Published in PLoS One on October 25, 2010
ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. PLoS One (2012) 0.94
Development and validation of a gene expression score that predicts response to fulvestrant in breast cancer patients. PLoS One (2014) 0.87
The role of profilin-1 in endothelial cell injury induced by advanced glycation end products (AGEs). Cardiovasc Diabetol (2013) 0.82
A potential therapeutic effect of CYP2C8 overexpression on anti-TNF-α activity. Int J Mol Med (2014) 0.80
Profilin-1 haploinsufficiency protects against obesity-associated glucose intolerance and preserves adipose tissue immune homeostasis. Diabetes (2013) 0.80
Transforming growth factor-beta increases the expression of vascular smooth muscle cell markers in human multi-lineage progenitor cells. Med Sci Monit (2011) 0.79
Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy. Cardiovasc Res (2016) 0.76
The Myocardin-related transcription factor MKL co-regulates the cellular levels of two profilin isoforms. J Biol Chem (2017) 0.75
Inflammation in atherosclerosis. Nature (2002) 28.92
Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med (1998) 25.66
The smooth muscle cell in culture. Physiol Rev (1979) 5.03
TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science (2005) 4.86
The interplay between Src family kinases and receptor tyrosine kinases. Oncogene (2004) 3.36
The role of profilin complexes in cell motility and other cellular processes. Trends Cell Biol (2004) 2.58
PDGF signaling in cells and mice. Cytokine Growth Factor Rev (2004) 2.57
Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and development. Cell (1994) 2.10
Regulation of cytoskeletal dynamics by actin-monomer-binding proteins. Trends Cell Biol (2004) 2.02
Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis. J Biol Chem (1988) 1.97
Profilin I is essential for cell survival and cell division in early mouse development. Proc Natl Acad Sci U S A (2001) 1.68
Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse. Circ Res (2007) 1.64
Profilin as a potential mediator of membrane-cytoskeleton communication. Trends Cell Biol (1993) 1.58
Vascular endothelial growth factor-A-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus: A potential predictor for the individual capacity to develop collaterals. Circulation (2000) 1.54
Role of endothelial dysfunction in insulin resistance. Am J Cardiol (2003) 1.34
Diabetes accelerates smooth muscle accumulation in lesions of atherosclerosis: lack of direct growth-promoting effects of high glucose levels. Diabetes (2001) 1.29
C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro. Arterioscler Thromb Vasc Biol (2004) 1.27
Profilin: emerging concepts and lingering misconceptions. Trends Biochem Sci (2006) 1.26
Peroxisome proliferator-activated receptor gamma: implications for cardiovascular disease. Hypertension (2004) 1.22
Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis. J Biol Chem (1999) 1.14
The potential influence of inflammation and insulin resistance on the pathogenesis and treatment of atherosclerosis-related complications in type 2 diabetes. J Clin Endocrinol Metab (2003) 1.08
C-Peptide induces vascular smooth muscle cell proliferation: involvement of SRC-kinase, phosphatidylinositol 3-kinase, and extracellular signal-regulated kinase 1/2. Circ Res (2006) 1.08
Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis. Diabetes (2008) 1.02
Vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1. J Biol Chem (2007) 0.93
Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the "French paradox". FASEB J (2002) 0.87
Profilin acts downstream of LDL to mediate diabetic endothelial cell dysfunction. FASEB J (2004) 0.82
Expression of profilin, an actin-binding protein, in rat experimental glomerulonephritis and its upregulation by basic fibroblast growth factor in cultured rat mesangial cells. J Am Soc Nephrol (2000) 0.81
Activation of DNA synthesis and AP-1 by profilin, an actin-binding protein, via binding to a cell surface receptor in cultured rat mesangial cells. J Am Soc Nephrol (2000) 0.79
Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med (2006) 4.46
Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA). Circulation (2013) 3.90
MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology (2008) 3.00
Pharmacogenetics of anesthetic and analgesic agents. Anesthesiology (2005) 2.81
PDGF signaling in cells and mice. Cytokine Growth Factor Rev (2004) 2.57
EAE/ASE recommendations for image acquisition and display using three-dimensional echocardiography. J Am Soc Echocardiogr (2012) 2.41
Optimizing engineered heart tissue for therapeutic applications as surrogate heart muscle. Circulation (2006) 2.26
