Published in Physiology (Bethesda) on August 01, 2004
Two routes to functional adaptation: Tibetan and Andean high-altitude natives. Proc Natl Acad Sci U S A (2007) 2.78
Hypoxia-responsive transcription factors. Pflugers Arch (2005) 2.64
uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol (2007) 2.11
Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci U S A (2009) 2.02
MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol Cell Biol (2011) 1.81
PGC-1 coactivators and skeletal muscle adaptations in health and disease. Curr Opin Genet Dev (2008) 1.80
A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove. Blood (2007) 1.69
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med (2006) 1.66
Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase. Cell Res (2008) 1.64
The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab (2010) 1.64
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem J (2007) 1.58
Regulation of human metabolism by hypoxia-inducible factor. Proc Natl Acad Sci U S A (2010) 1.56
Neuroglobin: an endogenous neuroprotectant. Curr Opin Pharmacol (2007) 1.53
Mechanisms in photodynamic therapy: part two-cellular signaling, cell metabolism and modes of cell death. Photodiagnosis Photodyn Ther (2005) 1.52
Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha. FEBS Lett (2005) 1.51
Revascularization of ischemic skeletal muscle by estrogen-related receptor-γ. Circ Res (2012) 1.51
Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species. Chem Res Toxicol (2012) 1.51
Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes. J Neuroinflammation (2007) 1.48
Sensing and signalling in response to oxygen deprivation in plants and other organisms. Ann Bot (2005) 1.48
Neuroprotection in diet-induced ketotic rat brain after focal ischemia. J Cereb Blood Flow Metab (2008) 1.44
The human side of hypoxia-inducible factor. Br J Haematol (2008) 1.41
Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma. BMC Cancer (2013) 1.40
Chronic hypoxia up-regulates alpha1H T-type channels and low-threshold catecholamine secretion in rat chromaffin cells. J Physiol (2007) 1.36
Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility. Oncogene (2010) 1.33
The increase in pulmonary arterial pressure caused by hypoxia depends on iron status. J Physiol (2008) 1.32
In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. Cancer Res (2010) 1.31
Multiscale models of angiogenesis. IEEE Eng Med Biol Mag (2009) 1.26
Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha. J Biol Chem (2006) 1.24
Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress. Neurochem Res (2007) 1.22
Reactive oxygen species regulate hypoxia-inducible factor 1alpha differentially in cancer and ischemia. Mol Cell Biol (2008) 1.21
Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen. FEBS J (2010) 1.20
A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1 alpha. J Cell Sci (2006) 1.20
HIF-1alpha: a master regulator of innate host defenses? J Clin Invest (2005) 1.18
Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci U S A (2009) 1.18
Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice. PLoS One (2011) 1.18
Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B. J Am Chem Soc (2009) 1.17
Ultrasensitive response motifs: basic amplifiers in molecular signalling networks. Open Biol (2013) 1.16
Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation. FASEB J (2011) 1.14
HIF-1α coordinates lymphangiogenesis during wound healing and in response to inflammation. FASEB J (2011) 1.13
Diabetic Retinopathy: Vascular and Inflammatory Disease. J Diabetes Res (2015) 1.13
Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proc Natl Acad Sci U S A (2013) 1.12
Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point. Free Radic Biol Med (2006) 1.11
Genetic organization and hypoxic activation of the Kaposi's sarcoma-associated herpesvirus ORF34-37 gene cluster. J Virol (2006) 1.11
Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting. BMC Syst Biol (2009) 1.10
Interaction between signalling pathways involved in skeletal muscle responses to endurance exercise. Pflugers Arch (2006) 1.10
Age-associated chronic diseases require age-old medicine: role of chronic inflammation. Prev Med (2011) 1.09
Imaging tumour hypoxia with positron emission tomography. Br J Cancer (2014) 1.09
O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration. Am J Physiol Cell Physiol (2008) 1.08
Reactive oxygen species in normal and tumor stem cells. Adv Cancer Res (2014) 1.06
Hydrogen sulfide increases hypoxia-inducible factor-1 activity independently of von Hippel-Lindau tumor suppressor-1 in C. elegans. Mol Biol Cell (2009) 1.06
Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells. J Exp Clin Cancer Res (2012) 1.05
Hypoxia inducible factor-1: its potential role in cerebral ischemia. Cell Mol Neurobiol (2012) 1.05
Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials. World J Gastroenterol (2014) 1.04
