The use of polymer-based electrospun nanofibers containing amorphous drug dispersions for the delivery of poorly water-soluble pharmaceuticals.

PubWeight™: 0.81‹?›

🔗 View Article (PMID 15212307)

Published in Pharmazie on May 01, 2004

Authors

M E Brewster1, G Verreck, I Chun, J Rosenblatt, J Mensch, A Van Dijck, M Noppe, A Ariën, M Bruining, J Peeters

Author Affiliations

1: Department of Pharmaceutical Sciences, Johnson & Johnson Pharmaceutical Research and Development, Beerse, Belgium. mbrewste@prdbe.jnj.com

Articles by these authors

Detection of hepatitis C viral sequences in non-A, non-B hepatitis. Lancet (1990) 8.56

Crystal structure of cyclin-dependent kinase 2. Nature (1993) 5.21

Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science (1998) 4.74

Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology (1991) 4.47

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J (1992) 4.21

Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts. Cell (1994) 3.42

A purified Drosophila septin complex forms filaments and exhibits GTPase activity. J Cell Biol (1996) 2.76

Actin dynamics in vivo. Curr Opin Cell Biol (1997) 2.58

BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer. Am J Hum Genet (2000) 2.31

PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc Natl Acad Sci U S A (1994) 2.29

Analysis of gene-specific DNA damage and repair using quantitative polymerase chain reaction. Methods (2000) 2.16

Early events in hepatitis C virus infection of chimpanzees. Proc Natl Acad Sci U S A (1990) 2.04

The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils. The inhibition of neutrophil movement and the elevation of cyclic AMP levels by catecholamines, prostaglandins, theophylline and cholera toxin. J Immunol (1975) 2.01

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. Blood (2001) 1.78

Evaluation of enzyme-linked immunoassay for serological diagnosis of cysticercosis. J Clin Microbiol (1995) 1.61

Effect of exercise and recovery on muscle protein synthesis in human subjects. Am J Physiol (1990) 1.48

Sensitive visualization of antigen-antibody reactions in dot and blot immune overlay assays with immunogold and immunogold/silver staining. J Immunol Methods (1984) 1.47

Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer. Am J Hum Genet (1997) 1.42

Contribution of three-dimensional volume contrast imaging to the sonographic assessment of the fetal uterus. Ultrasound Obstet Gynecol (2005) 1.38

Update on resistance of Bacteroides fragilis group and related species with special attention to carbapenems 2006-2009. Anaerobe (2011) 1.36

Effect of short-term fasting on lipolytic responsiveness in normal and obese human subjects. Am J Physiol (1987) 1.26

Substrate metabolism during different exercise intensities in endurance-trained women. J Appl Physiol (1985) (2000) 1.21

HCV testing in low-risk population. Lancet (1990) 1.14

Actin, cofilin and cognition. Nature (1998) 1.14

Assessment of the mathematical issues involved in measuring the fractional synthesis rate of protein using the flooding dose technique. Clin Sci (Lond) (1993) 1.14

Evaluation of virulence of Mycoplasma hyopneumoniae field isolates. Vet Microbiol (2003) 1.12

Effect of high pressure, detergents and phospholipase on the break in the Arrhenius plot of Azotobacter nitrogenase. Eur J Biochem (1978) 1.09

High-speed, three-dimensional kinematic analysis of the normal wrist. J Hand Surg Am (1998) 1.09

Efficient and sustained gene expression in primary T lymphocytes and primary and cultured tumor cells mediated by adeno-associated virus plasmid DNA complexed to cationic liposomes. Mol Cell Biol (1994) 1.08

Alterations of the mineralization profile and osteocalcin concentrations in osteoarthritic cortical iliac crest bone. Calcif Tissue Int (1992) 1.05

The influence of familial and hereditary factors on the prognosis of breast cancer. Ann Oncol (1999) 1.05

Evaluation of oral fenoterol in chronic asthmatic patients. Chest (1978) 1.04

Defective lentiviral vectors are efficiently trafficked by HIV-1 and inhibit its replication. Mol Ther (2001) 1.03

Estrogen receptor status as a prognostic indicator for stage I breast cancer patients. Breast Cancer Res Treat (1982) 1.02

A multiplex PCR to identify porcine mycoplasmas present in broth cultures. Vet Res Commun (2006) 1.01

