Published in J Biol Chem on July 12, 2004
A cleavable propeptide influences Toxoplasma infection by facilitating the trafficking and secretion of the TgMIC2-M2AP invasion complex. Mol Biol Cell (2006) 1.49
Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii. Mol Microbiol (2010) 1.36
Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes. Philos Trans R Soc Lond B Biol Sci (2010) 1.19
Acidocalcisomes. Cell Calcium (2011) 1.18
Ablation of a small transmembrane protein of Trypanosoma brucei (TbVTC1) involved in the synthesis of polyphosphate alters acidocalcisome biogenesis and function, and leads to a cytokinesis defect. Biochem J (2007) 1.16
Invertebrate aquaporins: a review. J Comp Physiol B (2008) 1.11
Identification of contractile vacuole proteins in Trypanosoma cruzi. PLoS One (2011) 1.05
Role of protein kinase A in Trypanosoma cruzi. Infect Immun (2008) 1.00
The role of acidocalcisomes in parasitic protists. J Eukaryot Microbiol (2009) 1.00
Nutrient transport and pathogenesis in selected parasitic protozoa. Eukaryot Cell (2011) 0.98
Hyperosmotic stress induces aquaporin-dependent cell shrinkage, polyphosphate synthesis, amino acid accumulation, and global gene expression changes in Trypanosoma cruzi. J Biol Chem (2011) 0.96
A contractile vacuole complex is involved in osmoregulation in Trypanosoma cruzi. Exp Parasitol (2007) 0.94
Characterization of farnesylated protein tyrosine phosphatase TcPRL-1 from Trypanosoma cruzi. Eukaryot Cell (2005) 0.89
Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence. Mol Microbiol (2013) 0.89
A Trypanosoma cruzi phosphatidylinositol 3-kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis. J Biol Chem (2008) 0.88
Aquaglyceroporins: generalized metalloid channels. Biochim Biophys Acta (2013) 0.87
New insights into roles of acidocalcisomes and contractile vacuole complex in osmoregulation in protists. Int Rev Cell Mol Biol (2013) 0.87
Functional characterization of a putative aquaporin from Encephalitozoon cuniculi, a microsporidia pathogenic to humans. Int J Parasitol (2005) 0.87
Rab11 regulates trafficking of trans-sialidase to the plasma membrane through the contractile vacuole complex of Trypanosoma cruzi. PLoS Pathog (2014) 0.86
Defining the role of a FYVE domain in the localization and activity of a cAMP phosphodiesterase implicated in osmoregulation in Trypanosoma cruzi. Mol Microbiol (2010) 0.86
Proline modulates the Trypanosoma cruzi resistance to reactive oxygen species and drugs through a novel D, L-proline transporter. PLoS One (2014) 0.86
Phospholipid and glycolipid composition of acidocalcisomes of Trypanosoma cruzi. Mol Biochem Parasitol (2007) 0.84
The role of acidocalcisomes in the stress response of Trypanosoma cruzi. Adv Parasitol (2011) 0.83
Functional characterization of a novel aquaporin from Dictyostelium discoideum amoebae implies a unique gating mechanism. J Biol Chem (2012) 0.81
Rab32 is essential for maintaining functional acidocalcisomes, and for growth and infectivity of Trypanosoma cruzi. J Cell Sci (2015) 0.80
Polyphosphate and acidocalcisomes. Biochem Soc Trans (2016) 0.78
The contractile vacuole as a key regulator of cellular water flow in Chlamydomonas reinhardtii. Eukaryot Cell (2014) 0.78
The origin and evolution of the acidocalcisome and its interactions with other organelles. Mol Biochem Parasitol (2015) 0.77
New subfamilies of major intrinsic proteins in fungi suggest novel transport properties in fungal channels: implications for the host-fungal interactions. BMC Evol Biol (2014) 0.77
TcPho91 is a contractile vacuole phosphate sodium symporter that regulates phosphate and polyphosphate metabolism in Trypanosoma cruzi. Mol Microbiol (2015) 0.77
Structural model of a putrescine-cadaverine permease from Trypanosoma cruzi predicts residues vital for transport and ligand binding. Biochem J (2013) 0.76
Generation and Identification of Peptide-Based Monoclonal Antibodies Against Vacuolar Proton Pyrophosphatase of Toxoplasma gondii. Monoclon Antib Immunodiagn Immunother (2015) 0.75
Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity. PLoS Pathog (2017) 0.75
Acidocalcisomes of eukaryotes. Curr Opin Cell Biol (2016) 0.75
Functional characterization of an aquaporin from a microsporidium, Nosema bombycis. PLoS One (2017) 0.75
Polyphosphate modulates blood coagulation and fibrinolysis. Proc Natl Acad Sci U S A (2006) 3.09
Specific chemotherapy of Chagas disease: controversies and advances. Trends Parasitol (2003) 2.93
Acidocalcisomes - conserved from bacteria to man. Nat Rev Microbiol (2005) 2.46
Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J Biol Chem (2004) 2.41
Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling. Trends Cell Biol (2010) 1.67
Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole. Mol Microbiol (2010) 1.61
Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins (2006) 1.47
