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The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity (2012) 1.96

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Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. PLoS Biol (2011) 1.56

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Novel approaches to inhibiting HIV-1 replication. Antiviral Res (2009) 1.48

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Rosuvastatin treatment reduces markers of monocyte activation in HIV-infected subjects on antiretroviral therapy. Clin Infect Dis (2013) 1.36

Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells. J Virol (2005) 1.31

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The key role of genomics in modern vaccine and drug design for emerging infectious diseases. PLoS Genet (2009) 1.18

Role of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion step. PLoS Pathog (2010) 1.14

Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol (2007) 1.09

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The fusion protein of respiratory syncytial virus triggers p53-dependent apoptosis. J Virol (2008) 1.04

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells. Proc Natl Acad Sci U S A (2010) 1.03

The broad anti-viral agent glycyrrhizin directly modulates the fluidity of plasma membrane and HIV-1 envelope. Biochem J (2005) 1.03

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PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection. PLoS Pathog (2010) 0.97

Effect of simvastatin, an established lipid-lowering drug, on pulmonary Chlamydia pneumoniae infection in mice. Antimicrob Agents Chemother (2005) 0.96

How HIV takes advantage of the cytoskeleton in entry and replication. Viruses (2011) 0.96

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Inhibition of human immunodeficiency virus (HIV-1) infection in human peripheral blood leucocytes-SCID reconstituted mice by rapamycin. Clin Exp Immunol (2009) 0.95

Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis. J Biol Chem (2014) 0.93

The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophages. Virus Res (2006) 0.91

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The effect of rosuvastatin in a murine model of influenza A infection. PLoS One (2012) 0.89

Statins, bugs and prophylaxis: intriguing possibilities. Crit Care (2006) 0.88

Ezrin is a component of the HIV-1 virological presynapse and contributes to the inhibition of cell-cell fusion. J Virol (2014) 0.88

Fluvastatin modulates renal water reabsorption in vivo through increased AQP2 availability at the apical plasma membrane of collecting duct cells. Pflugers Arch (2011) 0.88

Sterol regulatory element-binding protein 2 couples HIV-1 transcription to cholesterol homeostasis and T cell activation. J Virol (2011) 0.88

Borna disease virus requires cholesterol in both cellular membrane and viral envelope for efficient cell entry. J Virol (2009) 0.87

Small rho GTPases and cholesterol biosynthetic pathway intermediates in African swine fever virus infection. J Virol (2011) 0.87

Modifiers of symptomatic embolic risk in infective endocarditis. Mayo Clin Proc (2011) 0.86

Statins disrupt CCR5 and RANTES expression levels in CD4(+) T lymphocytes in vitro and preferentially decrease infection of R5 versus X4 HIV-1. PLoS One (2007) 0.85

Attacking pathogens through their hosts. Genome Biol (2006) 0.84

LFA-1 antagonists as agents limiting human immunodeficiency virus type 1 infection and transmission and potentiating the effect of the fusion inhibitor T-20. Antimicrob Agents Chemother (2009) 0.84

HMG CoA reductase inhibitors (statins) to treat Epstein-Barr virus-driven lymphoma. Br J Cancer (2005) 0.84

Cholesterol-depleting statin drugs protect postmitotically differentiated human neurons against ethanol- and human immunodeficiency virus type 1-induced oxidative stress in vitro. J Virol (2006) 0.84

Caveolin-1 suppresses human immunodeficiency virus-1 replication by inhibiting acetylation of NF-κB. Virology (2012) 0.83

Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial. Trop Med Int Health (2015) 0.83

High serum cholesterol levels are associated with herpes zoster infection after heart transplantation. Clin Infect Dis (2010) 0.83

Targeting platelet-derived soluble CD40 ligand: a new treatment strategy for HIV-associated neuroinflammation? J Neuroinflammation (2013) 0.83

A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors. Oncotarget (2013) 0.83

A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction. Biochimie (2012) 0.82

The "Statinth" wonder of the world: a panacea for all illnesses or a bubble about to burst. J Negat Results Biomed (2005) 0.82

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Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1. Sci Rep (2015) 0.80

Simvastatin modulates cellular components in influenza A virus-infected cells. Int J Mol Med (2014) 0.80

The landscape of host transcriptional response programs commonly perturbed by bacterial pathogens: towards host-oriented broad-spectrum drug targets. PLoS One (2013) 0.79

Alterations in cholesterol metabolism restrict HIV-1 trans infection in nonprogressors. MBio (2014) 0.79

Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis. Steroids (2015) 0.79

Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking. J Mol Model (2012) 0.79

