Published in Nature on July 04, 2004
The protective antigen component of anthrax toxin forms functional octameric complexes. J Mol Biol (2009) 2.69
Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel. Proc Natl Acad Sci U S A (2004) 2.23
Receptor-specific requirements for anthrax toxin delivery into cells. Proc Natl Acad Sci U S A (2005) 2.15
Human monoclonal anti-protective antigen antibody completely protects rabbits and is synergistic with ciprofloxacin in protecting mice and guinea pigs against inhalation anthrax. Infect Immun (2006) 1.59
Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays. Clin Vaccine Immunol (2006) 1.50
Characterization of the interaction between anthrax toxin and its cellular receptors. Cell Microbiol (2007) 1.49
Membrane translocation by anthrax toxin. Mol Aspects Med (2009) 1.42
Sepsis and pathophysiology of anthrax in a nonhuman primate model. Am J Pathol (2006) 1.39
Ratcheting up protein translocation with anthrax toxin. Protein Sci (2012) 1.38
A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1. Infect Immun (2006) 1.38
Atomic structure of anthrax protective antigen pore elucidates toxin translocation. Nature (2015) 1.35
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. PLoS Pathog (2006) 1.34
Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT). Proc Natl Acad Sci U S A (2011) 1.31
Polyvalent inhibitors of anthrax toxin that target host receptors. Proc Natl Acad Sci U S A (2006) 1.29
Passive protection against anthrax by using a high-affinity antitoxin antibody fragment lacking an Fc region. Infect Immun (2005) 1.28
Complement and the multifaceted functions of VWA and integrin I domains. Structure (2006) 1.22
Anthrax vaccine design: strategies to achieve comprehensive protection against spore, bacillus, and toxin. Med Immunol (2005) 1.22
Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines. Infect Immun (2005) 1.22
Receptors of anthrax toxin and cell entry. Mol Aspects Med (2009) 1.18
A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation. Proc Natl Acad Sci U S A (2006) 1.18
Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation. PLoS One (2007) 1.16
Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells. J Biol Chem (2007) 1.14
Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin. Proc Natl Acad Sci U S A (2010) 1.11
Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions? Proteins (2010) 1.11
Frequency and domain specificity of toxin-neutralizing paratopes in the human antibody response to anthrax vaccine adsorbed. Infect Immun (2009) 1.11
Characterization of a permissive epitope insertion site in adenovirus hexon. J Virol (2006) 1.10
The cytoplasmic domain of anthrax toxin receptor 1 affects binding of the protective antigen. Infect Immun (2008) 1.09
The dark sides of capillary morphogenesis gene 2. EMBO J (2011) 1.08
Identification of linear epitopes in Bacillus anthracis protective antigen bound by neutralizing antibodies. J Biol Chem (2009) 1.06
Cytokine response and survival of mice immunized with an adenovirus expressing Bacillus anthracis protective antigen domain 4. Infect Immun (2006) 1.06
Neutralizing monoclonal antibodies directed against defined linear epitopes on domain 4 of anthrax protective antigen. Infect Immun (2009) 1.05
Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism. PLoS One (2010) 1.03
X-ray crystal structure of the B component of Hemolysin BL from Bacillus cereus. Proteins (2008) 1.02
A viral nanoparticle with dual function as an anthrax antitoxin and vaccine. PLoS Pathog (2007) 1.02
Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen. J Mol Biol (2009) 1.01
Domain specificity of the human antibody response to Bacillus anthracis protective antigen. Vaccine (2008) 1.00
Evidence that histidine protonation of receptor-bound anthrax protective antigen is a trigger for pore formation. Biochemistry (2010) 0.99
Antibodies against anthrax: mechanisms of action and clinical applications. Toxins (Basel) (2011) 0.99
Rabies virus glycoprotein as a carrier for anthrax protective antigen. Virology (2006) 0.98
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Monitoring anthrax toxin receptor dissociation from the protective antigen by NMR. Protein Sci (2009) 0.96
A receptor-based switch that regulates anthrax toxin pore formation. PLoS Pathog (2011) 0.96
Model of the toxic complex of anthrax: responsive conformational changes in both the lethal factor and the protective antigen heptamer. Protein Sci (2006) 0.95
Selection and evaluation of the immunogenicity of protective antigen mutants as anthrax vaccine candidates. Vaccine (2007) 0.92
