Published in Cell on June 25, 2004
O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding. Science (2010) 2.98
POMT2 mutations cause alpha-dystroglycan hypoglycosylation and Walker-Warburg syndrome. J Med Genet (2005) 2.80
Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE. Science (2012) 2.22
Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding. J Virol (2005) 2.17
A dystroglycan mutation associated with limb-girdle muscular dystrophy. N Engl J Med (2011) 1.67
Characterization of the interaction of lassa fever virus with its cellular receptor alpha-dystroglycan. J Virol (2005) 1.56
Enhanced laminin binding by alpha-dystroglycan after enzymatic deglycosylation. Biochem J (2005) 1.56
Muscular dystrophies due to glycosylation defects. Neurotherapeutics (2008) 1.51
Intragenic deletion in the LARGE gene causes Walker-Warburg syndrome. Hum Genet (2007) 1.51
Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence. Proc Natl Acad Sci U S A (2011) 1.47
Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE. J Biol Chem (2009) 1.46
Site mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle. J Biol Chem (2010) 1.43
Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization. Development (2006) 1.39
Golgi glycosylation. Cold Spring Harb Perspect Biol (2011) 1.35
Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase. Proc Natl Acad Sci U S A (2009) 1.32
Glycomic analyses of mouse models of congenital muscular dystrophy. J Biol Chem (2011) 1.32
Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection. Proc Natl Acad Sci U S A (2011) 1.32
Decoding arenavirus pathogenesis: essential roles for alpha-dystroglycan-virus interactions and the immune response. Virology (2010) 1.28
Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport. PLoS Pathog (2011) 1.25
Old World and clade C New World arenaviruses mimic the molecular mechanism of receptor recognition used by alpha-dystroglycan's host-derived ligands. J Virol (2007) 1.24
Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev (2005) 1.13
Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell. Mol Biol Cell (2007) 1.12
Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy. Hum Mol Genet (2008) 1.10
Congenital muscular dystrophies involving the O-mannose pathway. Curr Mol Med (2007) 1.06
Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane. Glycobiology (2015) 1.06
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LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy. Nature (2013) 1.04
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Golgi glycosylation and human inherited diseases. Cold Spring Harb Perspect Biol (2011) 0.99
Two opposing roles of O-glycans in tumor metastasis. Trends Mol Med (2012) 0.99
Muscle dystroglycan organizes the postsynapse and regulates presynaptic neurotransmitter release at the Drosophila neuromuscular junction. PLoS One (2008) 0.99
Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats. J Biol Chem (2009) 0.99
The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation. Elife (2014) 0.98
Transgenic overexpression of LARGE induces α-dystroglycan hyperglycosylation in skeletal and cardiac muscle. PLoS One (2010) 0.95
Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization. J Biol Chem (2010) 0.93
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O-Mannosylation and human disease. Cell Mol Life Sci (2012) 0.91
Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2. Glycobiology (2012) 0.91
Protein O-mannosylation in animal development and physiology: from human disorders to Drosophila phenotypes. Semin Cell Dev Biol (2010) 0.91
LARGE expression augments the glycosylation of glycoproteins in addition to α-dystroglycan conferring laminin binding. PLoS One (2011) 0.90
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes. J Biol Chem (2014) 0.89
High-resolution array-CGH profiling of germline and tumor-specific copy number alterations on chromosome 22 in patients affected with schwannomas. Hum Genet (2005) 0.88
Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV. Nat Struct Mol Biol (2016) 0.87
Soleus muscle in glycosylation-deficient muscular dystrophy is protected from contraction-induced injury. Am J Physiol Cell Physiol (2010) 0.87
Binding of Lassa virus perturbs extracellular matrix-induced signal transduction via dystroglycan. Cell Microbiol (2012) 0.86
Loss of LARGE2 disrupts functional glycosylation of α-dystroglycan in prostate cancer. J Biol Chem (2012) 0.86
Sarcolemma instability during mechanical activity in Largemyd cardiac myocytes with loss of dystroglycan extracellular matrix receptor function. Hum Mol Genet (2011) 0.86
Type I interferon is a therapeutic target for virus-induced lethal vascular damage. Proc Natl Acad Sci U S A (2014) 0.86
The evolution of the dystroglycan complex, a major mediator of muscle integrity. Biol Open (2015) 0.85
Fer kinase regulates cell migration through α-dystroglycan glycosylation. Mol Biol Cell (2012) 0.85
Sarcospan: a small protein with large potential for Duchenne muscular dystrophy. Skelet Muscle (2013) 0.85
