Published in Neuropsychopharmacology on February 21, 2007
Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev (2012) 2.54
Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatr Dis Treat (2009) 1.48
Research in people with psychosis risk syndrome: a review of the current evidence and future directions. J Child Psychol Psychiatry (2010) 1.36
N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A (2010) 1.28
A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. J Med Chem (2010) 1.27
Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine. J Psychiatr Res (2008) 1.26
The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex. J Neurosci (2012) 1.24
Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation. Int J Neuropsychopharmacol (2014) 1.18
Depression: a repair response to stress-induced neuronal microdamage that can grade into a chronic neuroinflammatory condition? Neurosci Biobehav Rev (2010) 1.17
Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells. Proc Natl Acad Sci U S A (2011) 1.10
Running exercise-induced up-regulation of hippocampal brain-derived neurotrophic factor is CREB-dependent. Hippocampus (2009) 1.09
Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Br J Pharmacol (2009) 1.08
Sigma receptors: potential targets for a new class of antidepressant drug. Pharmacol Ther (2010) 1.05
Vagal nerve stimulation rapidly activates brain-derived neurotrophic factor receptor TrkB in rat brain. PLoS One (2012) 1.03
Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression. J Neurochem (2009) 1.01
Mice with altered BDNF signaling as models for mood disorders and antidepressant effects. Front Behav Neurosci (2014) 0.99
Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS One (2011) 0.99
Persistent neural activity in the prefrontal cortex: a mechanism by which BDNF regulates working memory? Prog Brain Res (2008) 0.97
Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration. Mol Psychiatry (2011) 0.97
Neuropeptides in depression: role of VGF. Behav Brain Res (2008) 0.97
Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF? Br J Pharmacol (2014) 0.96
The Role of Neurotrophins in Major Depressive Disorder. Transl Neurosci (2013) 0.94
BDNF - a key transducer of antidepressant effects. Neuropharmacology (2015) 0.93
Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression. J Neurosci (2013) 0.92
Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Proc Natl Acad Sci U S A (2010) 0.92
Imipramine treatment improves cognitive outcome associated with enhanced hippocampal neurogenesis after traumatic brain injury in mice. J Neurotrauma (2011) 0.92
Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes. Front Behav Neurosci (2011) 0.92
Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. Transl Psychiatry (2013) 0.92
Future Antidepressant Targets: Neurotrophic Factors and Related Signaling Cascades. Drug Discov Today Ther Strateg (2008) 0.90
Differential effects of acute and repeated citalopram in mouse models of anxiety and depression. Int J Neuropsychopharmacol (2009) 0.89
Functional interactions between steroid hormones and neurotrophin BDNF. World J Biol Chem (2010) 0.88
A review of antidepressant therapy in primary care: current practices and future directions. Prim Care Companion CNS Disord (2013) 0.88
BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice. J Psychiatry Neurosci (2014) 0.87
Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress. Evid Based Complement Alternat Med (2013) 0.87
Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine. Transl Psychiatry (2015) 0.86
Reproductive aging, sex steroids, and mood disorders. Harv Rev Psychiatry (2009) 0.86
Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus. Neuropharmacology (2011) 0.86
Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms. Front Behav Neurosci (2014) 0.86
N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain. Neuroscientist (2012) 0.85
Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women. Br J Psychiatry (2012) 0.85
The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease. PLoS One (2013) 0.84
Adult-onset fluoxetine treatment does not improve behavioral impairments and may have adverse effects on the Ts65Dn mouse model of Down syndrome. Neural Plast (2012) 0.83
Darkness reduces BDNF expression in the visual cortex and induces repressive chromatin remodeling at the BDNF gene in both hippocampus and visual cortex. Cell Mol Neurobiol (2010) 0.83
Citalopram enhances neurovascular regeneration and sensorimotor functional recovery after ischemic stroke in mice. Neuroscience (2013) 0.83
Therapeutic modalities for treatment resistant depression: focus on vagal nerve stimulation and ketamine. Clin Psychopharmacol Neurosci (2014) 0.83
Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, β-catenin and antidepressant-like effects. Br J Pharmacol (2012) 0.83
The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development. PLoS One (2012) 0.83
From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF). Pharmaceutics (2013) 0.83
Nimodipine activates TrkB neurotrophin receptors and induces neuroplastic and neuroprotective signaling events in the mouse hippocampus and prefrontal cortex. Cell Mol Neurobiol (2014) 0.82
Effects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia. Clin Interv Aging (2014) 0.81
Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo. Cell Mol Neurobiol (2009) 0.81
Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats. Lipids Health Dis (2013) 0.80
Signaling mechanisms involved in the acute effects of estradiol on 5-HT clearance. Int J Neuropsychopharmacol (2014) 0.80
Vagal Nerve Stimulation for Treatment-Resistant Depression. Neurotherapeutics (2017) 0.80
Association between BDNF gene polymorphisms and serotonergic activity using loudness dependence of auditory evoked potentials in healthy subjects. PLoS One (2013) 0.78
Differential behavioral and neurochemical effects of exercise, reboxetine and citalopram with the forced swim test. Life Sci (2009) 0.78
