Published in DNA Repair (Amst) on July 28, 2004
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr Biol (2004) 4.35
The structural determinants of checkpoint activation. Genes Dev (2007) 3.53
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell (2006) 2.73
Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol Cell Biol (2007) 2.02
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response. J Cell Biol (2009) 1.77
A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks. Proc Natl Acad Sci U S A (2010) 1.77
ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress. Mol Cell Biol (2006) 1.73
Plx1 is required for chromosomal DNA replication under stressful conditions. EMBO J (2008) 1.73
Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling. Genes Dev (2005) 1.71
Coordination of dual incision and repair synthesis in human nucleotide excision repair. EMBO J (2009) 1.68
Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast. EMBO Rep (2007) 1.66
Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection. J Virol (2006) 1.61
Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo. J Virol (2006) 1.47
Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection. J Cell Sci (2006) 1.43
DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases. J Mol Biol (2008) 1.36
DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation. Mol Cell Biol (2006) 1.35
Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites. Proc Natl Acad Sci U S A (2005) 1.31
Continued primer synthesis at stalled replication forks contributes to checkpoint activation. J Cell Biol (2010) 1.27
Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage. Cancer Res (2007) 1.27
Impaired DNA replication within progenitor cell pools promotes leukemogenesis. PLoS Biol (2005) 1.25
ATMIN defines an NBS1-independent pathway of ATM signalling. EMBO J (2007) 1.25
ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis. PLoS One (2007) 1.20
Protein phosphatase 5 is required for ATR-mediated checkpoint activation. Mol Cell Biol (2005) 1.19
Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replication. J Biol Chem (2012) 1.18
Activation of ATR and related PIKKs. Cell Cycle (2008) 1.12
Micron-scale coherence in interphase chromatin dynamics. Proc Natl Acad Sci U S A (2013) 1.11
A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint. Proc Natl Acad Sci U S A (2009) 1.04
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks. Mol Biol Cell (2008) 1.02
Alternative mechanisms for coordinating polymerase alpha and MCM helicase. Mol Cell Biol (2009) 1.02
MIDGET unravels functions of the Arabidopsis topoisomerase VI complex in DNA endoreduplication, chromatin condensation, and transcriptional silencing. Plant Cell (2007) 1.01
Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells. Mol Biol Cell (2007) 1.00
Human DNA polymerase eta activity and translocation is regulated by phosphorylation. Proc Natl Acad Sci U S A (2008) 1.00
DNA double-strand break signaling and human disorders. Genome Integr (2010) 1.00
Differential effects of DNA double-strand break repair pathways on single-strand and self-complementary adeno-associated virus vector genomes. J Virol (2010) 0.95
The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR. J Cell Sci (2007) 0.92
Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell lines. Head Neck (2010) 0.90
The phosphoinositide-3-OH-kinase-related kinases of Arabidopsis thaliana. EMBO Rep (2005) 0.90
S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability. Cell Cycle (2015) 0.86
6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death. Mol Neurodegener (2011) 0.86
The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage. Nat Commun (2015) 0.86
Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1. Mol Cell Biol (2007) 0.85
ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells. PLoS One (2011) 0.85
In my end is my beginning: control of end resection and DSBR pathway 'choice' by cyclin-dependent kinases. Oncogene (2005) 0.84
Regulation of PCNA polyubiquitination in human cells. BMC Res Notes (2010) 0.82
Back to the origin: reconsidering replication, transcription, epigenetics, and cell cycle control. Genes Cancer (2012) 0.82
ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment. Mutat Res (2010) 0.81
Mitochondria regulate DNA damage and genomic instability induced by high LET radiation. Life Sci Space Res (Amst) (2014) 0.80
Mta2 promotes Tipin-dependent maintenance of replication fork integrity. Cell Cycle (2014) 0.79
Regulation of zygotic genome activation and DNA damage checkpoint acquisition at the mid-blastula transition. Cell Cycle (2014) 0.79
Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase. PLoS One (2014) 0.76
Role of Protein Phosphorylation in the Regulation of Cell Cycle and DNA-Related Processes in Bacteria. Front Microbiol (2016) 0.76
The Intra-S Checkpoint Responses to DNA Damage. Genes (Basel) (2017) 0.76
MiR-488 inhibits proliferation and cisplatin sensibility in non-small-cell lung cancer (NSCLC) cells by activating the eIF3a-mediated NER signaling pathway. Sci Rep (2017) 0.75
PCNA-Ub polyubiquitination inhibits cell proliferation and induces cell-cycle checkpoints. Cell Cycle (2016) 0.75
G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells. Biochem Biophys Res Commun (2016) 0.75
The shelterin complex and hematopoiesis. J Clin Invest (2016) 0.75
Deletion of MAG1 and MRE11 enhances the sensitivity of the Saccharomyces cerevisiae HUG1P-GFP promoter-reporter construct to genotoxicity. Biosens Bioelectron (2008) 0.75
The impact of replication stress on replication dynamics and DNA damage in vertebrate cells. Nat Rev Genet (2017) 0.75
Double-strand break end resection and repair pathway choice. Annu Rev Genet (2011) 7.31
Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55
ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol (2004) 4.39
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol (2008) 3.07
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell (2003) 2.96