Mouse models of fukutin-related protein mutations show a wide range of disease phenotypes. Hum Genet (2013) 0.85
Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain. J Biol Chem (2014) 0.85
The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy. FEBS J (2013) 0.85
Proteomic analysis of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor complexes. J Biol Chem (2012) 0.84
Role of DC-SIGN in Lassa virus entry into human dendritic cells. J Virol (2013) 0.84
Reduced glycosylation of α-dystroglycans on carcinoma cells contributes to formation of highly infiltrative histological patterns in prostate cancer. Prostate (2011) 0.84
Human natural killer-1 sulfotransferase (HNK-1ST)-induced sulfate transfer regulates laminin-binding glycans on α-dystroglycan. J Biol Chem (2012) 0.83
Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin. J Cell Biol (2015) 0.83
Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis. J Virol (2016) 0.83
Probing the stability of the "naked" mucin-like domain of human α-dystroglycan. BMC Biochem (2013) 0.81
High throughput screening for compounds that alter muscle cell glycosylation identifies new role for N-glycans in regulating sarcolemmal protein abundance and laminin binding. J Biol Chem (2012) 0.80
Analytical tools for the study of cellular glycosylation in the immune system. Front Immunol (2013) 0.79
Cell entry of Lassa virus induces tyrosine phosphorylation of dystroglycan. Cell Microbiol (2012) 0.78
Insertion of a myc-tag within α-dystroglycan domains improves its biochemical and microscopic detection. BMC Biochem (2012) 0.78
Identification of antithrombin-modulating genes. Role of LARGE, a gene encoding a bifunctional glycosyltransferase, in the secretion of proteins? PLoS One (2013) 0.78
Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of α-dystroglycan in cells and tissues. J Biol Chem (2014) 0.78
A Method to Produce and Purify Full-Length Recombinant Alpha Dystroglycan: Analysis of N- and O-Linked Monosaccharide Composition in CHO Cells with or without LARGE Overexpression. PLoS Curr (2013) 0.78
The Structure of the T190M Mutant of Murine α-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy. PLoS One (2015) 0.77
C. elegans dystroglycan coordinates responsiveness of follower axons to dorsal/ventral and anterior/posterior guidance cues. Dev Neurobiol (2012) 0.77
Structural basis of laminin binding to the LARGE glycans on dystroglycan. Nat Chem Biol (2016) 0.77
LARGE2-dependent glycosylation confers laminin-binding ability on proteoglycans. Glycobiology (2016) 0.75
Integrin and dystroglycan compensate each other to mediate laminin-dependent basement membrane assembly and epiblast polarization. Matrix Biol (2016) 0.75
Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window? PLoS One (2016) 0.75
Direct Mapping of Additional Modifications on Phosphorylated O-glycans of α-Dystroglycan by Mass Spectrometry Analysis in Conjunction with Knocking Out of Causative Genes for Dystroglycanopathy. Mol Cell Proteomics (2016) 0.75
Protein O-linked mannose β-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) is a gatekeeper enzyme for functional glycosylation of α-dystroglycan. J Biol Chem (2016) 0.75
Genetic Engineering of Dystroglycan in Animal Models of Muscular Dystrophy. Biomed Res Int (2015) 0.75
An evaluation of the evolution of the gene structure of dystroglycan. BMC Res Notes (2017) 0.75
Finding the sweet spot: assembly and glycosylation of the dystrophin-associated glycoprotein complex. Anat Rec (Hoboken) (2014) 0.75
Structural flexibility of human α-dystroglycan. FEBS Open Bio (2017) 0.75
Interleukin-10 determines viral clearance or persistence in vivo. Nat Med (2006) 8.01
Defective membrane repair in dysferlin-deficient muscular dystrophy. Nature (2003) 6.50
Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. Am J Hum Genet (2008) 5.53
TAM receptors are pleiotropic inhibitors of the innate immune response. Cell (2007) 5.32
Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies. Nature (2002) 5.21
Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science (2013) 4.18
Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. Nature (2002) 3.96
Dystroglycan: from biosynthesis to pathogenesis of human disease. J Cell Sci (2006) 3.92
Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts. Science (2003) 3.21
Dystrophic heart failure blocked by membrane sealant poloxamer. Nature (2005) 3.16
Muscular dystrophies involving the dystrophin-glycoprotein complex: an overview of current mouse models. Curr Opin Genet Dev (2002) 3.15
Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr Opin Neurobiol (2003) 3.10
Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha 1 interaction domain. Neuron (2004) 3.05
Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic. Nat Immunol (2007) 3.04
Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell (2011) 3.03
Titin mutation segregates with hereditary myopathy with early respiratory failure. Brain (2012) 3.02
