Published in PLoS Genet on February 02, 2007
Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet (2009) 8.44
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Proc Natl Acad Sci U S A (2008) 4.76
Common disorders are quantitative traits. Nat Rev Genet (2009) 4.34
Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One (2009) 2.03
Advances in breast cancer: pathways to personalized medicine. Clin Cancer Res (2008) 1.59
Phosphodiesterase 11A (PDE11A) and genetic predisposition to adrenocortical tumors. Clin Cancer Res (2008) 1.31
An improved PSO algorithm for generating protective SNP barcodes in breast cancer. PLoS One (2012) 1.29
Child development and molecular genetics: 14 years later. Child Dev (2012) 1.23
Breast cancer epidemiology according to recognized breast cancer risk factors in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial Cohort. BMC Cancer (2009) 1.22
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. Br J Cancer (2009) 1.19
Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility. PLoS Genet (2010) 1.19
Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast. Breast Cancer Res (2009) 1.16
Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Hum Mol Genet (2010) 1.16
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. Cancer Epidemiol Biomarkers Prev (2009) 1.15
Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis. Diagn Pathol (2012) 1.12
Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. Carcinogenesis (2008) 1.11
Comparison of population-based association study methods correcting for population stratification. PLoS One (2008) 1.11
A role for XRCC2 gene polymorphisms in breast cancer risk and survival. J Med Genet (2011) 1.10
Genetic variation in the chromosome 17q23 amplicon and breast cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 1.05
Variation in genes required for normal mitosis and risk of breast cancer. Breast Cancer Res Treat (2009) 1.04
Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies. Breast Cancer Res (2008) 1.04
Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer. Clin Cancer Res (2009) 1.02
Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 1.01
Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women. Cancer Epidemiol Biomarkers Prev (2008) 1.01
Polygenic susceptibility to breast cancer: current state-of-the-art. Future Oncol (2009) 0.98
Germline mutations and polymorphisms in the origins of cancers in women. J Oncol (2010) 0.96
The interleukin 10 -819C/T polymorphism and cancer risk: a HuGE review and meta-analysis of 73 studies including 15,942 cases and 22,336 controls. OMICS (2013) 0.92
MicroRNA binding site polymorphisms as biomarkers in cancer management and research. Pharmgenomics Pers Med (2014) 0.91
Unique SNP in CD44 intron 1 and its role in breast cancer development. Anticancer Res (2010) 0.91
The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohort. Breast Cancer Res (2011) 0.88
Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer. PLoS One (2009) 0.86
Combined effect of CYP1B1, COMT, GSTP1, and MnSOD genotypes and risk of postmenopausal breast cancer. J Gynecol Oncol (2011) 0.84
Association between the RAD51 135 G>C polymorphism and risk of cancer: a meta-analysis of 19,068 cases and 22,630 controls. PLoS One (2013) 0.84
A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects. J Med Genet (2015) 0.82
Association of the vascular endothelial growth factor -2578C/A polymorphism with cancer risk: A meta-analysis update. Biomed Rep (2014) 0.81
Genetic associations with sporadic neuroendocrine tumor risk. Carcinogenesis (2011) 0.81
Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression. Cancer Prev Res (Phila) (2011) 0.80
Genetic 135G/C polymorphism of RAD51 gene and risk of cancer: a meta-analysis of 28,956 cases and 28,372 controls. Fam Cancer (2014) 0.80
ESR1 single nucleotide polymorphisms predict breast cancer susceptibility in the central European Caucasian population. Int J Clin Exp Med (2013) 0.79
Double-bottom chaotic map particle swarm optimization based on chi-square test to determine gene-gene interactions. Biomed Res Int (2014) 0.79
Association between the Functional Polymorphism of Vascular Endothelial Growth Factor Gene and Breast Cancer: A Meta-Analysis. Iran J Med Sci (2015) 0.79
The utility of comparative genetics to inform breast cancer prevention strategies. Genetics (2009) 0.78
Association between the polymorphism rs3217927 of CCND2 and the risk of childhood acute lymphoblastic leukemia in a Chinese population. PLoS One (2014) 0.78
Genetic variation and its role in malignancy. Int J Biomed Sci (2011) 0.77
Association between RAD51 polymorphism and breast cancer susceptibility: a meta analysis. Int J Clin Exp Med (2015) 0.75
Association between vascular endothelial growth factor +936C/T polymorphism and breast cancer risk: a meta-analysis of 18 case-control studies. Int J Mol Epidemiol Genet (2016) 0.75
In search of breast cancer culprits: suspecting the suspected and the unsuspected. Breast Cancer (Auckl) (2008) 0.75
Method for generating multiple risky barcodes of complex diseases using ant colony algorithm. Theor Biol Med Model (2017) 0.75
RAD51 135G>C substitution increases breast cancer risk in an ethnic-specific manner: a meta-analysis on 21,236 cases and 19,407 controls. Sci Rep (2015) 0.75
The 'Pokemon' (ZBTB7) Gene: No Evidence of Association with Sporadic Breast Cancer. Clin Med Oncol (2008) 0.75
Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature-based meta-analysis and meta-regression analysis. Exp Ther Med (2013) 0.75
Unravelling genes and pathways implicated in working memory of schizophrenia in Han Chinese. Int J Mol Sci (2015) 0.75
Efficiency and power in genetic association studies. Nat Genet (2005) 25.56
Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med (2000) 25.49
Searching for genetic determinants in the new millennium. Nature (2000) 17.50
Association mapping in structured populations. Am J Hum Genet (2000) 16.79
Trimming, weighting, and grouping SNPs in human case-control association studies. Genome Res (2001) 9.41
Association study designs for complex diseases. Nat Rev Genet (2001) 8.91
A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35
Truncated product method for combining P-values. Genet Epidemiol (2002) 7.07
Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium. J Natl Cancer Inst (2006) 5.60
Population genetics--making sense out of sequence. Nat Genet (1999) 5.28
A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. Br J Cancer (2002) 4.18
Association studies for finding cancer-susceptibility genetic variants. Nat Rev Cancer (2004) 3.64
Rank truncated product of P-values, with application to genomewide association scans. Genet Epidemiol (2003) 3.34
How many more breast cancer predisposition genes are there? Breast Cancer Res (1999) 3.10
