Published in Eur Biophys J on June 25, 2004
Influenza virus M2 protein mediates ESCRT-independent membrane scission. Cell (2010) 4.33
Genomic signatures of human versus avian influenza A viruses. Emerg Infect Dis (2006) 3.51
Membrane organization and lipid rafts. Cold Spring Harb Perspect Biol (2011) 2.98
Influenza virus assembly and budding. Virology (2011) 2.90
Distinct domains of the influenza a virus M2 protein cytoplasmic tail mediate binding to the M1 protein and facilitate infectious virus production. J Virol (2006) 2.18
The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding. J Virol (2008) 2.12
The cytoplasmic tail of the influenza A virus M2 protein plays a role in viral assembly. J Virol (2006) 2.07
Influenza virus morphogenesis and budding. Virus Res (2009) 2.07
Influenza virus m2 ion channel protein is necessary for filamentous virion formation. J Virol (2010) 1.73
Immobilization of the influenza A M2 transmembrane peptide in virus envelope-mimetic lipid membranes: a solid-state NMR investigation. Biochemistry (2009) 1.54
NMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel. J Am Chem Soc (2011) 1.53
Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane. J Cell Biol (2012) 1.44
Membrane-dependent effects of a cytoplasmic helix on the structure and drug binding of the influenza virus M2 protein. J Am Chem Soc (2011) 1.29
Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis. Virol J (2009) 1.18
Influenza A: understanding the viral life cycle. Yale J Biol Med (2009) 1.17
Lipid raft disruption by cholesterol depletion enhances influenza A virus budding from MDCK cells. J Virol (2007) 1.15
Association of influenza virus proteins with membrane rafts. Adv Virol (2011) 1.04
NMR determination of protein partitioning into membrane domains with different curvatures and application to the influenza M2 peptide. Biophys J (2012) 1.04
Helical membrane protein conformations and their environment. Eur Biophys J (2013) 0.99
A comprehensive map of the influenza A virus replication cycle. BMC Syst Biol (2013) 0.93
Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein. Protein Sci (2013) 0.92
Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors. Annu Rev Biochem (2011) 0.92
Viral membrane scission. Annu Rev Cell Dev Biol (2013) 0.92
The cholesterol recognition/interaction amino acid consensus motif of the influenza A virus M2 protein is not required for virus replication but contributes to virulence. Virology (2010) 0.91
Structural Influences: Cholesterol, Drug, and Proton Binding to Full-Length Influenza A M2 Protein. Biophys J (2016) 0.86
Mutations in the membrane-proximal region of the influenza A virus M2 protein cytoplasmic tail have modest effects on virus replication. J Virol (2011) 0.85
Intrinsic cytoskeleton-dependent clustering of influenza virus M2 protein with hemagglutinin assessed by FLIM-FRET. J Virol (2010) 0.85
Inhibition of influenza M2-induced cell death alleviates its negative contribution to vaccination efficiency. PLoS One (2008) 0.84
Function of membrane rafts in viral lifecycles and host cellular response. Biochem Res Int (2011) 0.82
Caveolin-1 influences human influenza A virus (H1N1) multiplication in cell culture. Virol J (2010) 0.82
Protein-lipid interactions critical to replication of the influenza A virus. FEBS Lett (2016) 0.82
In silico investigations of possible routes of assembly of ORF 3a from SARS-CoV. J Mol Model (2011) 0.81
Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation. PLoS Pathog (2015) 0.78
Cholesterol-Dependent Conformational Exchange of the C-Terminal Domain of the Influenza A M2 Protein. Biochemistry (2015) 0.78
Susceptibility of outer hair cells to cholesterol chelator 2-hydroxypropyl-β-cyclodextrine is prestin-dependent. Sci Rep (2016) 0.78
Combined effect of cortical cytoskeleton and transmembrane proteins on domain formation in biomembranes. J Chem Phys (2014) 0.78
Elucidation of the Rotavirus NSP4-Caveolin-1 and -Cholesterol Interactions Using Synthetic Peptides. J Amino Acids (2012) 0.76
Lateral Organization of Influenza Virus Proteins in the Budozone Region of the Plasma Membrane. J Virol (2017) 0.75
Cell Cycle-independent Role of Cyclin D3 in Host Restriction of Influenza Virus Infection. J Biol Chem (2017) 0.75
Construction and characterization of insect cell-derived influenza VLP: cell binding, fusion, and EGFP incorporation. J Biomed Biotechnol (2010) 0.75
Host cellular protein TRAPPC6AΔ interacts with influenza A virus M2 protein and regulates viral propagation by modulating M2 trafficking. J Virol (2016) 0.75
A rapid method of total lipid extraction and purification. Can J Biochem Physiol (1959) 173.74
