Published in J Biol Chem on July 12, 2004
Two distinct but interchangeable mechanisms for flipping of lipid-linked oligosaccharides. EMBO J (2006) 1.78
Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). Pflugers Arch (2006) 1.11
ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: relevance to pathomechanisms of pseudoxanthoma elasticum. Biochem Biophys Res Commun (2011) 0.88
Novel roles for ATP-binding cassette G transporters in lipid redistribution in Toxoplasma. Mol Microbiol (2010) 0.87
Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans. J Amino Acids (2011) 0.83
Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application. Zhong Nan Da Xue Xue Bao Yi Xue Ban (2011) 0.82
Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutations. J Biol Chem (2013) 0.82
Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable. Biochim Biophys Acta (2010) 0.80
Mutations at the signature sequence of CFTR create a Cd(2+)-gated chloride channel. J Gen Physiol (2009) 0.79
Attempts to characterize the NBD heterodimer of MRP1: transient complex formation involves Gly771 of the ABC signature sequence but does not enhance the intrinsic ATPase activity. Biochem J (2005) 0.79
A single amino acid substitution in CFTR converts ATP to an inhibitory ligand. J Gen Physiol (2014) 0.79
Role of the N-terminal transmembrane domain in the endo-lysosomal targeting and function of the human ABCB6 protein. Biochem J (2015) 0.77
Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. Physiol Rev (2006) 2.95
Pseudoxanthoma elasticum: clinical phenotypes, molecular genetics and putative pathomechanisms. Exp Dermatol (2008) 2.35
Challenges with advanced therapy medicinal products and how to meet them. Nat Rev Drug Discov (2010) 2.09
The role of ABC transporters in drug resistance, metabolism and toxicity. Curr Drug Deliv (2004) 1.96
The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox). Drug Discov Today (2008) 1.93
Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem (2002) 1.86
High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter. Mol Pharmacol (2004) 1.67
BiSearch: primer-design and search tool for PCR on bisulfite-treated genomes. Nucleic Acids Res (2005) 1.58
Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers. Mob DNA (2011) 1.56
Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib). Cancer Res (2005) 1.48
Expression and in vivo rescue of human ABCC6 disease-causing mutants in mouse liver. PLoS One (2011) 1.41
ABCG2 -- a transporter for all seasons. FEBS Lett (2004) 1.38
High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells. Biochim Biophys Acta (2008) 1.36
Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1. Biochim Biophys Acta (2002) 1.34
The R1141X loss-of-function mutation of the ABCC6 gene is a strong genetic risk factor for coronary artery disease. Genet Test Mol Biomarkers (2010) 1.31
Single nucleotide polymorphisms modify the transporter activity of ABCG2. Cancer Chemother Pharmacol (2005) 1.30
Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation. J Biol Chem (2002) 1.26
The role of multidrug transporters in drug availability, metabolism and toxicity. Toxicol Lett (2003) 1.20
Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface. J Biol Chem (2004) 1.19
Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance? Expert Opin Drug Metab Toxicol (2011) 1.13
The BiSearch web server. BMC Bioinformatics (2006) 1.13
Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate. Biofactors (2003) 1.09
Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition. Biochim Biophys Acta (2005) 1.09
ABCC6 is a basolateral plasma membrane protein. Circ Res (2013) 1.08
The molecular and physiological roles of ABCC6: more than meets the eye. Front Genet (2012) 1.08
Membrane topology of human ABC proteins. FEBS Lett (2005) 1.07
Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells. Biochem Biophys Res Commun (2003) 1.06
How segmental duplications shape our genome: recent evolution of ABCC6 and PKD1 Mendelian disease genes. Mol Biol Evol (2008) 1.05
Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization. Biochem Biophys Res Commun (2004) 1.05
Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery. Stem Cells (2009) 1.05
Clustering of disease-causing mutations on the domain-domain interfaces of ABCC6. Biochem Biophys Res Commun (2009) 1.03
C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins. Biochem Biophys Res Commun (2003) 1.03
Tyrosine kinase inhibitor resistance in cancer: role of ABC multidrug transporters. Drug Resist Updat (2005) 1.01
Membrane cholesterol selectively modulates the activity of the human ABCG2 multidrug transporter. Biochim Biophys Acta (2007) 0.99
Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells. Nucleic Acids Res (2012) 0.98