Nonparametric tests of association of multiple genes with human disease. Am J Hum Genet (2005) 2.87
Association of a common variant of the CASP8 gene with reduced risk of breast cancer. J Natl Cancer Inst (2004) 2.66
A genome wide linkage search for breast cancer susceptibility genes. Genes Chromosomes Cancer (2006) 2.35
A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer. Cancer Res (2003) 2.21
A statistical consideration in psychological research. Psychol Bull (1951) 2.10
The admixture maximum likelihood test: a novel experiment-wise test of association between disease and multiple SNPs. Genet Epidemiol (2006) 2.06
Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer. Hum Mol Genet (2005) 2.05
Variants in DNA double-strand break repair genes and breast cancer susceptibility. Hum Mol Genet (2002) 2.04
A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability. Nat Genet (2000) 1.80
Unbiased methods for population-based association studies. Genet Epidemiol (2001) 1.76
IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. Hum Mol Genet (2005) 1.62
Centralizing the non-central chi-square: A new method to correct for population stratification in genetic case-control association studies. Genet Epidemiol (2006) 1.33
A note on permutation tests in multistage association scans. Am J Hum Genet (2006) 1.28
Genetic variants in epigenetic genes and breast cancer risk. Carcinogenesis (2006) 1.24
Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer. Cancer Res (2006) 1.21
Polymorphisms in the human aromatase cytochrome P450 gene (CYP19) and breast cancer risk. Carcinogenesis (2000) 1.12
Common ERBB2 polymorphisms and risk of breast cancer in a white British population: a case-control study. Breast Cancer Res (2005) 1.04
Common polymorphisms in checkpoint kinase 2 are not associated with breast cancer risk. Cancer Epidemiol Biomarkers Prev (2003) 0.95
Single-nucleotide polymorphisms in the RB1 gene and association with breast cancer in the British population. Br J Cancer (2006) 0.86
Common polymorphisms in ERCC2 (Xeroderma pigmentosum D) are not associated with breast cancer risk. Cancer Epidemiol Biomarkers Prev (2005) 0.83
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
International network of cancer genome projects. Nature (2010) 20.35
Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet (2008) 15.43
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med (2008) 9.64
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat Genet (2006) 9.17
Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet (2002) 8.89
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Nat Genet (2009) 8.30
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Nat Genet (2006) 7.72
Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res (2005) 7.66
Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet (2010) 7.62
A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res (2006) 6.91
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet (2005) 6.70
ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nat Genet (2006) 6.67
Cancer Incidence in BRCA1 mutation carriers. J Natl Cancer Inst (2002) 6.58
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22
The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. J Clin Oncol (2002) 6.16
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet (2009) 6.04
Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst (2008) 5.82
Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype. Clin Cancer Res (2005) 5.70
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet (2013) 5.58
Statistical analysis of pathogenicity of somatic mutations in cancer. Genetics (2006) 5.56
Breast-cancer risk in families with mutations in PALB2. N Engl J Med (2014) 4.97
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet (2010) 4.96
Polygenic inheritance of breast cancer: Implications for design of association studies. Genet Epidemiol (2003) 4.94
Integrated evaluation of DNA sequence variants of unknown clinical significance: application to BRCA1 and BRCA2. Am J Hum Genet (2004) 4.61
Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet (2010) 4.51
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet (2009) 4.38
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Multiple loci on 8q24 associated with prostate cancer susceptibility. Nat Genet (2009) 3.94
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet (2010) 3.86
Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA (2012) 3.85
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
Risk factors for the incidence of breast cancer: do they affect survival from the disease? J Clin Oncol (2008) 3.73
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet (2003) 3.70
Association studies for finding cancer-susceptibility genetic variants. Nat Rev Cancer (2004) 3.64
RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. Am J Hum Genet (2007) 3.63
Polymorphisms associated with circulating sex hormone levels in postmenopausal women. J Natl Cancer Inst (2004) 3.53
Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer. PLoS Biol (2008) 3.49
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet (2013) 3.42
Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet (2008) 3.41
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
Cancer risks and mortality in heterozygous ATM mutation carriers. J Natl Cancer Inst (2005) 3.09
A common 8q24 variant in prostate and breast cancer from a large nested case-control study. Cancer Res (2007) 3.08
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet (2011) 3.07
Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium. Cancer Epidemiol Biomarkers Prev (2008) 3.05
Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study. Lancet Oncol (2011) 3.04
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Nat Genet (2010) 2.99
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature (2011) 2.96
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat Genet (2010) 2.96
Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE. J Natl Cancer Inst (2013) 2.93
Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. J Natl Cancer Inst (2009) 2.88
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the international BRCA1/2 carrier cohort study: a report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators' Group. J Clin Oncol (2006) 2.81
A genome-wide association study of testicular germ cell tumor. Nat Genet (2009) 2.79
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Ann Intern Med (2006) 2.74
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum Mol Genet (2011) 2.72
Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer. J Clin Oncol (2013) 2.71
Beyond GWASs: illuminating the dark road from association to function. Am J Hum Genet (2013) 2.67