Neuronal cell adhesion genes and antidepressant response in three independent samples. Pharmacogenomics J (2015) 0.78
Two Chronic Stress Models Based on Movement Restriction in Rats Respond Selectively to Antidepressant Drugs: Aldolase C As a Potential Biomarker. Int J Neuropsychopharmacol (2015) 0.77
Effects of Long-Term Treatment with Estradiol and Estrogen Receptor Subtype Agonists on Serotonergic Function in Ovariectomized Rats. Neuroendocrinology (2015) 0.77
Neuronal plasticity and neurotrophic factors in drug responses. Mol Psychiatry (2017) 0.76
Effects of Citalopram on Sutural and Calvarial Cell Processes. PLoS One (2015) 0.76
Chronic fluoxetine dissociates contextual from auditory fear memory. Neurosci Lett (2016) 0.75
Reversion of BDNF, Akt and CREB in Hippocampus of Chronic Unpredictable Stress Induced Rats: Effects of Phytochemical, Bacopa Monnieri. Psychiatry Investig (2016) 0.75
Role of TrkB in the anxiolytic-like and antidepressant-like effects of vagal nerve stimulation: Comparison with desipramine. Neuroscience (2016) 0.75
Imipramine protects retinal ganglion cells from oxidative stress through the tyrosine kinase receptor B signaling pathway. Neural Regen Res (2016) 0.75
Possible associations of NTRK2 polymorphisms with antidepressant treatment outcome: findings from an extended tag SNP approach. PLoS One (2013) 0.75
Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies. Int J Mol Sci (2017) 0.75
Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. J Neurosci Res (2016) 0.75
Novel insights into the behavioral analysis of mice subjected to the forced-swim test. Transl Psychiatry (2015) 0.75
Neurotrophin Genes and Antidepressant-Worsening Suicidal Ideation: A Prospective Case-Control Study. Int J Neuropsychopharmacol (2016) 0.75
The Combination of Long-term Ketamine and Extinction Training Contributes to Fear Erasure by Bdnf Methylation. Front Cell Neurosci (2017) 0.75
Rapid activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway by electroconvulsive shock in the rat prefrontal cortex is not associated with TrkB neurotrophin receptor activation. Cell Mol Neurobiol (2007) 0.75
Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection. Neural Plast (2017) 0.75
Isoflurane produces antidepressant effects and induces TrkB signaling in rodents. Sci Rep (2017) 0.75
The 5-HT1B serotonin receptor regulates methylphenidate-induced gene expression in the striatum: Differential effects on immediate-early genes. J Psychopharmacol (2017) 0.75
Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior. Mol Psychiatry (2017) 0.75
The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science (2008) 4.36
Neuregulin-1 type III determines the ensheathment fate of axons. Neuron (2005) 4.19
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med (2009) 4.11
Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J Neurosci (2005) 3.02
Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J Neurosci (2003) 2.66
Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons. Cell Host Microbe (2010) 2.65
Fear erasure in mice requires synergy between antidepressant drugs and extinction training. Science (2011) 2.25
MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron (2005) 2.15
Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance. Nat Neurosci (2013) 2.14
Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron (2006) 1.97
Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes. J Neurosci (2004) 1.96
Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature (2002) 1.88
Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum. J Neurosci (2007) 1.75
The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching. Nat Neurosci (2010) 1.74
Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron (2006) 1.74
Contribution of common genetic variants to antidepressant response. Biol Psychiatry (2012) 1.73
Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment. Neuropsychopharmacology (2006) 1.72
Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis. Proc Natl Acad Sci U S A (2005) 1.67
Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron (2002) 1.65
Epigenetic modifications induced by early enrichment are associated with changes in timing of induction of BDNF expression. Neurosci Lett (2011) 1.62
Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. J Neurosci (2008) 1.60
Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease. Exp Neurol (2010) 1.59
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect. Proc Natl Acad Sci U S A (2008) 1.54
Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice. Eur J Neurosci (2002) 1.51
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biol Psychiatry (2010) 1.49
Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis. J Neurosci (2002) 1.48
Stable isotopic labeling by amino acids in cultured primary neurons: application to brain-derived neurotrophic factor-dependent phosphotyrosine-associated signaling. Mol Cell Proteomics (2008) 1.46
Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc Natl Acad Sci U S A (2004) 1.42
Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease. Cell Mol Life Sci (2011) 1.42
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor. J Biol Chem (2003) 1.41
Reversible and covalent binding of drugs to human serum albumin: methodological approaches and physiological relevance. Curr Med Chem (2002) 1.38
Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides. J Biol Chem (2002) 1.37
Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury. J Neurochem (2008) 1.36
Characterization of divIVA and other genes located in the chromosomal region downstream of the dcw cluster in Streptococcus pneumoniae. J Bacteriol (2003) 1.36
A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein. EMBO J (2004) 1.36
BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci (2006) 1.33
Neurotrophins, synaptic plasticity and dementia. Curr Opin Neurobiol (2007) 1.32
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol (2007) 1.30