Utility of intraoperative transesophageal echocardiography for diagnosis of pulmonary embolism. Anesth Analg (2004) 2.26
Cardiac output monitoring using indicator-dilution techniques: basics, limits, and perspectives. Anesth Analg (2010) 2.23
3D echocardiography: a review of the current status and future directions. J Am Soc Echocardiogr (2007) 2.12
Impact of intraoperative transesophageal echocardiography on surgical decisions in 12,566 patients undergoing cardiac surgery. Ann Thorac Surg (2008) 1.89
Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Anesthesiology (2009) 1.85
Safety and efficacy of exercise training in various forms of pulmonary hypertension. Eur Respir J (2012) 1.83
Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias. Circulation (2005) 1.78
Expression of platelet-derived growth factor-C and insulin-like growth factor I in hepatic stellate cells is inhibited by miR-29. Lab Invest (2012) 1.75
Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res (2006) 1.74
The role of Epstein-Barr virus in acute and chronic hepatitis. J Hepatol (2006) 1.69
Safety of transesophageal echocardiography. J Am Soc Echocardiogr (2010) 1.67
Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse. Circ Res (2007) 1.64
Prognostic impact of NT-proBNP and renal function in comparison to contemporary multi-marker risk scores in heart failure patients. Eur J Heart Fail (2008) 1.62
Effects of C5 complement inhibitor pexelizumab on outcome in high-risk coronary artery bypass grafting: combined results from the PRIMO-CABG I and II trials. J Thorac Cardiovasc Surg (2010) 1.60
Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Circ Cardiovasc Genet (2009) 1.59
Does rotational thromboelastometry (ROTEM) improve prediction of bleeding after cardiac surgery? Anesth Analg (2012) 1.58
Angiotensin-converting enzyme inhibition or mineralocorticoid receptor blockade do not affect prevalence of atrial fibrillation in patients undergoing cardiac surgery. Crit Care Med (2012) 1.58
Microscopic annealing process and its impact on superconductivity in T'-structure electron-doped copper oxides. Nat Mater (2007) 1.56
Heart-type fatty acid binding protein is an independent predictor of death and ventricular dysfunction after coronary artery bypass graft surgery. Anesth Analg (2010) 1.55
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. Nat Cell Biol (2003) 1.53
Platelet-derived growth factor receptor-mediated signal transduction from endosomes. J Biol Chem (2003) 1.49
Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells. Cancer Res (2007) 1.49
Severity of intraoperative tricuspid regurgitation predicts poor late survival following cardiac transplantation. Ann Thorac Surg (2004) 1.49
Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses. Mol Ther (2006) 1.49
Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry. Int J Cardiol (2012) 1.48
Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1. Nat Genet (2011) 1.48
A practical approach to a comprehensive epicardial and epiaortic echocardiographic examination. J Cardiothorac Vasc Anesth (2003) 1.46
17Beta-estradiol attenuates PDGF signaling in vascular smooth muscle cells at the postreceptor level. Am J Physiol Heart Circ Physiol (2005) 1.46
In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells. Cell Physiol Biochem (2011) 1.43
Pro: Aprotinin has a good efficacy and safety profile relative to other alternatives for prevention of bleeding in cardiac surgery. Anesth Analg (2006) 1.42
Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction. PLoS One (2011) 1.42
A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (2007) 1.41
Full-dose aprotinin use in coronary artery bypass graft surgery: an analysis of perioperative pharmacotherapy and patient outcomes. Anesth Analg (2006) 1.41
Type A aortic dissection after nonaortic cardiac surgery. Circulation (2013) 1.40
Echocardiographic evaluation of mitral inflow hemodynamics after asymmetric double-orifice repair. Anesth Analg (2014) 1.39
The feasibility of epicardial echocardiography for measuring aortic valve area by the continuity equation. Anesth Analg (2009) 1.39
Pexelizumab reduces death and myocardial infarction in higher risk cardiac surgical patients. Ann Thorac Surg (2006) 1.39
Late rupture of polytetrafluoroethylene neochordae after mitral valve repair. J Thorac Cardiovasc Surg (2008) 1.39
Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J (2012) 1.38
Case 6-2006. Percutaneous superior vena cava cannulation for repeat sternotomy in cardiac operations. J Cardiothorac Vasc Anesth (2006) 1.38
