Published in Blood on August 12, 2004
A Rac switch regulates random versus directionally persistent cell migration. J Cell Biol (2005) 4.40
An actin-based wave generator organizes cell motility. PLoS Biol (2007) 3.36
GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays (2007) 3.26
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell (2010) 3.19
Signaling in innate immunity and inflammation. Cold Spring Harb Perspect Biol (2012) 3.11
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell (2012) 2.69
Rho GTPases: functions and association with cancer. Clin Exp Metastasis (2007) 1.98
Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J Cell Biol (2006) 1.86
CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner. J Exp Med (2007) 1.85
TGF-β signaling in myeloid cells is required for tumor metastasis. Cancer Discov (2013) 1.76
Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell (2006) 1.60
The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb Perspect Biol (2009) 1.53
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood (2006) 1.49
Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2. Blood (2006) 1.44
Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood (2006) 1.41
Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor. J Cell Biol (2007) 1.41
Rho GTPases in hematopoiesis and hemopathies. Blood (2009) 1.37
Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development. Blood (2008) 1.37
beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1. Mol Biol Cell (2006) 1.32
Role of osteopontin in neutrophil function. Immunology (2007) 1.25
Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood (2005) 1.16
Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion. Curr Biol (2009) 1.15
Mechanistic insights into the regulation of the spermatogonial stem cell niche. Cell Cycle (2006) 1.12
Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue. Dev Cell (2011) 1.11
Critical roles for Rac GTPases in T-cell migration to and within lymph nodes. Blood (2010) 1.11
Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J Immunol (2009) 1.10
Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2009) 1.09
In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue. PLoS One (2009) 1.06
Rac1 expression by fibroblasts is required for tissue repair in vivo. Am J Pathol (2009) 1.03
The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis. Mol Cell Biol (2011) 0.93
Immune pathology associated with altered actin cytoskeleton regulation. Autoimmunity (2010) 0.92
A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res Ther (2010) 0.91
Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self-propagating inflammatory program. PLoS Pathog (2014) 0.88
Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation. J Cell Biol (2010) 0.88
Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice. J Immunol (2010) 0.88
GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production. Mol Biol Cell (2012) 0.86
Neutrophil transcriptional profile changes during transit from bone marrow to sites of inflammation. Cell Mol Immunol (2014) 0.85
Activation of the A(3) adenosine receptor inhibits fMLP-induced Rac activation in mouse bone marrow neutrophils. Biochem Pharmacol (2010) 0.85
Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages. J Biol Chem (2009) 0.84
Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils. Philos Trans R Soc Lond B Biol Sci (2013) 0.83
Impaired resolution of inflammation in the Endoglin heterozygous mouse model of chronic colitis. Mediators Inflamm (2014) 0.83
Rac2-deficiency leads to exacerbated and protracted colitis in response to Citrobacter rodentium infection. PLoS One (2013) 0.83
How to understand and outwit adaptation. Dev Cell (2014) 0.82
Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxis. PLoS One (2013) 0.82
P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. Blood (2014) 0.81
The role of p38 MAPK in neutrophil functions: single cell chemotaxis and surface marker expression. Analyst (2013) 0.81
Interstitial leukocyte migration in vivo. Curr Opin Cell Biol (2013) 0.81
Locally excitable Cdc42 signals steer cells during chemotaxis. Nat Cell Biol (2015) 0.81
Establishment and maintenance of cell polarity during leukocyte chemotaxis. Cell Adh Migr (2007) 0.80
DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation. J Immunol (2014) 0.80
Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell (2015) 0.80
Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases. Open Rheumatol J (2012) 0.78
Treponema denticola major outer sheath protein impairs the cellular phosphoinositide balance that regulates neutrophil chemotaxis. PLoS One (2013) 0.78
Deleting Rac1 improves vertebral bone quality and resistance to fracture in a murine ovariectomy model. Osteoporos Int (2010) 0.78