LARGE can functionally bypass alpha-dystroglycan glycosylation defects in distinct congenital muscular dystrophies. Nat Med (2004) 3.00
O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding. Science (2010) 2.98
Sarcolemma-localized nNOS is required to maintain activity after mild exercise. Nature (2008) 2.87
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev (2007) 2.79
Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection. J Virol (2005) 2.75
Does Toll-like receptor 3 play a biological role in virus infections? Virology (2004) 2.73
Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection. Nat Immunol (2004) 2.64
Dystrophin-glycoprotein complex: post-translational processing and dystroglycan function. J Biol Chem (2003) 2.56
Dysferlin and the plasma membrane repair in muscular dystrophy. Trends Cell Biol (2004) 2.41
Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone? Am J Physiol Heart Circ Physiol (2007) 2.41
New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor. J Virol (2002) 2.35
Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo. Nat Immunol (2002) 2.31
Somatic mosaicism for copy number variation in differentiated human tissues. Hum Mutat (2008) 2.30
Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE. Science (2012) 2.22
IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. J Exp Med (2008) 2.20
Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections. Cell Host Microbe (2008) 2.18
A vector series for rapid PCR-mediated C-terminal in situ tagging of Trypanosoma brucei genes. Mol Biochem Parasitol (2005) 2.18
Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding. J Virol (2005) 2.17
Age-related somatic structural changes in the nuclear genome of human blood cells. Am J Hum Genet (2012) 2.15
Viral targeting of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion. J Clin Invest (2004) 2.11
Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science (2003) 2.05
A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection. Proc Natl Acad Sci U S A (2009) 2.04
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab (2011) 2.02
Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. Cell (2002) 2.01
Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Immunity (2005) 2.00
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat Neurosci (2007) 1.95
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology (2007) 1.94
ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome. Nat Genet (2012) 1.93
Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injury. J Clin Invest (2007) 1.88
IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection. Proc Natl Acad Sci U S A (2008) 1.84
Two distinct mechanisms target membrane proteins to the axonal surface. Neuron (2003) 1.82
Dysferlin and muscle membrane repair. Curr Opin Cell Biol (2007) 1.82
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity. J Clin Invest (2003) 1.80
Lateral transmission of force is impaired in skeletal muscles of dystrophic mice and very old rats. J Physiol (2011) 1.80
Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization. Neuron (2003) 1.80
IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory. Proc Natl Acad Sci U S A (2004) 1.79
Exon array CGH: detection of copy-number changes at the resolution of individual exons in the human genome. Am J Hum Genet (2005) 1.78
Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions. Virology (2003) 1.75
Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle. J Gen Physiol (2010) 1.73
Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus. Proc Natl Acad Sci U S A (2011) 1.73
A full-coverage, high-resolution human chromosome 22 genomic microarray for clinical and research applications. Hum Mol Genet (2002) 1.69
A dystroglycan mutation associated with limb-girdle muscular dystrophy. N Engl J Med (2011) 1.67
Titin founder mutation is a common cause of myofibrillar myopathy with early respiratory failure. J Neurol Neurosurg Psychiatry (2013) 1.64
The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence. FASEB J (2006) 1.64
Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. PLoS Genet (2010) 1.62
Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection. J Clin Invest (2006) 1.59
Limb-girdle muscular dystrophy in the United States. J Neuropathol Exp Neurol (2006) 1.59
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Science (2013) 1.57
Characterization of the interaction of lassa fever virus with its cellular receptor alpha-dystroglycan. J Virol (2005) 1.56
Genomic microarrays in the spotlight. Trends Genet (2004) 1.55
IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection. Proc Natl Acad Sci U S A (2010) 1.54
Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy. J Neurosci (2008) 1.54
A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes. J Clin Invest (2004) 1.51
Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of α-dystroglycan. Am J Hum Genet (2013) 1.50
Dystroglycan loss disrupts polarity and beta-casein induction in mammary epithelial cells by perturbing laminin anchoring. J Cell Sci (2006) 1.49