A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65
Functional rafts in cell membranes. Nature (1997) 38.89
Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell (1992) 17.81
Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol (1998) 14.83
Membrane protein folding and stability: physical principles. Annu Rev Biophys Biomol Struct (1999) 10.13
Lipid domain structure of the plasma membrane revealed by patching of membrane components. J Cell Biol (1998) 8.91
Influenza virus M2 protein has ion channel activity. Cell (1992) 8.52
Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell (1985) 6.44
Cholesterol modification of hedgehog signaling proteins in animal development. Science (1996) 5.66
Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior. Proc Natl Acad Sci U S A (1994) 5.61
Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. EMBO J (1997) 5.52
Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions. J Virol (1988) 5.31
Influenza viruses select ordered lipid domains during budding from the plasma membrane. J Biol Chem (1999) 4.83
VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. J Cell Biol (1992) 4.81
Structural characteristics of the M2 protein of influenza A viruses: evidence that it forms a tetrameric channel. Virology (1991) 4.77
Cholesterol is required for surface transport of influenza virus hemagglutinin. J Cell Biol (1998) 4.35
Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci U S A (2000) 4.14
VIP21/caveolin is a cholesterol-binding protein. Proc Natl Acad Sci U S A (1995) 3.97
Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds. Virology (1991) 3.83
Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated. J Biol Chem (1999) 3.81
Virus maturation by budding. Microbiol Mol Biol Rev (1998) 3.78
Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis. Cell (1990) 3.75
Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles. Nat Cell Biol (2000) 3.55
Influenza virus assembly and lipid raft microdomains: a role for the cytoplasmic tails of the spike glycoproteins. J Virol (2000) 3.39
Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape. EMBO J (1997) 3.23
Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue. Biophys J (1995) 3.06
Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells. J Physiol (1996) 3.03
Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture. J Virol (2002) 2.97
Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem (1998) 2.95
Specific structural alteration of the influenza haemagglutinin by amantadine. EMBO J (1990) 2.93
Inhibition of uncoating of fowl plague virus by l-adamantanamine hydrochloride. Virology (1969) 2.91
Modulation of phospholipid acyl chain order by cholesterol. A solid-state 2H nuclear magnetic resonance study. Biochemistry (1990) 2.90
Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells. Biochemistry (1993) 2.84
Cholesterol and sphingolipid enhance the Triton X-100 insolubility of glycosylphosphatidylinositol-anchored proteins by promoting the formation of detergent-insoluble ordered membrane domains. J Biol Chem (1998) 2.78
Differential extractability of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and nonpolar fibroblasts. J Cell Biol (1989) 2.75
An investigation of the role of transmembrane domains in Golgi protein retention. EMBO J (1995) 2.71
Characterization of the influenza virus M2 integral membrane protein and expression at the infected-cell surface from cloned cDNA. J Virol (1985) 2.58
Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology (1998) 2.54
Influenza virus matrix protein is the major driving force in virus budding. J Virol (2000) 2.49
Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers. Protein Sci (2003) 2.43
The M1 and M2 proteins of influenza A virus are important determinants in filamentous particle formation. Virology (1998) 2.43
Measles virus structural components are enriched into lipid raft microdomains: a potential cellular location for virus assembly. J Virol (2000) 2.40
Influenza virus M2 protein ion channel activity stabilizes the native form of fowl plague virus hemagglutinin during intracellular transport. J Virol (1994) 2.31
Evidence that the amantadine-induced, M2-mediated conversion of influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans Golgi compartment. Virology (1992) 2.25
Definitive assignment of proton selectivity and attoampere unitary current to the M2 ion channel protein of influenza A virus. J Virol (2001) 2.22
The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer. Proc Natl Acad Sci U S A (1997) 2.19
Rescue of vector-expressed fowl plague virus hemagglutinin in biologically active form by acidotropic agents and coexpressed M2 protein. J Virol (1994) 2.17
