|
1
|
Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction.
|
Circulation
|
2003
|
2.56
|
|
2
|
The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes.
|
Diabetes
|
2002
|
2.20
|
|
3
|
Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.
|
Curr Med Chem
|
2005
|
1.72
|
|
4
|
Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure.
|
Am J Physiol Heart Circ Physiol
|
2004
|
1.67
|
|
5
|
Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis.
|
Shock
|
2003
|
1.64
|
|
6
|
Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst.
|
FASEB J
|
2004
|
1.64
|
|
7
|
Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst.
|
Mol Med
|
2002
|
1.62
|
|
8
|
Parenteral administration of glipizide sodium salt, an inhibitor of adenosine triphosphate-sensitive potassium channels, prolongs short-term survival after severe controlled hemorrhage in rats.
|
Crit Care Med
|
2003
|
1.46
|
|
9
|
Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice.
|
Shock
|
2002
|
1.44
|
|
10
|
Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep.
|
Am J Physiol Lung Cell Mol Physiol
|
2003
|
1.32
|
|
11
|
A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging.
|
J Pharmacol Exp Ther
|
2004
|
1.32
|
|
12
|
Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation.
|
Am J Respir Crit Care Med
|
2002
|
1.31
|
|
13
|
Adenosine receptor activation ameliorates type 1 diabetes.
|
FASEB J
|
2007
|
1.27
|
|
14
|
Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure.
|
Int J Mol Med
|
2006
|
1.21
|
|
15
|
Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity.
|
Oncol Rep
|
2004
|
1.18
|
|
16
|
Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide.
|
Infect Immun
|
2002
|
1.13
|
|
17
|
Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis.
|
Shock
|
2004
|
1.13
|
|
18
|
Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation.
|
Br J Pharmacol
|
2002
|
1.12
|
|
19
|
Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation.
|
Mol Med
|
2004
|
1.11
|
|
20
|
Inosine exerts a broad range of antiinflammatory effects in a murine model of acute lung injury.
|
Ann Surg
|
2002
|
1.07
|
|
21
|
Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy.
|
J Cell Mol Med
|
2008
|
1.05
|
|
22
|
Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma.
|
Med Sci Monit
|
2004
|
1.03
|
|
23
|
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging.
|
Int J Mol Med
|
2002
|
1.03
|
|
24
|
The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation.
|
J Pharmacol Exp Ther
|
2004
|
0.99
|
|
25
|
Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation.
|
Mol Med
|
2002
|
0.96
|
|
26
|
Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes.
|
Diabetes
|
2003
|
0.94
|
|
27
|
Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents.
|
Biochem Pharmacol
|
2002
|
0.94
|
|
28
|
Na+/H+ exchanger blockade inhibits enterocyte inflammatory response and protects against colitis.
|
Am J Physiol Gastrointest Liver Physiol
|
2002
|
0.90
|
|
29
|
alpha-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stress.
|
Eur J Pharmacol
|
2009
|
0.89
|
|
30
|
The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).
|
Bioorg Med Chem Lett
|
2004
|
0.88
|
|
31
|
Lipotoxicity in renal proximal tubular cells: relationship between endoplasmic reticulum stress and oxidative stress pathways.
|
Free Radic Biol Med
|
2010
|
0.86
|
|
32
|
Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction.
|
Shock
|
2004
|
0.84
|
|
33
|
PCB-induced endothelial cell dysfunction: role of poly(ADP-ribose) polymerase.
|
Biochem Pharmacol
|
2009
|
0.81
|
|
34
|
Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.
|
J Med Chem
|
2005
|
0.81
|