Published in Mol Ther on September 01, 2004
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NF-kappaB regulation in the immune system. Nat Rev Immunol (2002) 15.80
The knockout mouse project. Nat Genet (2004) 7.80
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Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature (2009) 5.37
Gene therapy: therapeutic gene causing lymphoma. Nature (2006) 4.89
Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell (2007) 4.87
A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci U S A (2003) 4.17
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Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos. Proc Natl Acad Sci U S A (2002) 3.53
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Development of a novel mouse glioma model using lentiviral vectors. Nat Med (2009) 3.08
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Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci (2005) 2.75
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A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol (2010) 2.32
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature (2005) 2.29
Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci (2003) 2.28
Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy. Blood (2005) 2.12
CtIP links DNA double-strand break sensing to resection. Mol Cell (2009) 2.11
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem (2002) 2.08
CRE recombinase-inducible RNA interference mediated by lentiviral vectors. Proc Natl Acad Sci U S A (2004) 1.95
Inflammation-associated cancer: NF-kappaB is the lynchpin. Trends Immunol (2005) 1.94
Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nat Cell Biol (2012) 1.87
Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity. Nat Cell Biol (2005) 1.75
Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration. BMC Biol (2009) 1.74
Adeno-associated virus effectively mediates conditional gene modification in the brain. Proc Natl Acad Sci U S A (2002) 1.72
Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model. Proc Natl Acad Sci U S A (2007) 1.69
Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma. Proc Natl Acad Sci U S A (2011) 1.68
Gene therapy with viral vectors. Annu Rev Pharmacol Toxicol (2002) 1.66
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell (2012) 1.65
Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell (2006) 1.62
Biodistribution and toxicity studies of VSVG-pseudotyped lentiviral vector after intravenous administration in mice with the observation of in vivo transduction of bone marrow. Mol Ther (2002) 1.57
Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A (2012) 1.57
Targeted delivery of proteins across the blood-brain barrier. Proc Natl Acad Sci U S A (2007) 1.50
Design and cloning of lentiviral vectors expressing small interfering RNAs. Nat Protoc (2006) 1.48
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol (2010) 1.47
Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci U S A (2014) 1.47
Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. Science (2004) 1.46
Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP. Proc Natl Acad Sci U S A (2009) 1.45
Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1). Proc Natl Acad Sci U S A (2005) 1.41
Editorial expression of concern: Experimental evidence of massive-scale emotional contagion through social networks. Proc Natl Acad Sci U S A (2014) 1.41
Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell (2008) 1.41
Reciprocity between phase shifts and amplitude changes in the mammalian circadian clock. Proc Natl Acad Sci U S A (2007) 1.41
IKK biology. Immunol Rev (2012) 1.40
Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2005) 1.38
Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse. Proc Natl Acad Sci U S A (2005) 1.36
Restoration of spermatogenesis by lentiviral gene transfer: offspring from infertile mice. Proc Natl Acad Sci U S A (2002) 1.35
Mechanisms of neovascularization and resistance to anti-angiogenic therapies in glioblastoma multiforme. J Mol Med (Berl) (2013) 1.31
Little evidence of bone marrow-derived hepatocytes in the replacement of injured liver. Proc Natl Acad Sci U S A (2003) 1.29
Efficient production of human FVIII in hemophilic mice using lentiviral vectors. Mol Ther (2003) 1.29
IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy. Mol Cell Biol (2003) 1.29
Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes. Endocrinology (2006) 1.28
Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease. Am J Pathol (2008) 1.27
Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. Stem Cells (2011) 1.26
Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer. Cancer Res (2011) 1.25
The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev (2012) 1.23
A role for IkappaB kinase 2 in bipolar spindle assembly. Proc Natl Acad Sci U S A (2007) 1.21
Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab (2007) 1.21
Generation of transgenic mice using lentiviral vectors: a novel preclinical assessment of lentiviral vectors for gene therapy. Mol Ther (2003) 1.20
Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neurosci (2008) 1.20
Dedifferentiation and reprogramming: origins of cancer stem cells. EMBO Rep (2014) 1.16
Applications of lentiviral vectors for shRNA delivery and transgenesis. Curr Gene Ther (2008) 1.14
Tumor suppressor protein (p)53, is a regulator of NF-kappaB repression by the glucocorticoid receptor. Proc Natl Acad Sci U S A (2011) 1.14
Impact, not impact factor. Proc Natl Acad Sci U S A (2015) 1.14
Adenovirus-mediated overexpression of follistatin enlarges intact liver of adult rats. Hepatology (2003) 1.10
Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics. Proc Natl Acad Sci U S A (2007) 1.10
Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity. Curr Biol (2005) 1.08
Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease. PLoS One (2011) 1.07
Gene therapy of Fanconi anemia: preclinical efficacy using lentiviral vectors. Blood (2002) 1.07
Bioscience in India: times are changing. Cell (2005) 1.06
Genic regions of a large salamander genome contain long introns and novel genes. BMC Genomics (2009) 1.06
Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes. Mol Ther (2002) 1.04
BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription. Proc Natl Acad Sci U S A (2003) 1.03
A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. PLoS Biol (2013) 1.01
Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development. Mol Cell Biol (2004) 1.01
Rapid generation of knockdown transgenic mice by silencing lentiviral vectors. Nat Protoc (2006) 0.99
Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. Mol Biol Cell (2012) 0.99
Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells. Proc Natl Acad Sci U S A (2011) 0.97
PNAS Plus: Refining a successful experiment. Proc Natl Acad Sci U S A (2012) 0.94
Neprilysin protects neurons against Abeta peptide toxicity. Brain Res (2007) 0.93
Inflammatory tales of liver cancer. Cancer Cell (2007) 0.88
Role of BRCA1 in brain development. Proc Natl Acad Sci U S A (2014) 0.87
A role for bone marrow-derived cells in the vasculature of noninjured CNS. Blood (2004) 0.86
Silence of the genes. Proc Natl Acad Sci U S A (2004) 0.84
Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy. Mol Ther (2004) 0.82
Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells. Atherosclerosis (2010) 0.82
Development of ecdysone-regulated lentiviral vectors. Mol Ther (2005) 0.82
Organotypic cerebellar cultures: apoptotic challenges and detection. J Vis Exp (2011) 0.80
Design and Cloning of an shRNA into a Lentiviral Silencing Vector: Version A. CSH Protoc (2008) 0.80
SARS: fear of global pandemic. Mol Ther (2003) 0.80
Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation. PLoS One (2011) 0.79
Effect of adenovirus-mediated overexpression of follistatin and extracellular domain of activin receptor type II on gonadotropin secretion in vitro and in vivo. Endocrinology (2002) 0.79
Success and setback: another adverse event. Mol Ther (2002) 0.78
Design and Cloning of an shRNA into a Lentiviral Silencing Vector: Version B. CSH Protoc (2008) 0.78
Choroidal neovascularization in transgenic mice expressing prokineticin 1: an animal model for age-related macular degeneration. Mol Ther (2005) 0.78
Stem cells at the dawn of the 21st century. Proc Natl Acad Sci U S A (2003) 0.77