Published in J Natl Cancer Inst on August 18, 2004
Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc Natl Acad Sci U S A (2006) 2.24
Medullary thyroid cancer: monitoring and therapy. Endocrinol Metab Clin North Am (2007) 1.14
Antitumor activity of lenvatinib (e7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer models. J Thyroid Res (2014) 1.02
The phosphatidylinositol 3-kinase/akt signaling pathway in medullary thyroid cancer. Surgery (2008) 0.84
Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation. Eur J Med Chem (2014) 0.80
A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. J Biol Chem (2015) 0.78
Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine. BMC Cancer (2015) 0.78
Review. Gastroenterol Hepatol (N Y) (2007) 0.75
Synergistic antitumour activity of RAF265 and ZSTK474 on human TT medullary thyroid cancer cells. J Cell Mol Med (2015) 0.75
MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit. Mol Cancer (2017) 0.75
New agent to treat advanced or metastasized thyroid cancer, its efficacy, safety, and mechanism. Thorac Cancer (2015) 0.75
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med (2008) 9.64
Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet (2002) 8.89
A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22
Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst (2008) 5.82
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet (2009) 4.38
Risk factors for the incidence of breast cancer: do they affect survival from the disease? J Clin Oncol (2008) 3.73
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet (2003) 3.70
Association studies for finding cancer-susceptibility genetic variants. Nat Rev Cancer (2004) 3.64
Polymorphisms associated with circulating sex hormone levels in postmenopausal women. J Natl Cancer Inst (2004) 3.53
Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer. PLoS Biol (2008) 3.49
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Association of a common variant of the CASP8 gene with reduced risk of breast cancer. J Natl Cancer Inst (2004) 2.66
FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation. Hum Mol Genet (2009) 2.62
Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene. Am J Hum Genet (2002) 2.57
Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer (2011) 2.42
Telomere length in prospective and retrospective cancer case-control studies. Cancer Res (2010) 2.30
Association between common variation in 120 candidate genes and breast cancer risk. PLoS Genet (2007) 2.27
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer. Cancer Res (2003) 2.21
Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer. Hum Mol Genet (2005) 2.05
Variants in DNA double-strand break repair genes and breast cancer susceptibility. Hum Mol Genet (2002) 2.04
Effect of germ-line genetic variation on breast cancer survival in a population-based study. Cancer Res (2002) 1.95
Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. Cancer Res (2007) 1.92
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers. Int J Cancer (2011) 1.81
BRCA1 and BRCA2 mutations in a population-based study of male breast cancer. Breast Cancer Res (2001) 1.66
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer (2010) 1.64
IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. Hum Mol Genet (2005) 1.62
A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression. PLoS Genet (2011) 1.60
Association of ESR1 gene tagging SNPs with breast cancer risk. Hum Mol Genet (2009) 1.58
Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker. Cancer Sci (2011) 1.57
Synergistic effects of a novel nanoporous stent coating and tacrolimus on intima proliferation in rabbits. Catheter Cardiovasc Interv (2003) 1.54
The dark side of E2F1: in transit beyond apoptosis. Cancer Res (2012) 1.52
Polymorphisms in DNA repair genes and epithelial ovarian cancer risk. Int J Cancer (2005) 1.44
Gene expression changes in response to E2F1 activation. Nucleic Acids Res (2002) 1.44
Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. Hum Mol Genet (2009) 1.42
Transactivation-deficient DeltaTA-p73 acts as an oncogene. Cancer Res (2002) 1.41
No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk. Cancer Epidemiol Biomarkers Prev (2010) 1.40
Prolonged cold ischemia does not trigger lethal rejection or accelerate the acute rejection in two allogeneic rat liver transplantation models. J Surg Res (2011) 1.40
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1. Am J Hum Genet (2013) 1.39
Fine scale mapping of the breast cancer 16q12 locus. Hum Mol Genet (2010) 1.39
Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. Cancer Res (2012) 1.37
Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis. J Biol Chem (2002) 1.37
RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. Neoplasia (2012) 1.36
Common variants in mismatch repair genes and risk of invasive ovarian cancer. Carcinogenesis (2006) 1.35
Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer. Hum Mutat (2007) 1.33