Rho'ing in and out of cells: viral interactions with Rho GTPase signaling. Small GTPases (2014) 0.78

Metabolic and anthropometric parameters contribute to ART-mediated CD4+ T cell recovery in HIV-1-infected individuals: an observational study. J Int AIDS Soc (2011) 0.78

Exploiting large-scale drug-protein interaction information for computational drug repurposing. BMC Bioinformatics (2014) 0.77

An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway. PLoS Biol (2016) 0.77

Regulatory T Cells Diminish HIV Infection in Dendritic Cells - Conventional CD4(+) T Cell Clusters. Front Immunol (2014) 0.77

CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit. AIDS Res Hum Retroviruses (2012) 0.76

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DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions. PLoS Negl Trop Dis (2016) 0.75

Cholesterol reducing agents inhibit assembly of type I parainfluenza viruses. Virology (2016) 0.75

Attenuation of immune activation in an open-label clinical trial for HIV-AIDS using a polyherbal formulation. Virusdisease (2014) 0.75

Current and Emerging Uses of Statins in Clinical Therapeutics: A Review. Lipid Insights (2016) 0.75

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In vivo effect of statins on the expression of the HIV co-receptors CCR5 and CXCR4. AIDS Res Ther (2013) 0.75

A high throughput Cre-lox activated viral membrane fusion assay identifies pharmacological inhibitors of HIV entry. Virology (2016) 0.75

Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport. Proc Natl Acad Sci U S A (2017) 0.75

Cholesterol 25-Hydroxylase Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication through Enzyme Activity Dependent and Independent Mechanisms. J Virol (2017) 0.75

Cholesterol is required for stability and infectivity of influenza A and respiratory syncytial viruses. Virology (2017) 0.75

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Plasma membrane rafts play a critical role in HIV-1 assembly and release. Proc Natl Acad Sci U S A (2001) 5.46

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Multimerization of human immunodeficiency virus type 1 Gag promotes its localization to barges, raft-like membrane microdomains. J Virol (2001) 2.82

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Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. Proc Natl Acad Sci U S A (2003) 1.69

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Lovastatin inhibits HIV-1 expression in H9 human T lymphocytes cultured in cholesterol-poor medium. Biomed Pharmacother (1994) 1.23

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Ligand stabilization of CXCR4/delta-opioid receptor heterodimers reveals a mechanism for immune response regulation. Eur J Immunol (2008) 1.97

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Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis. J Cell Biol (2004) 1.72

A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med (2007) 1.71

Filamin-A regulates actin-dependent clustering of HIV receptors. Nat Cell Biol (2007) 1.71

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The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. J Clin Invest (2002) 1.55

The biological response modifier AM3 attenuates the inflammatory cell response and hepatic fibrosis in rats with biliary cirrhosis. Gut (2010) 1.45

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CD69 downregulates autoimmune reactivity through active transforming growth factor-beta production in collagen-induced arthritis. J Clin Invest (2003) 1.41

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CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues. Eur J Immunol (2009) 1.34

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CCR5 expression influences the progression of human breast cancer in a p53-dependent manner. J Exp Med (2003) 1.25

GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway. EMBO J (2002) 1.25

Statins induce regulatory T cell recruitment via a CCL1 dependent pathway. J Immunol (2008) 1.22

Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis. FASEB J (2002) 1.21

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Atorvastatin reduces CD68, FABP4, and HBP expression in oxLDL-treated human macrophages. Biochem Biophys Res Commun (2004) 1.20

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Atorvastatin treatment induced peroxisome proliferator-activated receptor alpha expression and decreased plasma nonesterified fatty acids and liver triglyceride in fructose-fed rats. J Pharmacol Exp Ther (2002) 1.13

p21CIP1/WAF1 controls proliferation of activated/memory T cells and affects homeostasis and memory T cell responses. J Immunol (2007) 1.13

Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways. Proc Natl Acad Sci U S A (2010) 1.12

Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non-obese diabetic mice. Eur J Immunol (2004) 1.12

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Novel interfering bifunctional molecules against the CCR5 coreceptor are efficient inhibitors of HIV-1 infection. Mol Ther (2003) 1.09

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A heterologous prime-boost regime using DNA and recombinant vaccinia virus expressing the Leishmania infantum P36/LACK antigen protects BALB/c mice from cutaneous leishmaniasis. Vaccine (2002) 1.06

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c-Myc is essential for hematopoietic stem cell differentiation and regulates Lin(-)Sca-1(+)c-Kit(-) cell generation through p21. Exp Hematol (2007) 1.03