Anthrax toxin-neutralizing antibody reconfigures the protective antigen heptamer into a supercomplex. Proc Natl Acad Sci U S A (2010) 0.92
Anthrax toxin protective antigen--insights into molecular switching from prepore to pore. Protein Sci (2012) 0.92
Domain flexibility modulates the heterogeneous assembly mechanism of anthrax toxin protective antigen. J Mol Biol (2011) 0.91
Efficient neutralization of antibody-resistant forms of anthrax toxin by a soluble receptor decoy inhibitor. Antimicrob Agents Chemother (2008) 0.91
Three-dimensional structure of different functional forms of the Vibrio cholerae hemolysin oligomer: a cryo-electron microscopic study. J Bacteriol (2010) 0.91
The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin. PLoS One (2010) 0.89
Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH. Protein Sci (2009) 0.89
Divalent metal ion coordination by residue T118 of anthrax toxin receptor 2 is not essential for protective antigen binding. PLoS One (2006) 0.87
Bacillus anthracis edema factor substrate specificity: evidence for new modes of action. Toxins (Basel) (2012) 0.87
Onset of anthrax toxin pore formation. Biophys J (2006) 0.87
GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro. Mol Microbiol (2011) 0.87
Anthrax LFn-PA Hybrid Antigens: Biochemistry, Immunogenicity, and Protection Against Lethal Ames Spore Challenge in Rabbits. Open Vaccine J (2009) 0.86
Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response. PLoS One (2007) 0.86
Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1. Clin Exp Immunol (2013) 0.85
Structural biology: anthrax hijacks host receptor. Nature (2004) 0.84
Monitoring the kinetics of the pH-driven transition of the anthrax toxin prepore to the pore by biolayer interferometry and surface plasmon resonance. Biochemistry (2013) 0.84
Imaging tumor endothelial marker 8 using an 18F-labeled peptide. Eur J Nucl Med Mol Imaging (2011) 0.84
pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2. Protein Sci (2012) 0.83
Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen binding. Biochemistry (2010) 0.82
Long-range stabilization of anthrax protective antigen upon binding to CMG2. Biochemistry (2014) 0.82
A novel mechanism for antibody-based anthrax toxin neutralization: inhibition of prepore-to-pore conversion. J Biol Chem (2012) 0.81
The structure of Mlc titration factor A (MtfA/YeeI) reveals a prototypical zinc metallopeptidase related to anthrax lethal factor. J Bacteriol (2012) 0.80
Biophysical characterization and immunization studies of dominant negative inhibitor (DNI), a candidate anthrax toxin subunit vaccine. Hum Vaccin Immunother (2013) 0.80
Identification and characterization of multiple rubisco activases in chemoautotrophic bacteria. Nat Commun (2015) 0.80
(19)F nuclear magnetic resonance and crystallographic studies of 5-fluorotryptophan-labeled anthrax protective antigen and effects of the receptor on stability. Biochemistry (2014) 0.80
Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells. PLoS One (2011) 0.80
Anti-infective immunoadhesins from plants. Plant Biotechnol J (2015) 0.78
Small molecule inhibitors of Bacillus anthracis protective antigen proteolytic activation and oligomerization. J Med Chem (2012) 0.78
1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2. J Med Chem (2013) 0.77
Polylysine-mediated translocation of the diphtheria toxin catalytic domain through the anthrax protective antigen pore. Biochemistry (2014) 0.77
The Ins and Outs of Anthrax Toxin. Toxins (Basel) (2016) 0.77
A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation. Biochemistry (2014) 0.77
Improving the anti-toxin abilities of the CMG2-Fc fusion protein with the aid of computational design. PLoS One (2014) 0.77
Structural characterisation of the virulence-associated protein VapG from the horse pathogen Rhodococcus equi. Vet Microbiol (2015) 0.77
The Disulfide Bond Cys255-Cys279 in the Immunoglobulin-Like Domain of Anthrax Toxin Receptor 2 Is Required for Membrane Insertion of Anthrax Protective Antigen Pore. PLoS One (2015) 0.76
Crystal structure of the Rad3/XPD regulatory domain of Ssl1/p44. J Biol Chem (2015) 0.76
Molecular assembly of lethal factor enzyme and pre-pore heptameric protective antigen in early stage of translocation. J Mol Model (2015) 0.76
Characterization of Protein-Protein Interfaces through a Protein Contact Network Approach. Front Bioeng Biotechnol (2015) 0.76
Interaction of the Clostridium difficile Binary Toxin CDT and Its Host Cell Receptor, Lipolysis-stimulated Lipoprotein Receptor (LSR). J Biol Chem (2015) 0.76
Biology and structure of leukocyte β 2 integrins and their role in inflammation. F1000Res (2016) 0.76