The genetics of ovarian cancer. Best Pract Res Clin Obstet Gynaecol (2002) 1.32
Marginal hepatectomy in the rat: from anatomy to surgery. Ann Surg (2006) 1.31
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. Nat Commun (2012) 1.27
Role of intestinal microbiota in transformation of bismuth and other metals and metalloids into volatile methyl and hydride derivatives in humans and mice. Appl Environ Microbiol (2008) 1.26
Genetic variants in epigenetic genes and breast cancer risk. Carcinogenesis (2006) 1.24
Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium. Proc Natl Acad Sci U S A (2002) 1.23
E2F1 in melanoma progression and metastasis. J Natl Cancer Inst (2009) 1.23
DNp73 a matter of cancer: mechanisms and clinical implications. Biochim Biophys Acta (2008) 1.22
Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. Cancer Res (2010) 1.22
Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk. Breast Cancer Res (2007) 1.22
Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer. Cancer Res (2006) 1.21
The effects of common genetic variants in oncogenes on ovarian cancer survival. Clin Cancer Res (2008) 1.21
STK15 polymorphisms and association with risk of invasive ovarian cancer. Cancer Epidemiol Biomarkers Prev (2004) 1.18
Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast. Breast Cancer Res (2009) 1.16
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. Cancer Epidemiol Biomarkers Prev (2009) 1.15
Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. Hum Mol Genet (2010) 1.15
Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts. Clin Cancer Res (2010) 1.14
Master regulators of FGFR2 signalling and breast cancer risk. Nat Commun (2013) 1.12
Histopathology, FIGO stage, and BRCA mutation status of ovarian cancers from the Gilda Radner Familial Ovarian Cancer Registry. Int J Gynecol Pathol (2004) 1.12
RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B. Cancer Res (2006) 1.12
Polymorphisms in the initiators of RET (rearranged during transfection) signaling pathway and susceptibility to sporadic medullary thyroid carcinoma. J Clin Endocrinol Metab (2005) 1.11
Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. Carcinogenesis (2008) 1.11
E2F1-induced apoptosis: turning killers into therapeutics. Trends Mol Med (2006) 1.11
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis. Arch Toxicol (2014) 1.10
The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene. Int J Cancer (2011) 1.09
DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling. Cancer Cell (2013) 1.08
Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer. PLoS One (2007) 1.08
Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Cancer Epidemiol Biomarkers Prev (2006) 1.06
Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo. Mol Cancer (2009) 1.06
BRCA2 Arg372Hispolymorphism and epithelial ovarian cancer risk. Int J Cancer (2003) 1.05
The virtual liver: state of the art and future perspectives. Arch Toxicol (2014) 1.05
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer. Mol Cancer (2011) 1.05
Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk. Cancer Epidemiol Biomarkers Prev (2008) 1.05
Polymorphisms in RET and its coreceptors and ligands as genetic modifiers of multiple endocrine neoplasia type 2A. Cancer Res (2006) 1.04
Association of the progesterone receptor gene with breast cancer risk: a single-nucleotide polymorphism tagging approach. Cancer Epidemiol Biomarkers Prev (2006) 1.03
The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6. Cancer Prev Res (Phila) (2011) 1.02
Transcriptional repression of the prosurvival endoplasmic reticulum chaperone GRP78/BIP by E2F1. J Biol Chem (2008) 1.02
Common variants in RB1 gene and risk of invasive ovarian cancer. Cancer Res (2006) 1.01
Mechanisms of Disease: cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy. Nat Clin Pract Oncol (2006) 1.01
Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women. Cancer Epidemiol Biomarkers Prev (2008) 1.01
The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis. Genes Chromosomes Cancer (2012) 1.00
Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer. Cancer Res (2008) 1.00
Autonomous growth and hepatocarcinogenesis in transgenic mice expressing the p53 family inhibitor DNp73. Carcinogenesis (2007) 1.00
HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion in rat. Histochem Cell Biol (2011) 0.99
Quantitative TP73 transcript analysis in hepatocellular carcinomas. Clin Cancer Res (2004) 0.99
Introducing a new section to Breast Cancer Research: endocrinology and hormone therapy. Breast Cancer Res (2003) 0.98
Kinetic modeling-based detection of genetic signatures that provide chemoresistance via the E2F1-p73/DNp73-miR-205 network. Cancer Res (2013) 0.98
Alterations of DeltaTA-p 73 splice transcripts during melanoma development and progression. Int J Cancer (2004) 0.98
Checks and balances: E2F-microRNA crosstalk in cancer control. Cell Cycle (2010) 0.97