Published in Genes Dev on March 15, 2011
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology (2012) 2.15
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A (2012) 1.88
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nat Cell Biol (2012) 1.81
Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. J Hepatol (2012) 1.51
Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox. Cancer Cell (2012) 1.27
Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer. Transl Gastrointest Cancer (2012) 1.26
Prevention of hepatocellular carcinoma: potential targets, experimental models, and clinical challenges. Curr Cancer Drug Targets (2012) 1.23
Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma. World J Gastroenterol (2011) 1.21
EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation. Nat Cell Biol (2014) 1.16
Role of JNK in mammary gland development and breast cancer. Cancer Res (2011) 1.14
JNK signalling in cancer: in need of new, smarter therapeutic targets. Br J Pharmacol (2014) 1.11
Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma. PLoS One (2013) 1.06
From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence. Liver Cancer (2013) 1.05
Molecular mechanisms of liver injury and hepatocarcinogenesis: focusing on the role of stress-activated MAPK. Patholog Res Int (2012) 1.04
Inflammation- and stress-related signaling pathways in hepatocarcinogenesis. World J Gastroenterol (2012) 1.04
BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling. Elife (2013) 1.02
The 2 Faces of JNK Signaling in Cancer. Genes Cancer (2013) 1.00
Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation. Proc Natl Acad Sci U S A (2014) 0.92
JNK is a novel regulator of intercellular adhesion. Tissue Barriers (2013) 0.90
Reversibility of regorafenib effects in hepatocellular carcinoma cells. Cancer Chemother Pharmacol (2013) 0.86
Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury. Gastroenterology (2015) 0.86
Multiple Protein Kinases via Activation of Transcription Factors NF-κB, AP-1 and C/EBP-δ Regulate the IL-6/IL-8 Production by HIV-1 Vpr in Astrocytes. PLoS One (2015) 0.84
β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. J Cell Physiol (2013) 0.83
JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships. Microbiol Mol Biol Rev (2016) 0.81
JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermoid carcinoma KB cells through snail and twist1. BMC Cancer (2013) 0.81
Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. Cancer Res (2014) 0.81
JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: connecting fibrosis, inflammation, and stemness for cancer prevention. Cell Cycle (2013) 0.81
JNK at the crossroad of obesity, insulin resistance, and cell stress response. Mol Metab (2016) 0.80
Stathmin mediates hepatocyte resistance to death from oxidative stress by down regulating JNK. PLoS One (2014) 0.80
A systems biology approach to the global analysis of transcription factors in colorectal cancer. BMC Cancer (2012) 0.80
Gankyrin drives malignant transformation of chronic liver damage-mediated fibrosis via the Rac1/JNK pathway. Cell Death Dis (2015) 0.80
Caspase-2 deficiency accelerates chemically induced liver cancer in mice. Cell Death Differ (2016) 0.79
Stress signaling and the shaping of the mammary tissue in development and cancer. Oncogene (2014) 0.79
In vivo gene manipulation reveals the impact of stress-responsive MAPK pathways on tumor progression. Cancer Sci (2015) 0.79
JNK: a double-edged sword in tumorigenesis. Hepatology (2011) 0.78
Mucin1 promotes the migration and invasion of hepatocellular carcinoma cells via JNK-mediated phosphorylation of Smad2 at the C-terminal and linker regions. Oncotarget (2015) 0.78
microRNA-622 acts as a tumor suppressor in hepatocellular carcinoma. Cancer Biol Ther (2015) 0.78
Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma. Cell Rep (2016) 0.78
The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity. Oncogene (2017) 0.77
TAK1 binding protein 2 is essential for liver protection from stressors. PLoS One (2014) 0.77
Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res (2015) 0.77
TAK1 regulates hepatic lipid homeostasis through SREBP. Oncogene (2016) 0.76
Knockdown of TMEM16A suppressed MAPK and inhibited cell proliferation and migration in hepatocellular carcinoma. Onco Targets Ther (2016) 0.76
Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol (2012) 0.76
Smad3 phospho-isoform signaling in hepatitis C virus-related chronic liver diseases. World J Gastroenterol (2014) 0.75
JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21. Oncogene (2017) 0.75
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. Cancer Cell (2017) 0.75
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
Immunity, inflammation, and cancer. Cell (2010) 28.27
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MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology (2007) 13.20
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science (2007) 12.91
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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem (1999) 10.14
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem (1995) 9.56
Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer (2009) 9.33
AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer (2003) 8.88
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell (2005) 8.78
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science (2000) 8.56
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell (2010) 8.04
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med (2007) 7.25
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A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (2008) 5.28
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The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron (1999) 4.51
Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem (2006) 4.15
Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell (2003) 3.92
Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity (1998) 3.70
Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res (2008) 3.67
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell (2008) 3.58
Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev (1999) 3.51
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet (1999) 3.42
Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A (2006) 3.33
Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature (2003) 3.25
JunD mediates survival signaling by the JNK signal transduction pathway. Mol Cell (2003) 2.39
Liver stem cells and hepatocellular carcinoma. Hepatology (2009) 2.27
Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. J Clin Invest (2008) 2.26
Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J (2002) 2.15
Partial hepatectomy in the mouse: technique and perioperative management. J Invest Surg (2003) 2.07
Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype. Am J Pathol (2008) 2.03
Sprouty proteins, masterminds of receptor tyrosine kinase signaling. Angiogenesis (2008) 1.95
c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology (2003) 1.87
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev (2006) 1.84
MicroRNA-21: from cancer to cardiovascular disease. Curr Drug Targets (2010) 1.82
Role of mitogen-activated protein kinase kinase 4 in cancer. Oncogene (2007) 1.79
Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 1.79
Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A (2007) 1.67
Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc Natl Acad Sci U S A (2010) 1.67
Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. Proc Natl Acad Sci U S A (1996) 1.63
c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol (2003) 1.58
Mouse liver tumorigenesis: models, mechanisms, and relevance to human disease. Semin Liver Dis (1999) 1.55
Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev (2010) 1.36
Activation of Jun kinase is an early event in hepatic regeneration. J Clin Invest (1995) 1.28
The role of the autonomic nervous system in liver regeneration and apoptosis--recent developments. Digestion (2002) 1.00
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol (2005) 9.76
Humanized mice in translational biomedical research. Nat Rev Immunol (2007) 8.83
MAP kinases in the immune response. Annu Rev Immunol (2001) 7.62
The JNK signal transduction pathway. Curr Opin Cell Biol (2007) 5.86
Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol (2003) 5.38
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (2008) 5.28
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A (2003) 5.01
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell (2008) 4.32
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A (2005) 3.68
Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol (2012) 3.41
Mechanism of p38 MAP kinase activation in vivo. Genes Dev (2003) 3.36
The JNK signal transduction pathway. Curr Opin Genet Dev (2002) 3.35
Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell (2006) 3.32
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol (2005) 3.14
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12
Targeting JNK for therapeutic benefit: from junk to gold? Nat Rev Drug Discov (2003) 3.11
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem (2005) 2.74
Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science (2008) 2.67
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev (2004) 2.51
A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A (2003) 2.47
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem (2002) 2.45
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell (2007) 2.43
A semisynthetic epitope for kinase substrates. Nat Methods (2007) 2.40
JunD mediates survival signaling by the JNK signal transduction pathway. Mol Cell (2003) 2.39
A genetically encoded fluorescent sensor of ERK activity. Proc Natl Acad Sci U S A (2008) 2.34
JNK2 is a positive regulator of the cJun transcription factor. Mol Cell (2006) 2.32
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol (2007) 2.23
Prevention of steatosis by hepatic JNK1. Cell Metab (2009) 2.20
Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol (2010) 2.19
Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell (2008) 2.16
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity (2007) 2.07
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 2.05
Regulation of the immune response by stress-activated protein kinases. Immunol Rev (2009) 2.00
Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature (2004) 1.99
Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol (2005) 1.97
Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. J Neurosci (2004) 1.94
Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor. J Am Coll Cardiol (2006) 1.89
Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J Exp Med (2006) 1.88
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A (2012) 1.88
Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem (2003) 1.83
A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun. EMBO J (2003) 1.83
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Gut (2006) 1.82
Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One (2009) 1.82
JNK regulates autocrine expression of TGF-beta1. Mol Cell (2004) 1.81
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol Cell Biol (2005) 1.80
Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 1.79
Role of JNK in tumor development. Cell Cycle (2003) 1.71
Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell (2007) 1.69
Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A (2007) 1.67
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol (2010) 1.64
Rat models of type 1 diabetes: genetics, environment, and autoimmunity. ILAR J (2004) 1.64
Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation. J Exp Med (2002) 1.61
Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections. J Immunol (2003) 1.61
Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. J Cell Sci (2008) 1.60
Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol (2012) 1.59
Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways. Gastroenterology (2012) 1.58
c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol (2003) 1.58
TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. J Immunol (2006) 1.57
Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol (2009) 1.56
Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol Cell Biol (2005) 1.53
Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem (2002) 1.52
Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep (2002) 1.52
Targeting dendritic cell signaling to regulate the response to immunization. Blood (2008) 1.50
Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. Blood (2011) 1.50
Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol Cell Biol (2002) 1.50
GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J (2004) 1.50
Humanized mouse models to study human diseases. Curr Opin Endocrinol Diabetes Obes (2010) 1.48
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev (2003) 1.48
Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. Nat Genet (2002) 1.48
Control of cellular senescence by CPEB. Genes Dev (2006) 1.47
Signal transduction. MAP kinase signaling specificity. Science (2002) 1.46
JNK regulates FoxO-dependent autophagy in neurons. Genes Dev (2011) 1.45
Creation of "humanized" mice to study human immunity. Curr Protoc Immunol (2008) 1.45
c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. Am J Pathol (2007) 1.44
Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol (2010) 1.42
Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells. J Immunol (2004) 1.41
Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A (2010) 1.41
p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nat Med (2011) 1.41
Re: expressing evaluative opinions; a position statement. Sci Justice (2011) 1.39
c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. J Exp Med (2002) 1.38
Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc Natl Acad Sci U S A (2006) 1.37
cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem Sci (2010) 1.36
Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev (2010) 1.36
The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. Mol Cell Biol (2002) 1.36
Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance. J Immunol (2007) 1.34
Specific pathophysiological functions of JNK isoforms in the brain. Eur J Neurosci (2005) 1.34
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med (2013) 1.33
Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem (2011) 1.33
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev (2004) 1.32
Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses. Cancer Res (2006) 1.31
Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice. Diabetes (2010) 1.30
Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells. Exp Hematol (2003) 1.30
TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats. J Immunol (2005) 1.29
Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2. FEBS Lett (2004) 1.28
JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure. Genes Dev (2003) 1.27
Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury. J Biol Chem (2003) 1.26