexes. Nature (2005) 2.22
The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2. J Cell Biol (2004) 2.22
Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol (2006) 2.17
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat Struct Mol Biol (2005) 2.12
Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB J (2008) 2.10
The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering. Cell (2006) 2.10
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol (2010) 2.08
Integrin structures and conformational signaling. Curr Opin Cell Biol (2006) 2.03
Structural basis of Dscam isoform specificity. Nature (2007) 2.02
Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins. Structure (2002) 2.00
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. Proc Natl Acad Sci U S A (2011) 1.99
Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction. Immunity (2004) 1.98
Therapeutic antagonists and conformational regulation of integrin function. Nat Rev Drug Discov (2003) 1.98
Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1. J Immunol (2003) 1.95
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand. Proc Natl Acad Sci U S A (2003) 1.93
Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster. Nat Struct Biol (2003) 1.92
Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. Proc Natl Acad Sci U S A (2009) 1.91
The structure of aquaporins. Q Rev Biophys (2006) 1.90
A mechanically stabilized receptor-ligand flex-bond important in the vasculature. Nature (2010) 1.90
Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly. Mol Cell (2007) 1.89
Crystal structure of autotaxin and insight into GPCR activation by lipid mediators. Nat Struct Mol Biol (2011) 1.87
Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature (2007) 1.87
Importance of force linkage in mechanochemistry of adhesion receptors. Biochemistry (2006) 1.87
Ligand-binding specificities of laminin-binding integrins: a comprehensive survey of laminin-integrin interactions using recombinant alpha3beta1, alpha6beta1, alpha7beta1 and alpha6beta4 integrins. Matrix Biol (2006) 1.82
The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3. Mol Cell (2009) 1.82
Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. J Mol Biol (2003) 1.81
Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature (2004) 1.81
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol (2005) 1.78
The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes. PLoS Pathog (2011) 1.78
Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. J Exp Med (2008) 1.76
Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force. Nat Immunol (2006) 1.74
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering. Proc Natl Acad Sci U S A (2005) 1.73
Structure of an integrin with an alphaI domain, complement receptor type 4. EMBO J (2009) 1.70
Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes. EMBO J (2002) 1.68
Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Sci Transl Med (2014) 1.67
Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure (2011) 1.63
Aquaporin-0 membrane junctions form upon proteolytic cleavage. J Mol Biol (2004) 1.63
Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor. Mol Cell Biol (2010) 1.63
Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface. Nature (2003) 1.61
RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner. Mol Cell (2013) 1.57
Structural transitions of complement component C3 and its activation products. Proc Natl Acad Sci U S A (2006) 1.57
Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides. J Biol Chem (2003) 1.56
Structural and functional characterization of the integral membrane protein VDAC-1 in lipid bilayer nanodiscs. J Am Chem Soc (2009) 1.55
Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Mol Cell (2007) 1.53
Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling. Blood (2007) 1.52