Published in Cell Signal on December 30, 2009
Optineurin regulates the interferon response in a cell cycle-dependent manner. PLoS Pathog (2015) 1.42
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. J Immunol (2010) 1.05
Oncogenic IRFs provide a survival advantage for Epstein-Barr virus- or human T-cell leukemia virus type 1-transformed cells through induction of BIC expression. J Virol (2011) 1.00
Periderm prevents pathological epithelial adhesions during embryogenesis. J Clin Invest (2014) 0.91
Upregulation of Interferon Regulatory Factor 6 Promotes Neuronal Apoptosis After Traumatic Brain Injury in Adult Rats. Cell Mol Neurobiol (2015) 0.85
Innate immune evasion strategies by human immunodeficiency virus type 1. ISRN AIDS (2013) 0.85
Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promoters. J Virol (2011) 0.82
Genetic polymorphism of interferon regulatory factor 5 (IRF5) correlates with allograft acute rejection of liver transplantation. PLoS One (2014) 0.76
Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer. J Virol (2016) 0.75
Activation of Vago by interferon regulatory factor (IRF) suggests an interferon system-like antiviral mechanism in shrimp. Sci Rep (2015) 0.75
Sequence and Expression Analysis of Interferon Regulatory Factor 10 (IRF10) in Three Diverse Teleost Fish Reveals Its Role in Antiviral Defense. PLoS One (2016) 0.75
Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate. J Dent Res (2017) 0.75
Down-Regulation of IRF6 Protects Cortical Neurons Against Traumatic Neuronal Injury Through Activating Akt-eNOS Pathway. Cell Mol Neurobiol (2016) 0.75
Role of interferon regulatory factor-1 in lipopolysaccharide-induced mitochondrial damage and oxidative stress responses in macrophages. Int J Mol Med (2017) 0.75
Knockdown of IRF6 Attenuates Hydrogen Dioxide-Induced Oxidative Stress via Inhibiting Mitochondrial Dysfunction in HT22 Cells. Cell Mol Neurobiol (2015) 0.75
IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature (2005) 13.23
IRF family of transcription factors as regulators of host defense. Annu Rev Immunol (2001) 8.18
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol (2006) 7.98
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol (1998) 7.43
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J (1998) 7.20
Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J (1998) 6.94
The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol (2008) 6.60
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature (2005) 5.37
Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity (2006) 5.36
An atomic model of the interferon-beta enhanceosome. Cell (2007) 4.22
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med (2004) 4.14
Virus Infection Induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression. Cell (2008) 3.48
CBP and p300: HATs for different occasions. Biochem Pharmacol (2004) 3.38
Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes. J Biol Chem (2001) 3.26
Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription. Mol Cell Biol (1999) 3.12
Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7. Mol Cell Biol (2000) 3.00
Interferon regulatory factors: the next generation. Gene (1999) 2.98
Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains. Mol Cell Biol (1999) 2.93
Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nat Immunol (2006) 2.85
Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene. FEBS Lett (1998) 2.76
Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. J Biol Chem (2003) 2.57
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation. EMBO J (2008) 2.53
Structure of IRF-1 with bound DNA reveals determinants of interferon regulation. Nature (1998) 2.48
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. J Biol Chem (2005) 2.47
Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3. J Biol Chem (2001) 2.47
Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J Biol Chem (2003) 2.45
Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response. Cytokine Growth Factor Rev (2007) 2.30
Multiple regulatory domains control IRF-7 activity in response to virus infection. J Biol Chem (2000) 2.20
Crystal structure of IRF-3 in complex with CBP. Structure (2005) 2.18
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol (2004) 2.06
Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes. Mol Cell Biol (2002) 2.03
X-ray crystal structure of IRF-3 and its functional implications. Nat Struct Biol (2003) 1.88
Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Nat Struct Biol (2003) 1.80
Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function. J Biol Chem (2005) 1.79
Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences. EMBO J (1999) 1.77
Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. Mol Cell Biol (2000) 1.73
Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch. J Biol Chem (2007) 1.72
The IKK-related kinases: from innate immunity to oncogenesis. Cell Res (2008) 1.71
Acetylation-dependent signal transduction for type I interferon receptor. Cell (2007) 1.68
Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history. Cytokine Growth Factor Rev (2008) 1.68
