Published in J Cell Sci on January 25, 2005
Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol (2005) 6.47
SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Mol Cell Biol (2006) 3.39
Nuclear shape, mechanics, and mechanotransduction. Circ Res (2008) 3.12
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron (2009) 3.10
Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells. J Cell Biol (2005) 2.66
Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Proc Natl Acad Sci U S A (2009) 2.59
Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. Exp Cell Res (2008) 2.52
Nuclear mechanics during cell migration. Curr Opin Cell Biol (2010) 2.32
Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections. J Cell Biol (2009) 2.16
Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. Mol Biol Cell (2005) 2.15
The nucleoskeleton as a genome-associated dynamic 'network of networks'. Nat Rev Mol Cell Biol (2011) 2.01
Nuclear positioning. Cell (2013) 2.01
A network of nuclear envelope membrane proteins linking centromeres to microtubules. Cell (2008) 1.88
A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane. J Cell Biol (2007) 1.87
UNC-83 IS a KASH protein required for nuclear migration and is recruited to the outer nuclear membrane by a physical interaction with the SUN protein UNC-84. Mol Biol Cell (2006) 1.79
Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem (2009) 1.79
Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. J Cell Sci (2009) 1.74
Lamin-binding Proteins. Cold Spring Harb Perspect Biol (2010) 1.69
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. EMBO J (2006) 1.61
Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement. Proc Natl Acad Sci U S A (2010) 1.61
Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton. J Cell Sci (2009) 1.58
Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet (2009) 1.48
The genome and the nucleus: a marriage made by evolution. Genome organisation and nuclear architecture. Chromosoma (2005) 1.45
Another way to move chromosomes. Chromosoma (2007) 1.40
The nuclear envelope at a glance. J Cell Sci (2010) 1.38
LINC complexes in health and disease. Nucleus (2011) 1.37
Accessorizing and anchoring the LINC complex for multifunctionality. J Cell Biol (2015) 1.35
Opposing microtubule motors drive robust nuclear dynamics in developing muscle cells. J Cell Sci (2012) 1.32
Herpes simplex virus infection induces phosphorylation and delocalization of emerin, a key inner nuclear membrane protein. J Virol (2007) 1.28
The LINC-less granulocyte nucleus. Eur J Cell Biol (2008) 1.26
Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope. J Biol Chem (2011) 1.22
Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds. PLoS One (2012) 1.17
Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells. Nucleic Acids Res (2011) 1.15
Nesprins: from the nuclear envelope and beyond. Expert Rev Mol Med (2013) 1.15
Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization. PLoS Genet (2014) 1.13
Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development. Dev Dyn (2010) 1.13
Keeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function. Biochem Soc Trans (2011) 1.11
Emergence of a prestressed eukaryotic nucleus during cellular differentiation and development. J R Soc Interface (2010) 1.09
Emerin-lacking mice show minimal motor and cardiac dysfunctions with nuclear-associated vacuoles. Am J Pathol (2006) 1.05
In situ mechanotransduction via vinculin regulates stem cell differentiation. Stem Cells (2013) 1.05
Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope. J Biol Chem (2010) 1.04
Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation. J Biol Chem (2009) 1.03
Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope. Cell Mol Life Sci (2010) 1.02
Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations. Mol Cell Proteomics (2010) 1.02
Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response. PLoS Genet (2014) 1.00
The nuclear envelope LEM-domain protein emerin. Nucleus (2013) 0.99
The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin. PLoS Genet (2014) 0.98
Emerin organizes actin flow for nuclear movement and centrosome orientation in migrating fibroblasts. Mol Biol Cell (2013) 0.98
Tyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases. J Cell Sci (2009) 0.97
Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins. PLoS One (2013) 0.95
Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy. Anat Rec A Discov Mol Cell Evol Biol (2006) 0.95
Nesprins: tissue-specific expression of epsilon and other short isoforms. PLoS One (2014) 0.92
Centrosome positioning in non-dividing cells. Protoplasma (2015) 0.89
Beyond lamins other structural components of the nucleoskeleton. Methods Cell Biol (2010) 0.88
Cytoskeletal tension induces the polarized architecture of the nucleus. Biomaterials (2015) 0.88
Making the LINC: SUN and KASH protein interactions. Biol Chem (2015) 0.88
Mammalian microtubule P-body dynamics are mediated by nesprin-1. J Cell Biol (2014) 0.88
Nuclear mechanics in cancer. Adv Exp Med Biol (2014) 0.88
Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunction. Int J Cell Biol (2012) 0.87
Disruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle. Hum Mol Genet (2014) 0.86
Nanomechanics of vascular endothelium. Cell Tissue Res (2014) 0.86
Mechanics of the nucleus. Compr Physiol (2011) 0.85
Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis. Mol Biol Cell (2011) 0.85
Muscle development, regeneration and laminopathies: how lamins or lamina-associated proteins can contribute to muscle development, regeneration and disease. Cell Mol Life Sci (2012) 0.83
Stabilization of the spectrin-like domains of nesprin-1α by the evolutionarily conserved "adaptive" domain. Cell Mol Bioeng (2010) 0.83
Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis. Mol Biol Cell (2013) 0.83
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease. Circ Res (2014) 0.83
Nuclear envelope and genome interactions in cell fate. Front Genet (2015) 0.81
The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions. PeerJ (2013) 0.81
A novel locus for dilated cardiomyopathy maps to canine chromosome 8. Genomics (2008) 0.80
Nuclear envelope: positioning nuclei and organizing synapses. Curr Opin Cell Biol (2015) 0.80
Defining contributions of paternally methylated imprinted genes at the Igf2-H19 and Dlk1-Gtl2 domains to mouse placentation by transcriptomic analysis. J Biol Chem (2009) 0.80
UnLINCing the nuclear envelope: towards an understanding of the physiological significance of nuclear positioning. Biochem Soc Trans (2011) 0.80
Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody. BMC Cell Biol (2016) 0.79
Focal adhesion kinase knockdown modulates the response of human corneal epithelial cells to topographic cues. Acta Biomater (2012) 0.78
Polygenic inheritance of cryptorchidism susceptibility in the LE/orl rat. Mol Hum Reprod (2015) 0.78
Nonsteroidal anti-inflammatory drug sulindac sulfide suppresses structural protein Nesprin-2 expression in colorectal cancer cells. Biochim Biophys Acta (2013) 0.78
Reinforcing the LINC complex connection to actin filaments: the role of FHOD1 in TAN line formation and nuclear movement. Cell Cycle (2015) 0.78
Beyond membrane channelopathies: alternative mechanisms underlying complex human disease. Acta Pharmacol Sin (2011) 0.78
Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro. Mol Med Rep (2014) 0.77
Protein interactions at the higher plant nuclear envelope: evidence for a linker of nucleoskeleton and cytoskeleton complex. Front Plant Sci (2014) 0.77
N-terminal nesprin-2 variants regulate β-catenin signalling. Exp Cell Res (2016) 0.76
Antisense oligonucleotide induction of progerin in human myogenic cells. PLoS One (2014) 0.75
Control of nuclear organization by F-actin binding proteins. Nucleus (2017) 0.75
Immunohistochemistry on a panel of Emery-Dreifuss muscular dystrophy samples reveals nuclear envelope proteins as inconsistent markers for pathology. Neuromuscul Disord (2016) 0.75
Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis. Hum Mol Genet (2017) 0.75
Going Nuclear: Evidence Implicating the Cell Nucleus in Mechanotransduction. J Biomech Eng (2016) 0.75
Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA. Mol Biol Cell (2016) 0.75
Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells. PLoS One (2017) 0.75
Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle. J Cell Biol (2017) 0.75
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem (2003) 6.84
Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat Genet (2010) 3.57
SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Mol Cell Biol (2006) 3.39
Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity. Hum Mol Genet (2007) 3.26
Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol (2004) 3.22
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut (2012) 3.13
Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation (2008) 2.39
Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization. Circ Res (2011) 2.26
The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton. J Biol Chem (2011) 2.21
Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization. Circ Res (2008) 2.16
Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol (2003) 2.15
In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke (2004) 2.06
Multiplex ligation-dependent probe amplification using a completely synthetic probe set. Biotechniques (2004) 2.04
The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300. Genomics (2002) 1.95
Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging. Circulation (2010) 1.93
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res (2002) 1.89
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death. Curr Biol (2005) 1.87
Modulating angiogenesis: the yin and the yang in ginseng. Circulation (2004) 1.86
Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res (2010) 1.81
Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med (2009) 1.80
Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem (2009) 1.79
Direct imaging of single-walled carbon nanotubes in cells. Nat Nanotechnol (2007) 1.73
