Published in ILAR J on January 01, 2004
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Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes. Nat Med (2012) 2.48
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Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model. ISME J (2009) 1.74
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Myogenic tone and reactivity of cerebral arteries in type II diabetic BBZDR/Wor rat. Eur J Pharmacol (2007) 1.06
Virus infections in type 1 diabetes. Cold Spring Harb Perspect Med (2012) 1.01
Developing tTA transgenic rats for inducible and reversible gene expression. Int J Biol Sci (2009) 1.00
The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Diabetes (2005) 0.98
Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex. Diabetes (2009) 0.96
Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats. Autoimmunity (2010) 0.93
CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. PLoS One (2009) 0.92
Immunotherapy for the prevention and treatment of type 1 diabetes: optimizing the path from bench to bedside. Diabetes Care (2009) 0.90
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Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene. Physiol Genomics (2009) 0.88
Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats. Genes Immun (2011) 0.88
Development of standardized insulin treatment protocols for spontaneous rodent models of type 1 diabetes. Comp Med (2012) 0.86
Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats. Physiol Genomics (2009) 0.85
Genes mediating environment interactions in type 1 diabetes. Rev Diabet Stud (2006) 0.82
Salicylate prevents virus-induced type 1 diabetes in the BBDR rat. PLoS One (2013) 0.81
Human C-reactive protein accentuates macrophage activity in biobreeding diabetic rats. J Diabetes Complications (2012) 0.81
Innate inflammation in type 1 diabetes. Transl Res (2015) 0.80
Targeting the trimolecular complex. Clin Immunol (2013) 0.80
Exercise-induced cardiac performance in autoimmune (type 1) diabetes is associated with a decrease in myocardial diacylglycerol. J Appl Physiol (1985) (2012) 0.79
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Current status and patent prospective of animal models in diabetic research. Adv Biomed Res (2015) 0.77
Variable immune cell frequencies in peripheral blood of LEW.1AR1-iddm rats over time compared to other congenic LEW strains. Clin Exp Immunol (2014) 0.77
Diabetes in Danish bank voles (M. glareolus): survivorship, influence on weight, and evaluation of polydipsia as a screening tool for hyperglycaemia. PLoS One (2011) 0.76
Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model. PLoS One (2013) 0.76
Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats. Genes Immun (2014) 0.76
Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model. PLoS One (2017) 0.75
Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue. Stem Cell Res Ther (2017) 0.75
Development of the Nonobese Diabetic Mouse and Contribution of Animal Models for Understanding Type 1 Diabetes. Pancreas (2017) 0.75
Spontaneous rodent models of diabetes and diabetic retinopathy. Int J Ophthalmol (2010) 0.75
Implication of the intestinal microbiome as a potential surrogate marker of immune responsiveness to experimental therapies in autoimmune diabetes. PLoS One (2017) 0.75
Long-term type 1 diabetes enhances in-stent restenosis after aortic stenting in diabetes-prone BB rats. J Biomed Biotechnol (2011) 0.75
Type 1 diabetes genes in rats: few or many? Diabetes (2009) 0.75
Type 1 Diabetes: Urinary Proteomics and Protein Network Analysis Support Perturbation of Lysosomal Function. Theranostics (2017) 0.75
Targeting Innate Immunity for Type 1 Diabetes Prevention. Curr Diab Rep (2017) 0.75
Is a β cell a β cell? Curr Opin Endocrinol Diabetes Obes (2017) 0.75
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol (2005) 9.76
Humanized mice in translational biomedical research. Nat Rev Immunol (2007) 8.83
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell (2008) 4.32
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab (2006) 4.11
The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet (2003) 3.96
Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol (2012) 3.41
A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity (2005) 3.07
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol (2007) 2.23
Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol (2010) 2.19
The role of JNK in the development of hepatocellular carcinoma. Genes Dev (2011) 2.07
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A (2012) 1.88
Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One (2009) 1.82
Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections. J Immunol (2003) 1.61
TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. J Immunol (2006) 1.57
Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS. Brain Res Mol Brain Res (2004) 1.51
The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha. Am J Pathol (2003) 1.49
Humanized mouse models to study human diseases. Curr Opin Endocrinol Diabetes Obes (2010) 1.48
Creation of "humanized" mice to study human immunity. Curr Protoc Immunol (2008) 1.45
Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells. J Immunol (2004) 1.41
Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A (2010) 1.41
Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance. J Immunol (2007) 1.34
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med (2013) 1.33
Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. Science (2002) 1.33
Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice. Diabetes (2010) 1.30
Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells. Exp Hematol (2003) 1.30
TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats. J Immunol (2005) 1.29
Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning. J Clin Invest (2003) 1.25
c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood (2014) 1.23
Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice. J Clin Invest (2007) 1.23
TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J Immunol (2007) 1.21
Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice. PLoS One (2008) 1.20
Ian4 is required for mitochondrial integrity and T cell survival. Proc Natl Acad Sci U S A (2003) 1.19
Evidence that the Y chromosome influences autoimmune disease in male and female mice. Proc Natl Acad Sci U S A (2006) 1.18
Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes. Antioxid Redox Signal (2010) 1.17
NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment. Transplantation (2003) 1.16
Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF. Blood (2012) 1.16
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A (2005) 1.13
Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice. Immunology (2012) 1.12
Humanized mice for the study of type 1 diabetes and beta cell function. Ann N Y Acad Sci (2008) 1.11
Regeneration in MRL mice: further genetic loci controlling the ear hole closure trait using MRL and M.m. Castaneus mice. Wound Repair Regen (2004) 1.10
The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease. Genome Res (2013) 1.10
Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice. Exp Biol Med (Maywood) (2008) 1.10
Maturation-dependent licensing of naive T cells for rapid TNF production. PLoS One (2010) 1.09
Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research. Ann N Y Acad Sci (2007) 1.09
Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish. Gen Comp Endocrinol (2010) 1.07
Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice. PLoS One (2012) 1.07
Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus. Mamm Genome (2009) 1.07
NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction. Diabetes (2003) 1.05
Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations. J Immunol (2003) 1.05
Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chem Biol (2011) 1.05
Humanized mice as a preclinical tool for infectious disease and biomedical research. Ann N Y Acad Sci (2011) 1.04
Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3. Diabetes (2004) 1.04
Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice. Clin Immunol (2004) 1.04
A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3. J Immunol (2006) 1.04
Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance. PLoS Genet (2012) 1.03
Cutting edge: the Y chromosome controls the age-dependent experimental allergic encephalomyelitis sexual dimorphism in SJL/J mice. J Immunol (2009) 1.03
NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection. Transplantation (2010) 1.03
Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice. Am J Pathol (2004) 1.01
Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol (2003) 1.00
LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation. Diabetes (2005) 0.99
Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS. Proc Natl Acad Sci U S A (2007) 0.98
Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice. Blood (2006) 0.98
The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats. Diabetes (2002) 0.98
The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Diabetes (2005) 0.98
Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance. J Immunol (2003) 0.97
Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms. Transplantation (2004) 0.96
Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex. Diabetes (2009) 0.96