Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

PubWeight™: 2.59‹?› | Rank: Top 1%

🔗 View Article (PMID 12759446)

Published in J Immunol on June 01, 2003

Authors

Michael Glogauer1, Christophe C Marchal, Fei Zhu, Aelaf Worku, Björn E Clausen, Irmgard Foerster, Peter Marks, Gregory P Downey, Mary Dinauer, David J Kwiatkowski

Author Affiliations

1: Brigham and Women's Hospital, Boston, MA 02115, USA. michael.glogauer@utoronto.ca

Articles citing this

A Rac switch regulates random versus directionally persistent cell migration. J Cell Biol (2005) 4.40

GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays (2007) 3.26

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation. Nature (2012) 2.18

Podocyte-specific loss of Cdc42 leads to congenital nephropathy. J Am Soc Nephrol (2012) 2.16

Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1. Circ Res (2008) 2.04

Requirement of Rac1 in the development of cardiac hypertrophy. Proc Natl Acad Sci U S A (2006) 2.02

Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol (2004) 1.87

Rac signaling in breast cancer: a tale of GEFs and GAPs. Cell Signal (2011) 1.61

Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell (2006) 1.60

Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils. J Autoimmun (2015) 1.54

Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment. Blood (2005) 1.52

Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood (2006) 1.49

Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood (2006) 1.41

Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor. J Cell Biol (2007) 1.41

Mechanisms and consequences of neutrophil interaction with the endothelium. Am J Pathol (2007) 1.38

Rho GTPases in hematopoiesis and hemopathies. Blood (2009) 1.37

Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development. Blood (2008) 1.37

Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol (2007) 1.37

Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4. J Biol Chem (2011) 1.26

The small GTPase Rac1 regulates auditory hair cell morphogenesis. J Neurosci (2009) 1.24

Vav proteins control MyD88-dependent oxidative burst. Blood (2006) 1.19

The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Blood (2009) 1.15

Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function. Proc Natl Acad Sci U S A (2009) 1.14

Rac1-mediated mitochondrial H2O2 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1. J Biol Chem (2010) 1.14

The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine. J Immunol (2007) 1.14

The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell Biol (2006) 1.13

Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J Immunol (2009) 1.10

Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2009) 1.09

Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Dev Biol (2008) 1.08

Neural crest cell-specific deletion of Rac1 results in defective cell-matrix interactions and severe craniofacial and cardiovascular malformations. Dev Biol (2010) 1.06

Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration. Am J Respir Crit Care Med (2007) 1.01

CXCR2: From Bench to Bedside. Front Immunol (2012) 1.01

Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia. Mol Cell Biol (2005) 1.01

Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis. J Biol Chem (2011) 0.99

Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis. Gastroenterology (2011) 0.97

Epidermal growth factor induction of front-rear polarity and migration in keratinocytes is mediated by integrin-linked kinase and ELMO2. Mol Biol Cell (2011) 0.97

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood (2012) 0.96

Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection. J Immunol (2010) 0.94

PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. Gastroenterology (2014) 0.93

The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis. Mol Cell Biol (2011) 0.93

Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking. Front Cell Neurosci (2015) 0.92

Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging. Cell Death Dis (2013) 0.92

Iloprost improves endothelial barrier function in lipopolysaccharide-induced lung injury. Eur Respir J (2012) 0.92

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. Blood (2010) 0.91

A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res Ther (2010) 0.91

Slit2 prevents neutrophil recruitment and renal ischemia-reperfusion injury. J Am Soc Nephrol (2013) 0.91

Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner. Am J Physiol Gastrointest Liver Physiol (2013) 0.91

Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis. J Leukoc Biol (2010) 0.90

Zoledronate and pamidronate depress neutrophil functions and survival in mice. Br J Pharmacol (2012) 0.89

ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice. Cell Microbiol (2010) 0.88

Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol (2011) 0.88

Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice. J Immunol (2010) 0.88

Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation. J Cell Biol (2010) 0.88

Apoptotic cell recognition receptors and scavenger receptors. Immunol Rev (2016) 0.87

Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors. Oncogene (2012) 0.86

Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages. J Biol Chem (2009) 0.84

Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task. Small GTPases (2014) 0.84

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1. J Clin Invest (2015) 0.83

Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems. Neural Dev (2015) 0.83

Rac1 is a critical mediator of endothelium-derived neurotrophic activity. Sci Signal (2009) 0.83

The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts. Am J Pathol (2008) 0.82

Rac1 activation induces tumour necrosis factor-α expression and cardiac dysfunction in endotoxemia. J Cell Mol Med (2010) 0.82

Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxis. PLoS One (2013) 0.82

Epithelial-specific knockout of the Rac1 gene leads to enamel defects. Eur J Oral Sci (2011) 0.81

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. Blood (2014) 0.81

Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol (2016) 0.81

Locally excitable Cdc42 signals steer cells during chemotaxis. Nat Cell Biol (2015) 0.81

Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements. Ann Biomed Eng (2010) 0.80

Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell (2015) 0.80

Hyperglycemia Impairs Neutrophil-Mediated Bacterial Clearance in Mice Infected with the Lyme Disease Pathogen. PLoS One (2016) 0.80

The RHO-1 RhoGTPase modulates fertility and multiple behaviors in adult C. elegans. PLoS One (2011) 0.80

Redundant functions of Rac GTPases in inner ear morphogenesis. Dev Biol (2011) 0.79

Actin filaments-A target for redox regulation. Cytoskeleton (Hoboken) (2016) 0.78

Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo. J Bone Miner Res (2015) 0.78

Deleting Rac1 improves vertebral bone quality and resistance to fracture in a murine ovariectomy model. Osteoporos Int (2010) 0.78

Regulation of cell protrusions by small GTPases during fusion of the neural folds. Elife (2016) 0.78

Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis. Free Radic Biol Med (2015) 0.78

Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases. Open Rheumatol J (2012) 0.78

Aberrant methylation of PSD disturbs Rac1-mediated immune responses governing neutrophil chemotaxis and apoptosis in ulcerative colitis-associated carcinogenesis. Int J Oncol (2011) 0.77

Rac1 deletion causes thymic atrophy. PLoS One (2011) 0.76

Rac1 Regulates Endometrial Secretory Function to Control Placental Development. PLoS Genet (2015) 0.76

Adenovirus-mediated genetic removal of signaling molecules in cultured primary mouse embryonic fibroblasts. J Vis Exp (2010) 0.76

Rac1 signaling is critical to cardiomyocyte polarity and embryonic heart development. J Am Heart Assoc (2014) 0.76

Optical Tools To Study the Isoform-Specific Roles of Small GTPases in Immune Cells. J Immunol (2016) 0.75

Different virulence of candida albicans is attributed to the ability of escape from neutrophil extracellular traps by secretion of DNase. Am J Transl Res (2017) 0.75

Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H. Sci Rep (2016) 0.75

Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. J Immunol (2016) 0.75

Ex vivo and in vitro effect of serum amyloid a in the induction of macrophage M2 markers and efferocytosis of apoptotic neutrophils. J Immunol (2015) 0.75

Tiam1/Rac1 complex controls Il17a transcription and autoimmunity. Nat Commun (2016) 0.75

Rac1 Signaling Is Required for Anterior Second Heart Field Cellular Organization and Cardiac Outflow Tract Development. J Am Heart Assoc (2015) 0.75

Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice. PLoS One (2016) 0.75

Mechanism of Diapedesis: Importance of the Transcellular Route. Adv Immunol (2015) 0.75

Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. PLoS One (2015) 0.75

Articles by these authors

HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12

LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80

Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med (2011) 6.74

A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood (2005) 6.07

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J Clin Invest (2003) 6.04

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med (2008) 5.15

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A (2002) 4.93

SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol (2003) 4.90

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem (2002) 4.19

Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors. J Clin Oncol (2010) 4.01

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci (2005) 4.00

Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. J Exp Med (2008) 3.97

Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol (2005) 3.75

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Thorac Oncol (2013) 3.71

Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science (2003) 3.70

Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci (2008) 3.64

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J Clin Invest (2007) 3.54

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J Neurosci (2007) 3.51

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures. Ann Neurol (2002) 3.37

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev (2005) 3.25

mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell (2008) 3.06

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab (2011) 2.91

Perivascular epithelioid cell neoplasms: pathology and pathogenesis. Hum Pathol (2009) 2.80

Rapid turnover of actin in dendritic spines and its regulation by activity. Nat Neurosci (2002) 2.78