A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol Syst Biol (2010) 2.92
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat Struct Mol Biol (2009) 2.64
Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc Natl Acad Sci U S A (2002) 2.57
Topoisomerase I poisoning results in PARP-mediated replication fork reversal. Nat Struct Mol Biol (2012) 2.44
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol (2010) 2.40
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. Mol Cell (2007) 2.30
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J (2010) 2.27
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J (2006) 2.25
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12
Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Struct Mol Biol (2006) 2.09
Checkpoint signaling from a single DNA interstrand crosslink. Mol Cell (2009) 1.92
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J (2008) 1.90
Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks. Mol Cell Biol (2006) 1.82
Mre11 assembles linear DNA fragments into DNA damage signaling complexes. PLoS Biol (2004) 1.79
Polo-like kinase 1 reaches beyond mitosis--cytokinesis, DNA damage response, and development. Curr Opin Cell Biol (2008) 1.76
RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA. Mol Cell (2012) 1.74
Plx1 is required for chromosomal DNA replication under stressful conditions. EMBO J (2008) 1.73
Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. Proc Natl Acad Sci U S A (2007) 1.52
GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication. Nat Cell Biol (2010) 1.39
RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks. Nat Struct Mol Biol (2011) 1.36
DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process. J Biol Chem (2004) 1.34
Mechanisms of replication fork protection: a safeguard for genome stability. Crit Rev Biochem Mol Biol (2012) 1.34
ATM and ATR check in on origins: a dynamic model for origin selection and activation. Cell Cycle (2005) 1.27
Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J Cell Biol (2005) 1.24
Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst) (2008) 1.23
The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding. EMBO J (2005) 1.22
Early neural cell death: dying to become neurons. Dev Biol (2004) 1.20
Activation of DSB processing requires phosphorylation of CtIP by ATR. Mol Cell (2012) 1.16
Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair. J Cell Biol (2011) 1.16
Cdc45 is a critical effector of myc-dependent DNA replication stress. Cell Rep (2013) 1.16
Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion. EMBO J (2009) 1.15
A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev Cell (2012) 1.13
Single-strand DNA gaps trigger an ATR- and Cdc7-dependent checkpoint. Cell Cycle (2003) 1.09
Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit. PLoS One (2007) 1.08
An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. Nat Cell Biol (2009) 1.05
The DNA damage response during an unperturbed S-phase. DNA Repair (Amst) (2007) 1.05
Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns. EMBO Rep (2010) 1.04
Studies of the properties of human origin recognition complex and its Walker A motif mutants. Proc Natl Acad Sci U S A (2004) 1.04
Studying the DNA damage response using in vitro model systems. DNA Repair (Amst) (2009) 1.03
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair. EMBO J (2009) 0.98
Replication-independent repair of DNA interstrand crosslinks. Mol Cell (2012) 0.95
Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor development. Photochem Photobiol (2002) 0.93
The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling. J Invest Dermatol (2004) 0.92
Xenopus cell-free extracts to study DNA damage checkpoints. Methods Mol Biol (2004) 0.92
Regulation of the G(2)/M transition in Xenopus oocytes by the cAMP-dependent protein kinase. J Biol Chem (2005) 0.92
DNA replication and homologous recombination factors: acting together to maintain genome stability. Chromosoma (2013) 0.92
Cep63 and cep152 cooperate to ensure centriole duplication. PLoS One (2013) 0.92
Xenopus cell-free extracts to study the DNA damage response. Methods Mol Biol (2004) 0.90
The Fanconi anemia pathway and ICL repair: implications for cancer therapy. Crit Rev Biochem Mol Biol (2010) 0.90
PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst) (2009) 0.90
MCM proteins and checkpoint kinases get together at the fork. Proc Natl Acad Sci U S A (2004) 0.88
The differences between ICL repair during and outside of S phase. Trends Biochem Sci (2013) 0.88
A role for programmed cell death during early neurogenesis in xenopus. Dev Biol (2003) 0.88
From oogenesis through gastrulation: developmental regulation of apoptosis. Semin Cell Dev Biol (2005) 0.84
Studying DNA replication fork stability in Xenopus egg extract. Methods Mol Biol (2011) 0.83
Origin-dependent initiation of DNA replication within telomeric sequences. Nucleic Acids Res (2009) 0.82
HMGA1 protein is a novel target of the ATM kinase. Eur J Cancer (2008) 0.81
Study of cell cycle checkpoints using Xenopus cell-free extracts. Methods Mol Biol (2011) 0.81
Ultraviolet-B-induced G1 arrest is mediated by downregulation of cyclin-dependent kinase 4 in transformed keratinocytes lacking functional p53. J Invest Dermatol (2002) 0.80
XNGNR1-dependent neurogenesis mediates early neural cell death. Mech Dev (2005) 0.79
The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell (2013) 0.79
Reduced cyclin D1 ubiquitination in UVB-induced murine squamous cell carcinomas. Biochem Biophys Res Commun (2002) 0.78
An ATM and ATR dependent pathway targeting centrosome dependent spindle assembly. Cell Cycle (2009) 0.77
GEMC1 is a novel TopBP1-interacting protein involved in chromosomal DNA replication. Cell Cycle (2010) 0.77
Studying essential DNA metabolism proteins in Xenopus egg extract. Int J Dev Biol (2016) 0.76
More tasks for Dna2 in S-phase. Cell Cycle (2012) 0.76
Responding to chromosomal breakage during M-phase: insights from a cell-free system. Cell Div (2009) 0.75