Expression, Purification, and Biophysical Characterization of a Secreted Anthrax Decoy Fusion Protein in Nicotiana benthamiana. Int J Mol Sci (2017) 0.75
Structure of anthrax lethal toxin prepore complex suggests a pathway for efficient cell entry. J Gen Physiol (2016) 0.75
Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting. J Biol Chem (2016) 0.75
Defensive strategies of Bacillus anthracis that promote a fatal disease. Drug Discov Today Dis Mech (2007) 0.75
Crystallization and preliminary X-ray analysis of the vWA domain of human anthrax toxin receptor 1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.75
ANTXR-1 and -2 independent modulation of a cytotoxicity mediated by anthrax toxin in human cells. J Vet Med Sci (2016) 0.75
Stability of domain 4 of the anthrax toxin protective antigen and the effect of the VWA domain of CMG2 on stability. Protein Sci (2016) 0.75
A Bivalent Anthrax-Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis. Front Immunol (2017) 0.75
The Diverse AAA+ Machines that Repair Inhibited Rubisco Active Sites. Front Mol Biosci (2017) 0.75
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat Struct Mol Biol (2009) 12.13
Talin binding to integrin beta tails: a final common step in integrin activation. Science (2003) 7.56
Structural basis of integrin activation by talin. Cell (2007) 5.37
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science (2005) 5.25
Structural determinants of integrin recognition by talin. Mol Cell (2003) 4.20
S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science (2002) 4.13
Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process. J Cell Biol (2003) 3.97
Structural basis for vinculin activation at sites of cell adhesion. Nature (2004) 3.62
Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice. J Clin Invest (2003) 3.57
The structure and regulation of vinculin. Trends Cell Biol (2006) 3.52
The phosphotyrosine binding-like domain of talin activates integrins. J Biol Chem (2002) 2.97
Cellular and systemic effects of anthrax lethal toxin and edema toxin. Mol Aspects Med (2009) 2.93
The roles of anthrax toxin in pathogenesis. Curr Opin Microbiol (2004) 2.89
Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A (2003) 2.89
Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin. Nature (2003) 2.83
Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity. Nat Biotechnol (2002) 2.77
Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization. J Biol Chem (2002) 2.76
Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice. Am J Pathol (2005) 2.45
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature (2012) 2.41
The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin. Cell (2006) 2.40
Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. J Cell Biol (2004) 2.31
Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A (2009) 2.22
Alanine-scanning mutations in domain 4 of anthrax toxin protective antigen reveal residues important for binding to the cellular receptor and to a neutralizing monoclonal antibody. J Biol Chem (2003) 2.19
Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis. J Cell Biol (2006) 2.15
Wide prevalence of heterosubtypic broadly neutralizing human anti-influenza A antibodies. Clin Infect Dis (2011) 2.12
The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. Nat Struct Biol (2002) 2.11
Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome. Cell Microbiol (2007) 2.09
Role of vinculin in regulating focal adhesion turnover. Eur J Cell Biol (2006) 2.03
Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model. J Infect Dis (2007) 2.01
Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats. Am J Physiol Regul Integr Comp Physiol (2004) 1.97
Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun (2004) 1.95
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat Struct Mol Biol (2003) 1.91
Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome. PLoS Pathog (2012) 1.90
Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine. Proc Natl Acad Sci U S A (2003) 1.87
Identification of small molecule inhibitors of anthrax lethal factor. Nat Struct Mol Biol (2003) 1.86
Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood (2010) 1.82
Structure and lytic activity of a Bacillus anthracis prophage endolysin. J Biol Chem (2005) 1.79
Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation. Trends Neurosci (2002) 1.76
Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Mol Cell Biol (2004) 1.76
Genome engineering in Bacillus anthracis using Cre recombinase. Infect Immun (2006) 1.74
Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'. Nat Chem Biol (2008) 1.74
Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells. Mol Cancer Ther (2004) 1.68