Serological identification of viral antigens after electrophoretic transfer. J Immunol Methods (1981) 0.98

Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis. Rheumatology (Oxford) (2005) 0.96

Itraconazole formulation studies of the melt-extrusion process with mixture design. Drug Dev Ind Pharm (2003) 0.95

Genotype by environment interactions in viability and developmental time in populations of cactophilic Drosophila. J Evol Biol (2006) 0.94

The use of human nasal in vitro cell systems during drug discovery and development. Toxicol In Vitro (2005) 0.92

Identification of virus-like particles in Eimeria stiedae. Mol Biochem Parasitol (1989) 0.92

Creating a sense of family in urban schools using the "sport for peace" curriculum. Res Q Exerc Sport (1999) 0.91

Patterns of Mycoplasma hyopneumoniae infections in Belgian farrow-to-finish pig herds with diverging disease-course. J Vet Med B Infect Dis Vet Public Health (2002) 0.91

Body size in Drosophila: genetic architecture, allometries and sexual dimorphism. Heredity (Edinb) (2008) 0.90

Cerebrospinal fluid proteins in neurology. Int Rev Neurobiol (1984) 0.90

Absorption of volatile fatty acids from the rumen of lactating dairy cows as influenced by volatile fatty acid concentration, pH and rumen liquid volume. Br J Nutr (1993) 0.90

Cellular composition of primary cultures from cerebral cortex, striatum, hippocampus, brainstem and cerebellum. Brain Res (1984) 0.89

Isotopic determination of fibronectin synthesis in humans. Metabolism (1991) 0.89

[Prenatal intestinal volvulus: A life-threatening event with good long-term outcome]. Arch Pediatr (2012) 0.88

Comparison of mass isotopomer dilution methods used to compute VLDL production in vivo. Am J Physiol (1996) 0.88

The contribution of inherited factors to the clinicopathological features and behavior of breast cancer. J Mammary Gland Biol Neoplasia (2001) 0.88

MR imaging in retinoblastoma. Eur Radiol (1997) 0.87

Inhibition of antibody-dependent cellular cytotoxicity by protein A from Staphylococcus aureus. J Immunol (1977) 0.87

Low levels of 25-hydroxyvitamin D before allogeneic hematopoietic SCT correlate with the development of chronic GVHD. Bone Marrow Transplant (2012) 0.87

Chelator-based catheter lock solutions in eradicating organisms in biofilm. Antimicrob Agents Chemother (2012) 0.86

Intestinal uptake and biodistribution of novel polymeric micelles after oral administration. J Control Release (2006) 0.86

A transcriptional switch between the Pig-1 and Sgs-4 genes of Drosophila melanogaster. Mol Cell Biol (1993) 0.85

In vitro susceptibilities of Mycoplasma hyopneumoniae field isolates. Antimicrob Agents Chemother (2004) 0.85

Polymorphisms of the VDR, ER and COLIA1 genes and osteoporotic hip fracture in elderly postmenopausal women. Osteoporos Int (2000) 0.85

The gas-phase ozonolysis of beta-caryophyllene (C(15)H(24)). Part II: A theoretical study. Phys Chem Chem Phys (2009) 0.85

Decomposition of substituted alkoxy radicals--part I: a generalized structure-activity relationship for reaction barrier heights. Phys Chem Chem Phys (2009) 0.84

Physiology of Aspergillus niger in oxygen-limited continuous cultures: Influence of aeration, carbon source concentration and dilution rate. Biotechnol Bioeng (2009) 0.84

Human gene marker/therapy clinical protocols. Hum Gene Ther (2000) 0.84

Lack of association between osteoarthritis of the hip and gene polymorphisms of VDR, COL1A1, and COL2A1 in postmenopausal women. Arthritis Rheum (1998) 0.83

Transport mechanisms of mmePEG750P(CL-co-TMC) polymeric micelles across the intestinal barrier. J Control Release (2007) 0.83

Recurrence of pulmonary embolism during anticoagulant treatment: a prospective study. Thorax (1987) 0.83

Schedule-dependent pulsed paclitaxel radiosensitization for thoracic malignancy. Am J Clin Oncol (2001) 0.83