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent. Proc Natl Acad Sci U S A (2011) 2.73

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest (2011) 2.72

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Mol Diagn (2013) 2.71

Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest (2003) 2.66

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. Arch Pathol Lab Med (2013) 2.66

Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med (2006) 2.48

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A (2008) 2.48

Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev (2010) 2.44

Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models. Genes Chromosomes Cancer (2005) 2.42

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin. Nat Immunol (2012) 2.40

A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity. Blood (2009) 2.35

Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity (2005) 2.35

Tuberous sclerosis complex proteins control axon formation. Genes Dev (2008) 2.33

Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A (2006) 2.28

Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Res (2006) 2.26

Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet (2002) 2.23

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell (2012) 2.22

Somatic LKB1 mutations promote cervical cancer progression. PLoS One (2009) 2.21

The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet (2004) 2.19

Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci U S A (2009) 2.12

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med (2008) 2.12

Response and acquired resistance to everolimus in anaplastic thyroid cancer. N Engl J Med (2014) 2.09

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma. Lancet (2003) 2.09

Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass. Blood (2004) 2.06

Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes. J Immunol (2007) 2.05

Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1. Circ Res (2008) 2.04

DC ablation in mice: promises, pitfalls, and challenges. Trends Immunol (2007) 2.02

Requirement of Rac1 in the development of cardiac hypertrophy. Proc Natl Acad Sci U S A (2006) 2.02

Cystic fibrosis mouse models. Am J Respir Cell Mol Biol (2006) 1.98

Identification of 54 large deletions/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations. Hum Genet (2007) 1.94

Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol (2008) 1.93

Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res (2003) 1.90

Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication. Circ Cardiovasc Genet (2008) 1.89

Unusually mild tuberous sclerosis phenotype is associated with TSC2 R905Q mutation. Ann Neurol (2006) 1.87

Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol (2005) 1.83

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80

A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease. Br J Haematol (2007) 1.77

Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease. Nat Immunol (2011) 1.76

Oxidative stress and acute lung injury. Am J Respir Cell Mol Biol (2003) 1.75

Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. Genomics (2003) 1.74

Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A. Proc Natl Acad Sci U S A (2011) 1.69

Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial. Lancet Respir Med (2013) 1.69

Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. J Neurosci (2009) 1.67

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Sci Transl Med (2012) 1.67

Insights into Langerhans cell function from Langerhans cell ablation models. Eur J Immunol (2008) 1.65

Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease. Immunol Rev (2002) 1.65

Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J Clin Invest (2010) 1.64

The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics (2004) 1.63

Langerhans cells are required for efficient presentation of topically applied hapten to T cells. J Immunol (2007) 1.61

Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions. Kidney Int (2013) 1.60

Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell (2006) 1.60

Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis. J Invest Dermatol (2009) 1.59

Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A (2011) 1.58

FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell (2010) 1.58

Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles. J Immunol (2004) 1.55

The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis. Blood (2013) 1.54

The introduction of systematic genomic testing for patients with non-small-cell lung cancer. J Thorac Oncol (2012) 1.53

Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropathol Exp Neurol (2004) 1.52

Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J Clin Invest (2007) 1.51

Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow. J Biol Chem (2008) 1.51

Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. Circ Cardiovasc Genet (2009) 1.51

Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal (2012) 1.50

1,25-dihydroxyvitamin D exerts similar immunosuppressive effects as UVR but is dispensable for local UVR-induced immunosuppression. J Invest Dermatol (2012) 1.50

Langerhans cells are negative regulators of the anti-Leishmania response. J Exp Med (2011) 1.49

Molecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans. Am J Respir Cell Mol Biol (2006) 1.47

Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway. Mol Cell Neurosci (2002) 1.47

Identification and expression of mouse Langerin (CD207) in dendritic cells. Int Immunol (2002) 1.44

Airway inflammation and infection in congenital bilateral absence of the vas deferens. Am J Respir Crit Care Med (2003) 1.44

ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol (2004) 1.43

Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Genetics (2002) 1.43

Neutrophil granule contents in the pathogenesis of lung injury. Curr Opin Hematol (2006) 1.43

Identification of a transcriptional profile associated with in vitro invasion in non-small cell lung cancer cell lines. Cancer Biol Ther (2004) 1.42

Rac2 concentrations in umbilical cord neutrophils. Biol Neonate (2006) 1.39