Published in Trends Cell Biol on August 01, 2004
The yeast actin cytoskeleton: from cellular function to biochemical mechanism. Microbiol Mol Biol Rev (2006) 2.55
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis. Nature (2012) 2.08
Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP. EMBO J (2007) 1.93
Anchoring junctions as drug targets: role in contraceptive development. Pharmacol Rev (2008) 1.76
Structure of the actin-depolymerizing factor homology domain in complex with actin. J Cell Biol (2008) 1.75
Quantitative proteomic analysis in metastatic renal cell carcinoma reveals a unique set of proteins with potential prognostic significance. Mol Cell Proteomics (2012) 1.72
Actin filament nucleation and elongation factors--structure-function relationships. Crit Rev Biochem Mol Biol (2009) 1.61
Profilin-1 is a negative regulator of mammary carcinoma aggressiveness. Br J Cancer (2007) 1.39
Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation. Mol Cell Biol (2008) 1.35
Profilin is essential for tip growth in the moss Physcomitrella patens. Plant Cell (2007) 1.33
Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins. J Cell Physiol (2009) 1.30
Dynamin and cytokinesis. Traffic (2006) 1.29
Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells. Proc Natl Acad Sci U S A (2010) 1.28
Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin. EMBO J (2011) 1.28
Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell (2012) 1.26
A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia. Am J Hum Genet (2006) 1.20
Profilin 1 is required for abscission during late cytokinesis of chondrocytes. EMBO J (2009) 1.19
Panallergens and their impact on the allergic patient. Allergy Asthma Clin Immunol (2010) 1.18
Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY. Mol Biol Cell (2012) 1.17
Changes in brain MicroRNAs contribute to cholinergic stress reactions. J Mol Neurosci (2009) 1.16
Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migration. Dev Cell (2009) 1.14
Profilin 1 is a potential biomarker for bladder cancer aggressiveness. Mol Cell Proteomics (2011) 1.14
Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol (2012) 1.12
Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli. Cell Mol Life Sci (2006) 1.10
Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells. Cancer Res (2009) 1.08
Molecular insights on context-specific role of profilin-1 in cell migration. Cell Adh Migr (2012) 1.07
Cytoplasmic Ig-domain proteins: cytoskeletal regulators with a role in human disease. Cell Motil Cytoskeleton (2009) 1.02
Non-redundant roles for Profilin2 and Profilin1 during vertebrate gastrulation. Dev Biol (2009) 1.01
Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells. Exp Cell Res (2009) 1.01
Piccolo regulates the dynamic assembly of presynaptic F-actin. J Neurosci (2011) 1.01
Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis. Oncogene (2013) 0.99
Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells. J Cell Physiol (2009) 0.98
The association of cortactin with profilin-1 is critical for smooth muscle contraction. J Biol Chem (2014) 0.96
Endogenous GluR1-containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: an electron microscopic immunocytochemical study. J Comp Neurol (2010) 0.95
Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons. EMBO Rep (2011) 0.95
Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner. Cell Motil Cytoskeleton (2006) 0.95
Evidence demonstrating role of microRNAs in the etiopathology of major depression. J Chem Neuroanat (2011) 0.94
Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation. Nat Cell Biol (2014) 0.94
Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation. J Cell Physiol (2010) 0.94
Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines. Cytoskeleton (Hoboken) (2012) 0.93
Diaphanous-related formin 2 and profilin I are required for gastrulation cell movements. PLoS One (2008) 0.93
A myosin IK-Abp1-PakB circuit acts as a switch to regulate phagocytosis efficiency. Mol Biol Cell (2010) 0.92
Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model. PLoS One (2011) 0.91
F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics. PLoS One (2010) 0.90
Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics. Neurobiol Dis (2008) 0.89
Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1. J Biol Chem (2015) 0.89
Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells. PLoS One (2010) 0.89
Role of c-Abl tyrosine kinase in smooth muscle cell migration. Am J Physiol Cell Physiol (2014) 0.86
The roles of the actin cytoskeleton in fear memory formation. Front Behav Neurosci (2011) 0.86
When fat is not bad: the regulation of actin dynamics by phospholipid signaling molecules. Front Plant Sci (2014) 0.86
Ras-related GTPases Rap1 and RhoA collectively induce the phagocytosis of serum-opsonized zymosan particles in macrophages. J Biol Chem (2011) 0.86
The effects of ADF/cofilin and profilin on the conformation of the ATP-binding cleft of monomeric actin. Biophys J (2009) 0.85
Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications. Dialogues Clin Neurosci (2014) 0.85
Analysis of nuclear actin by overexpression of wild-type and actin mutant proteins. Histochem Cell Biol (2013) 0.85
Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids. BMC Cell Biol (2009) 0.85
Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis. Mol Cancer (2014) 0.85
Topology of molecular machines of the endoplasmic reticulum: a compilation of proteomics and cytological data. Histochem Cell Biol (2008) 0.84
Silencing profilin-1 inhibits gastric cancer progression via integrin β1/focal adhesion kinase pathway modulation. World J Gastroenterol (2015) 0.84
A common variant in myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults. Transl Psychiatry (2013) 0.83
Role of the actin-binding protein profilin1 in radial migration and glial cell adhesion of granule neurons in the cerebellum. Cell Adh Migr (2012) 0.83
Profilin-1 versus profilin-2: two faces of the same coin? Breast Cancer Res (2013) 0.83
The cytoskeleton and neurite initiation. Bioarchitecture (2014) 0.83
Integrative proteomic and microRNA analysis of primary human coronary artery endothelial cells exposed to low-dose gamma radiation. Radiat Environ Biophys (2012) 0.83
RhoA/mDia-1/profilin-1 signaling targets microvascular endothelial dysfunction in diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol (2015) 0.82
Profilin 1 as a target for cathepsin X activity in tumor cells. PLoS One (2013) 0.82
Quantitative proteomics approach to screening of potential diagnostic and therapeutic targets for laryngeal carcinoma. PLoS One (2014) 0.82
Mechanisms of three-dimensional growth of thyroid cells during long-term simulated microgravity. Sci Rep (2015) 0.82
Preserved morphology and physiology of excitatory synapses in profilin1-deficient mice. PLoS One (2012) 0.82
Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1. PLoS One (2015) 0.82
Pathogenetic and therapeutic applications of microRNAs in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry (2015) 0.81
Actin filaments at the leading edge of cancer cells are characterized by a high mobile fraction and turnover regulation by profilin I. PLoS One (2014) 0.81
Molecular profiling reveals similarities and differences between primitive subsets of hematopoietic cells generated in vitro from human embryonic stem cells and in vivo during embryogenesis. Exp Hematol (2008) 0.81
A Legionella effector modulates host cytoskeletal structure by inhibiting actin polymerization. Microbes Infect (2013) 0.81
Protein interaction patterns in different cellular environments are revealed by in-cell NMR. Sci Rep (2015) 0.80
Profilin-1 haploinsufficiency protects against obesity-associated glucose intolerance and preserves adipose tissue immune homeostasis. Diabetes (2013) 0.80
Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow. Blood (2014) 0.80
The RNA-binding protein human antigen R controls global changes in gene expression during Schwann cell development. J Neurosci (2012) 0.80
Neurogenic and myogenic contributions to hereditary motor neuron disease. Neurodegener Dis (2012) 0.80
Towards scarless wound healing: a comparison of protein expression between human, adult and foetal fibroblasts. Biomed Res Int (2014) 0.79
Selectivity in subunit composition of Ena/VASP tetramers. Biosci Rep (2015) 0.79
Structural basis for mutation-induced destabilization of profilin 1 in ALS. Proc Natl Acad Sci U S A (2015) 0.79
Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation. J Neurosci (2015) 0.79
Profilin1 regulates invadopodium maturation in human breast cancer cells. Eur J Cell Biol (2014) 0.79
Profilin isoforms modulate astrocytic morphology and the motility of astrocytic processes. PLoS One (2015) 0.78
Characterization of a profilin-like protein from Schistosoma japonicum, a potential new vaccine candidate. Parasitol Res (2008) 0.78
Genotoxicants target distinct molecular networks in neonatal neurons. Environ Health Perspect (2006) 0.78
Determinants of food allergy. Immunol Allergy Clin North Am (2012) 0.78
The eukaryotic flagellum makes the day: novel and unforeseen roles uncovered after post-genomics and proteomics data. Curr Protein Pept Sci (2012) 0.78
Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137. PLoS One (2012) 0.77
Immunological responses and actin dynamics in macrophages are controlled by N-cofilin but are independent from ADF. PLoS One (2012) 0.77
An ectromelia virus profilin homolog interacts with cellular tropomyosin and viral A-type inclusion protein. Virol J (2007) 0.77
Mouse cytosolic sulfotransferase SULT2B1b interacts with cytoskeletal proteins via a proline/serine-rich C-terminus. FEBS J (2010) 0.77
Profilin1 biology and its mutation, actin(g) in disease. Cell Mol Life Sci (2016) 0.76
Profilin1 regulates sternum development and endochondral bone formation. J Biol Chem (2012) 0.76
Cathepsin X Cleaves Profilin 1 C-Terminal Tyr139 and Influences Clathrin-Mediated Endocytosis. PLoS One (2015) 0.76
Profilin phosphorylation as a VEGFR effector in angiogenesis. Nat Cell Biol (2012) 0.76
Gene expression profiling of the cephalothorax and eyestalk in Penaeus monodon during ovarian maturation. Int J Biol Sci (2012) 0.76
Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy. Cardiovasc Res (2016) 0.76
Profiling Ethylene-Responsive Genes Expressed in the Latex of the Mature Virgin Rubber Trees Using cDNA Microarray. PLoS One (2016) 0.76