Published in Physiology (Bethesda) on August 01, 2004
ADP-ribosylation factor-like 3 is involved in kidney and photoreceptor development. Am J Pathol (2006) 1.45
miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol (2012) 1.34
Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice. Dev Cell (2007) 1.33
New insights into the biology of renal cell carcinoma. Hematol Oncol Clin North Am (2011) 1.31
Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals. Purinergic Signal (2007) 1.27
Cell biology of polycystin-2. Cell Signal (2006) 1.21
Loss of polycystin-1 causes centrosome amplification and genomic instability. Hum Mol Genet (2008) 1.20
Drosophila provides rapid modeling of renal development, function, and disease. Am J Physiol Renal Physiol (2010) 1.18
A mouse model for Meckel syndrome type 3. J Am Soc Nephrol (2009) 1.16
The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies. Cell Mol Life Sci (2012) 0.99
Mutant kinesin-2 motor subunits increase chromosome loss. Mol Biol Cell (2005) 0.98
Purinergic signaling in the lumen of a normal nephron and in remodeled PKD encapsulated cysts. Purinergic Signal (2008) 0.97
Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A (2007) 0.97
The role for HNF-1beta-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells. PLoS One (2007) 0.96
Knockdown of bicaudal C in zebrafish (Danio rerio) causes cystic kidneys: a nonmammalian model of polycystic kidney disease. Comp Med (2010) 0.94
Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways. BMC Nephrol (2010) 0.93
mTOR is out of control in polycystic kidney disease. Proc Natl Acad Sci U S A (2006) 0.84
Nephrocystin and ciliary defects not only in the kidney? Pediatr Nephrol (2007) 0.84
Mechanisms of p53-mediated repression of the human polycystic kidney disease-1 promoter. Biochim Biophys Acta (2010) 0.81
Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site. J Cell Sci (2015) 0.78
Intracellular localization of α-tubulin acetyltransferase ATAT1 in rat ciliated cells. Med Mol Morphol (2015) 0.77
Unconventional Functions of Mitotic Kinases in Kidney Tumorigenesis. Front Oncol (2015) 0.75
Genetic spectrum of Saudi Arabian patients with antenatal cystic kidney disease and ciliopathy phenotypes using a targeted renal gene panel. J Med Genet (2016) 0.75
Routes and machinery of primary cilium biogenesis. Cell Mol Life Sci (2017) 0.75
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet (2005) 6.15
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell (2004) 6.10
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development (2005) 4.64
Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet (2007) 3.79
Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. Curr Biol (2007) 3.76
The primary cilium as a complex signaling center. Curr Biol (2009) 3.73
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis. J Cell Biol (2011) 3.11
An incredible decade for the primary cilium: a look at a once-forgotten organelle. Am J Physiol Renal Physiol (2005) 3.07
Intraflagellar transport is essential for endochondral bone formation. Development (2006) 2.90
Ciliary dysfunction in developmental abnormalities and diseases. Curr Top Dev Biol (2008) 2.88
Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus. Development (2005) 2.36
Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol (2009) 2.09
Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J Clin Invest (2002) 2.07
The primary cilium in cell signaling and cancer. Cancer Res (2006) 1.97
Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool. J Neurosci (2007) 1.92
Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4. J Am Soc Nephrol (2010) 1.85
Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol Biol Cell (2007) 1.82
Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia. Am J Physiol Cell Physiol (2005) 1.74
Loss of the Tg737 protein results in skeletal patterning defects. Dev Dyn (2003) 1.71
Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk mice. Am J Physiol Renal Physiol (2005) 1.66
Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. Cell Physiol Biochem (2010) 1.63
Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis. Mol Biol Cell (2008) 1.59
XBX-1 encodes a dynein light intermediate chain required for retrograde intraflagellar transport and cilia assembly in Caenorhabditis elegans. Mol Biol Cell (2003) 1.57
A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and Mammalian cells. Mol Biol Cell (2003) 1.56
Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells. Am J Physiol Renal Physiol (2006) 1.47
The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception. J Cell Sci (2005) 1.44
Development of the post-natal growth plate requires intraflagellar transport proteins. Dev Biol (2007) 1.44
Soluble levels of cytosolic tubulin regulate ciliary length control. Mol Biol Cell (2011) 1.41
Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation. Cancer Res (2002) 1.38
Identification of CHE-13, a novel intraflagellar transport protein required for cilia formation. Exp Cell Res (2003) 1.38
Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice. Lab Invest (2005) 1.38
The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and men. Dev Dyn (2008) 1.36
Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition. Circ Res (2011) 1.31
Primary cilia regulate Shh activity in the control of molar tooth number. Development (2009) 1.31
Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals. Purinergic Signal (2007) 1.27
Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines. Dev Dyn (2008) 1.27
IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans. J Cell Sci (2006) 1.24
An essential role for dermal primary cilia in hair follicle morphogenesis. J Invest Dermatol (2008) 1.22
The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proc Natl Acad Sci U S A (2010) 1.15
The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J Cell Sci (2009) 1.12
Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation. Dev Biol (2011) 1.09
Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia. Mol Biol Cell (2006) 1.08
Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model. Nat Med (2012) 1.05
Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development (2011) 1.05
Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice. Proc Natl Acad Sci U S A (2013) 0.98
Altered pH(i) regulation and Na(+)/HCO3(-) transporter activity in choroid plexus of cilia-defective Tg737(orpk) mutant mouse. Am J Physiol Cell Physiol (2006) 0.98
Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption. J Am Soc Nephrol (2013) 0.96
GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail. Dev Dyn (2011) 0.94
Microtubule modifications and stability are altered by cilia perturbation and in cystic kidney disease. Cytoskeleton (Hoboken) (2012) 0.88
Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis. Cilia (2012) 0.85
Role for primary cilia in the regulation of mouse ovarian function. Dev Dyn (2008) 0.84
Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement. J Am Soc Nephrol (2012) 0.84
Utilization of conditional alleles to study the role of the primary cilium in obesity. Methods Cell Biol (2009) 0.83
Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease. Am J Physiol Cell Physiol (2012) 0.82
Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways. Am J Physiol Lung Cell Mol Physiol (2013) 0.79
Generating conditional mutants to analyze ciliary functions: the use of Cre-lox technology to disrupt cilia in specific organs. Methods Cell Biol (2009) 0.79
Assessing the pathogenic potential of human Nephronophthisis disease-associated NPHP-4 missense mutations in C. elegans. Hum Mol Genet (2011) 0.79
Quantitative peptidomics of Purkinje cell degeneration mice. PLoS One (2013) 0.78