Published in Proc Natl Acad Sci U S A on August 25, 2004
Drug resistance in leishmaniasis. J Glob Infect Dis (2010) 1.52
Drug targets in Leishmania. J Parasit Dis (2010) 1.26
A comparative study of methylglyoxal metabolism in trypanosomatids. FEBS J (2008) 1.26
Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome. Biochem J (2005) 1.23
Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials. Antimicrob Agents Chemother (2008) 1.04
Phenotypic characterization of a glucose transporter null mutant in Leishmania mexicana. Mol Biochem Parasitol (2007) 1.01
Structural variation in bacterial glyoxalase I enzymes: investigation of the metalloenzyme glyoxalase I from Clostridium acetobutylicum. J Biol Chem (2011) 0.93
Trypanothione-dependent glyoxalase I in Trypanosoma cruzi. Biochem J (2006) 0.91
Characterization of the gene encoding glyoxalase II from Leishmania donovani: a potential target for anti-parasite drugs. Biochem J (2006) 0.90
Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification. PLoS One (2009) 0.88
Niche metabolism in parasitic protozoa. Philos Trans R Soc Lond B Biol Sci (2006) 0.82
Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.79
Methylglyoxal metabolism in trypanosomes and leishmania. Semin Cell Dev Biol (2011) 0.78
Characteristic Variations and Similarities in Biochemical, Molecular, and Functional Properties of Glyoxalases across Prokaryotes and Eukaryotes. Int J Mol Sci (2017) 0.75
Improved method for the determination of blood glutathione. J Lab Clin Med (1963) 13.04
Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol (2003) 3.17
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids. Science (1985) 2.94
Chemotherapy of human African trypanosomiasis: current and future prospects. Trends Parasitol (2003) 2.58
Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy. Gen Pharmacol (1996) 2.39
Metabolism of methylglyoxal in microorganisms. Annu Rev Microbiol (1984) 2.32
Studies on the inhibition of glyoxalase I by S-substituted glutathiones. J Med Chem (1971) 1.97
Plant-like traits associated with metabolism of Trypanosoma parasites. Proc Natl Acad Sci U S A (2003) 1.59
Ovothiol and trypanothione as antioxidants in trypanosomatids. Mol Biochem Parasitol (2001) 1.46
Letter: A note on the molar absorptivity of reduced Ellman's reagent, 3-carboxylato-4-nitrothiophenolate. Anal Biochem (1973) 1.39
Determination of the structure of Escherichia coli glyoxalase I suggests a structural basis for differential metal activation. Biochemistry (2000) 1.25
Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue. Biochemistry (1999) 1.18
Glyoxalase II of African trypanosomes is trypanothione-dependent. J Biol Chem (2004) 1.17
Structure-activity study on the in vitro antiprotozoal activity of glutathione derivatives. J Med Chem (2000) 1.13
Glutathionylspermidine metabolism in Escherichia coli. Biochem J (1995) 1.13
Optimized heterologous expression of the human zinc enzyme glyoxalase I. Biochem J (1996) 1.10
Antimalarial activity in vitro of the glyoxalase I inhibitor diester, S-p-bromobenzylglutathione diethyl ester. Biochem Pharmacol (1994) 1.08
Overproduction and characterization of a dimeric non-zinc glyoxalase I from Escherichia coli: evidence for optimal activation by nickel ions. Biochemistry (1998) 1.06
A 33-kDa allergen from rice (Oryza sativa L. Japonica). cDNA cloning, expression, and identification as a novel glyoxalase I. J Biol Chem (2001) 1.04
Glyoxalase I, a zinc metalloenzyme of mammals and yeast. Biochem Biophys Res Commun (1978) 1.04
Cancerostatic action of methylglyoxal. Science (1968) 1.01
Kinetic evaluation of substrate specificity in the glyoxalase-I-catalyzed disproportionation of -ketoaldehydes. Biochemistry (1972) 1.00
Yeast glyoxalase I is a monomeric enzyme with two active sites. J Biol Chem (2000) 0.98
DNA-damaging activity of biotic and xenobiotic aldehydes in Chinese hamster ovary cells. Cell Biochem Funct (1984) 0.97
Active monomeric and dimeric forms of Pseudomonas putida glyoxalase I: evidence for 3D domain swapping. Biochemistry (1998) 0.97
Glyoxalase I of the malarial parasite Plasmodium falciparum: evidence for subunit fusion. FEBS Lett (2003) 0.96
An XAS investigation of product and inhibitor complexes of Ni-containing GlxI from Escherichia coli: mechanistic implications. Biochemistry (2001) 0.91
S-(N-aryl-N-hydroxycarbamoyl)glutathione derivatives are tight-binding inhibitors of glyoxalase I and slow substrates for glyoxalase II. J Med Chem (1994) 0.88
Methylglyoxal-catabolizing enzymes of Leishmania donovani promastigotes. Mol Biochem Parasitol (1989) 0.87
Substrate specificity of bovine liver formaldehyde dehydrogenase. J Biol Chem (1986) 0.85
Effects of pH and thiols on the kinetics of yeast glyoxalase I. An evaluation of the random pathway mechanism. Biochemistry (1975) 0.84
D-lactate production by Leishmania braziliensis through the glyoxalase pathway. Mol Biochem Parasitol (1988) 0.83
Inhibition of proliferation of human leukaemia 60 cells by methylglyoxal in vitro. Leuk Res (1993) 0.82
Reversal of the reaction catalyzed by glyoxalase I. Calculation of the equilibrium constant for the enzymatic reaction. J Biol Chem (1983) 0.82
A comparative study of D-lactate, L-lactate and glycerol formation by four species of Leishmania and by Trypanosoma lewisi and Trypanosoma brucei gambiense. Mol Biochem Parasitol (1988) 0.81
A rapid assay for the glyoxalase enzyme system. Anal Biochem (1971) 0.80
Caution: the glycylmethyl and glycylethyl esters of glutathione are substrates for glyoxalase I. Biochim Biophys Acta (1992) 0.77
Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89
The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48
Drug resistance in leishmaniasis. Clin Microbiol Rev (2006) 7.35
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature (2010) 2.90
Target assessment for antiparasitic drug discovery. Trends Parasitol (2007) 1.96
Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani. J Biol Chem (2004) 1.86
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. Antimicrob Agents Chemother (2010) 1.49
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J Med Chem (2011) 1.33
Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes. Mol Microbiol (2008) 1.33
Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol (2010) 1.33
The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis. Sci Transl Med (2012) 1.32
Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase. Biochem J (2003) 1.29
Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities. J Biol Chem (2008) 1.26
A comparative study of methylglyoxal metabolism in trypanosomatids. FEBS J (2008) 1.26
Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome. Biochem J (2005) 1.23
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods. Mol Microbiol (2009) 1.20
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi. J Biol Chem (2002) 1.15
Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis. Biochem J (2006) 1.11
Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate. Mol Microbiol (2006) 1.11
Trypanothione biosynthesis in Leishmania major. Mol Biochem Parasitol (2005) 1.11
Properties of trypanothione synthetase from Trypanosoma brucei. Mol Biochem Parasitol (2003) 1.09
One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening. J Med Chem (2009) 1.08
MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii. Eukaryot Cell (2005) 1.07
Leishmania major elongation factor 1B complex has trypanothione S-transferase and peroxidase activity. J Biol Chem (2004) 1.06
Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay. Antimicrob Agents Chemother (2013) 1.06
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett (2006) 1.05
Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates. Mol Biochem Parasitol (2010) 1.05
Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials. Antimicrob Agents Chemother (2008) 1.04
Target validation: linking target and chemical properties to desired product profile. Curr Top Med Chem (2011) 1.04
A new expression vector for Crithidia fasciculata and Leishmania. Mol Biochem Parasitol (2002) 1.01
Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design. J Biol Chem (2004) 1.01
Assessing the essentiality of Leishmania donovani nitroreductase and its role in nitro drug activation. Antimicrob Agents Chemother (2012) 0.99
Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function. J Biol Chem (2003) 0.98
Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis. ChemMedChem (2009) 0.98
Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase. ChemMedChem (2009) 0.98
Differential toxicity of antimonial compounds and their effects on glutathione homeostasis in a human leukaemia monocyte cell line. Biochem Pharmacol (2005) 0.97
Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening. Bioorg Med Chem Lett (2006) 0.97
Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent? PLoS Negl Trop Dis (2011) 0.96
Refinement of techniques for the propagation of Leishmania donovani in hamsters. Acta Trop (2006) 0.96
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis. J Biol Chem (2009) 0.95
Trypanothione S-transferase activity in a trypanosomatid ribosomal elongation factor 1B. J Biol Chem (2004) 0.94
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity. Antimicrob Agents Chemother (2009) 0.93
A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes. PLoS Negl Trop Dis (2012) 0.92
Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors. J Med Chem (2009) 0.91
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major. FEBS J (2007) 0.91
Trypanothione-dependent glyoxalase I in Trypanosoma cruzi. Biochem J (2006) 0.91
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi. Mol Biochem Parasitol (2009) 0.90
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata. Biochem J (2002) 0.90
The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis. Antimicrob Agents Chemother (2013) 0.89
Investigation of trypanothione reductase as a drug target in Trypanosoma brucei. ChemMedChem (2009) 0.89
Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis. Proc Natl Acad Sci U S A (2013) 0.89
Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog. J Biol Chem (2013) 0.88
Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme. Mol Microbiol (2006) 0.88
Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice. Mol Microbiol (2010) 0.88
Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother (2007) 0.86
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi. J Biol Chem (2003) 0.86
Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography. J Med Chem (2011) 0.85
ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides. FEBS J (2008) 0.85
Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors. ChemMedChem (2011) 0.85
Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome. Mol Microbiol (2012) 0.84
Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major. J Biol Chem (2011) 0.84
Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase. Anal Biochem (2009) 0.83
Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy. Mol Microbiol (2013) 0.82
Properties of phosphoenolpyruvate mutase, the first enzyme in the aminoethylphosphonate biosynthetic pathway in Trypanosoma cruzi. J Biol Chem (2003) 0.82
Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products. Bioorg Med Chem (2005) 0.82
Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1. ChemMedChem (2010) 0.81
Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase. Bioorg Med Chem (2003) 0.81
Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group. Bioorg Med Chem Lett (2002) 0.80
Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism. J Biol Chem (2011) 0.80
Infectious disease: Genomics decodes drug action. Nature (2012) 0.79
Triclosan is minimally effective in rodent malaria models. Nat Med (2011) 0.79
8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase. Mem Inst Oswaldo Cruz (2003) 0.79
Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.79
Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major. Mol Biochem Parasitol (2006) 0.79
Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham. Z Naturforsch C (2008) 0.78
Quinol derivatives as potential trypanocidal agents. Bioorg Med Chem (2011) 0.78
Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: substitution of the glycine part. Bioorg Med Chem Lett (2002) 0.78
Methylglyoxal metabolism in trypanosomes and leishmania. Semin Cell Dev Biol (2011) 0.78
Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases. Biochem J (2008) 0.77
Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488. ChemMedChem (2011) 0.77
Synthesis and evaluation of indatraline-based inhibitors for trypanothione reductase. ChemMedChem (2010) 0.77
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature (2016) 0.77
Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei. Mol Microbiol (2014) 0.76
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need. Nat Rev Microbiol (2017) 0.75