The transmembrane domain of influenza hemagglutinin exhibits a stringent length requirement to support the hemifusion to fusion transition. J Cell Biol (2000) 2.13
Topology of eukaryotic type II membrane proteins: importance of N-terminal positively charged residues flanking the hydrophobic domain. Cell (1991) 2.11
Formation of wild-type and chimeric influenza virus-like particles following simultaneous expression of only four structural proteins. J Virol (2001) 2.04
Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly. Biochemistry (1999) 2.02
The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels. J Virol (1996) 2.01
Maturation of influenza A virus hemagglutinin--estimates of the pH encountered during transport and its regulation by the M2 protein. Virology (1992) 1.98
Transmembrane domain of influenza virus neuraminidase, a type II protein, possesses an apical sorting signal in polarized MDCK cells. J Virol (1996) 1.95
Nuclear import and export of viruses and virus genomes. Virology (1998) 1.91
Permeation and activation of the M2 ion channel of influenza A virus. J Biol Chem (2000) 1.90
Mutations in the middle of the transmembrane domain reverse the polarity of transport of the influenza virus hemagglutinin in MDCK epithelial cells. J Cell Biol (1998) 1.89
Role of the membrane-proximal domain in the initial stages of human immunodeficiency virus type 1 envelope glycoprotein-mediated membrane fusion. J Virol (1999) 1.89
Characterization of the membrane association of the influenza virus matrix protein in living cells. Virology (1996) 1.87
Ectoenzymes of the kidney microvillar membrane. Differential solubilization by detergents can predict a glycosyl-phosphatidylinositol membrane anchor. Biochem J (1988) 1.85
The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus. J Cell Biol (1996) 1.83
Oligomerization of VIP21-caveolin in vitro is stabilized by long chain fatty acylation or cholesterol. FEBS Lett (1996) 1.82
Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proc Natl Acad Sci U S A (2003) 1.82
Host cell dependence of viral morphology. Proc Natl Acad Sci U S A (1998) 1.78
Studies of influenza haemagglutinin-mediated membrane fusion. Virology (1986) 1.78
Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains. J Biol Chem (1999) 1.75
Lipid rafts and pseudotyping. J Virol (2001) 1.75
Growth restriction of influenza A virus by M2 protein antibody is genetically linked to the M1 protein. Proc Natl Acad Sci U S A (1989) 1.69
Implications of lipid microdomains for membrane curvature, budding and fission. Curr Opin Cell Biol (2001) 1.67
Do lipid rafts mediate virus assembly and pseudotyping? J Gen Virol (2003) 1.67
Analysis of the posttranslational modifications of the influenza virus M2 protein. J Virol (1995) 1.65
Membrane interaction of influenza virus M1 protein. Virology (2000) 1.63
Regulation of pH by the M2 protein of influenza A viruses. Virus Res (1992) 1.63
The cytoplasmic tails of the influenza virus spike glycoproteins are required for normal genome packaging. Virology (2000) 1.61
Functional reconstitution in lipid vesicles of influenza virus M2 protein expressed by baculovirus: evidence for proton transfer activity. J Gen Virol (1994) 1.60
Membrane interface-interacting sequences within the ectodomain of the human immunodeficiency virus type 1 envelope glycoprotein: putative role during viral fusion. J Virol (2000) 1.58
Cholesterol binding at the cholesterol recognition/ interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide. Proc Natl Acad Sci U S A (2001) 1.57
Transport of viral proteins to the apical membranes and interaction of matrix protein with glycoproteins in the assembly of influenza viruses. Virus Res (2001) 1.56
Two strains of the Madin-Darby canine kidney (MDCK) cell line have distinct glycosphingolipid compositions. EMBO J (1986) 1.55
Association of influenza virus NP and M1 proteins with cellular cytoskeletal elements in influenza virus-infected cells. J Virol (1997) 1.54
The role of nuclear import and export in influenza virus infection. Trends Cell Biol (1996) 1.52
Acylation of viral spike glycoproteins: a feature of enveloped RNA viruses. Virology (1982) 1.52
Palmitoylation of the influenza A virus M2 protein. Virology (1990) 1.51
Expression of the influenza A virus M2 protein is restricted to apical surfaces of polarized epithelial cells. J Virol (1992) 1.42
Fluorometric investigations of the interaction of polyene antibiotics with sterols. Biochemistry (1972) 1.42
Palmitylation of the influenza virus hemagglutinin (H3) is not essential for virus assembly or infectivity. J Virol (1996) 1.41
