The aging stress response.

The hallmarks of aging. Cell (2013) 14.29

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal (2012) 5.65

Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell (2012) 2.15

Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. Cell (2011) 2.10

Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab (2011) 2.06

Cellular strategies of protein quality control. Cold Spring Harb Perspect Biol (2011) 1.74

Axis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol (2012) 1.74

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab (2015) 1.48

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol (2012) 1.46

Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging. Aging (Albany NY) (2011) 1.35

Aging and osteoarthritis. Curr Opin Rheumatol (2011) 1.31

Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA (2011) 1.31

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech (2013) 1.28

Oxidative stress and epigenetic regulation in ageing and age-related diseases. Int J Mol Sci (2013) 1.25

Deubiquitinases as a signaling target of oxidative stress. Cell Rep (2012) 1.25

The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. Arch Immunol Ther Exp (Warsz) (2012) 1.23

Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Cell Rep (2014) 1.13

Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond. FEMS Microbiol Rev (2013) 1.13

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease. J Exp Biol (2014) 1.10

Protein aggregation and degradation mechanisms in neurodegenerative diseases. Am J Neurodegener Dis (2013) 1.09

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med (2013) 1.04

Oxidative damage to macromolecules in human Parkinson disease and the rotenone model. Free Radic Biol Med (2013) 1.03

Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial superoxide flashes: from discovery to new controversies. J Gen Physiol (2012) 1.01

Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death. ACS Chem Biol (2013) 0.99

Nuclear transport: a switch for the oxidative stress-signaling circuit? J Signal Transduct (2011) 0.98

A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One (2011) 0.98

Age-related oxidative stress compromises endosomal proteostasis. Cell Rep (2012) 0.98

The aging signature: a hallmark of induced pluripotent stem cells? Aging Cell (2013) 0.96

Is histone acetylation the most important physiological function for CBP and p300? Aging (Albany NY) (2012) 0.95

Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice. Cell Death Dis (2015) 0.94

Age-related cognitive decline: can neural stem cells help us? Aging (Albany NY) (2012) 0.93

Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain. Neurobiol Aging (2014) 0.93

Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress. Blood (2012) 0.93

The DNA replication stress hypothesis of Alzheimer's disease. ScientificWorldJournal (2012) 0.93

Promotion of lung health: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc (2014) 0.93

Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression. Proc Natl Acad Sci U S A (2012) 0.92

The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex. PLoS Genet (2012) 0.92

Joint inhibition of TOR and JNK pathways interacts to extend the lifespan of Brachionus manjavacas (Rotifera). Exp Gerontol (2014) 0.91

Oxidative stress and immunosenescence: therapeutic effects of melatonin. Oxid Med Cell Longev (2012) 0.91

Nutraceutical interventions for promoting healthy aging in invertebrate models. Oxid Med Cell Longev (2012) 0.90

Protein carbamylation is a hallmark of aging. Proc Natl Acad Sci U S A (2015) 0.89

Renin-Angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction. Int J Inflam (2012) 0.89

Cancer surgery in the elderly. ScientificWorldJournal (2012) 0.89

Innate regeneration in the aging heart: healing from within. Mayo Clin Proc (2013) 0.89

HIF-1 and SKN-1 coordinate the transcriptional response to hydrogen sulfide in Caenorhabditis elegans. PLoS One (2011) 0.87

Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process. Int J Cell Biol (2012) 0.87

Sphingolipids and lifespan regulation. Biochim Biophys Acta (2013) 0.87

dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies. Aging (Albany NY) (2012) 0.87

Oxidation as "the stress of life". Aging (Albany NY) (2011) 0.87

Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification. Chem Biol (2013) 0.87

Diet and aging. Oxid Med Cell Longev (2012) 0.86

Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism. Sci Rep (2013) 0.85

Extension of Saccharomyces paradoxus chronological lifespan by retrotransposons in certain media conditions is associated with changes in reactive oxygen species. Genetics (2014) 0.85

Metabolism, longevity and epigenetics. Cell Mol Life Sci (2013) 0.85

Activation of the stress proteome as a mechanism for small molecule therapeutics. Hum Mol Genet (2012) 0.85

Metabolic modulation of chromatin: implications for DNA repair and genomic integrity. Front Genet (2013) 0.85

Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells. Stem Cell Res Ther (2015) 0.85

Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice. Antioxid Redox Signal (2013) 0.85

Nutraceuticals for geriatrics. J Tradit Complement Med (2014) 0.85

Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice. BMC Microbiol (2016) 0.83

The cell biology of aging. Mol Biol Cell (2015) 0.82

Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila. J Biomed Sci (2012) 0.82

Green tea polyphenols extend the lifespan of male drosophila melanogaster while impairing reproductive fitness. J Med Food (2014) 0.82

Interactions between oxygen homeostasis, food availability, and hydrogen sulfide signaling. Front Genet (2012) 0.82

Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans. Aging Cell (2014) 0.82

TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells. Sci Rep (2016) 0.81

Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice. J Gerontol A Biol Sci Med Sci (2014) 0.81

Role of Toll-like receptor 2 and 4 signaling pathways on the inflammatory response to resistance training in elderly subjects. Age (Dordr) (2014) 0.81

Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury. F1000Res (2014) 0.81

Corneal epithelial wound healing promoted by verbascoside-based liposomal eyedrops. Biomed Res Int (2014) 0.80

A new role for laminins as modulators of protein toxicity in Caenorhabditis elegans. Aging Cell (2011) 0.80

Role of macrophage migration inhibitory factor in age-related lung disease. Am J Physiol Lung Cell Mol Physiol (2015) 0.80

Endostatin and kidney fibrosis in aging: a case for antagonistic pleiotropy? Am J Physiol Heart Circ Physiol (2014) 0.80

Bioinformatic analysis of pathogenic missense mutations of activin receptor like kinase 1 ectodomain. PLoS One (2011) 0.80

Durable spatiotemporal surveillance of Caenorhabditis elegans response to environmental cues. Lab Chip (2014) 0.80

Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism. Rejuvenation Res (2015) 0.80

The RNA Splicing Response to DNA Damage. Biomolecules (2015) 0.79

Adenosine and blood platelets. Purinergic Signal (2011) 0.79

Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice. Aging Cell (2013) 0.78

Endoplasmic reticulum stress regulation of the Kar2p/BiP chaperone alleviates proteotoxicity via dual degradation pathways. Mol Biol Cell (2011) 0.78

Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem (2014) 0.78

Clinical implications of cellular stress responses. Bosn J Basic Med Sci (2012) 0.77

The effects of aging on the development of osteoarthritis. HSS J (2011) 0.77

Integromics network meta-analysis on cardiac aging offers robust multi-layer modular signatures and reveals micronome synergism. BMC Genomics (2015) 0.77

Role of p38MAPK and oxidative stress in copper-induced senescence. Age (Dordr) (2013) 0.77

Mitochondrial DNA 4977 bp deletion is a common phenomenon in hair and increases with age. Bosn J Basic Med Sci (2012) 0.77

Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1. Exp Mol Med (2016) 0.77

Molecular and Functional Characterization of Thioredoxin 1 from Korean Rose Bitterling (Rhodeus uyekii). Int J Mol Sci (2015) 0.77

Adaptation or malignant transformation: the two faces of epigenetically mediated response to stress. Biomed Res Int (2013) 0.77

Role of Carbonyl Modifications on Aging-Associated Protein Aggregation. Sci Rep (2016) 0.76

Aging studies in Drosophila melanogaster. Methods Mol Biol (2013) 0.76

Sirtuins, tissue maintenance, and tumorigenesis. Genes Cancer (2013) 0.76

Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review. Int J Nanomedicine (2014) 0.76

Degradation of Redox-Sensitive Proteins including Peroxiredoxins and DJ-1 is Promoted by Oxidation-induced Conformational Changes and Ubiquitination. Sci Rep (2016) 0.76

Genome maintenance and human longevity. Curr Opin Genet Dev (2014) 0.75

Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively. Chin Med J (Engl) (2015) 0.75

Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics. DNA Repair (Amst) (2012) 0.75

Age-Dependent Neuroimmune Modulation of IGF-1R in the Traumatic Mice. Immun Ageing (2012) 0.75

Mitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila. Mech Ageing Dev (2014) 0.75

Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans. J Gerontol A Biol Sci Med Sci (2016) 0.75