Ras-proximate-1 GTPase-activating protein and Rac2 may play pivotal roles in the initial development of myelodysplastic syndrome. Oncol Lett (2012) 0.77
A dual role model for active Rac1 in cell migration. Small GTPases (2013) 0.76
The C-terminal region of the major outer sheath protein of Treponema denticola inhibits neutrophil chemotaxis. Mol Oral Microbiol (2017) 0.76
The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils. J Immunol Res (2015) 0.75
Milk fat globule-epidermal growth factor-factor VIII-derived peptide MSP68 is a cytoskeletal immunomodulator of neutrophils that inhibits Rac1. J Surg Res (2016) 0.75
Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. J Immunol (2016) 0.75
ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis. Cell Commun Signal (2017) 0.75
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet (2002) 7.12
Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med (2011) 6.74
Activation of antibacterial autophagy by NADPH oxidases. Proc Natl Acad Sci U S A (2009) 3.87
Stem cell depletion through epidermal deletion of Rac1. Science (2005) 3.26
Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol (2003) 2.59
Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity (2006) 2.57
Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med (2006) 2.48
Time scale and other invariants of integrative mechanical behavior in living cells. Phys Rev E Stat Nonlin Soft Matter Phys (2003) 2.42
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut (2011) 2.26
Cystic fibrosis mouse models. Am J Respir Cell Mol Biol (2006) 1.98
Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol (2008) 1.93
Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol (2005) 1.83
Oxidative stress and acute lung injury. Am J Respir Cell Mol Biol (2003) 1.75
Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial. Lancet Respir Med (2013) 1.69
Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Sci Transl Med (2012) 1.67
The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics (2004) 1.63
Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions. Kidney Int (2013) 1.60
Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow. J Biol Chem (2008) 1.51
The N. gonorrhoeae type IV pilus stimulates mechanosensitive pathways and cytoprotection through a pilT-dependent mechanism. PLoS Biol (2005) 1.50
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood (2006) 1.49
Molecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans. Am J Respir Cell Mol Biol (2006) 1.47
A common cofilin activity cycle in invasive tumor cells and inflammatory cells. J Cell Sci (2009) 1.45
Airway inflammation and infection in congenital bilateral absence of the vas deferens. Am J Respir Crit Care Med (2003) 1.44
Neutrophil granule contents in the pathogenesis of lung injury. Curr Opin Hematol (2006) 1.43
Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor. J Cell Biol (2007) 1.41
The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis. Mol Biol Cell (2014) 1.38
Anti-synthetase syndrome in ANA and anti-Jo-1 negative patients presenting with idiopathic interstitial pneumonia. Respir Med (2009) 1.36
Lung inflammation as a therapeutic target in cystic fibrosis. Am J Respir Cell Mol Biol (2004) 1.28
Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway. Blood (2005) 1.27
Proteases and lung injury. Crit Care Med (2003) 1.27
Air travel in women with lymphangioleiomyomatosis. Thorax (2006) 1.27
Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol (2011) 1.27
Genetic ablation of Rac1 in cartilage results in chondrodysplasia. Dev Biol (2007) 1.26
Rac2 is required for the formation of neutrophil extracellular traps. J Leukoc Biol (2011) 1.25
Role of osteopontin in neutrophil function. Immunology (2007) 1.25
Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A (2011) 1.25
Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome. Crit Care (2006) 1.23
Identifying the relative contributions of Rac1 and Rac2 to osteoclastogenesis. J Bone Miner Res (2008) 1.21
Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol (2004) 1.21
Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol (2006) 1.21
Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation. Am J Physiol Cell Physiol (2010) 1.20
Filamin A regulates cell spreading and survival via beta1 integrins. Exp Cell Res (2007) 1.20
Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation. J Biol Chem (2010) 1.18
L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration. Blood (2003) 1.17
Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol (2009) 1.14
Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. J Virol (2006) 1.13
