Published in Proc Natl Acad Sci U S A on August 01, 1990
Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Proc Natl Acad Sci U S A (1997) 6.09
Equilibrium centrifugation studies of hepatitis C virus: evidence for circulating immune complexes. J Virol (1993) 4.13
Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc Natl Acad Sci U S A (1994) 3.56
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. Proc Natl Acad Sci U S A (1995) 3.20
Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection. J Virol (2003) 2.60
The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae. J Gen Virol (2010) 2.26
Improved serodiagnosis of hepatitis C virus infection with synthetic peptide antigen from capsid protein. Proc Natl Acad Sci U S A (1991) 1.81
Effects of anticoagulants and storage of blood samples on efficacy of the polymerase chain reaction assay for hepatitis C virus. J Clin Microbiol (1992) 1.73
Nonstructural protein precursor NS4A/B from hepatitis C virus alters function and ultrastructure of host secretory apparatus. J Virol (2003) 1.62
Detection of intrahepatic replication of hepatitis C virus RNA by in situ hybridization and comparison with histopathology. Proc Natl Acad Sci U S A (1992) 1.56
Hepatitis C: progress and problems. Clin Microbiol Rev (1994) 1.37
A unique, predominant hepatitis C virus variant found in an infant born to a mother with multiple variants. J Virol (1993) 1.23
Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models. J Infect Dis (2010) 1.21
Detection of hepatitis C virus RNA by a combined reverse transcription PCR assay: comparison with nested amplification and antibody testing. J Clin Microbiol (1995) 1.20
Hypervariable region 1 sequence stability during hepatitis C virus replication in chimpanzees. J Virol (2000) 1.18
Characterization of long-term cultures of hepatitis C virus. J Virol (1996) 1.18
Sequence analysis of the hepatitis C virus genome recovered from serum, liver, and peripheral blood mononuclear cells of infected chimpanzees. J Virol (1997) 1.17
Detection of genomic and intermediate replicative strands of hepatitis C virus in liver tissue by in situ hybridization. J Clin Invest (1993) 1.17
Polymerase chain reaction for the diagnosis of viral hepatitis B and C. Gut (1993) 1.11
The physical state of the negative strand of hepatitis C virus RNA in serum of patients with chronic hepatitis C. Proc Natl Acad Sci U S A (1994) 1.08
Serological markers of posttransfusion hepatitis C viral infection. J Clin Microbiol (1992) 1.04
Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation. Nucleic Acids Res (2008) 1.02
Detection of replicative hepatitis C virus sequences in hepatocellular carcinoma. Am J Pathol (1992) 0.95
Cryoglobulinemia related to hepatitis C virus infection. Dig Dis Sci (2007) 0.90
Hepatitis C virus-induced cytoplasmic organelles use the nuclear transport machinery to establish an environment conducive to virus replication. PLoS Pathog (2013) 0.88
Optimal induction of T-cell responses against hepatitis C virus E2 by antigen engineering in DNA immunization. J Virol (2003) 0.87
Viral markers in the treatment of hepatitis B and C. Gut (1993) 0.86
Detection of the hepatitis C virus genome in acute and chronic experimental infection in chimpanzees. J Clin Microbiol (1991) 0.83
Chronic liver disease and active hepatitis C virus infection in patients with antibodies to this virus. J Clin Pathol (1994) 0.83
HCV animal models: a journey of more than 30 years. Viruses (2009) 0.78
Transfusion transmission of HCV, a long but successful road map to safety. Antivir Ther (2012) 0.78
Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain HCV-RMT. PLoS One (2013) 0.75
Infection of Common Marmosets with GB Virus B Chimeric Virus Encoding the Major Nonstructural Proteins NS2 to NS4A of Hepatitis C Virus. J Virol (2016) 0.75
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science (1989) 37.89
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science (1989) 18.79
Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc Natl Acad Sci U S A (1990) 8.92
Detection of hepatitis C viral sequences in non-A, non-B hepatitis. Lancet (1990) 8.56
Hepatitis C virus: the major causative agent of viral non-A, non-B hepatitis. Br Med Bull (1990) 4.16
Non-A, non-B hepatitis in chimpanzees and marmosets. J Infect Dis (1981) 4.15
Transmissible agent in non-A, non-B hepatitis. Lancet (1978) 2.78
Non-A, non-B hepatitis: ultrastructural evidence for two agents in experimentally infected chimpanzees. Science (1979) 2.78
Determining the size of non-A, non-B hepatitis virus by filtration. J Infect Dis (1987) 2.68
Inactivation of hepatitis B virus and non-A, non-B hepatitis by chloroform. Infect Immun (1983) 1.35
Posttransfusion non-A, non-B hepatitis: physicochemical properties of two distinct agents. J Infect Dis (1983) 1.32
Production of antibody associated with non-A, non-B hepatitis in a chimpanzee lymphoblastoid cell line established by in vitro transformation with Epstein-Barr virus. Proc Natl Acad Sci U S A (1985) 1.32
Cytoplasmic antigen in hepatocytes of chimpanzees infected with non-A, non-B hepatitis virus or hepatitis delta virus: relationship to interferon. Hepatology (1989) 1.21
Further studies by immunofluorescence of the monoclonal antibodies associated with experimental non-A, non-B hepatitis in chimpanzees and their relation to D hepatitis. Hepatology (1987) 1.11
Cytoplasmic tubular structures in liver of HBsAg carrier chimpanzees infected with delta agent and comparison with cytoplasmic structures in non-A, non-B hepatitis. Hepatology (1983) 0.95
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science (1989) 37.89
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science (1989) 18.79
Binding of hepatitis C virus to CD81. Science (1998) 12.40
DNA polymerase associated with human hepatitis B antigen. J Virol (1973) 10.71
Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc Natl Acad Sci U S A (1990) 8.92
Detection of hepatitis C viral sequences in non-A, non-B hepatitis. Lancet (1990) 8.56
Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med (1989) 8.10
