Published in J Mol Biol on August 20, 2004
Towards third generation matrix metalloproteinase inhibitors for cancer therapy. Br J Cancer (2006) 2.20
Matrix metalloproteases: underutilized targets for drug delivery. J Drug Target (2007) 1.21
Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease. EXS (2012) 1.03
MMP-12 catalytic domain recognizes triple helical peptide models of collagen V with exosites and high activity. J Biol Chem (2008) 0.97
MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis. Cardiovasc Res (2010) 0.94
Solution structure of inhibitor-free human metalloelastase (MMP-12) indicates an internal conformational adjustment. J Mol Biol (2007) 0.89
Stictamides A-C, MMP12 inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid subunits. J Org Chem (2011) 0.88
Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins. Curr Drug Targets (2013) 0.87
Matrix Metalloproteinases and Bladder Cancer: What is New? ISRN Urol (2012) 0.85
Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation. J Biol Chem (2010) 0.83
Matrix metalloproteinase 12 is induced by heterogeneous nuclear ribonucleoprotein K and promotes migration and invasion in nasopharyngeal carcinoma. BMC Cancer (2014) 0.82
Characterization of Ca2+ interactions with matrix metallopeptidase-12: implications for matrix metallopeptidase regulation. Biochem J (2006) 0.80
Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins. J Biol Chem (2012) 0.79
An integrated computational approach to rationalize the activity of non-zinc-binding MMP-2 inhibitors. PLoS One (2012) 0.77
Allosteric inhibition of the neuropeptidase neurolysin. J Biol Chem (2014) 0.77
Myroilysin Is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Is Activated by a Cysteine Switch Mechanism. J Biol Chem (2017) 0.75
Probing water-protein contacts in a MMP-12/CGS27023A complex by nuclear magnetic resonance spectroscopy. J Biomol NMR (2012) 0.75
Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders. Prog Mol Biol Transl Sci (2017) 0.75
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med (2004) 18.86
Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science (2003) 11.39
Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N Engl J Med (2010) 6.45
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes (2005) 5.22
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest (2005) 4.81
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest (2002) 4.75
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A (2007) 3.76
The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes (2002) 3.63
Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. Lancet (2003) 3.31
Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42. J Cell Biol (2004) 3.06
Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes (2007) 2.91
Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc Natl Acad Sci U S A (2006) 2.88
The universal dynamics of cell spreading. Curr Biol (2007) 2.74
Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med (2005) 2.72
Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents. J Clin Endocrinol Metab (2004) 2.61
High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic phenotype. Diabetes (2007) 2.59
Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin. J Cell Biol (2006) 2.32
Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL. Magn Reson Med (2008) 2.27
Johnson-Kendall-Roberts theory applied to living cells. Phys Rev Lett (2005) 2.13
The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning. J Clin Endocrinol Metab (2005) 1.74
A medium-throughput crystallization approach. Acta Crystallogr D Biol Crystallogr (2002) 1.72
Interethnic differences in muscle, liver and abdominal fat partitioning in obese adolescents. PLoS One (2007) 1.66
The human tissue plasminogen activator-Cre mouse: a new tool for targeting specifically neural crest cells and their derivatives in vivo. Dev Biol (2003) 1.56
Control of puberty in farmed fish. Gen Comp Endocrinol (2009) 1.51
Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype. Development (2006) 1.37
Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation. J Clin Endocrinol Metab (2003) 1.36
Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility. J Cell Sci (2010) 1.35
Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proc Natl Acad Sci U S A (2011) 1.32
Intrahepatic fat accumulation and alterations in lipoprotein composition in obese adolescents: a perfect proatherogenic state. Diabetes Care (2007) 1.30
Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals. Proc Natl Acad Sci U S A (2008) 1.30
Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells. Cancer Res (2010) 1.30
Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia. J Clin Invest (2010) 1.27
Aspiration of biological viscoelastic drops. Phys Rev Lett (2010) 1.26
Primitive duplicate Hox clusters in the European eel's genome. PLoS One (2012) 1.21
Prototypical type I E-cadherin and type II cadherin-7 mediate very distinct adhesiveness through their extracellular domains. J Biol Chem (2005) 1.20
Regulation of apoptotic mediators reveals dynamic responses to thermal stress in the reef building coral Acropora millepora. PLoS One (2011) 1.20
Structure of the Escherichia coli heptosyltransferase WaaC: binary complexes with ADP and ADP-2-deoxy-2-fluoro heptose. J Mol Biol (2006) 1.16
Beta1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells. Development (2009) 1.16
α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength. J Biol Chem (2012) 1.14
Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. Diabetes (2012) 1.13
Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty. Biol Reprod (2004) 1.09
Epibranchial ganglia orchestrate the development of the cranial neurogenic crest. Proc Natl Acad Sci U S A (2010) 1.09
Spreading dynamics and wetting transition of cellular aggregates. Proc Natl Acad Sci U S A (2011) 1.09
Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system. Development (2004) 1.08
Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes. Proc Natl Acad Sci U S A (2012) 1.05
Separation force measurements reveal different types of modulation of E-cadherin-based adhesion by nectin-1 and -3. J Biol Chem (2004) 1.05
Assessment of patient-led or physician-driven continuous glucose monitoring in patients with poorly controlled type 1 diabetes using basal-bolus insulin regimens: a 1-year multicenter study. Diabetes Care (2012) 1.05
Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage. Retrovirology (2013) 1.04
From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria. J Med Chem (2012) 1.02
Androgen-dependent stimulation of brain dopaminergic systems in the female European eel (Anguilla anguilla). Endocrinology (2006) 1.01
Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors. Bioorg Med Chem Lett (2005) 1.00
The plant uncoupling protein homologues: a new family of energy-dissipating proteins in plant mitochondria. Plant Physiol Biochem (2004) 1.00
First draft genome sequence of the Japanese eel, Anguilla japonica. Gene (2012) 1.00
Changes in cholesterol levels in the plasma membrane modulate cell signaling and regulate cell adhesion and migration on fibronectin. Cell Motil Cytoskeleton (2007) 0.99
Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells. Cell Signal (2011) 0.95
Simple rules for a "simple" nervous system? Molecular and biomathematical approaches to enteric nervous system formation and malformation. Dev Biol (2013) 0.95
Analysis of the inflammatory response induced by rhMMP-12 catalytic domain instilled in mouse airways. Int Immunopharmacol (2005) 0.94
Endocrine evidence that silvering, a secondary metamorphosis in the eel, is a pubertal rather than a metamorphic event. Neuroendocrinology (2006) 0.93
Adenine phosphoribosyltransferase isoforms of Arabidopsis and their potential contributions to adenine and cytokinin metabolism. Physiol Plant (2002) 0.93
The presence and ancestral role of gonadotropin-releasing hormone in the reproduction of scleractinian coral, Euphyllia ancora. Endocrinology (2005) 0.93
E-cadherin-dependent stimulation of traction force at focal adhesions via the Src and PI3K signaling pathways. Biophys J (2012) 0.92
Role of E-cadherin in membrane-cortex interaction probed by nanotube extrusion. Biophys J (2009) 0.92
Multiple kisspeptin receptors in early osteichthyans provide new insights into the evolution of this receptor family. PLoS One (2012) 0.91
Changes in the endoplasmic reticulum lipid properties in response to low temperature in Brassica napus. Plant Physiol Biochem (2004) 0.90
