Published in Genet Med on July 21, 2004
Managing incidental findings and research results in genomic research involving biobanks and archived data sets. Genet Med (2012) 9.65
Disclosure of APOE genotype for risk of Alzheimer's disease. N Engl J Med (2009) 6.43
Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease. Neurology (2008) 2.66
Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism. Proc Natl Acad Sci U S A (2007) 2.41
The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation. J Neurosci (2006) 2.34
APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry (2011) 2.31
Health behavior changes after genetic risk assessment for Alzheimer disease: The REVEAL Study. Alzheimer Dis Assoc Disord (2008) 2.30
Estimating risks of common complex diseases across genetic and environmental factors: the example of Crohn disease. J Med Genet (2007) 1.97
Genetic testing for Alzheimer's disease and its impact on insurance purchasing behavior. Health Aff (Millwood) (2005) 1.93
Cerebral perfusion and oxygenation differences in Alzheimer's disease risk. Neurobiol Aging (2008) 1.82
Genetics, transcriptomics, and proteomics of Alzheimer's disease. J Clin Psychiatry (2006) 1.81
Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease. CMAJ (2008) 1.70
Latent structure and factorial invariance of a neuropsychological test battery for the study of preclinical Alzheimer's disease. Neuropsychology (2010) 1.49
Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial. Ann Intern Med (2016) 1.47
Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors. Genet Med (2011) 1.44
Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study. BMC Med (2006) 1.42
Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease. Neurology (2010) 1.41
Communicating genetic risk information for common disorders in the era of genomic medicine. Annu Rev Genomics Hum Genet (2013) 1.33
Effect of parental family history of Alzheimer's disease on serial position profiles. Alzheimers Dement (2008) 1.32
Genetic aspects of Alzheimer disease. Genet Med (2008) 1.26
Effect of Alzheimer disease genetic risk disclosure on dietary supplement use. Am J Clin Nutr (2010) 1.25
Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease. Neurology (2011) 1.23
Effects of ApoE4 and maternal history of dementia on hippocampal atrophy. Neurobiol Aging (2010) 1.22
"I know what you told me, but this is what I think:" perceived risk of Alzheimer disease among individuals who accurately recall their genetics-based risk estimate. Genet Med (2010) 1.19
Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes. Hum Genomics (2010) 1.12
Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience. Genet Med (2008) 1.08
White matter integrity and vulnerability to Alzheimer's disease: preliminary findings and future directions. Biochim Biophys Acta (2011) 1.07
Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF Studies. J Clin Neurol (2009) 1.06
Family history of Alzheimer's disease and hippocampal structure in healthy people. Am J Psychiatry (2010) 1.05
Genetic aspects of Alzheimer disease. Neurologist (2009) 1.03
Decreased cognition in children with risk factors for Alzheimer's disease. Biol Psychiatry (2008) 1.03
Comparing test-specific distress of susceptibility versus deterministic genetic testing for Alzheimer's disease. Alzheimers Dement (2008) 1.00
Genetic susceptibility testing for neurodegenerative diseases: ethical and practice issues. Prog Neurobiol (2013) 0.98
The role of disease perceptions and results sharing in psychological adaptation after genetic susceptibility testing: the REVEAL Study. Eur J Hum Genet (2010) 0.98
Children of persons with Alzheimer disease: what does the future hold? Alzheimer Dis Assoc Disord (2008) 0.97
Alzheimer disease family history impacts resting state functional connectivity. Ann Neurol (2012) 0.97
Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults. Neurology (2012) 0.95
Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease. Genet Med (2012) 0.95
Structural brain changes in normal individuals with a maternal history of Alzheimer's. Neurobiol Aging (2011) 0.94
Role of mitochondrial homeostasis and dynamics in Alzheimer's disease. Neurobiol Dis (2012) 0.93
Mitochondrial genomic analysis of late onset Alzheimer's disease reveals protective haplogroups H6A1A/H6A1B: the Cache County Study on Memory in Aging. PLoS One (2012) 0.92
Changes to perceptions of the pros and cons of genetic susceptibility testing after APOE genotyping for Alzheimer disease risk. Genet Med (2011) 0.90
Differences between African American and White research volunteers in their attitudes, beliefs and knowledge regarding genetic testing for Alzheimer's disease. J Genet Couns (2011) 0.89
Explaining behavior change after genetic testing: the problem of collinearity between test results and risk estimates. Genet Test (2008) 0.89
R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study. JAMA Neurol (2015) 0.88
Cognitive activities and cognitive performance in middle-aged adults at risk for Alzheimer's disease. Psychol Aging (2013) 0.87