TOR signaling in growth and metabolism. Cell (2006) 35.29

Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol (2007) 33.06

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39

Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63

Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40

Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91

A C. elegans mutant that lives twice as long as wild type. Nature (1993) 20.42

Aging: a theory based on free radical and radiation chemistry. J Gerontol (1956) 20.39

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81

The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab (2005) 13.91

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (1997) 13.61

Autophagy regulates lipid metabolism. Nature (2009) 13.33

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 12.98

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature (2004) 12.36

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol (2010) 12.26

The genetics of ageing. Nature (2010) 12.08

Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature (2004) 11.59

Autophagy and the integrated stress response. Mol Cell (2010) 11.21

Oxidative stress, caloric restriction, and aging. Science (1996) 11.07

Extension of murine life span by overexpression of catalase targeted to mitochondria. Science (2005) 10.11

p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol (2004) 9.96

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (2005) 9.57

Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A (2004) 9.25

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun (2000) 9.09

Gene regulation and DNA damage in the ageing human brain. Nature (2004) 9.01

Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48

Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (2003) 8.43

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23

Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol (2009) 7.74

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell (2010) 7.59

Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature (2007) 7.12

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab (2007) 7.07

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev (2004) 6.98

The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition (1992) 6.77

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science (2005) 6.69

Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol (2005) 6.34

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature (1996) 6.32

Rates of behavior and aging specified by mitochondrial function during development. Science (2002) 6.28

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet (2002) 6.26

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev (2008) 6.18

Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature (2007) 5.94

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science (2001) 5.93

Opposing activities protect against age-onset proteotoxicity. Science (2006) 5.85

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76

FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A (2008) 5.71

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature (2006) 5.57

DNA repair, genome stability, and aging. Cell (2005) 5.52

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48

Gene-expression profile of the ageing brain in mice. Nat Genet (2000) 5.46

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab (2008) 5.44

Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science (2006) 5.39

SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30

Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A (2008) 5.14

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell (2010) 5.09

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet (2008) 4.93

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol (2005) 4.91

SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89

Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science (2009) 4.80

Misfolded proteins partition between two distinct quality control compartments. Nature (2008) 4.75

Autophagy gone awry in neurodegenerative diseases. Nat Neurosci (2010) 4.72

Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell (2003) 4.63

Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab (2007) 4.59

Modulation of mammalian life span by the short isoform of p53. Genes Dev (2004) 4.52

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med (2008) 4.44

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab (2010) 4.44

Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2002) 4.25

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci (2010) 4.22

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J (2002) 4.17

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest (2008) 4.09

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature (1998) 4.06

Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci U S A (2009) 4.02

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell (2009) 4.01

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc Natl Acad Sci U S A (2006) 3.97

Autophagy regulates adipose mass and differentiation in mice. J Clin Invest (2009) 3.95

SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2007) 3.94

Global changes to the ubiquitin system in Huntington's disease. Nature (2007) 3.91

Conserved metabolic regulatory functions of sirtuins. Cell Metab (2008) 3.86

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell (2007) 3.78

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77

The heat shock response: life on the verge of death. Mol Cell (2010) 3.71

SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One (2008) 3.66

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One (2010) 3.62

Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol (2007) 3.61

Neural mechanisms of ageing and cognitive decline. Nature (2010) 3.59

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell (2008) 3.58

Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet (2007) 3.53

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy (2007) 3.45

Gene regulation and DNA damage in the ageing human brain. Nature (2004) 9.01

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci (2008) 4.04

Neural mechanisms of ageing and cognitive decline. Nature (2010) 3.59

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med (2002) 3.31

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature (2011) 3.18

Evolution of the aging brain transcriptome and synaptic regulation. PLoS One (2008) 2.23

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 2.10

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron (2002) 1.82

The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum Mol Genet (2005) 1.66

A RIP tide in neuronal signal transduction. Neuron (2002) 1.48

A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem (2005) 1.16

Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium. J Biol Chem (2006) 1.02

Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Mol Cell (2013) 0.88

Physiology: Inflammation links ageing to the brain. Nature (2013) 0.84

Addendum: REST and stress resistance in ageing and Alzheimer's disease. Nature (2016) 0.75