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci (2010) 1.29
Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptors. Cytokine Growth Factor Rev (2002) 1.26
The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus. J Neurosci (2010) 1.26
Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains. J Biol Chem (2005) 1.25
Oxidative stress-related biomarkers in autism: systematic review and meta-analyses. Free Radic Biol Med (2012) 1.24
The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex. J Neurosci (2012) 1.24
Pro-NGF secreted by astrocytes promotes motor neuron cell death. Mol Cell Neurosci (2006) 1.23
Analysis and visualization of gene expression data using self-organizing maps. Neural Netw (2002) 1.22
Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. PLoS One (2011) 1.22
Telomerase activity in the subventricular zone of adult mice. Mol Cell Neurosci (2003) 1.21
Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments. Proc Natl Acad Sci U S A (2011) 1.20
Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice. J Pharmacol Exp Ther (2002) 1.19
Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal (2011) 1.19
Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. PLoS Med (2012) 1.19
Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning. Mol Cell Neurosci (2004) 1.17
Phage-display and correlated mutations identify an essential region of subdomain 1C involved in homodimerization of Escherichia coli FtsA. Proteins (2003) 1.17
Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice. J Neurochem (2010) 1.17
Drug binding to human serum albumin: abridged review of results obtained with high-performance liquid chromatography and circular dichroism. Chirality (2006) 1.16
Altered differentiation of neural stem cells in fragile X syndrome. Proc Natl Acad Sci U S A (2005) 1.16
BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology (2012) 1.16
TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain. J Biol Chem (2007) 1.15
Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein. Neurobiol Dis (2005) 1.15
Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation. J Biol Chem (2005) 1.15
Antipsychotic drug treatment induces differential gene expression in the rat cortex. J Neurochem (2002) 1.14
BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A (2012) 1.13
Ankyrin Repeat-rich Membrane Spanning/Kidins220 protein regulates dendritic branching and spine stability in vivo. Dev Neurobiol (2009) 1.12
Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB. Proc Natl Acad Sci U S A (2007) 1.12
Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons. J Biol Chem (2008) 1.12
Nuclear localization of the p75 neurotrophin receptor intracellular domain. J Biol Chem (2009) 1.11
TrkB as a potential synaptic and behavioral tag. J Neurosci (2011) 1.11
Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nat Commun (2013) 1.10
Experience-dependent expression of NPAS4 regulates plasticity in adult visual cortex. J Physiol (2012) 1.10
JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem (2003) 1.09
Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines. Cell Mol Neurobiol (2005) 1.08
Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis. Pharmacogenet Genomics (2012) 1.08
Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues. Histochem Cell Biol (2008) 1.07
Mesolimbic dopamine release is linked to symptom severity in pathological gambling. Neuroimage (2012) 1.07
Decreased BDNF signalling in transgenic mice reduces epileptogenesis. Eur J Neurosci (2002) 1.04
Transient reversal of episome silencing precedes VP16-dependent transcription during reactivation of latent HSV-1 in neurons. PLoS Pathog (2012) 1.04
Mechanisms of neurotrophin receptor vesicular transport. J Neurobiol (2004) 1.04
Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia. Hum Mol Genet (2009) 1.04
Effects of fluoxetine on behavioral deficits evoked by chronic social stress in rats. Behav Brain Res (2006) 1.03
Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing. J Neurosci (2009) 1.03
Long-lasting behavioural and molecular alterations induced by early postnatal fluoxetine exposure are restored by chronic fluoxetine treatment in adult mice. Eur Neuropsychopharmacol (2008) 1.03
In heterozygous GDNF knockout mice the response of striatal dopaminergic system to acute morphine is altered. Synapse (2006) 1.02
Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in Angelman syndrome model mice by ErbB inhibitors. Biol Psychiatry (2012) 1.02
Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity in rats. Eur J Neurosci (2010) 1.02
The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E. J Cell Biol (2004) 1.01
Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro. Mol Biol Cell (2008) 1.01
Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiol Aging (2011) 1.01
APP is phosphorylated by TrkA and regulates NGF/TrkA signaling. J Neurosci (2011) 1.01
Neuropathy target esterase is required for adult vertebrate axon maintenance. J Neurosci (2009) 1.01
Resistance to salt-induced hypertension in catechol-O-methyltransferase-gene-disrupted mice. J Hypertens (2003) 1.01
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor. Genes Dev (2012) 1.01
A role for huntington disease protein in dendritic RNA granules. J Biol Chem (2010) 1.01
BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse. Neurobiol Dis (2010) 1.00
Axonal growth: where neurotrophins meet Wnts. Curr Opin Cell Biol (2005) 1.00
The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts. J Neurosci (2007) 1.00
Distribution of catechol-O-methyltransferase (COMT) proteins and enzymatic activities in wild-type and soluble COMT deficient mice. J Neurochem (2010) 0.99
Issues about the physiological functions of prolyl oligopeptidase based on its discordant spatial association with substrates and inconsistencies among mRNA, protein levels, and enzymatic activity. J Histochem Cytochem (2009) 0.99
Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein. J Neurosci Res (2004) 0.99