Effects of high hydrostatic pressure on the pituitary-gonad axis in the European eel, Anguilla anguilla (L.). Gen Comp Endocrinol (2007) 0.90
Mechanosensitive shivering of model tissues under controlled aspiration. Proc Natl Acad Sci U S A (2011) 0.89
VGLUT2-dependent glutamatergic transmission in primary afferents is required for intact nociception in both acute and persistent pain modalities. Pain (2012) 0.89
Stereoselective glycal fluorophosphorylation: synthesis of ADP-2-fluoroheptose, an inhibitor of the LPS biosynthesis. Chemistry (2008) 0.89
New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls. Blood (2006) 0.87
N-cadherin and β1-integrins cooperate during the development of the enteric nervous system. Dev Biol (2012) 0.87
Development of real-time RT-PCR assays for eel gonadotropins and their application to the comparison of in vivo and in vitro effects of sex steroids. Gen Comp Endocrinol (2007) 0.87
Differential expression and regulation of gonadotropins and their receptors in the Japanese eel, Anguilla japonica. Gen Comp Endocrinol (2007) 0.87
Sox10 and Itgb1 interaction in enteric neural crest cell migration. Dev Biol (2013) 0.86
Biochemical and biophysical origins of cadherin selectivity and adhesion strength. Curr Opin Cell Biol (2012) 0.86
Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem (2007) 0.85
Negative feedback from integrins to cadherins: a micromechanical study. Biophys J (2011) 0.85
Pituitary gonadotropins FSH and LH are oppositely regulated by the activin/follistatin system in a basal teleost, the eel. Gen Comp Endocrinol (2011) 0.85
Comparative evolutionary histories of kisspeptins and kisspeptin receptors in vertebrates reveal both parallel and divergent features. Front Endocrinol (Lausanne) (2012) 0.84
Clinical and biochemical characteristics of normotensive patients with primary aldosteronism: a comparison with hypertensive cases. Clin Endocrinol (Oxf) (2008) 0.84
Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase. Bioorg Med Chem (2008) 0.83
Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration. Cell Signal (2008) 0.83
Development of a stickleback kidney cell culture assay for the screening of androgenic and anti-androgenic endocrine disrupters. Aquat Toxicol (2006) 0.83
Cortisol mobilizes mineral stores from vertebral skeleton in the European eel: an ancestral origin for glucocorticoid-induced osteoporosis? J Endocrinol (2009) 0.83
Alternative oxidase involvement in cold stress response of Arabidopsis thaliana fad2 and FAD3+ cell suspensions altered in membrane lipid composition. Plant Cell Physiol (2007) 0.83
Comparative aspects of GH and metabolic regulation in lower vertebrates. Neuroendocrinology (2007) 0.82
Dopamine inhibits reproduction in female zebrafish (Danio rerio) via three pituitary D2 receptor subtypes. Endocrinology (2013) 0.82
Endocrine control of Anguilla anguilla glass eel dispersal: effect of thyroid hormones on locomotor activity and rheotactic behavior. Horm Behav (2005) 0.82
Systematic synthesis of inhibitors of the two first enzymes of the bacterial heptose biosynthetic pathway: towards antivirulence molecules targeting lipopolysaccharide biosynthesis. Chemistry (2011) 0.82
Differential regulation of the expression of cytochrome P450 aromatase, estrogen and androgen receptor subtypes in the brain-pituitary-ovarian axis of the Japanese eel (Anguilla japonica) reveals steroid dependent and independent mechanisms. Gen Comp Endocrinol (2011) 0.82
A RasGAP SH3 peptide aptamer inhibits RasGAP-Aurora interaction and induces caspase-independent tumor cell death. PLoS One (2008) 0.82
A quantitative real-time RT-PCR assay for European eel tyrosine hydroxylase. Gen Comp Endocrinol (2005) 0.82
18F-FDOPA PET/CT imaging of insulinoma revisited. Eur J Nucl Med Mol Imaging (2014) 0.81
Two distinct dopamine D2 receptor genes in the European eel: molecular characterization, tissue-specific transcription, and regulation by sex steroids. Endocrinology (2008) 0.81
Differential expression of beta3 integrin gene in chick and mouse cranial neural crest cells. Dev Dyn (2003) 0.81
Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives. Bioorg Med Chem Lett (2004) 0.80