Published in Med Hypotheses on January 01, 2004
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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51
Puzzles, promises and a cure for ageing. Nature (2008) 3.23
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Aging (Albany NY) (2009) 2.32
The aging stress response. Mol Cell (2010) 2.19
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The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Res Rev (2009) 1.79
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AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction. Aging Cell (2010) 1.14
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Caloric restriction mimetic 2-deoxyglucose antagonizes doxorubicin-induced cardiomyocyte death by multiple mechanisms. J Biol Chem (2011) 0.92
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AMP activated protein kinase is indispensable for myocardial adaptation to caloric restriction in mice. PLoS One (2013) 0.82
Humulus japonicus extract exhibits antioxidative and anti-aging effects via modulation of the AMPK-SIRT1 pathway. Exp Ther Med (2015) 0.81
Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy. Int J Breast Cancer (2013) 0.80
Treadmill training increases SIRT-1 and PGC-1 α protein levels and AMPK phosphorylation in quadriceps of middle-aged rats in an intensity-dependent manner. Mediators Inflamm (2014) 0.78
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Mimetics of hormetic agents: stress-resistance triggers. Dose Response (2010) 0.77
Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism. FASEB J (2017) 0.76
(Healthy) ageing: focus on iodothyronines. Int J Mol Sci (2013) 0.76
Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep (2016) 0.75
Low-insulin-response diets may decrease plasma C-reactive protein by influencing adipocyte function. Med Hypotheses (2005) 0.86
Secondary hyperparathyroidism promotes the acute phase response -- a rationale for supplemental vitamin D in prevention of vascular events in the elderly. Med Hypotheses (2005) 0.84
Up-regulation of PPARgamma coactivator-1alpha as a strategy for preventing and reversing insulin resistance and obesity. Med Hypotheses (2005) 0.83
Practical prevention of cardiac remodeling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies. Med Hypotheses (2010) 0.83
Does bitter melon contain an activator of AMP-activated kinase? Med Hypotheses (2004) 0.79
De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome. Med Hypotheses (2005) 0.78
A taurine-supplemented vegan diet may blunt the contribution of neutrophil activation to acute coronary events. Med Hypotheses (2004) 0.76
Adjuvant strategies for prevention of glomerulosclerosis. Med Hypotheses (2006) 0.75