Identification of a DNA methylation-dependent activator sequence in the pseudoxanthoma elasticum gene, ABCC6. J Biol Chem (2005) 0.98
Neonatal FcR overexpression boosts humoral immune response in transgenic mice. J Immunol (2010) 0.97
The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes. J Biol Chem (2010) 0.96
Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum. Cell Cycle (2011) 0.95
Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. J Biol Chem (2002) 0.94
Calcium signaling in pluripotent stem cells. Mol Cell Endocrinol (2011) 0.93
State-dependent inhibition of cystic fibrosis transmembrane conductance regulator chloride channels by a novel peptide toxin. J Biol Chem (2007) 0.93
Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance. Biochem Pharmacol (2012) 0.92
Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter. J Biol Chem (2008) 0.91
Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. J Biol Chem (2003) 0.91
Selectivity of kinases on the activation of tenofovir, an anti-HIV agent. Eur J Pharm Sci (2012) 0.89
ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions. Biochim Biophys Acta (2011) 0.89
Combined localization and real-time functional studies using a GFP-tagged ABCG2 multidrug transporter. Biochem Biophys Res Commun (2008) 0.88
Evaluation of ABCG2 expression in human embryonic stem cells: crossing the same river twice? Stem Cells (2010) 0.88
ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: relevance to pathomechanisms of pseudoxanthoma elasticum. Biochem Biophys Res Commun (2011) 0.88
ABCC6 expression is regulated by CCAAT/enhancer-binding protein activating a primate-specific sequence located in the first intron of the gene. J Invest Dermatol (2012) 0.88
Characterization of calcium signals in human embryonic stem cells and in their differentiated offspring by a stably integrated calcium indicator protein. Cell Signal (2013) 0.88
Ins and outs of the ABCG2 multidrug transporter: an update on in vitro functional assays. Adv Drug Deliv Rev (2008) 0.87
Cell surface membrane proteins as personalized biomarkers: where we stand and where we are headed. Biomark Med (2013) 0.87
TTRAP is a novel component of the non-canonical TRAF6-TAK1 TGF-β signaling pathway. PLoS One (2011) 0.86
Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary. Forensic Sci Int (2011) 0.86
Interaction of ABC multidrug transporters with anticancer protein kinase inhibitors: substrates and/or inhibitors? Curr Cancer Drug Targets (2009) 0.86
The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury. Am J Pathol (2014) 0.85
Mitoxantrone is expelled by the ABCG2 multidrug transporter directly from the plasma membrane. Biochim Biophys Acta (2010) 0.85
ABCMdb: a database for the comparative analysis of protein mutations in ABC transporters, and a potential framework for a general application. Hum Mutat (2012) 0.85
Expression levels of the ABCG2 multidrug transporter in human erythrocytes correspond to pharmacologically relevant genetic variations. PLoS One (2012) 0.84
Mechanism of lysophosphatidic acid-induced amyloid fibril formation of beta(2)-microglobulin in vitro under physiological conditions. Biochemistry (2009) 0.84
Effects of the gout-causing Q141K polymorphism and a CFTR ΔF508 mimicking mutation on the processing and stability of the ABCG2 protein. Biochem Biophys Res Commun (2013) 0.84
The high turnover Drosophila multidrug resistance-associated protein shares the biochemical features of its human orthologues. Biochim Biophys Acta (2008) 0.84
The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology. Cancer Lett (2005) 0.84
Functional expression of a multidrug P-glycoprotein transporter of Leishmania. Biochem Biophys Res Commun (2005) 0.83
Application of a human multidrug transporter (ABCG2) variant as selectable marker in gene transfer to progenitor cells. Hum Gene Ther (2003) 0.83
PI3-kinase and mTOR inhibitors differently modulate the function of the ABCG2 multidrug transporter. Biochem Biophys Res Commun (2012) 0.83
Dynamic ABCG2 expression in human embryonic stem cells provides the basis for stress response. Eur Biophys J (2012) 0.82
Regulation of the function of the human ABCG2 multidrug transporter by cholesterol and bile acids: effects of mutations in potential substrate and steroid binding sites. Drug Metab Dispos (2014) 0.81
Analysis of large structural changes of the factor VIII gene, involving intron 1 and 22, in severe hemophilia A. Haematologica (2003) 0.81
Occurrence of pheochromocytoma in a MEN2A family with codon 609 mutation of the RET proto-oncogene. J Clin Endocrinol Metab (2002) 0.81
Identification of cohesive ends and genes encoding the terminase of phage 16-3. J Bacteriol (2005) 0.81