A randomized noninferiority trial of condensed protocols for genetic risk disclosure of Alzheimer's disease. Alzheimers Dement (2014) 0.87
FDG- and amyloid-PET in Alzheimer's disease: is the whole greater than the sum of the parts? Q J Nucl Med Mol Imaging (2011) 0.86
Maternal family history is associated with Alzheimer's disease biomarkers. J Alzheimers Dis (2012) 0.84
Evaluation of exposure-specific risks from two independent samples: a simulation study. BMC Med Res Methodol (2011) 0.84
Family history and APOE-4 genetic risk in Alzheimer's disease. Neuropsychol Rev (2012) 0.83
Prevalence of Alzheimer's pathologic endophenotypes in asymptomatic and mildly impaired first-degree relatives. PLoS One (2013) 0.82
Impact of genetic risk assessment on nutrition-related lifestyle behaviours. Proc Nutr Soc (2012) 0.81
Influence of Alzheimer disease family history and genetic risk on cognitive performance in healthy middle-aged and older people. Am J Geriatr Psychiatry (2012) 0.81
Estimating and disclosing the risk of developing Alzheimer's disease: challenges, controversies and future directions. Future Neurol (2010) 0.81
Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults. J Alzheimers Dis (2016) 0.80
APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts. PLoS Med (2017) 0.79
Machine learning amplifies the effect of parental family history of Alzheimer's disease on list learning strategy. J Int Neuropsychol Soc (2012) 0.78
New approaches to genetic counseling and testing for Alzheimer's disease and frontotemporal degeneration. Curr Neurol Neurosci Rep (2012) 0.78
The concept of FDG-PET endophenotype in Alzheimer's disease. Neurol Sci (2011) 0.77
Associations between self-referral and health behavior responses to genetic risk information. Genome Med (2015) 0.76
Psychological, behavioral and social effects of disclosing Alzheimer's disease biomarkers to research participants: a systematic review. Alzheimers Res Ther (2016) 0.76
Brain atrophy rates in first degree relatives at risk for Alzheimer's. Neuroimage Clin (2014) 0.76
Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer's Disease. Aging Dis (2016) 0.76
Ethical challenges in preclinical Alzheimer's disease observational studies and trials: Results of the Barcelona summit. Alzheimers Dement (2016) 0.75
Factors affecting recall of different types of personal genetic information about Alzheimer's disease risk: the REVEAL study. Public Health Genomics (2015) 0.75
Complement factor H polymorphism and age-related macular degeneration. Science (2005) 17.79
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature (2006) 11.59
Mild cognitive impairment. Lancet (2006) 10.21
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
Managing incidental findings and research results in genomic research involving biobanks and archived data sets. Genet Med (2012) 9.65
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Disclosure of APOE genotype for risk of Alzheimer's disease. N Engl J Med (2009) 6.43
Diagnostic clinical genome and exome sequencing. N Engl J Med (2014) 5.55
Protective variant for hippocampal atrophy identified by whole exome sequencing. Ann Neurol (2015) 5.10
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30
The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement (2011) 4.25
The PhenX Toolkit: get the most from your measures. Am J Epidemiol (2011) 4.19
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Sex ratio of multiple sclerosis in Canada: a longitudinal study. Lancet Neurol (2006) 3.74
Risk of dementia among white and African American relatives of patients with Alzheimer disease. JAMA (2002) 3.16
Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans. Alzheimers Dement (2010) 3.11
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature (2004) 2.98
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol (2010) 2.91
The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genet Med (2009) 2.91
Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans. Alzheimers Dement (2010) 2.79
Disclosing pathogenic genetic variants to research participants: quantifying an emerging ethical responsibility. Genome Res (2012) 2.76
Point-counterpoint. Ethics and genomic incidental findings. Science (2013) 2.73
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. JAMA (2013) 2.58
Timing of birth and risk of multiple sclerosis: population based study. BMJ (2004) 2.56
Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. Blood (2009) 2.50
Who seeks genetic susceptibility testing for Alzheimer's disease? Findings from a multisite, randomized clinical trial. Genet Med (2004) 2.44
A network model to predict the risk of death in sickle cell disease. Blood (2007) 2.39
The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement (2013) 2.32
Health behavior changes after genetic risk assessment for Alzheimer disease: The REVEAL Study. Alzheimer Dis Assoc Disord (2008) 2.30
Cerebrospinal fluid proteomic biomarkers for Alzheimer's disease. Ann Neurol (2007) 2.30
Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance. Hum Mol Genet (2005) 2.26
Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet (2012) 2.23
Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet (2009) 2.23
Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. Arthritis Rheum (2013) 2.17
Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder. Neuropsychopharmacology (2010) 2.16
Hippocampal sclerosis in advanced age: clinical and pathological features. Brain (2011) 2.16
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron (2013) 2.13
MRI parameters for prediction of multiple sclerosis diagnosis in children with acute CNS demyelination: a prospective national cohort study. Lancet Neurol (2011) 2.12
Genetics of multiple sclerosis. Lancet Neurol (2004) 2.12
Processes and preliminary outputs for identification of actionable genes as incidental findings in genomic sequence data in the Clinical Sequencing Exploratory Research Consortium. Genet Med (2013) 2.08
Low-dose acetazolamide reverses periventricular white matter hyperintensities in iNPH. Neurology (2014) 2.08
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Rare variants in the CYP27B1 gene are associated with multiple sclerosis. Ann Neurol (2011) 2.07
A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat Genet (2005) 2.03
Genetic risk assessment for adult children of people with Alzheimer's disease: the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) study. J Geriatr Psychiatry Neurol (2005) 2.03
SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk. Ann Neurol (2011) 2.01
Direct to consumer genetic testing: Avoiding a culture war. Genet Med (2009) 2.00
Analysis of the glucocerebrosidase gene in Parkinson's disease. Mov Disord (2005) 1.99
Comprehensive search for Alzheimer disease susceptibility loci in the APOE region. Arch Neurol (2012) 1.97
Genetic testing for Alzheimer's disease and its impact on insurance purchasing behavior. Health Aff (Millwood) (2005) 1.93
Extended results of the Alzheimer's disease anti-inflammatory prevention trial. Alzheimers Dement (2011) 1.87
Hemolysis-associated priapism in sickle cell disease. Blood (2005) 1.86
Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet (2006) 1.86
Methodological Considerations in Studying Centenarians: Lessons Learned From the Georgia Centenarian Studies. Annu Rev Gerontol Geriatr (2007) 1.85
Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study. Am J Geriatr Psychiatry (2011) 1.83
Performance of random forest when SNPs are in linkage disequilibrium. BMC Bioinformatics (2009) 1.81
Reasons for seeking genetic susceptibility testing among first-degree relatives of people with Alzheimer disease. Alzheimer Dis Assoc Disord (2003) 1.79
Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study. Arch Neurol (2006) 1.78
Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Biol Psychiatry (2011) 1.76
A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17. Brain (2006) 1.75
Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease. CMAJ (2008) 1.70
Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. Proc Natl Acad Sci U S A (2009) 1.69
Trail Making Test errors in normal aging, mild cognitive impairment, and dementia. Arch Clin Neuropsychol (2008) 1.69
Biogerontology, "anti-aging medicine," and the challenges of human enhancement. Hastings Cent Rep (2003) 1.68
Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals. Exp Gerontol (2002) 1.68
Genetic testing for Alzheimer's and long-term care insurance. Health Aff (Millwood) (2010) 1.67
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol (2011) 1.65
Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects. Am J Addict (2007) 1.63
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet (2012) 1.63
Using AD biomarker research results for clinical care: a survey of ADNI investigators. Neurology (2013) 1.63
Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Arch Neurol (2011) 1.59
Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. Neuropsychopharmacology (2010) 1.58
Association between SORL1 and Alzheimer's disease in a genome-wide study. Neuroreport (2007) 1.57
Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene. Neurology (2012) 1.56
The inheritance of resistance alleles in multiple sclerosis. PLoS Genet (2007) 1.54
Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype. Blood Cells Mol Dis (2013) 1.54
Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging. CMAJ (2004) 1.52
Regulation: The FDA is overcautious on consumer genomics. Nature (2014) 1.52
The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus. Neurosurgery (2005) 1.52
Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway. Br J Haematol (2006) 1.51
Epidemiology of apathy in older adults: the Cache County Study. Am J Geriatr Psychiatry (2007) 1.50
Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis. Am J Clin Nutr (2008) 1.49
Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial. Ann Intern Med (2016) 1.47
A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression. Blood (2011) 1.47
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46
Personalized genetic risk counseling to motivate diabetes prevention: a randomized trial. Diabetes Care (2012) 1.46
A novel PS1 gene mutation in a large Aboriginal kindred. Can J Neurol Sci (2010) 1.46