Identification of organelles in bacteria similar to acidocalcisomes of unicellular eukaryotes. J Biol Chem (2003) 1.47
Calcium regulation in protozoan parasites. Curr Opin Microbiol (2003) 1.41
Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis. Mol Microbiol (2005) 1.38
Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies. J Biol Chem (2003) 1.31
Acidocalcisomes and the contractile vacuole complex are involved in osmoregulation in Trypanosoma cruzi. J Biol Chem (2004) 1.26
A vacuolar-type H+-pyrophosphatase governs maintenance of functional acidocalcisomes and growth of the insect and mammalian forms of Trypanosoma brucei. J Biol Chem (2002) 1.22
A pyrophosphatase regulating polyphosphate metabolism in acidocalcisomes is essential for Trypanosoma brucei virulence in mice. J Biol Chem (2003) 1.20
Acidocalcisomes are functionally linked to the contractile vacuole of Dictyostelium discoideum. J Biol Chem (2001) 1.18
Ablation of a small transmembrane protein of Trypanosoma brucei (TbVTC1) involved in the synthesis of polyphosphate alters acidocalcisome biogenesis and function, and leads to a cytokinesis defect. Biochem J (2007) 1.16
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrob Agents Chemother (2002) 1.14
Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes. J Biol Chem (2012) 1.14
Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter. Nat Commun (2013) 1.12
New and reemerging infectious diseases. Emerg Infect Dis (2003) 1.11
The H(+)-pyrophosphatase of Rhodospirillum rubrum is predominantly located in polyphosphate-rich acidocalcisomes. J Biol Chem (2004) 1.10
Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi. Int J Antimicrob Agents (2004) 1.10
Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate. J Infect Dis (2002) 1.10
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. Bioorg Med Chem Lett (2003) 1.08
Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth. Antimicrob Agents Chemother (2010) 1.07
Target of rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma brucei. J Biol Chem (2010) 1.05
Identification of contractile vacuole proteins in Trypanosoma cruzi. PLoS One (2011) 1.05
Characterization of isolated acidocalcisomes from Toxoplasma gondii tachyzoites reveals a novel pool of hydrolyzable polyphosphate. J Biol Chem (2002) 1.04
Proteomics in Trypanosoma cruzi--localization of novel proteins to various organelles. Proteomics (2008) 1.04
A lipid-modified phosphoinositide-specific phospholipase C (TcPI-PLC) is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi. J Biol Chem (2005) 1.03
Adaptor protein-3 (AP-3) complex mediates the biogenesis of acidocalcisomes and is essential for growth and virulence of Trypanosoma brucei. J Biol Chem (2011) 1.03
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease. Antimicrob Agents Chemother (2003) 1.02
Polyphosphate and its diverse functions in host cells and pathogens. PLoS Pathog (2013) 1.01
Formation and remodeling of inositolphosphoceramide during differentiation of Trypanosoma cruzi from trypomastigote to amastigote. Eukaryot Cell (2003) 1.01
The interplay between folding-facilitating mechanisms in Trypanosoma cruzi endoplasmic reticulum. Mol Biol Cell (2003) 1.01
A solanesyl-diphosphate synthase localizes in glycosomes of Trypanosoma cruzi. J Biol Chem (2006) 1.00
Antiparasitic activity of risedronate in a murine model of acute Chagas' disease. Int J Antimicrob Agents (2004) 1.00
The role of acidocalcisomes in parasitic protists. J Eukaryot Microbiol (2009) 1.00
Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes. J Biol Chem (2010) 0.98
Magic-angle spinning (31)P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible. FEBS Lett (2002) 0.98
Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity. Proc Natl Acad Sci U S A (2013) 0.97
Overexpression of a Zn2+-sensitive soluble exopolyphosphatase from Trypanosoma cruzi depletes polyphosphate and affects osmoregulation. J Biol Chem (2007) 0.96
Hyperosmotic stress induces aquaporin-dependent cell shrinkage, polyphosphate synthesis, amino acid accumulation, and global gene expression changes in Trypanosoma cruzi. J Biol Chem (2011) 0.96
Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase. J Med Chem (2005) 0.95
Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ. J Biol Chem (2003) 0.94
Polyphosphate content and fine structure of acidocalcisomes of Plasmodium falciparum. Microsc Microanal (2004) 0.94
A contractile vacuole complex is involved in osmoregulation in Trypanosoma cruzi. Exp Parasitol (2007) 0.94
Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg Med Chem (2007) 0.93
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase. Bioorg Med Chem Lett (2005) 0.93
An acidocalcisomal exopolyphosphatase from Leishmania major with high affinity for short chain polyphosphate. J Biol Chem (2002) 0.93