The interferon regulatory factor family in host defense: mechanism of action. J Biol Chem (2007) 1.67
Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction. Virology (2006) 1.56
The mengovirus leader protein blocks interferon-alpha/beta gene transcription and inhibits activation of interferon regulatory factor 3. Cell Microbiol (2007) 1.47
Signaling through IFN regulatory factor-5 sensitizes p53-deficient tumors to DNA damage-induced apoptosis and cell death. Cancer Res (2005) 1.45
Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J Biol Chem (2008) 1.44
Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes. J Biol Chem (2003) 1.39
Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3. Virology (2001) 1.39
Interferon regulatory factor family of transcription factors and regulation of oncogenesis. Cancer Sci (2008) 1.35
Cytosolic DNA recognition for triggering innate immune responses. Adv Drug Deliv Rev (2007) 1.30
Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination. Mol Cell Biol (2007) 1.23
Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J Virol (2008) 1.19
Thogoto virus ML protein suppresses IRF3 function. Virology (2005) 1.19
Differential activation of IFN regulatory factor (IRF)-3 and IRF-5 transcription factors during viral infection. J Immunol (2006) 1.19
Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. Mol Cell (2007) 1.18
Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat Struct Mol Biol (2008) 1.17
Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. J Biol Chem (2007) 1.16
A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization. J Biol Chem (2004) 1.12
IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway. J Biol Chem (2008) 1.12
Turning NF-kappaB and IRFs on and off in DC. Trends Immunol (2008) 1.12
Regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7. J Biol Chem (2005) 1.07
Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3. J Mol Biol (2008) 1.00
Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding. Nucleic Acids Res (2007) 0.96
Interferon regulatory factor-8 modulates the development of tumour-induced CD11b+Gr-1+ myeloid cells. J Cell Mol Med (2009) 0.94
Assembling the human IFN-beta enhanceosome in solution. J Mol Biol (2008) 0.91
Molecular characterization of IRF3 and IRF7 in rainbow trout, Oncorhynchus mykiss: functional analysis and transcriptional modulation. Mol Immunol (2008) 0.87
IRF-1 promotes apoptosis in p53-damaged basal-type human mammary epithelial cells: a model for early basal-type mammary carcinogenesis. Adv Exp Med Biol (2008) 0.84
Targeting IRFs by ubiquitination: regulating antiviral responses. Biochem Soc Trans (2008) 0.84
Interferon regulatory factor-1 regulates reconstituted extracellular matrix (rECM)-mediated apoptosis in human mammary epithelial cells. Oncogene (2006) 0.82
Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces. Structure (2010) 1.65
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding. Proc Natl Acad Sci U S A (2010) 1.65
Allosteric action in real time: time-resolved crystallographic studies of a cooperative dimeric hemoglobin. Proc Natl Acad Sci U S A (2006) 1.45
Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat Struct Mol Biol (2008) 1.17
Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis. Structure (2009) 1.15
Residue F4 plays a key role in modulating oxygen affinity and cooperativity in Scapharca dimeric hemoglobin. Biochemistry (2005) 1.06
Ligand migration and binding in the dimeric hemoglobin of Scapharca inaequivalvis. Biochemistry (2007) 1.00
Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3. J Mol Biol (2008) 1.00
Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures. Proc Natl Acad Sci U S A (2011) 0.93
Sulfide binding is mediated by zinc ions discovered in the crystal structure of a hydrothermal vent tubeworm hemoglobin. Proc Natl Acad Sci U S A (2005) 0.93
Ligand-linked structural transitions in crystals of a cooperative dimeric hemoglobin. Biochemistry (2003) 0.93
Crystal structure of the hemoglobin dodecamer from Lumbricus erythrocruorin: allosteric core of giant annelid respiratory complexes. J Mol Biol (2004) 0.92
An optical signal correlated with the allosteric transition in Scapharca inaequivalvis HbI. Biochemistry (2006) 0.92
Resolution of structural heterogeneity in dynamic crystallography. Acta Crystallogr D Biol Crystallogr (2013) 0.88
Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling. J Biol Chem (2007) 0.87
Time-resolved x-ray crystallography of heme proteins. Methods Enzymol (2008) 0.85
Immobilization of Scapharca HbI crystals improves data quality in time-resolved crystallographic experiments. Micron (2004) 0.83
Insight into the allosteric mechanism of Scapharca dimeric hemoglobin. Biochemistry (2014) 0.80
Catalytic implications from the Drosophila protein L-isoaspartyl methyltransferase structure and site-directed mutagenesis. Biochemistry (2003) 0.78
Protein conformational dynamics of homodimeric hemoglobin revealed by combined time-resolved spectroscopic probes. Chemphyschem (2010) 0.78
Tertiary and quaternary allostery in tetrameric hemoglobin from Scapharca inaequivalvis. Biochemistry (2013) 0.76