Diffusion limited oxygen delivery following head injury. Crit Care Med (2004) 1.72
Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol (2005) 1.70
Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Regul Pept (2005) 1.68
A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation. PLoS Genet (2006) 1.66
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. EMBO J (2006) 1.61
Evidence of macrophage receptors capable of direct recognition of xenogeneic epitopes without opsonization. Xenotransplantation (2005) 1.61
Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques. Circ Res (2013) 1.58
Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy. J Clin Endocrinol Metab (2002) 1.56
Mutant huntingtin is present in neuronal grafts in Huntington disease patients. Ann Neurol (2014) 1.55
Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification. J Am Soc Nephrol (2009) 1.49
Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia. Am J Pathol (2004) 1.48
Rho and vascular disease. Atherosclerosis (2005) 1.42
Nesprins: intracellular scaffolds that maintain cell architecture and coordinate cell function? Expert Rev Mol Med (2005) 1.39
Nesprins LINC the nucleus and cytoskeleton. Curr Opin Cell Biol (2010) 1.38
Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice. Neurobiol Dis (2008) 1.38
Induction, differentiation, and remodeling of blood vessels after transplantation of Bcl-2-transduced endothelial cells. Proc Natl Acad Sci U S A (2004) 1.37
Inositol hexakisphosphate mobilizes an endomembrane store of calcium in guard cells. Proc Natl Acad Sci U S A (2003) 1.37
Krüppel-like factor 4 (KLF4/GKLF) is a target of bone morphogenetic proteins and transforming growth factor beta 1 in the regulation of vascular smooth muscle cell phenotype. J Biol Chem (2003) 1.35
Effect of ultrasmall superparamagnetic iron oxide nanoparticles (Ferumoxtran-10) on human monocyte-macrophages in vitro. Biomaterials (2006) 1.35
Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells. PLoS One (2009) 1.30
Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore. J Biol Chem (2001) 1.29
Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy. Exp Cell Res (2007) 1.29
Mineral surface in calcified plaque is like that of bone: further evidence for regulated mineralization. Arterioscler Thromb Vasc Biol (2008) 1.29
Citrate bridges between mineral platelets in bone. Proc Natl Acad Sci U S A (2014) 1.29
Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery. J Neurotrauma (2009) 1.28
Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligands. J Biol Chem (2010) 1.27
An interaction between Sla1p and Sla2p plays a role in regulating actin dynamics and endocytosis in budding yeast. J Cell Sci (2003) 1.26
Patterns of evolutionary conservation in the nesprin genes highlight probable functionally important protein domains and isoforms. Biochem Soc Trans (2008) 1.26
Radionuclide imaging for the detection of inflammation in vulnerable plaques. J Am Coll Cardiol (2006) 1.25
Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds. Blood (2011) 1.24
Tumor necrosis factor-alpha promotes macrophage-induced vascular smooth muscle cell apoptosis by direct and autocrine mechanisms. Arterioscler Thromb Vasc Biol (2003) 1.22
Cell nuclei spin in the absence of lamin b1. J Biol Chem (2007) 1.22
Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease. Hum Mol Genet (2010) 1.21
The vascular biology of calcification. Semin Dial (2007) 1.19
Molecular mechanisms mediating vascular calcification: role of matrix Gla protein. Nephrology (Carlton) (2006) 1.19
Quantitative imaging of human red blood cells infected with Plasmodium falciparum. Biophys J (2010) 1.18
Effect of sintered silicate-substituted hydroxyapatite on remodelling processes at the bone-implant interface. Biomaterials (2004) 1.17
Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds. PLoS One (2012) 1.17
Migration of adventitial myofibroblasts following vascular balloon injury: insights from in vivo gene transfer to rat carotid arteries. Cardiovasc Res (2003) 1.17
The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation. Biophys J (2010) 1.15
Nesprins: from the nuclear envelope and beyond. Expert Rev Mol Med (2013) 1.15
Inflammation ushers in calcification: a cycle of damage and protection? Circulation (2007) 1.14
A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis. PLoS One (2012) 1.12
pH-dependent toxicity of high aspect ratio ZnO nanowires in macrophages due to intracellular dissolution. ACS Nano (2010) 1.11
Toxicity and imaging of multi-walled carbon nanotubes in human macrophage cells. Biomaterials (2009) 1.11
Human macrophage-induced vascular smooth muscle cell apoptosis requires NO enhancement of Fas/Fas-L interactions. Arterioscler Thromb Vasc Biol (2002) 1.09
Comparison of connexin expression patterns in the developing mouse heart and human foetal heart. Mol Cell Biochem (2003) 1.09
Membrane potential stabilization in amphibian skeletal muscle fibres in hypertonic solutions. J Physiol (2003) 1.08
Properties of the demarcation membrane system in living rat megakaryocytes. Biophys J (2003) 1.06