Importance of mitochondria in survival of Cryptococcus neoformans under low oxygen conditions and tolerance to cobalt chloride. PLoS Pathog (2008) 1.04
Metabolic function in Drosophila melanogaster in response to hypoxia and pure oxygen. J Exp Biol (2009) 1.04
Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation. Neoplasia (2010) 1.03
Tristetraprolin: roles in cancer and senescence. Ageing Res Rev (2012) 1.03
Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors. J Biomed Biotechnol (2010) 1.02
Suppression of breast cancer metastasis through the inhibition of VEGF-mediated tumor angiogenesis. Cancer Ther (2007) 1.02
The hypoxic testicle: physiology and pathophysiology. Oxid Med Cell Longev (2012) 1.01
A protein therapeutic modality founded on molecular regulation. Proc Natl Acad Sci U S A (2011) 1.01
Effects of histone deacetylase inhibitors on HIF-1. Cell Cycle (2006) 1.01
Hydrogen sulfide inhibits hypoxia- but not anoxia-induced hypoxia-inducible factor 1 activation in a von hippel-lindau- and mitochondria-dependent manner. Antioxid Redox Signal (2011) 1.00
Expression of hypoxia-inducible factor-1alpha and -2alpha in human choroidal neovascular membranes. Graefes Arch Clin Exp Ophthalmol (2009) 1.00
New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma. Int J Med Sci (2015) 1.00
Prolyl 4-hydroxylase activity-responsive transcription factors: from hydroxylation to gene expression and neuroprotection. Front Biosci (2008) 0.99
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth. Cell Cycle (2013) 0.98
PGC-1β regulates angiogenesis in skeletal muscle. Am J Physiol Endocrinol Metab (2011) 0.98
The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes. J Biol Chem (2011) 0.98
Three autocrine feedback loops determine HIF1 alpha expression in chronic hypoxia. Biochim Biophys Acta (2007) 0.97
HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs). Breast Cancer Res (2013) 0.96
Hypoxia, angiogenesis and liver fibrogenesis in the progression of chronic liver diseases. World J Gastroenterol (2010) 0.96
Theoretical models for coronary vascular biomechanics: progress & challenges. Prog Biophys Mol Biol (2010) 0.96
Copper response regulator1-dependent and -independent responses of the Chlamydomonas reinhardtii transcriptome to dark anoxia. Plant Cell (2013) 0.94
Tubular von Hippel-Lindau knockout protects against rhabdomyolysis-induced AKI. J Am Soc Nephrol (2013) 0.94
Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism. PLoS One (2013) 0.94
Overexpression of MMP-9 and HIF-1α in Breast Cancer Cells under Hypoxic Conditions. J Breast Cancer (2011) 0.94
Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke. Antioxid Redox Signal (2010) 0.94
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Am J Pathol (2006) 0.93
Coordination changes and auto-hydroxylation of FIH-1: uncoupled O2-activation in a human hypoxia sensor. J Inorg Biochem (2008) 0.93
Proteostasis and REDOX state in the heart. Am J Physiol Heart Circ Physiol (2011) 0.93
Neuronal HIF-1 alpha protein and VEGFR-2 immunoreactivity in functionally related motor areas following a focal M1 infarct. J Cereb Blood Flow Metab (2007) 0.93
Histone deacetylases in viral infections. Clin Epigenetics (2010) 0.93
Roles for HIF-1α in neural stem cell function and the regenerative response to stroke. Behav Brain Res (2011) 0.92
Spectroscopic studies of the mononuclear non-heme Fe(II) enzyme FIH: second-sphere contributions to reactivity. J Am Chem Soc (2013) 0.92
MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner. J Biol Chem (2014) 0.92
Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism. Neoplasia (2007) 0.92
Inverse solvent isotope effects demonstrate slow aquo release from hypoxia inducible factor-prolyl hydroxylase (PHD2). Biochemistry (2012) 0.91
Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1alpha and the von Hippel-Lindau protein. J Physiol (2006) 0.91
Obstructive sleep apnea and cognitive impairment: addressing the blood-brain barrier. Sleep Med Rev (2013) 0.91
Newly discovered angiogenesis inhibitors and their mechanisms of action. Acta Pharmacol Sin (2012) 0.91
p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast cancer cells. Cancer Invest (2010) 0.91
Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1). Curr Pharm Des (2006) 0.91
Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1α and vascular endothelial growth factor signaling. Circulation (2014) 0.91
The protective role of 5-HMF against hypoxic injury. Cell Stress Chaperones (2010) 0.91
Suppression of hypoxia-induced HIF-1alpha and of angiogenesis in endothelial cells by myo-inositol trispyrophosphate-treated erythrocytes. Proc Natl Acad Sci U S A (2006) 0.90
Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia. Am J Physiol Cell Physiol (2015) 0.89
Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling. J Am Soc Nephrol (2015) 0.89
Hypoxia-induced angiogenesis is delayed in aging mouse brain. Brain Res (2011) 0.89
The second coordination sphere of FIH controls hydroxylation. Biochemistry (2011) 0.89