Published in Nature on July 08, 2004
VFDB: a reference database for bacterial virulence factors. Nucleic Acids Res (2005) 4.77
A global perspective on hantavirus ecology, epidemiology, and disease. Clin Microbiol Rev (2010) 4.64
Prediction and prevention of the next pandemic zoonosis. Lancet (2012) 3.44
Global capacity for emerging infectious disease detection. Proc Natl Acad Sci U S A (2010) 3.30
Use of unstructured event-based reports for global infectious disease surveillance. Emerg Infect Dis (2009) 3.20
Poxvirus tropism. Nat Rev Microbiol (2005) 3.07
PATRIC: the VBI PathoSystems Resource Integration Center. Nucleic Acids Res (2006) 3.06
Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy. Proc Natl Acad Sci U S A (2009) 3.01
Emerging infections: a perpetual challenge. Lancet Infect Dis (2008) 2.75
Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States. PLoS Pathog (2010) 2.67
Time-dependent spectral analysis of epidemiological time-series with wavelets. J R Soc Interface (2007) 2.59
Coral pathogens identified for White Syndrome (WS) epizootics in the Indo-Pacific. PLoS One (2008) 2.48
Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution. PLoS Genet (2011) 2.44
A synchronized global sweep of the internal genes of modern avian influenza virus. Nature (2014) 2.41
Pacific-wide simplified syndromic surveillance for early warning of outbreaks. Glob Public Health (2012) 2.37
Vaccines for the twenty-first century society. Nat Rev Immunol (2011) 2.34
House-to-house human movement drives dengue virus transmission. Proc Natl Acad Sci U S A (2012) 2.32
Emerging infectious diseases: a 10-year perspective from the National Institute of Allergy and Infectious Diseases. Emerg Infect Dis (2005) 2.30
The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China. J Virol (2011) 2.23
The arrival, establishment and spread of exotic diseases: patterns and predictions. Nat Rev Microbiol (2010) 2.05
Serotype 1-specific monoclonal antibody-based antigen capture immunoassay for detection of circulating nonstructural protein NS1: Implications for early diagnosis and serotyping of dengue virus infections. J Clin Microbiol (2006) 1.99
Sustaining surveillance: evaluating syndromic surveillance in the Pacific. Glob Public Health (2012) 1.91
Quorum-quenching microbial infections: mechanisms and implications. Philos Trans R Soc Lond B Biol Sci (2007) 1.85
Global public health security. Emerg Infect Dis (2007) 1.83
Plant-made vaccine antigens and biopharmaceuticals. Trends Plant Sci (2009) 1.81
Metagenomic diagnosis of bacterial infections. Emerg Infect Dis (2008) 1.74
Emerging infectious diseases: threats to human health and global stability. PLoS Pathog (2013) 1.65
Interdisciplinary approaches to understanding disease emergence: the past, present, and future drivers of Nipah virus emergence. Proc Natl Acad Sci U S A (2012) 1.65
Applications of next-generation sequencing technologies to diagnostic virology. Int J Mol Sci (2011) 1.64
Complex history of the amphibian-killing chytrid fungus revealed with genome resequencing data. Proc Natl Acad Sci U S A (2013) 1.60
Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents. PLoS Pathog (2013) 1.58
Global mapping of infectious disease. Philos Trans R Soc Lond B Biol Sci (2013) 1.55
Toward a genome-wide systems biology analysis of host-pathogen interactions in group A Streptococcus. Am J Pathol (2005) 1.53
Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium. J Virol (2007) 1.52
Global drivers of human pathogen richness and prevalence. Proc Biol Sci (2010) 1.51
Real time bayesian estimation of the epidemic potential of emerging infectious diseases. PLoS One (2008) 1.46
Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions. Nat Rev Microbiol (2010) 1.46
Antibacterial and Antifungal Activity of ZnO Containing Glasses. PLoS One (2015) 1.44
Ixodes ricinus ticks are reservoir hosts for Rickettsia helvetica and potentially carry flea-borne Rickettsia species. Parasit Vectors (2009) 1.43
Regional-scale climate-variability synchrony of cholera epidemics in West Africa. BMC Infect Dis (2007) 1.41
Superior infectivity for mosquito vectors contributes to competitive displacement among strains of dengue virus. BMC Ecol (2008) 1.41
An inhibitor of gram-negative bacterial virulence protein secretion. Cell Host Microbe (2008) 1.39
Geographic area-based rate as a novel indicator to enhance research and precision intervention for more effective HIV/AIDS control. Prev Med Rep (2017) 1.38
First reported case of Cryptococcus gattii in the Southeastern USA: implications for travel-associated acquisition of an emerging pathogen. PLoS One (2009) 1.34
Generating aptamers for recognition of virus-infected cells. Clin Chem (2009) 1.31
Anatomy of the epidemiological literature on the 2003 SARS outbreaks in Hong Kong and Toronto: a time-stratified review. PLoS Med (2010) 1.31
Global burden, distribution, and interventions for infectious diseases of poverty. Infect Dis Poverty (2014) 1.31
Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals. Microbes Infect (2011) 1.31
Induction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following Infection with Dengue Virus. PLoS Pathog (2011) 1.30
Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host. Proc Natl Acad Sci U S A (2007) 1.28
Cytopathic bovine viral diarrhea viruses (BVDV): emerging pestiviruses doomed to extinction. Vet Res (2010) 1.27
Migration of Norway rats resulted in the worldwide distribution of Seoul hantavirus today. J Virol (2011) 1.27
Human ecology in pathogenic landscapes: two hypotheses on how land use change drives viral emergence. Curr Opin Virol (2013) 1.26
Arboviral encephalitides: transmission, emergence, and pathogenesis. J Neuroimmune Pharmacol (2010) 1.24
VirulentPred: a SVM based prediction method for virulent proteins in bacterial pathogens. BMC Bioinformatics (2008) 1.24
Quantifying travel behavior for infectious disease research: a comparison of data from surveys and mobile phones. Sci Rep (2014) 1.23
The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi. PLoS One (2012) 1.23
Memory generation and maintenance of CD8+ T cell function during viral persistence. J Immunol (2007) 1.23
Predicting undetected infections during the 2007 foot-and-mouth disease outbreak. J R Soc Interface (2008) 1.23
New methodology for estimating the burden of infectious diseases in Europe. PLoS Med (2012) 1.21
Microfluidic systems for pathogen sensing: a review. Sensors (Basel) (2009) 1.20
The regulatory network of natural competence and transformation of Vibrio cholerae. PLoS Genet (2012) 1.20
Surprise is a Neglected Aspect of Emerging Infectious Disease. Ecohealth (2014) 1.18
Landscape diversity related to Buruli ulcer disease in Côte d'Ivoire. PLoS Negl Trop Dis (2008) 1.18
Role of sand lizards in the ecology of Lyme and other tick-borne diseases in the Netherlands. Parasit Vectors (2010) 1.18
Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice. J Immunol (2011) 1.16
Noise, nonlinearity and seasonality: the epidemics of whooping cough revisited. J R Soc Interface (2008) 1.16
Isolation, phylogenetic analysis and anti-infective activity screening of marine sponge-associated actinomycetes. Mar Drugs (2010) 1.15
Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proc Natl Acad Sci U S A (2011) 1.15
Quorum sensing contributes to natural transformation of Vibrio cholerae in a species-specific manner. J Bacteriol (2011) 1.15
Metagenomic study of the viruses of African straw-coloured fruit bats: detection of a chiropteran poxvirus and isolation of a novel adenovirus. Virology (2013) 1.13
SAGES: a suite of freely-available software tools for electronic disease surveillance in resource-limited settings. PLoS One (2011) 1.13
Molecular characterization of the 2011 Hong Kong scarlet fever outbreak. J Infect Dis (2012) 1.13
Threats from emerging and re-emerging neglected tropical diseases (NTDs). Infect Ecol Epidemiol (2012) 1.12
Discovery of DNA viruses in wild-caught mosquitoes using small RNA high throughput sequencing. PLoS One (2011) 1.12
Investigation of antimicrobial and protease-inhibitory activity from cultured cyanobacteria. Pharm Biol (2009) 1.12
Global distribution of outbreaks of water-associated infectious diseases. PLoS Negl Trop Dis (2012) 1.12
Infectious causes of cancer and their detection. J Biol (2009) 1.11
Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother (2005) 1.10
Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone. FASEB J (2012) 1.10
Moving Beyond Too Little, Too Late: Managing Emerging Infectious Diseases in Wild Populations Requires International Policy and Partnerships. Ecohealth (2014) 1.10
Emergence of a bacterial clone with enhanced virulence by acquisition of a phage encoding a secreted phospholipase A2. Proc Natl Acad Sci U S A (2006) 1.09
Future infectious disease threats to Europe. Am J Public Health (2011) 1.09
Clonality and α-a recombination in the Australian Cryptococcus gattii VGII population--an emerging outbreak in Australia. PLoS One (2011) 1.08
Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus. J Virol (2010) 1.07
A versatile PDMS/paper hybrid microfluidic platform for sensitive infectious disease diagnosis. Anal Chem (2014) 1.07
Vaccines, new opportunities for a new society. Proc Natl Acad Sci U S A (2014) 1.06
Preventing pandemics via international development: a systems approach. PLoS Med (2012) 1.05
Emerging trends in plasma-free manufacturing of recombinant protein therapeutics expressed in mammalian cells. Biotechnol J (2009) 1.05
An Outbreak of Human Fascioliasis gigantica in Southwest China. PLoS One (2013) 1.05
ISS--an electronic syndromic surveillance system for infectious disease in rural China. PLoS One (2013) 1.04
What gets measured gets done: an assessment of local data uses and needs in large urban health departments. J Public Health Manag Pract (2014) 1.03
