Published in Biochem Pharmacol on September 15, 2004
Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature (2011) 5.20
Histone recognition and large-scale structural analysis of the human bromodomain family. Cell (2012) 5.15
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci (2007) 5.02
Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding. Genome Res (2008) 4.11
Transcription factors in long-term memory and synaptic plasticity. Physiol Rev (2009) 3.73
Bromodomains as therapeutic targets. Expert Rev Mol Med (2011) 2.52
Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease. Am J Hum Genet (2005) 2.40
Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory. Learn Mem (2008) 2.15
A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn Mem (2006) 2.11
Histone modifying enzymes: structures, mechanisms, and specificities. Biochim Biophys Acta (2008) 2.07
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol (2006) 2.00
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nat Rev Immunol (2008) 1.99
Experience-dependent epigenetic modifications in the central nervous system. Biol Psychiatry (2008) 1.79
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J (2005) 1.68
Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction. Virology (2006) 1.56
Mechanism of action of a distal NF-kappaB-dependent enhancer. Mol Cell Biol (2006) 1.53
Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits. Learn Mem (2007) 1.48
The epigenetics of autoimmunity. Cell Mol Immunol (2011) 1.47
Expression of HDAC1 and CBP/p300 in human colorectal carcinomas. J Clin Pathol (2007) 1.43
Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. Hum Mol Genet (2007) 1.36
Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation. Nat Struct Mol Biol (2013) 1.33
Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A (2011) 1.30
Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus. Proc Natl Acad Sci U S A (2009) 1.29
Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity. J Biol Chem (2009) 1.29
Genome-wide assessment of differential roles for p300 and CBP in transcription regulation. Nucleic Acids Res (2010) 1.25
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. J Am Chem Soc (2014) 1.23
Genetic heterogeneity in Rubinstein-Taybi syndrome: delineation of the phenotype of the first patients carrying mutations in EP300. J Med Genet (2007) 1.23
Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood (2006) 1.21
Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Cell Cycle (2010) 1.18
Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol. Alcohol Clin Exp Res (2011) 1.18
Differences in specificity and selectivity between CBP and p300 acetylation of histone H3 and H3/H4. Biochemistry (2013) 1.17
Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse. Cell Death Dis (2010) 1.15
Hypoxia-induced and stress-specific changes in chromatin structure and function. Mutat Res (2007) 1.15
Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb. Nucleic Acids Res (2011) 1.13
Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300. Circulation (2008) 1.13
Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptides. Biophys Chem (2011) 1.13
Histone modifiers in cancer: friends or foes? Genes Cancer (2011) 1.10
Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association. PLoS Pathog (2011) 1.10
Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8. Cancer Lett (2009) 1.06
Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder. Endocr Relat Cancer (2008) 1.06
Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. Biochemistry (2007) 1.05
Cellular signaling and potential new treatment targets in diabetic retinopathy. Exp Diabetes Res (2007) 1.02
Protein lysine acetylation by p300/CBP. Chem Rev (2015) 1.02
p53 and p16(INK4A) independent induction of senescence by chromatin-dependent alteration of S-phase progression. Nat Commun (2011) 1.00
Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells. J Biol Chem (2011) 1.00
Repression of miR-142 by p300 and MAPK is required for survival signalling via gp130 during adaptive hypertrophy. EMBO Mol Med (2012) 0.99
Epigenetic regulation of a murine retrotransposon by a dual histone modification mark. PLoS Genet (2010) 0.99
Structural insights into interferon regulatory factor activation. Cell Signal (2009) 0.98
Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. Mol Cell Neurosci (2007) 0.98
E1A interacts with two opposing transcriptional pathways to induce quiescent cells into S phase. J Virol (2010) 0.98
p300 alters keratinocyte cell growth and differentiation through regulation of p21(Waf1/CIP1). PLoS One (2010) 0.98
Transcriptional coactivators are not required for herpes simplex virus type 1 immediate-early gene expression in vitro. J Virol (2009) 0.97
CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Nucleic Acids Res (2014) 0.97
Epigenetic mechanisms in memory and synaptic function. Epigenomics (2011) 0.96
Histone hyperacetylation in the coding region of chromatin undergoing transcription in SV40 minichromosomes is a dynamic process regulated directly by the presence of RNA polymerase II. J Mol Biol (2006) 0.95
Minireview: role of protein methylation and demethylation in nuclear hormone signaling. Mol Endocrinol (2009) 0.95
p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair. Nucleic Acids Res (2012) 0.95
Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways. Cell Cycle (2011) 0.95
Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway. Virology (2009) 0.94
Epigenetics-beyond the genome in alcoholism. Alcohol Res (2012) 0.94
Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells. J Biol Chem (2012) 0.93
Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders. Curr Pharm Des (2013) 0.93
Epigenetics: new questions on the response to hypoxia. Int J Mol Sci (2011) 0.93
Epigenetic control of the immune escape mechanisms in malignant carcinomas. Mol Cell Biol (2007) 0.92
Changing the selectivity of p300 by acetyl-CoA modulation of histone acetylation. ACS Chem Biol (2014) 0.92
Extracellular signal-regulated kinase 1/2-mediated phosphorylation of p300 enhances myosin heavy chain I/beta gene expression via acetylation of nuclear factor of activated T cells c1. Nucleic Acids Res (2011) 0.92
Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. J Biol Chem (2010) 0.91
PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus. Epigenetics (2008) 0.91
Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis. Prog Neurobiol (2008) 0.91
Synergistic activation of human involucrin gene expression by Fra-1 and p300--evidence for the presence of a multiprotein complex. J Invest Dermatol (2007) 0.91
Roles of coactivators in hypoxic induction of the erythropoietin gene. PLoS One (2010) 0.90
A non-isotopic in vitro assay for histone acetylation. J Biotechnol (2007) 0.90
Pancreatic β-cell prosurvival effects of the incretin hormones involve post-translational modification of Kv2.1 delayed rectifier channels. Cell Death Differ (2011) 0.89
Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation. J Biol Chem (2014) 0.89
Message in a nucleus: signaling to the transcriptional machinery. Curr Opin Genet Dev (2008) 0.89
Genetic lesions in diffuse large B-cell lymphomas. Ann Oncol (2015) 0.89
TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms. PLoS One (2009) 0.89
RSF1 is a positive regulator of NF-κB-induced gene expression required for ovarian cancer chemoresistance. Cancer Res (2014) 0.89
p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI). Mol Pain (2012) 0.88
Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoD. Biochem Biophys Res Commun (2008) 0.87
The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Mol Endocrinol (2013) 0.87
MSK2 inhibits p53 activity in the absence of stress. Sci Signal (2009) 0.87
Identification of lysine acetyltransferase p300 substrates using 4-pentynoyl-coenzyme A and bioorthogonal proteomics. Bioorg Med Chem Lett (2011) 0.86
PIASy represses CCAAT/enhancer-binding protein delta (C/EBPdelta) transcriptional activity by sequestering C/EBPdelta to the nuclear periphery. J Biol Chem (2008) 0.86
The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53. PLoS One (2008) 0.85
Transcription factor YY1 and its associated acetyltransferases CBP and p300 interact with hepatitis delta antigens and modulate hepatitis delta virus RNA replication. J Virol (2008) 0.85
Defining genetic factors that modulate intergenerational CAG repeat instability in Drosophila melanogaster. Genetics (2010) 0.85
Deficit in long-term synaptic plasticity is rescued by a computationally predicted stimulus protocol. J Neurosci (2013) 0.85
Open access chemical probes for epigenetic targets. Future Med Chem (2015) 0.84
Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner. J Immunol (2009) 0.84
Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens. J Mol Biol (2007) 0.83
The role of the transcriptional coactivator p300 in prostate cancer progression. Adv Exp Med Biol (2008) 0.83
Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin (2015) 0.83
SUMOylation regulates the nuclear mobility of CREB binding protein and its association with nuclear bodies in live cells. Biochem Biophys Res Commun (2009) 0.83
The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target. Oncotarget (2016) 0.83
The cis-regulatory code of Hox function in Drosophila. EMBO J (2012) 0.83
Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes. Glia (2010) 0.82
Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling. Cardiovasc Res (2012) 0.82