Published in J Neurosci on July 28, 2004
Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development. Neuron (2013) 1.79
Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. J Neurosci (2008) 1.60
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. Hum Mol Genet (2014) 1.55
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect. Proc Natl Acad Sci U S A (2008) 1.54
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biol Psychiatry (2010) 1.49
Cardiovascular actions of neurotrophins. Physiol Rev (2009) 1.45
Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci Signal (2009) 1.36
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc Natl Acad Sci U S A (2005) 1.33
NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons. Proc Natl Acad Sci U S A (2008) 1.31
N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A (2010) 1.28
A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors. Mol Biol Cell (2005) 1.27
A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. Proc Natl Acad Sci U S A (2006) 1.20
Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB. Proc Natl Acad Sci U S A (2007) 1.12
Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons. J Biol Chem (2008) 1.12
The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain. Proc Natl Acad Sci U S A (2007) 1.12
Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells. Proc Natl Acad Sci U S A (2011) 1.10
Bidirectional regulation of kainate receptor surface expression in hippocampal neurons. J Biol Chem (2008) 1.05
Spinal 5-HT7 receptor activation induces long-lasting phrenic motor facilitation. J Physiol (2011) 1.03
Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol (2009) 1.03
A cross-talk between TrkB and Ret tyrosine kinases receptors mediates neuroblastoma cells differentiation. PLoS One (2008) 1.03
Neurotrophin B receptor kinase increases Kv subfamily member 1.3 (Kv1.3) ion channel half-life and surface expression. Neuroscience (2006) 1.03
Isoform-specific dephosphorylation of dynamin1 by calcineurin couples neurotrophin receptor endocytosis to axonal growth. Neuron (2011) 1.00
Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS One (2011) 0.99
Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway. Proc Natl Acad Sci U S A (2005) 0.98
Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation. Proc Natl Acad Sci U S A (2009) 0.98
Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction. Neurobiol Dis (2011) 0.97
Bone marrow stromal cells protect oligodendrocytes from oxygen-glucose deprivation injury. J Neurosci Res (2008) 0.97
Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance. Oncogene (2014) 0.96
Regulation of trafficking of activated TrkA is critical for NGF-mediated functions. Traffic (2011) 0.96
A single Aplysia neurotrophin mediates synaptic facilitation via differentially processed isoforms. Cell Rep (2013) 0.95
Trophic factor expression in phrenic motor neurons. Respir Physiol Neurobiol (2008) 0.93
Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection. Br J Pharmacol (2009) 0.92
β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem (2011) 0.91
Novel small molecule activators of the Trk family of receptor tyrosine kinases. Biochim Biophys Acta (2012) 0.91
PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons. EMBO J (2007) 0.90
Tuning and fine-tuning of synapses with adenosine. Curr Neuropharmacol (2009) 0.89
High-resolution fractionation of signaling endosomes containing different receptors. Traffic (2009) 0.88
Propofol-induced changes in neurotrophic signaling in the developing nervous system in vivo. PLoS One (2012) 0.88
TrkB kinase activity is critical for recovery of respiratory function after cervical spinal cord hemisection. Exp Neurol (2014) 0.88
Brain-derived neurotrophic factor and neurotrophin receptors modulate glutamate-induced phase shifts of the suprachiasmatic nucleus. Eur J Neurosci (2006) 0.88
Dopamine receptors - IUPHAR Review 13. Br J Pharmacol (2015) 0.87
Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). Brain Struct Funct (2014) 0.86
Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus. Neuropharmacology (2011) 0.86
Regulation of TrkB receptor translocation to lipid rafts by adenosine A(2A) receptors and its functional implications for BDNF-induced regulation of synaptic plasticity. Purinergic Signal (2013) 0.86
EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons. Nat Neurosci (2013) 0.85
How does angiotensin AT(2) receptor activation help neuronal differentiation and improve neuronal pathological situations? Front Endocrinol (Lausanne) (2012) 0.85
In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J Neurosci (2014) 0.85
Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons. J Neurosci Res (2006) 0.84