Structure, sequence and expression of the hepatitis delta (delta) viral genome. Nature (1986) 7.38
Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States. Arch Gen Psychiatry (2001) 7.30
Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end. Proc Natl Acad Sci U S A (1991) 7.13
Viral clearance without destruction of infected cells during acute HBV infection. Science (1999) 6.78
Analysis of a successful immune response against hepatitis C virus. Immunity (1999) 6.31
A colour test for the measurement of antibody to certain mycoplasma species based upon the inhibition of acid production. J Hyg (Lond) (1966) 6.23
Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Proc Natl Acad Sci U S A (1997) 6.09
A novel virus in swine is closely related to the human hepatitis E virus. Proc Natl Acad Sci U S A (1997) 6.07
Protective effect of antibody to parainfluenza type 1 virus. N Engl J Med (1966) 5.97
Color test for the measurement of antibody to T-strain mycoplasmas. J Bacteriol (1966) 5.61
Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes. Semin Liver Dis (1995) 5.53
Nucleotide sequence and mutation rate of the H strain of hepatitis C virus. Proc Natl Acad Sci U S A (1991) 5.51
The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. Science (2000) 5.49
Crystal structure of cyclin-dependent kinase 2. Nature (1993) 5.21
delta Agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees. Proc Natl Acad Sci U S A (1980) 5.12
An African primate lentivirus (SIVsm) closely related to HIV-2. Nature (1989) 5.03
Lack of protective immunity against reinfection with hepatitis C virus. Science (1992) 4.94
Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc Natl Acad Sci U S A (1996) 4.82
A long-term study of hepatitis C virus replication in non-A, non-B hepatitis. N Engl J Med (1991) 4.79
Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science (1998) 4.74
A virus discovery method incorporating DNase treatment and its application to the identification of two bovine parvovirus species. Proc Natl Acad Sci U S A (2001) 4.62
Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila. Proc Natl Acad Sci U S A (1984) 4.59
The molecular organization of the Antennapedia locus of Drosophila. Cell (1983) 4.50
Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses. J Virol (1987) 4.49
Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology (1991) 4.47
Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology (1990) 4.43
The hippocampus, memory, and place cells: is it spatial memory or a memory space? Neuron (1999) 4.36
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan. Nucleic Acids Res (1989) 4.29
Transmission of the hepatitis B virus-associated delta antigen to chimpanzees. J Infect Dis (1980) 4.28
Hepatitis C in hospital employees with needlestick injuries. Ann Intern Med (1991) 4.24
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J (1992) 4.21
Hepatitis C virus: the major causative agent of viral non-A, non-B hepatitis. Br Med Bull (1990) 4.16
Non-A, non-B hepatitis in chimpanzees and marmosets. J Infect Dis (1981) 4.15
Equilibrium centrifugation studies of hepatitis C virus: evidence for circulating immune complexes. J Virol (1993) 4.13
Control of fatty acid metabolism. I. Induction of the enzymes of fatty acid oxidation in Escherichia coli. J Bacteriol (1969) 4.12
Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J Clin Invest (1996) 4.10
Hepatitis C virus: an infectious molecular clone of a second major genotype (2a) and lack of viability of intertypic 1a and 2a chimeras. Virology (1999) 4.04
A proposed system for the nomenclature of hepatitis C viral genotypes. Hepatology (1994) 4.01
Confirmation of hepatitis C virus infection by new four-antigen recombinant immunoblot assay. Lancet (1991) 3.97
Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries. J Clin Microbiol (2002) 3.83
Genetic and experimental evidence for cross-species infection by swine hepatitis E virus. J Virol (1998) 3.73
Sequence analysis of the 5' noncoding region of hepatitis C virus. Proc Natl Acad Sci U S A (1992) 3.72
Diagnosing small bowel Crohn's disease with wireless capsule endoscopy. Gut (2003) 3.69
Detection of serum hepatitis B virus DNA in patients with chronic hepatitis using the polymerase chain reaction assay. Proc Natl Acad Sci U S A (1989) 3.67
Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc Natl Acad Sci U S A (1994) 3.56
Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line. Proc Natl Acad Sci U S A (1992) 3.55
A microtiter solid-phase radioimmunoassay for hepatitis A antigen and antibody. J Immunol (1976) 3.53
The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes. Immunity (2001) 3.52
Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. J Clin Invest (1995) 3.47
Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. Lancet (1989) 3.42
Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts. Cell (1994) 3.42
At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide. Proc Natl Acad Sci U S A (1993) 3.37
Transfusion-associated hepatitis not due to viral hepatitis type A or B. N Engl J Med (1975) 3.31
Epidemic and endemic hepatitis in India: evidence for a non-A, non-B hepatitis virus aetiology. Lancet (1980) 3.31
Australia antigen: large-scale purification from human serum and biochemical studies of its proteins. J Virol (1971) 3.28
A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc Natl Acad Sci U S A (1996) 3.25
Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS. Science (1984) 3.20
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. Proc Natl Acad Sci U S A (1995) 3.20
Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome. J Gen Virol (1993) 3.18
Propagation of human hepatitis A virus in African green monkey kidney cell culture: primary isolation and serial passage. Infect Immun (1981) 3.18
Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J Immunol (1992) 3.13
Access of vulnerable groups to antiretroviral therapy among persons in care for HIV disease in the United States. HCSUS Consortium. HIV Cost and Services Utilization Study. Health Serv Res (2000) 3.09
Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses. J Virol (1994) 3.06