Lipid composition of Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) insect cells used for baculovirus infection. FEBS Lett (1998) 1.38
Transmembrane orientation of hydrophobic alpha-helices is regulated both by the relationship of helix length to bilayer thickness and by the cholesterol concentration. Biochemistry (1997) 1.36
Effects of antibody to the influenza A virus M2 protein on M2 surface expression and virus assembly. Virology (1995) 1.35
Viral ion channels: structure and function. Biochim Biophys Acta (2002) 1.31
Sphingomyelin and cholesterol promote HIV-1 gp41 pretransmembrane sequence surface aggregation and membrane restructuring. J Biol Chem (2002) 1.31
Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low-density membrane domains in the absence of caveolin. Biochem Biophys Res Commun (1998) 1.30
Interaction of Sendai viral F, HN, and M proteins with host cytoskeletal and lipid components in Sendai virus-infected BHK cells. Virology (1995) 1.27
Hydrophobic mismatch and the incorporation of peptides into lipid bilayers: a possible mechanism for retention in the Golgi. Biochemistry (1998) 1.25
Identification of a conserved domain of the HIV-1 transmembrane protein gp41 which interacts with cholesteryl groups. Biochim Biophys Acta (2002) 1.22
Biosynthesis of the influenza virus envelope in abortive infection. J Gen Virol (1979) 1.22
Interaction of PIP(2) with the XIP region of the cardiac Na/Ca exchanger. Am J Physiol Cell Physiol (2000) 1.15
In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435. Antimicrob Agents Chemother (2010) 2.28
Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target. Angew Chem Int Ed Engl (2010) 1.19
Tracking the evolution of multiple in vitro hepatitis C virus replicon variants under protease inhibitor selection pressure by 454 deep sequencing. J Virol (2010) 1.17
Cell targeting by a generic receptor-targeted polymer nanocontainer platform. J Control Release (2005) 1.11
Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors. Gastroenterology (2008) 1.07
Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett (2008) 1.06
Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor. Biochemistry (2010) 1.00
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase. Bioorg Med Chem Lett (2009) 0.97
Inactivation of Hantaan virus-containing samples for subsequent investigations outside biosafety level 3 facilities. Intervirology (2005) 0.95
Type III restriction endonuclease EcoP15I is a heterotrimeric complex containing one Res subunit with several DNA-binding regions and ATPase activity. Nucleic Acids Res (2011) 0.87
Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors. Bioorg Med Chem Lett (2008) 0.83
Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem (2013) 0.81
2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem (2010) 0.81
Unravelling the interaction of human cytomegalovirus with dendritic cells by using SuperSAGE. J Gen Virol (2009) 0.81
Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors. Bioorg Med Chem Lett (2008) 0.81
TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage. Antimicrob Agents Chemother (2012) 0.80
A novel method for cloning of non-cytolytic viruses. J Virol Methods (2006) 0.80
Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase. Antimicrob Agents Chemother (2011) 0.79
Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties. Angew Chem Int Ed Engl (2012) 0.79
Molecular analysis of restriction endonuclease EcoRII from Escherichia coli reveals precise regulation of its enzymatic activity by autoinhibition. Mol Microbiol (2009) 0.78
Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituents. Bioorg Med Chem Lett (2010) 0.78
Development of a high-content screening assay to identify compounds interfering with the formation of the hepatitis C virus replication complex. J Virol Methods (2010) 0.78
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055. Bioorg Med Chem Lett (2012) 0.78
Functional consequences of mutating conserved SF2 helicase motifs in the Type III restriction endonuclease EcoP15I translocase domain. Biochimie (2012) 0.77
Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase. J Med Chem (2014) 0.76
Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication. Bioorg Med Chem Lett (2012) 0.76
The natural diyne-furan fatty acid EV-086 is an inhibitor of fungal delta-9 fatty acid desaturation with efficacy in a model of skin dermatophytosis. Antimicrob Agents Chemother (2013) 0.75
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series. Bioorg Med Chem Lett (2012) 0.75
Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors. Bioorg Med Chem Lett (2007) 0.75