Published in Circulation on August 30, 2004
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Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor. Br J Pharmacol (2007) 1.16
Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity. Mol Cells (2012) 1.13
Detection of adulteration of notoginseng root extract with other panax species by quantitative HPLC coupled with PCA. J Agric Food Chem (2009) 1.10
Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice. Br J Pharmacol (2006) 1.07
Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats. Evid Based Complement Alternat Med (2011) 1.05
Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells. Phytomedicine (2010) 1.05
Effect of sugar positions in ginsenosides and their inhibitory potency on Na+/K+-ATPase activity. Acta Pharmacol Sin (2008) 1.05
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Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. Int J Oncol (2013) 0.95
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Active ingredients in Chinese medicines promoting blood circulation as Na+/K+ -ATPase inhibitors. Acta Pharmacol Sin (2011) 0.89
Identification and Analysis of the Novel pGAPDH-w Gene Differentially Expressed in Wild Ginseng. J Pharmacopuncture (2013) 0.89
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Adulteration and cultivation region identification of American ginseng using HPLC coupled with multivariate analysis. J Pharm Biomed Anal (2014) 0.87
A ginseng-derived oestrogen receptor beta (ERbeta) agonist, Rb1 ginsenoside, attenuates capillary morphogenesis. Br J Pharmacol (2007) 0.86
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Comparative study on saponin fractions from Panax notoginseng inhibiting inflammation-induced endothelial adhesion molecule expression and monocyte adhesion. Chin Med (2011) 0.86
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Evaluation of effectiveness of herbal medication in cancer care: a review study. Iran J Cancer Prev (2012) 0.83
The amelioration of N-acetyl-p-benzoquinone imine toxicity by ginsenoside Rg3: the role of Nrf2-mediated detoxification and Mrp1/Mrp3 transports. Oxid Med Cell Longev (2013) 0.82
Korean Red Ginseng protects endothelial cells from serum-deprived apoptosis by regulating Bcl-2 family protein dynamics and caspase S-nitrosylation. J Ginseng Res (2013) 0.82
The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats. BMC Complement Altern Med (2012) 0.82
Accumulation characteristics and correlation analysis of five ginsenosides with different cultivation ages from different regions. J Ginseng Res (2015) 0.81
Rk1, a ginsenoside, is a new blocker of vascular leakage acting through actin structure remodeling. PLoS One (2013) 0.81
Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine. J Clin Med (2016) 0.81
Red ginseng extract facilitates the early differentiation of human embryonic stem cells into mesendoderm lineage. Evid Based Complement Alternat Med (2010) 0.80
Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5 promotes angiogenesis and vasorelaxation. J Biol Chem (2014) 0.79
Dietary supplements and sports performance: herbals. J Int Soc Sports Nutr (2006) 0.79
Discrimination of white ginseng origins using multivariate statistical analysis of data sets. J Ginseng Res (2014) 0.79
Chinese medicinal compound delisheng has satisfactory anti-tumor activity, and is associated with up-regulation of endostatin in human hepatocellular carcinoma cell line HepG2 in three-dimensional culture. World J Gastroenterol (2007) 0.79
Effects of ginsenoside Rb₁ on skin changes. J Biomed Biotechnol (2012) 0.79
Effect of Fermented Red Ginseng Extract Enriched in Ginsenoside Rg3 on the Differentiation and Mineralization of Preosteoblastic MC3T3-E1 Cells. J Med Food (2015) 0.78
Saponin accumulation in the seedling root of Panax notoginseng. Chin Med (2011) 0.77
Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors. Br J Pharmacol (2015) 0.77
Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3. Br J Pharmacol (2015) 0.76
Inhibition of TLR ligand- and interferon gamma-induced murine microglial activation by Panax notoginseng. J Neuroimmune Pharmacol (2011) 0.76
Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy (2016) 0.75
Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites. Evid Based Complement Alternat Med (2016) 0.75
Comparative analysis of the expression level of recombinant ginsenoside-transforming β-glucosidase in GRAS hosts and mass production of the ginsenoside Rh2-Mix. PLoS One (2017) 0.75
Ginsenoside Rg1 attenuates adjuvant-induced arthritis in rats via modulation of PPAR-γ/NF-κB signal pathway. Oncotarget (2017) 0.75
Angiogenic growth factors in myocardial infarction: a critical appraisal. Heart Fail Rev (2017) 0.75
Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor. J Ginseng Res (2016) 0.75
Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice. Science (2009) 8.61
Contaminated heparin associated with adverse clinical events and activation of the contact system. N Engl J Med (2008) 7.05
Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem (2003) 6.84
Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature (2005) 4.97
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events. Nat Biotechnol (2008) 4.46
Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin. Nat Biotechnol (2008) 4.37
Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air. Proc Natl Acad Sci U S A (2009) 3.91
Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift. Science (2009) 3.88
Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity. Hum Mol Genet (2007) 3.26
Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol (2004) 3.22
Outbreak of adverse reactions associated with contaminated heparin. N Engl J Med (2008) 3.16
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut (2012) 3.13
Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses. Proc Natl Acad Sci U S A (2008) 2.77
Structural insights into biological roles of protein-glycosaminoglycan interactions. Chem Biol (2005) 2.67
Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle. J Cell Sci (2005) 2.47
Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation (2008) 2.39
Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J Clin Invest (2005) 2.38
Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses. Virology (2011) 2.28
Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization. Circ Res (2011) 2.26
Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization. Circ Res (2008) 2.16
Frontiers in glycomics: bioinformatics and biomarkers in disease. An NIH white paper prepared from discussions by the focus groups at a workshop on the NIH campus, Bethesda MD (September 11-13, 2006). Proteomics (2008) 2.09
In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke (2004) 2.06
Glycomics: an integrated systems approach to structure-function relationships of glycans. Nat Methods (2005) 2.06
Advancing glycomics: implementation strategies at the consortium for functional glycomics. Glycobiology (2006) 2.05
Extrapolating from sequence--the 2009 H1N1 'swine' influenza virus. Nat Biotechnol (2009) 1.96
Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957. PLoS One (2010) 1.95
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res (2002) 1.89
Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro. Arterioscler Thromb Vasc Biol (2003) 1.85
Glycan receptor binding of the influenza A virus H7N9 hemagglutinin. Cell (2013) 1.84
Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res (2010) 1.81
Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med (2009) 1.80
Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets. Proc Natl Acad Sci U S A (2012) 1.80
Lung endothelial heparan sulfates mediate cationic peptide-induced barrier dysfunction: a new role for the glycocalyx. Am J Physiol Lung Cell Mol Physiol (2003) 1.76
Direct imaging of single-walled carbon nanotubes in cells. Nat Nanotechnol (2007) 1.73
Diffusion limited oxygen delivery following head injury. Crit Care Med (2004) 1.72
Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol (2005) 1.70
Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Regul Pept (2005) 1.68
HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. J Biol Chem (2005) 1.66
Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity. Cell (2013) 1.64
Evidence of macrophage receptors capable of direct recognition of xenogeneic epitopes without opsonization. Xenotransplantation (2005) 1.61
Poly(beta-amino ester)s promote cellular uptake of heparin and cancer cell death. Chem Biol (2004) 1.61
Glycomics: a pathway to a class of new and improved therapeutics. Nat Rev Drug Discov (2004) 1.61
Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead. Cardiovasc Res (2007) 1.56
Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy. J Clin Endocrinol Metab (2002) 1.56
Crystal structure of heparinase II from Pedobacter heparinus and its complex with a disaccharide product. J Biol Chem (2006) 1.55
Mutant huntingtin is present in neuronal grafts in Huntington disease patients. Ann Neurol (2014) 1.55
The many faces of the YopM effector from plague causative bacterium Yersinia pestis and its implications for host immune modulation. Innate Immun (2010) 1.53
Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D. J Biol Chem (2002) 1.53
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy. Blood (2007) 1.49
Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification. J Am Soc Nephrol (2009) 1.49
Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis. Proc Natl Acad Sci U S A (2002) 1.49
Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia. Am J Pathol (2004) 1.48
The angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem Pharmacol (2006) 1.47
Monitoring of heparin and its low-molecular-weight analogs by silicon field effect. Proc Natl Acad Sci U S A (2006) 1.45
A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets. PLoS One (2011) 1.43
Biologically active decorin is a monomer in solution. J Biol Chem (2003) 1.40
Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice. Neurobiol Dis (2008) 1.38
Glycans as receptors for influenza pathogenesis. Glycoconj J (2010) 1.38
Inositol hexakisphosphate mobilizes an endomembrane store of calcium in guard cells. Proc Natl Acad Sci U S A (2003) 1.37
Orthogonal analytical approaches to detect potential contaminants in heparin. Proc Natl Acad Sci U S A (2009) 1.36
Quantitative description of glycan-receptor binding of influenza A virus H7 hemagglutinin. PLoS One (2013) 1.35
Effect of ultrasmall superparamagnetic iron oxide nanoparticles (Ferumoxtran-10) on human monocyte-macrophages in vitro. Biomaterials (2006) 1.35
Structural specificity of heparin binding in the fibroblast growth factor family of proteins. Proc Natl Acad Sci U S A (2003) 1.34
Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab (2003) 1.34
Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. J Clin Invest (2010) 1.32
Targeting an antimicrobial effector function in insect immunity as a pest control strategy. Proc Natl Acad Sci U S A (2009) 1.32
The impact of heparanese and heparin on cancer metastasis and angiogenesis. Pathophysiol Haemost Thromb (2006) 1.29
Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore. J Biol Chem (2001) 1.29
Mineral surface in calcified plaque is like that of bone: further evidence for regulated mineralization. Arterioscler Thromb Vasc Biol (2008) 1.29
Citrate bridges between mineral platelets in bone. Proc Natl Acad Sci U S A (2014) 1.29
Angiogenesis: from plants to blood vessels. Trends Pharmacol Sci (2006) 1.28
Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery. J Neurotrauma (2009) 1.28
Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligands. J Biol Chem (2010) 1.27
Dynamic regulation of tumor growth and metastasis by heparan sulfate glycosaminoglycans. Semin Thromb Hemost (2002) 1.25
The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery. J Biol Chem (2004) 1.23
Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus. PLoS One (2011) 1.21
Decoding the distribution of glycan receptors for human-adapted influenza A viruses in ferret respiratory tract. PLoS One (2012) 1.21
The heparin/heparan sulfate 2-O-sulfatase from Flavobacterium heparinum. Molecular cloning, recombinant expression, and biochemical characterization. J Biol Chem (2003) 1.20
Determinants of glycan receptor specificity of H2N2 influenza A virus hemagglutinin. PLoS One (2010) 1.20
Quantitative imaging of human red blood cells infected with Plasmodium falciparum. Biophys J (2010) 1.18
Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain. Eur J Neurosci (2004) 1.18
Effect of sintered silicate-substituted hydroxyapatite on remodelling processes at the bone-implant interface. Biomaterials (2004) 1.17
Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factor. Arterioscler Thromb Vasc Biol (2003) 1.17
Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins. Nat Biotechnol (2010) 1.17
The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation. Biophys J (2010) 1.15
Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells. FEBS Lett (2006) 1.15
Networks link antigenic and receptor-binding sites of influenza hemagglutinin: mechanistic insight into fitter strain propagation. Sci Rep (2011) 1.14
Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix. Blood (2002) 1.13
A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis. PLoS One (2012) 1.12
pH-dependent toxicity of high aspect ratio ZnO nanowires in macrophages due to intracellular dissolution. ACS Nano (2010) 1.11
Toxicity and imaging of multi-walled carbon nanotubes in human macrophage cells. Biomaterials (2009) 1.11
Comparison of connexin expression patterns in the developing mouse heart and human foetal heart. Mol Cell Biochem (2003) 1.09
Membrane potential stabilization in amphibian skeletal muscle fibres in hypertonic solutions. J Physiol (2003) 1.08
The anti-angiogenic effect of sinomenine. Angiogenesis (2005) 1.08
Low molecular weight heparins: structural differentiation by bidimensional nuclear magnetic resonance spectroscopy. Semin Thromb Hemost (2007) 1.08
A simplified method for quantifying cell migration/wound healing in 96-well plates. J Biomol Screen (2010) 1.08