High-affinity neurotrophin receptors and ligands promote leukemogenesis. Blood (2008) 0.84
7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders. Transl Neurodegener (2016) 0.84
The physiology of membrane transport and endomembrane-based signalling. EMBO J (2006) 0.83
The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability. Mol Cell Biol (2009) 0.82
Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay. Neurobiol Dis (2011) 0.82
Homeostatic control of brain function - new approaches to understand epileptogenesis. Front Cell Neurosci (2013) 0.81
Norepinephrine Protects against Amyloid-β Toxicity via TrkB. J Alzheimers Dis (2015) 0.80
Regulation of neuronal PLCgamma by chronic morphine. Brain Res (2007) 0.80
Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice. J Comp Neurol (2014) 0.80
Precursor B cell receptor signaling activity can be uncoupled from surface expression. J Immunol (2006) 0.79
Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling. Mol Cell Neurosci (2015) 0.78
Coincidence detection in a neural correlate of classical conditioning is initiated by bidirectional 3-phosphoinositide-dependent kinase-1 signalling and modulated by adenosine receptors. J Physiol (2015) 0.78
Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes. Purinergic Signal (2015) 0.78
Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory. Mol Psychiatry (2015) 0.78
A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. PLoS One (2013) 0.77
Retrograde TrkAIII transport from ERGIC to ER: a re-localisation mechanism for oncogenic activity. Oncotarget (2015) 0.76
Role of IGF1R(+) MSCs in modulating neuroplasticity via CXCR4 cross-interaction. Sci Rep (2016) 0.75
Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology. PLoS One (2015) 0.75
Induction of serpinb1a by PACAP or NGF is required for PC12 cells survival after serum withdrawal. J Neurochem (2014) 0.75
Tropomyosin-receptor-kinases signaling in the nervous system. Maedica (Buchar) (2013) 0.75
The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor. J Biol Chem (2017) 0.75
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell (2007) 8.99
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science (2006) 5.89
Neuregulin-1 type III determines the ensheathment fate of axons. Neuron (2005) 4.19
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med (2009) 4.11
ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci (2005) 3.76
A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science (2010) 3.61
Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci (2004) 3.47
Neurotrophin signalling in health and disease. Clin Sci (Lond) (2006) 2.85
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat Med (2010) 2.75
Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons. Cell Host Microbe (2010) 2.65
Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. J Neurosci (2005) 2.44
Neuronal release of proBDNF. Nat Neurosci (2009) 2.36
MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron (2005) 2.15
Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance. Nat Neurosci (2013) 2.14
Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron (2006) 1.97
Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature (2002) 1.88
Variant BDNF (Val66Met) impact on brain structure and function. Cogn Affect Behav Neurosci (2006) 1.85
Long-distance control of synapse assembly by target-derived NGF. Neuron (2010) 1.81
CCM2 mediates death signaling by the TrkA receptor tyrosine kinase. Neuron (2009) 1.79
Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biol Psychiatry (2011) 1.77
Altered fear learning across development in both mouse and human. Proc Natl Acad Sci U S A (2012) 1.77
The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching. Nat Neurosci (2010) 1.74
Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron (2006) 1.74
Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron (2002) 1.65
Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain. Neuropsychopharmacology (2007) 1.64
Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. J Neurosci (2008) 1.60
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect. Proc Natl Acad Sci U S A (2008) 1.54
BDNF Val66Met polymorphism is associated with unstable angina. Clin Chim Acta (2008) 1.52
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biol Psychiatry (2010) 1.49
Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis. J Neurosci (2002) 1.48
Stable isotopic labeling by amino acids in cultured primary neurons: application to brain-derived neurotrophic factor-dependent phosphotyrosine-associated signaling. Mol Cell Proteomics (2008) 1.46
Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory. J Neurosci (2009) 1.46
Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants. J Neurosci (2012) 1.45
Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc Natl Acad Sci U S A (2004) 1.42
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor. J Biol Chem (2003) 1.41
DSM-5 and RDoC: progress in psychiatry research? Nat Rev Neurosci (2013) 1.38
Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides. J Biol Chem (2002) 1.37
A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein. EMBO J (2004) 1.36
Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder. Ann N Y Acad Sci (2010) 1.35
BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci (2006) 1.33
Neurotrophins, synaptic plasticity and dementia. Curr Opin Neurobiol (2007) 1.32
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol (2007) 1.30
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci (2010) 1.29
A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors. Mol Biol Cell (2005) 1.27
Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptors. Cytokine Growth Factor Rev (2002) 1.26
The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus. J Neurosci (2010) 1.26
Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains. J Biol Chem (2005) 1.25
The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex. J Neurosci (2012) 1.24
Pro-NGF secreted by astrocytes promotes motor neuron cell death. Mol Cell Neurosci (2006) 1.23
Selective early-acquired fear memories undergo temporary suppression during adolescence. Proc Natl Acad Sci U S A (2011) 1.23
Telomerase activity in the subventricular zone of adult mice. Mol Cell Neurosci (2003) 1.21
Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments. Proc Natl Acad Sci U S A (2011) 1.20
Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal (2011) 1.19
Early-life stress has persistent effects on amygdala function and development in mice and humans. Proc Natl Acad Sci U S A (2013) 1.19
BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology (2012) 1.16
TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain. J Biol Chem (2007) 1.15
BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function. Proc Natl Acad Sci U S A (2010) 1.15
Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation. J Biol Chem (2005) 1.15
Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo. J Neurosci (2009) 1.13
BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A (2012) 1.13
Neurotrophic factor control of adult SVZ neurogenesis. Dev Neurobiol (2010) 1.13
Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons. J Biol Chem (2008) 1.12
Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB. Proc Natl Acad Sci U S A (2007) 1.12
Ankyrin Repeat-rich Membrane Spanning/Kidins220 protein regulates dendritic branching and spine stability in vivo. Dev Neurobiol (2009) 1.12
Nuclear localization of the p75 neurotrophin receptor intracellular domain. J Biol Chem (2009) 1.11
TrkB as a potential synaptic and behavioral tag. J Neurosci (2011) 1.11
Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nat Commun (2013) 1.10
JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem (2003) 1.09
Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice. Biol Psychiatry (2012) 1.05
Slitrks as emerging candidate genes involved in neuropsychiatric disorders. Trends Neurosci (2011) 1.04
Transient reversal of episome silencing precedes VP16-dependent transcription during reactivation of latent HSV-1 in neurons. PLoS Pathog (2012) 1.04
Olfactory ensheathing cells genetically modified to secrete GDNF to promote spinal cord repair. Brain (2003) 1.04
Mechanisms of neurotrophin receptor vesicular transport. J Neurobiol (2004) 1.04
Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing. J Neurosci (2009) 1.03
Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in Angelman syndrome model mice by ErbB inhibitors. Biol Psychiatry (2012) 1.02
The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E. J Cell Biol (2004) 1.01
Impact of the BDNF Val66Met polymorphism on cognition: implications for behavioral genetics. Neuroscientist (2012) 1.01
APP is phosphorylated by TrkA and regulates NGF/TrkA signaling. J Neurosci (2011) 1.01
Neuropathy target esterase is required for adult vertebrate axon maintenance. J Neurosci (2009) 1.01
Single-cell characterization of retrograde signaling by brain-derived neurotrophic factor. J Neurosci (2006) 1.01
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor. Genes Dev (2012) 1.01
A role for huntington disease protein in dendritic RNA granules. J Biol Chem (2010) 1.01
The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts. J Neurosci (2007) 1.00
Axonal growth: where neurotrophins meet Wnts. Curr Opin Cell Biol (2005) 1.00