An antibody-based microarray assay for small RNA detection. Nucleic Acids Res (2006) 1.65
Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge. Infect Immun (2005) 1.64
Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold. Protein Sci (2007) 1.63
Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design. Proc Natl Acad Sci U S A (2005) 1.63
Fluid support worsens outcome and negates the benefit of protective antigen-directed monoclonal antibody in a lethal toxin-infused rat Bacillus anthracis shock model. Crit Care Med (2007) 1.63
Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats. Crit Care Med (2009) 1.60
Expression of Bacillus anthracis protective antigen in transgenic chloroplasts of tobacco, a non-food/feed crop. Vaccine (2004) 1.56
Characterization of an actin-binding site within the talin FERM domain. J Mol Biol (2004) 1.55
CA-074Me protection against anthrax lethal toxin. Infect Immun (2009) 1.55
Role of N-terminal amino acids in the potency of anthrax lethal factor. PLoS One (2008) 1.54
Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R. J Biol Chem (2006) 1.53
Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins. Mol Cell (2003) 1.51
Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis. J Infect Dis (2004) 1.51
Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice. Cell Host Microbe (2010) 1.51
Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1. PLoS Pathog (2010) 1.50
Characterization of the interaction between anthrax toxin and its cellular receptors. Cell Microbiol (2007) 1.49
Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein. Protein Sci (2006) 1.45
Anthrax protective antigen cleavage and clearance from the blood of mice and rats. Infect Immun (2007) 1.45
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem (2007) 1.41
Substrate cleavage analysis of furin and related proprotein convertases. A comparative study. J Biol Chem (2008) 1.40
Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. PLoS Pathog (2010) 1.39
Potent antitumor activity of a urokinase-activated engineered anthrax toxin. Proc Natl Acad Sci U S A (2003) 1.38
Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage. Microb Pathog (2007) 1.36
Structural determinants of integrin binding to the talin rod. J Biol Chem (2009) 1.35
Effective mucosal immunity to anthrax: neutralizing antibodies and Th cell responses following nasal immunization with protective antigen. J Immunol (2003) 1.34
Efficient synthetic inhibitors of anthrax lethal factor. Proc Natl Acad Sci U S A (2005) 1.32
Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. J Biol Chem (2004) 1.32
Anthrax toxins induce shock in rats by depressed cardiac ventricular function. PLoS One (2007) 1.32
Anthrax toxin: structures, functions and tumour targeting. Expert Opin Biol Ther (2003) 1.32
The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS). PLoS Pathog (2009) 1.30
Key tissue targets responsible for anthrax-toxin-induced lethality. Nature (2013) 1.28
BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin. Mol Cancer Ther (2005) 1.27
αE-catenin is an autoinhibited molecule that coactivates vinculin. Proc Natl Acad Sci U S A (2012) 1.25
Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. J Biol Chem (2005) 1.23
Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody. Infect Immun (2009) 1.22
A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins. Protein Expr Purif (2011) 1.21
Structural basis of von Willebrand factor activation by the snake toxin botrocetin. Structure (2002) 1.21
Imaging specific cell-surface proteolytic activity in single living cells. Nat Methods (2006) 1.20
Codon-optimized fluorescent proteins designed for expression in low-GC gram-positive bacteria. Appl Environ Microbiol (2009) 1.19
Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice. Infect Immun (2006) 1.19
Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin. Nat Biotechnol (2005) 1.17
Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development. Mol Cell Biol (2006) 1.16
Anthrax lethal factor represses glucocorticoid and progesterone receptor activity. Proc Natl Acad Sci U S A (2003) 1.16
The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod. J Biol Chem (2006) 1.15
Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation. Structure (2004) 1.15
Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles. Clin Vaccine Immunol (2009) 1.15
Importance of Vp1 calcium-binding residues in assembly, cell entry, and nuclear entry of simian virus 40. J Virol (2003) 1.15
Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells. J Biol Chem (2007) 1.14
Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding. Proc Natl Acad Sci U S A (2009) 1.14