Chemotactic signaling pathways in neutrophils: from receptor to actin assembly. Crit Rev Oral Biol Med (2002) 1.13
Tumor necrosis factor-α accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am J Respir Cell Mol Biol (2014) 1.12
Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice. Endocrinology (2003) 1.12
Role of innate immune cells and their products in lung immunopathology. Int J Biochem Cell Biol (2008) 1.10
Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J Immunol (2009) 1.10
Diabetes and periodontal diseases: interplay and links. Curr Diabetes Rev (2011) 1.10
Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2009) 1.09
Remote ischemic preconditioning decreases adhesion and selectively modifies functional responses of human neutrophils. J Surg Res (2010) 1.08
Neural crest cell-specific deletion of Rac1 results in defective cell-matrix interactions and severe craniofacial and cardiovascular malformations. Dev Biol (2010) 1.06
Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol (2011) 1.06
Cytoskeletal remodeling in leukocyte function. Curr Opin Hematol (2004) 1.06
Translocation of the tetraspanin CD63 in association with human eosinophil mediator release. Blood (2002) 1.04
Leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and Akt. Am J Physiol Gastrointest Liver Physiol (2004) 1.03
Mesenchymal stem cells ameliorate rhabdomyolysis-induced acute kidney injury via the activation of M2 macrophages. Stem Cell Res Ther (2014) 1.03
Eukaryotic picoplankton communities of the Mediterranean Sea in summer assessed by molecular approaches (DGGE, TTGE, QPCR). FEMS Microbiol Ecol (2006) 1.03
CD44 is a phagocytic receptor. Blood (2006) 1.03
The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils. J Leukoc Biol (2009) 1.02
Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway. Am J Respir Cell Mol Biol (2009) 1.02
Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPbeta-dependent pathway. Am J Physiol Cell Physiol (2008) 1.01
Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1. FASEB J (2011) 1.01
Polarization and directed migration of murine neutrophils is dependent on cell surface expression of CD44. Cell Immunol (2005) 1.00
iMapper: a web application for the automated analysis and mapping of insertional mutagenesis sequence data against Ensembl genomes. Bioinformatics (2008) 1.00
Signalling platforms that modulate the inflammatory response: new targets for drug development. Nat Rev Drug Discov (2006) 1.00
Rare lung disease II: pulmonary alveolar proteinosis. Can Respir J (2008) 0.99
Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol (2013) 0.99
Role of PAR2 in murine pulmonary pseudomonal infection. Am J Physiol Lung Cell Mol Physiol (2007) 0.98
The role of Rac1 and Rac2 in bacterial killing. Cell Immunol (2005) 0.98
Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis. Gastroenterology (2011) 0.97
CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages. Blood (2007) 0.97
Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression. J Immunol (2008) 0.96
Treatment of autoimmune arthritis using RNA interference-modulated dendritic cells. J Immunol (2010) 0.96
Control of neutrophil pseudopods by fluid shear: role of Rho family GTPases. Am J Physiol Cell Physiol (2004) 0.96
The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J (2013) 0.95
Gelsolin mediates collagen phagocytosis through a rac-dependent step. Mol Biol Cell (2003) 0.95
Filamin A regulates monocyte migration through Rho small GTPases during osteoclastogenesis. J Bone Miner Res (2010) 0.95
Supersensitivity to amphetamine in protein kinase-C interacting protein/HINT1 knockout mice. Neuropsychopharmacology (2007) 0.95
On, around, and through: neutrophil-endothelial interactions in innate immunity. Physiology (Bethesda) (2011) 0.95
Inactivation of macrophage Rab7 by Burkholderia cenocepacia. J Innate Immun (2010) 0.94
Macrophage mesenchymal migration requires podosome stabilization by filamin A. J Biol Chem (2012) 0.94
Rac regulates PtdInsP₃ signaling and the chemotactic compass through a redox-mediated feedback loop. Blood (2011) 0.94
Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med (2005) 0.94
SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1. J Biol Chem (2004) 0.94
Matrix metalloproteinases and protein tyrosine kinases: potential novel targets in acute lung injury and ARDS. Chest (2014) 0.93
The major outer sheath protein of Treponema denticola selectively inhibits Rac1 activation in murine neutrophils. Cell Microbiol (2007) 0.93
Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides. J Biol Chem (2001) 0.92
Innate immunity and arthritis: neutrophil Rac and toll-like receptor 4 expression define outcomes in infection-triggered arthritis. Arthritis Rheum (2005) 0.92