Role for a P-type H+-ATPase in the acidification of the endocytic pathway of Trypanosoma cruzi. Biochem J (2005) 0.92
Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi. J Med Chem (2002) 0.92
Trypanosoma brucei vacuolar transporter chaperone 4 (TbVtc4) is an acidocalcisome polyphosphate kinase required for in vivo infection. J Biol Chem (2013) 0.92
In with the TRP channels: intracellular functions for TRPM1 and TRPM2. Sci Signal (2009) 0.91
Calcium- and polyphosphate-containing acidocalcisomes in chicken egg yolk. Biol Cell (2010) 0.90
Volutin granules of Eimeria parasites are acidic compartments and have physiological and structural characteristics similar to acidocalcisomes. J Eukaryot Microbiol (2011) 0.90
Localization and developmental regulation of a dispersed gene family 1 protein in Trypanosoma cruzi. Infect Immun (2009) 0.89
Characterization of farnesylated protein tyrosine phosphatase TcPRL-1 from Trypanosoma cruzi. Eukaryot Cell (2005) 0.89
Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis. J Med Chem (2006) 0.89
The acidocalcisome vacuolar transporter chaperone 4 catalyzes the synthesis of polyphosphate in insect-stages of Trypanosoma brucei and T. cruzi. J Eukaryot Microbiol (2014) 0.89
Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence. Mol Microbiol (2013) 0.89
Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP. Biochem J (2010) 0.88
A Trypanosoma cruzi phosphatidylinositol 3-kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis. J Biol Chem (2008) 0.88
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg Med Chem (2011) 0.88
Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas' disease. Antimicrob Agents Chemother (2010) 0.87
Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents. Eur J Med Chem (2012) 0.87
Risedronate metal complexes potentially active against Chagas disease. J Inorg Biochem (2010) 0.87
Proton-pyrophosphatase and polyphosphate in acidocalcisome-like vesicles from oocytes and eggs of Periplaneta americana. Insect Biochem Mol Biol (2008) 0.87
Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation. Bioorg Med Chem Lett (2007) 0.86
Defining the role of a FYVE domain in the localization and activity of a cAMP phosphodiesterase implicated in osmoregulation in Trypanosoma cruzi. Mol Microbiol (2010) 0.86
Molecular characterization of Trypanosoma brucei P-type H+-ATPases. J Biol Chem (2006) 0.86
Acidocalcisomes as calcium- and polyphosphate-storage compartments during embryogenesis of the insect Rhodnius prolixus Stahl. PLoS One (2011) 0.86
Determining adult type 2 diabetes-related health care needs in an indigenous population from rural Guatemala: a mixed-methods preliminary study. BMC Health Serv Res (2012) 0.86
Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei. Acta Crystallogr D Biol Crystallogr (2004) 0.85
Acidocalcisomes of trypanosomatids have species-specific elemental composition. Protist (2004) 0.85
Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase. J Med Chem (2012) 0.84
A proton pumping pyrophosphatase in the Golgi apparatus and plasma membrane vesicles of Trypanosoma cruzi. Mol Biochem Parasitol (2002) 0.84
Phospholipid and glycolipid composition of acidocalcisomes of Trypanosoma cruzi. Mol Biochem Parasitol (2007) 0.84
The phosphatidylinositol-phospholipase C from Trypanosoma cruzi is active on inositolphosphoceramide. Mol Biochem Parasitol (2002) 0.84
Molecular and electrophysiological characterization of a novel cation channel of Trypanosoma cruzi. PLoS Pathog (2012) 0.84
1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase. Org Biomol Chem (2012) 0.84
Trypanosoma cruzi: antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro. Exp Parasitol (2009) 0.83
Dynamics of polymorphism of acidocalcisomes in Leishmania parasites. Histochem Cell Biol (2004) 0.83
Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase. Dalton Trans (2012) 0.82
Ammonium production during hypo-osmotic stress leads to alkalinization of acidocalcisomes and cytosolic acidification in Trypanosoma cruzi. Mol Biochem Parasitol (2006) 0.82
A plasma membrane P-type H(+)-ATPase regulates intracellular pH in Leishmania mexicana amazonensis. Mol Biochem Parasitol (2002) 0.82
Trypanosoma cruzi H+-ATPase 1 (TcHA1) and 2 (TcHA2) genes complement yeast mutants defective in H+ pumps and encode plasma membrane P-type H+-ATPases with different enzymatic properties. J Biol Chem (2002) 0.82
A 43-nucleotide U-rich element in 3'-untranslated region of large number of Trypanosoma cruzi transcripts is important for mRNA abundance in intracellular amastigotes. J Biol Chem (2012) 0.82
The changing role of indigenous lay midwives in Guatemala: new frameworks for analysis. Midwifery (2013) 0.82
Farnesyl diphosphate synthase localizes to the cytoplasm of Trypanosoma cruzi and T. brucei. Exp Parasitol (2008) 0.81