A minimal model for multiple epidemics and immunity spreading. PLoS One (2010) 1.03
Evolution and emergence of infectious diseases in theoretical and real-world networks. Nat Commun (2015) 1.03
Emerging infectious diseases in 2012: 20 years after the institute of medicine report. MBio (2012) 1.03
Comparison of multiple vaccine vectors in a single heterologous prime-boost trial. Vaccine (2008) 1.03
Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid dendritic cells. Clin Diagn Lab Immunol (2005) 1.02
Current advancements and potential strategies in the development of MERS-CoV vaccines. Expert Rev Vaccines (2014) 1.02
In vitro and in vivo studies identify important features of dengue virus pr-E protein interactions. PLoS Pathog (2010) 1.02
HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication. Proc Natl Acad Sci U S A (2002) 17.22
Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis (2008) 11.01
Universal voluntary testing and treatment for prevention of HIV transmission. JAMA (2009) 7.20
Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J Exp Med (2008) 5.14
HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol (2008) 5.01
The 1918 influenza pandemic: insights for the 21st century. J Infect Dis (2007) 4.99
Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy. J Infect Dis (2008) 4.86
B cells in HIV infection and disease. Nat Rev Immunol (2009) 4.73
Medicine. The need for a global HIV vaccine enterprise. Science (2003) 4.70
The research agenda of the National Institute of Allergy and Infectious Diseases for antimicrobial resistance. J Infect Dis (2008) 3.84
Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: a randomized clinical trial. JAMA (2013) 3.82
An HIV vaccine--evolving concepts. N Engl J Med (2007) 3.78
HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J Clin Invest (2005) 3.62
The persistent legacy of the 1918 influenza virus. N Engl J Med (2009) 3.58
Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus. J Infect Dis (2007) 3.50
Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals. Proc Natl Acad Sci U S A (2003) 3.47
Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication. AIDS (2010) 3.26
The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J Immunol (2008) 2.85
Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals. Proc Natl Acad Sci U S A (2005) 2.80
Emerging infections: a perpetual challenge. Lancet Infect Dis (2008) 2.75
Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Recommendations of the Panel on Clinical Practices for Treatment of HIV. MMWR Recomm Rep (2002) 2.70
Evaluation of initial CD4+ T cell counts in individuals with newly diagnosed human immunodeficiency virus infection, by sex and race, in urban settings. J Infect Dis (2002) 2.57
Influenza vaccines for the future. N Engl J Med (2010) 2.54
Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7. Proc Natl Acad Sci U S A (2006) 2.54
Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc Natl Acad Sci U S A (2003) 2.51
Dengue and hemorrhagic fever: a potential threat to public health in the United States. JAMA (2008) 2.45
Development of effective vaccines against pandemic influenza. Immunity (2006) 2.45
Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy. J Infect Dis (2011) 2.40
Pathogenic mechanisms of HIV disease. Annu Rev Pathol (2011) 2.36
Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Ann Intern Med (2002) 2.36
The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmission. PLoS Pathog (2011) 2.32
Emerging infectious diseases: a 10-year perspective from the National Institute of Allergy and Infectious Diseases. Emerg Infect Dis (2005) 2.30
The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1. Proc Natl Acad Sci U S A (2009) 2.30
Compromised B cell responses to influenza vaccination in HIV-infected individuals. J Infect Dis (2005) 2.12
A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection. N Engl J Med (2016) 2.09
B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy. Blood (2010) 2.05
HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2007) 2.01
Pathogenic mechanisms of B-lymphocyte dysfunction in HIV disease. J Allergy Clin Immunol (2008) 2.01
Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily. J Exp Med (2004) 2.00
Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions. J Infect Dis (2012) 2.00
Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function. J Infect Dis (2003) 1.97
Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells. Hepatology (2009) 1.92
Induction of unnatural immunity: prospects for a broadly protective universal influenza vaccine. Nat Med (2010) 1.90
The next influenza pandemic: can it be predicted? JAMA (2007) 1.86
Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals. Proc Natl Acad Sci U S A (2007) 1.82
Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies. J Biol Chem (2002) 1.79
Normalization of B cell counts and subpopulations after antiretroviral therapy in chronic HIV disease. J Infect Dis (2008) 1.79
Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7. Blood (2006) 1.73
Effect of histone deacetylase inhibitors on HIV production in latently infected, resting CD4(+) T cells from infected individuals receiving effective antiretroviral therapy. J Infect Dis (2012) 1.72
Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection. J Exp Med (2006) 1.72
An HIV vaccine--challenges and prospects. N Engl J Med (2008) 1.69
What is a pandemic? J Infect Dis (2009) 1.69
Emerging infectious diseases: threats to human health and global stability. PLoS Pathog (2013) 1.65
CD25+ regulatory T cells isolated from HIV-infected individuals suppress the cytolytic and nonlytic antiviral activity of HIV-specific CD8+ T cells in vitro. AIDS Res Hum Retroviruses (2007) 1.64
HIV reservoirs: pathogenesis and obstacles to viral eradication and cure. AIDS (2012) 1.59
Thirty years of HIV and AIDS: future challenges and opportunities. Ann Intern Med (2011) 1.56
Emerging infectious diseases: a clear and present danger to humanity. JAMA (2004) 1.55
Pandemic influenza's 500th anniversary. Clin Infect Dis (2010) 1.55
Epstein-Barr virus: an important vaccine target for cancer prevention. Sci Transl Med (2011) 1.54
Pilot study of the effects of intermittent interleukin-2 on human immunodeficiency virus (HIV)-specific immune responses in patients treated during recently acquired HIV infection. J Infect Dis (2001) 1.54
Perturbations in B cell responsiveness to CD4+ T cell help in HIV-infected individuals. Proc Natl Acad Sci U S A (2003) 1.53
Research funding. A framework for decisions about research with HPAI H5N1 viruses. Science (2013) 1.52
A way forward: the National HIV/AIDS Strategy and reducing HIV incidence in the United States. J Acquir Immune Defic Syndr (2010) 1.48
Characteristics and Clinical Management of a Cluster of 3 Patients With Ebola Virus Disease, Including the First Domestically Acquired Cases in the United States. Ann Intern Med (2015) 1.47
Intradermal influenza vaccination--can less be more? N Engl J Med (2004) 1.47
Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cells. PLoS One (2007) 1.45
HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV. J Transl Med (2011) 1.45
Deleterious effect of HIV-1 plasma viremia on B cell costimulatory function. J Immunol (2003) 1.44
Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals. PLoS Pathog (2008) 1.44
Insights into B cells and HIV-specific B-cell responses in HIV-infected individuals. Immunol Rev (2013) 1.38
A proof-of-concept study of short-cycle intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection. J Infect Dis (2004) 1.37
Two overrepresented B cell populations in HIV-infected individuals undergo apoptosis by different mechanisms. Proc Natl Acad Sci U S A (2006) 1.36
Chikungunya at the door--déjà vu all over again? N Engl J Med (2014) 1.32
Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome. J Clin Invest (2014) 1.29
Pandemic influenza viruses--hoping for the road not taken. N Engl J Med (2013) 1.26
Toward an AIDS-free generation. JAMA (2012) 1.25
Smallpox vaccination policy--the need for dialogue. N Engl J Med (2002) 1.24
Asthma in the inner city: the perspective of the National Institute of Allergy and Infectious Diseases. J Allergy Clin Immunol (2010) 1.23
The United States President's Emergency Plan for AIDS Relief: a story of partnerships and smart investments to turn the tide of the global AIDS pandemic. J Acquir Immune Defic Syndr (2012) 1.23
Dengue research opportunities in the Americas. J Infect Dis (2012) 1.22
The 2009 H1N1 pandemic influenza virus: what next? MBio (2010) 1.22
Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals. Proc Natl Acad Sci U S A (2004) 1.21
HIV-1 vaccines and adaptive trial designs. Sci Transl Med (2011) 1.21
CpG oligonucleotides enhance proliferative and effector responses of B Cells in HIV-infected individuals. J Immunol (2008) 1.21
H7N9 avian influenza A virus and the perpetual challenge of potential human pandemicity. MBio (2013) 1.20
Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors. J Clin Invest (2011) 1.18
HIV-AIDS: much accomplished, much to do. Nat Immunol (2013) 1.18
Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily. J Exp Med (2004) 1.18
HIV vaccine development--improving on natural immunity. N Engl J Med (2011) 1.16
Effect of antiretroviral therapy on HIV reservoirs in elite controllers. J Infect Dis (2013) 1.15
Paucity of HIV DNA methylation in latently infected, resting CD4+ T cells from infected individuals receiving antiretroviral therapy. J Virol (2012) 1.15
Productive HIV infection of resting CD4+ T cells: role of lymphoid tissue microenvironment and effect of immunomodulating agents. AIDS Res Hum Retroviruses (2003) 1.14
IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa. Blood (2012) 1.14
R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells. Proc Natl Acad Sci U S A (2006) 1.13