Published in Am J Physiol Cell Physiol on May 07, 2008
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature (2014) 4.10
Assessing bioenergetic function in response to oxidative stress by metabolic profiling. Free Radic Biol Med (2011) 2.40
Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biol Chem (2012) 2.08
Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell (2014) 1.53
A high-throughput respirometric assay for mitochondrial biogenesis and toxicity. Anal Biochem (2010) 1.38
The rate of oxygen utilization by cells. Free Radic Biol Med (2011) 1.36
Bioenergetic characterization of mouse podocytes. Am J Physiol Cell Physiol (2010) 1.16
Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform. J Bioenerg Biomembr (2012) 0.98
HIF-1α in heart: protective mechanisms. Am J Physiol Heart Circ Physiol (2013) 0.85
The self-organizing fractal theory as a universal discovery method: the phenomenon of life. Theor Biol Med Model (2011) 0.81
Alveolar type II cells maintain bioenergetic homeostasis in hypoxia through metabolic and molecular adaptation. Am J Physiol Lung Cell Mol Physiol (2014) 0.79
Competitive HIF Prolyl Hydroxylase Inhibitors Show Protection against Oxidative Stress by a Mechanism Partially Dependent on Glycolysis. ISRN Neurosci (2013) 0.76
Analytic Models of Oxygen and Nutrient Diffusion, Metabolism Dynamics, and Architecture Optimization in Three-Dimensional Tissue Constructs with Applications and Insights in Cerebral Organoids. Tissue Eng Part C Methods (2016) 0.76
HIF-1α in the heart: remodeling nucleotide metabolism. J Mol Cell Cardiol (2015) 0.75
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science (2001) 23.83
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (2001) 22.06
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell (2001) 19.75
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab (2006) 13.22
A conserved family of prolyl-4-hydroxylases that modify HIF. Science (2001) 11.50
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab (2006) 10.14
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev (2002) 7.08
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J (2003) 6.44
HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol (1985) (2000) 5.75
The influence of respiration and ATP hydrolysis on the proton-electrochemical gradient across the inner membrane of rat-liver mitochondria as determined by ion distribution. Eur J Biochem (1974) 4.70
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci U S A (2006) 4.08
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem (2002) 3.91
Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc Natl Acad Sci U S A (1996) 3.89
Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) (2004) 3.79
Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J Biol Chem (2006) 3.43
Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol (1995) 2.90
Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol (2000) 2.29
Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors. FASEB J (2003) 1.78
von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Proc Natl Acad Sci U S A (2003) 1.78
Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates. Proc Natl Acad Sci U S A (2000) 1.74
Oxygen conformance of cellular respiration in hepatocytes. Am J Physiol (1993) 1.42
Metabolic responses to cardiac hypoxia. Increased production of succinate by rabbit papillary muscles. Circ Res (1978) 1.41
Mitochondrial function as a determinant of recovery or death in cell response to injury. Mol Cell Biochem (1998) 1.39
Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. Cancer Res (2004) 1.33
Specificity of carnitine action on fatty acid oxidation by heart muscle. Am J Physiol (1962) 1.29
Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury. Am J Physiol Renal Physiol (2000) 1.14
Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes. J Biol Chem (2003) 1.06
Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules. Am J Physiol Renal Physiol (2003) 1.06
Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. Am J Physiol Heart Circ Physiol (2002) 1.03
Multiple end products of anaerobiosis in diving vertebrates. Comp Biochem Physiol B (1975) 1.00
The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition. Am J Physiol Cell Physiol (2006) 0.99
Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance. Acta Physiol (Oxf) (2007) 0.98
Metabolic consequences of diving in animals and man. Science (1975) 0.97
De novo alanine synthesis in isolated oxygen-deprived rabbit myocardium. J Biol Chem (1977) 0.95
Effects and metabolism of fumarate in the perfused rat heart. A 13C mass isotopomer study. Am J Physiol (1997) 0.94
Pathways of succinate formation and their contribution to improvement of cardiac function in the hypoxic rat heart. Biochem Med Metab Biol (1988) 0.91
Myocardial hibernation. Ital Heart J (2002) 0.88
Protein synthesis during oxygen conformance and severe hypoxia in the mouse muscle cell line C2C12. Biochim Biophys Acta (2000) 0.87
Purification and properties of dolphin muscle aspartate and alanine transaminases and thier possible roles in the energy metabolism of diving mammals. Biochem J (1974) 0.87
Development of an HPLC-fluorescence determination method for carboxylic acids related to the tricarboxylic acid cycle as a metabolome tool. Biomed Chromatogr (2005) 0.85
Metabolic arrest: the most effective means of protecting tissues against hypoxia. Prog Clin Biol Res (1983) 0.85
Hypoxia causes downregulation of protein and RNA synthesis in noncontracting Mammalian cardiomyocytes. Circ Res (2002) 0.85
Substrate support for renal functions during hypoxia in the perfused rat kidney. Am J Physiol (1984) 0.84
Augmented conversion of aspartate and glutamate to succinate during anoxia in rabbit heart. Am J Physiol (1979) 0.84
Evidence for succinate production by reduction of fumarate during hypoxia in isolated adult rat heart cells. Arch Biochem Biophys (1987) 0.83
Control of oxidative metabolism in volume-overloaded rat hearts: effects of different lipid substrates. Am J Physiol (1994) 0.78
Metabolic aspects of hibernating myocardium. Z Kardiol (1995) 0.77
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med (2011) 4.68
Regulation of HIF-1alpha stability through S-nitrosylation. Mol Cell (2007) 3.50
Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. Sci Signal (2010) 2.36
Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer. Clin Cancer Res (2012) 2.14
GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res (2004) 1.49
Apoptotic caspases regulate induction of iPSCs from human fibroblasts. Cell Stem Cell (2010) 1.37
Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. Cancer Res (2004) 1.33
Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. Cancer Res (2005) 1.29
Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth. Cancer Res (2007) 1.27
Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling. FASEB J (2005) 1.27
Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation. Cancer Res (2006) 1.26
Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. Cell Res (2011) 1.26
Systemic dissemination of viral vectors during intratumoral injection. Mol Cancer Ther (2003) 1.18
Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. Mol Vis (2005) 1.18
GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. J Exp Med (2002) 1.13
Age-associated changes in hearts of male Fischer 344/Brown Norway F1 rats. Ann Clin Lab Sci (2006) 1.09
Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo. Cancer Res (2008) 1.09
Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol (2008) 1.05
The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition. Am J Physiol Cell Physiol (2006) 0.99
Soluble TGFbeta type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats. Int J Radiat Oncol Biol Phys (2003) 0.98
A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells. Clin Cancer Res (2004) 0.98
A novel method for viral gene delivery in solid tumors. Cancer Res (2005) 0.97
Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals. Dis Markers (2002) 0.95
Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation (2008) 0.95
Novel l-adenosine analogs as cardioprotective agents. Bioorg Med Chem (2008) 0.92
In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy. AJR Am J Roentgenol (2008) 0.91
A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas. Mol Cancer Ther (2007) 0.89
Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction. Am J Physiol Heart Circ Physiol (2008) 0.87
A unique role of the DNA fragmentation factor in maintaining genomic stability. Proc Natl Acad Sci U S A (2006) 0.86
Systemic virus dissemination during local gene delivery in solid tumors and its control with an alginate solution. Conf Proc IEEE Eng Med Biol Soc (2004) 0.86
HIF-1α in heart: protective mechanisms. Am J Physiol Heart Circ Physiol (2013) 0.85
Distinctive gene transduction efficiencies of commonly used viral vectors in the retina. Curr Eye Res (2008) 0.85
Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death. Liver Transpl (2010) 0.85
[Antitumoral action of interferons and interleukins in combination with radiotherapy. Part I: immunologic basis]. Strahlenther Onkol (2004) 0.85
Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery. Mol Cancer Ther (2006) 0.84
Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo. Cancer Res (2011) 0.84
Inhibition of inducible nitric oxide synthase prevents mitochondrial damage and improves survival of steatotic partial liver grafts. Transplantation (2010) 0.83
Cell death-stimulated cell proliferation: a tissue regeneration mechanism usurped by tumors during radiotherapy. Semin Radiat Oncol (2013) 0.83
Imaging molecular pathways: reporter genes. Radiat Res (2012) 0.83
Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct. Int J Hyperthermia (2006) 0.83
Effect of warfarin on outcomes in septuagenarian patients with atrial fibrillation. Am J Cardiol (2011) 0.82
Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression. Cancer Res (2005) 0.81
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA. Transl Cancer Res (2012) 0.81
Molecular analysis of genetic instability caused by chronic inflammation. Methods Mol Biol (2009) 0.81
A comparison of antiangiogenic therapies for the prevention of liver metastases. J Surg Res (2005) 0.80
Acetaminophen protects against iron-induced cardiac damage in gerbils. Ann Clin Lab Sci (2007) 0.80
Effect of experimental hyperhomocysteinemia on cardiac structure and function in the rat. Ann Clin Lab Sci (2004) 0.80
Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy. Int J Radiat Oncol Biol Phys (2010) 0.79
[Antitumoral action of interferons and interleukins in combination with radiotherapy. Part II: radiobiological and immunologic strategies]. Strahlenther Onkol (2004) 0.79
Non-invasive, quantitative monitoring of hyperthermia-induced EGFR activation in xenograft tumours. Int J Hyperthermia (2011) 0.79
Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy. Int J Hyperthermia (2006) 0.79
Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma. Cancer Res (2006) 0.79
Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase. Clin Cancer Res (2003) 0.78
Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression. Sci China Life Sci (2014) 0.78
Fabrication of Murine Ventricular Balloons for the Langendorff Heart Preparation. J Biotechnol Biomater (2011) 0.78
9-Phenanthrol and flufenamic acid inhibit calcium oscillations in HL-1 mouse cardiomyocytes. Cell Calcium (2013) 0.77
Down-regulation of calponin destabilizes actin cytoskeletal structure in A7r5 cells. Can J Physiol Pharmacol (2007) 0.76
Increased skin carcinogenesis in caspase-activated DNase knockout mice. Carcinogenesis (2009) 0.76
Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy. Cancer Invest (2008) 0.76
Need radioprotection? A MEPE/OF45 mimetic may do the job. Cell Cycle (2010) 0.75
Myosin light chain kinase/actin interaction in phorbol dibutyrate-stimulated smooth muscle cells. J Pharmacol Sci (2011) 0.75
[A novel model for visualization of tumor cell-induced angiogenesis in vivo]. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) (2002) 0.75
Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation. Am J Physiol Heart Circ Physiol (2006) 0.75
[Inhibitation of tumor angiogenesis, growth and metastasis by blocking VEGF paracrine pathway]. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) (2002) 0.75
Cell cycle deregulation and xeroderma pigmentosum group C cell transformation. J Invest Dermatol (2002) 0.75