Fetal intracerebral hemorrhage and COL4A1 mutation: promise and uncertainty. Ultrasound Obstet Gynecol (2013) 0.83

The effect of electrostatic charge interactions on release rates of gentamicin from collagen matrices. Pharm Res (1995) 0.83

Visualization of intracranial translucency at the 11-13-week scan is improved after specific training. Ultrasound Obstet Gynecol (2011) 0.82

[Prenatal diagnosis of cleft lip with or without cleft palate: retrospective study and review]. J Gynecol Obstet Biol Reprod (Paris) (2012) 0.82

Prediction of drug solubility in amphiphilic di-block copolymer micelles: the role of polymer-drug compatibility. Pharmazie (2007) 0.81

Low-volatility poly-oxygenates in the OH-initiated atmospheric oxidation of alpha-pinene: impact of non-traditional peroxyl radical chemistry. Phys Chem Chem Phys (2007) 0.81

Increased GFAp levels in CSF as a marker of organicity in patients with Alzheimer's disease and other types of irreversible chronic organic brain syndrome. J Neurol (1986) 0.81

Resistance mechanism against fluoroquinolones in Mycoplasma hyopneumoniae field isolates. Microb Drug Resist (2007) 0.81

Parallel artificial membrane permeability assay (PAMPA) combined with a 10-day multiscreen Caco-2 cell culture as a tool for assessing new drug candidates. Pharmazie (2008) 0.80

Determination in human cerebrospinal fluid of glial fibrillary acidic protein, S-100 and myelin basic protein as indices of non-specific or specific central nervous tissue pathology. Clin Chim Acta (1986) 0.80

A theoretical study of the OH-initiated gas-phase oxidation mechanism of β-pinene (C10H16): first generation products. Phys Chem Chem Phys (2012) 0.80

Determination of ionization constants in mixed aqueous solvents of varying composition by a single titration. J Pharm Sci (1978) 0.80

Glucose kinetics in interstitial fluid can be predicted by compartmental modeling. Am J Physiol (1997) 0.80

Characterization of glassy itraconazole: a comparative study of its molecular mobility below T(g) with that of structural analogues using MTDSC. Int J Pharm (2001) 0.79

Delipidated serum abolishes the inhibitory effect of serum on in vitro liposome-mediated transfection. Biochim Biophys Acta (2001) 0.79

Identification of several forms of the glial fibrillary acidic protein, or alpha-albumin, by a specific monoclonal antibody. J Neurochem (1984) 0.79

Glial cells identified by anti-alpha-albumin (anti-GFA) in human pineal gland. J Neurochem (1982) 0.79

[Problems and needs of informal caregivers of persons with dementia: a comparison between the initial stage and subsequent stages of the illness process]. Tijdschr Gerontol Geriatr (2010) 0.79

Abstracts of the 6th FECS Conference 1998 Lectures. Environ Sci Pollut Res Int (1998) 0.79

Supersaturating drug delivery systems: effect of hydrophilic cyclodextrins and other excipients on the formation and stabilization of supersaturated drug solutions. Pharmazie (2008) 0.79

Ypel1: a novel nuclear protein that induces an epithelial-like morphology in fibroblasts. Genes Cells (2001) 0.78

Kinetic parameters for gas-phase reactions: experimental and theoretical challenges. Phys Chem Chem Phys (2007) 0.78

Composition of fresh frozen plasma. Crit Care Med (1986) 0.78

Characterization of self-assembling copolymers in aqueous solutions using Electron Paramagnetic Resonance and Fluorescence spectroscopy. J Control Release (2006) 0.78

Deletion of frizzled-related protein reduces voluntary running exercise performance in mice. Osteoarthritis Cartilage (2008) 0.78

Passage rate and total clearance rate from the rumen of cows fed on grass silages differing in cell-wall content. Br J Nutr (1995) 0.78

Inferior outcome of cadaveric kidneys preserved for more than 24 hr in histidine-tryptophan-ketoglutarate solution. Leuven Collaborative Group for Transplantation. Transplantation (1998) 0.78

Plasma-cell dyscrasia following prolonged stimulation of reticuloendothelial system. Lancet (1970) 0.78

Theoretical study of the gas-phase ozonolysis of beta-pinene (C10H16). Phys Chem Chem Phys (2009) 0.78