Heparin concentration-based anticoagulation for cardiac surgery fails to reliably predict heparin bolus dose requirements. Anesth Analg (2009) 1.38
Acute hemodynamic collapse after induction of general anesthesia for emergent pulmonary embolectomy. Anesth Analg (2006) 1.38
The Mechanism of Mitral Regurgitation Influences the Temporal Dynamics of the Vena Contracta Area as Measured with Color Flow Doppler. Anesth Analg (2016) 1.38
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol (2013) 1.37
Myocardial infarction following coronary artery bypass graft surgery increases healthcare resource utilization. Crit Care Med (2007) 1.35
Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. Mol Biol Cell (2005) 1.35
Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis. J Hepatol (2012) 1.34
Plasma neutrophil gelatinase-associated lipocalin and acute postoperative kidney injury in adult cardiac surgical patients. Anesth Analg (2010) 1.34
EAE/ASE recommendations for image acquisition and display using three-dimensional echocardiography. Eur Heart J Cardiovasc Imaging (2012) 1.33
Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases. Proc Natl Acad Sci U S A (2004) 1.33
Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. J Biol Chem (2009) 1.31
A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration. J Cell Sci (2004) 1.30
Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries. Circ Res (2004) 1.24
Live 3-dimensional transesophageal echocardiography initial experience using the fully-sampled matrix array probe. J Am Coll Cardiol (2008) 1.24
Diversity promotes temporal stability across levels of ecosystem organization in experimental grasslands. PLoS One (2010) 1.23
Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation. J Am Coll Cardiol (2010) 1.23
Pericytes and ocular diseases. Exp Eye Res (2007) 1.21
Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis. Arterioscler Thromb Vasc Biol (2006) 1.21
microRNA are Central Players in Anti- and Profibrotic Gene Regulation during Liver Fibrosis. Front Physiol (2012) 1.20
Troponin is superior to electrocardiogram and creatinine kinase MB for predicting clinically significant myocardial injury after coronary artery bypass grafting. Eur Heart J (2009) 1.20
The effect of the perioperative blood transfusion and blood conservation in cardiac surgery Clinical Practice Guidelines of the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists upon clinical practices. J Extra Corpor Technol (2010) 1.19
Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species. J Biol Chem (2007) 1.19
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res (2009) 1.19
Hepatic granulomas: histological and molecular pathological approach to differential diagnosis--a study of 442 cases. Liver Int (2008) 1.18
Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes. J Biol Chem (2007) 1.18
Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells. J Hepatol (2010) 1.18
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans. J Clin Invest (2011) 1.16
Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy. Int J Oncol (2011) 1.15
Cardiac c-kit+AT2+ cell population is increased in response to ischemic injury and supports cardiomyocyte performance. Stem Cells (2009) 1.15
Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesis. Diabetes (2011) 1.15
Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. Mol Cell Biol (2004) 1.14
Phosphodiesterase type 5 inhibition is a novel therapeutic option in Raynaud disease. Arch Intern Med (2006) 1.14
Real-time three-dimensional transesophageal echocardiography in valve disease: comparison with surgical findings and evaluation of prosthetic valves. J Am Soc Echocardiogr (2008) 1.14
Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells. J Biol Chem (2003) 1.12
N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy. Am J Pathol (2010) 1.11
The influence of epiaortic ultrasonography on intraoperative surgical management in 6051 cardiac surgical patients. Ann Thorac Surg (2008) 1.11
A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation. Cell Microbiol (2008) 1.10
PDGF receptor-α does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway. PLoS Pathog (2012) 1.10
Imatinib mesylate for the treatment of pulmonary arterial hypertension. Expert Opin Investig Drugs (2011) 1.10
Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (2008) 1.10
Effect of exercise and respiratory training on clinical progression and survival in patients with severe chronic pulmonary hypertension. Respiration (2011) 1.10
Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important. J Biol Chem (2005) 1.10