Published in J Biol Chem on August 31, 2004
Overexpression of SUR2A generates a cardiac phenotype resistant to ischemia. FASEB J (2006) 1.32
Cardiac ATP-sensitive K+ channel associates with the glycolytic enzyme complex. FASEB J (2011) 0.92
VAMP-1, VAMP-2, and syntaxin-4 regulate ANP release from cardiac myocytes. J Mol Cell Cardiol (2010) 0.91
Selective interaction of syntaxin 1A with KCNQ2: possible implications for specific modulation of presynaptic activity. PLoS One (2009) 0.89
Neuroprotective role of ATP-sensitive potassium channels in cerebral ischemia. Acta Pharmacol Sin (2012) 0.84
Syntaxin 1A regulates surface expression of beta-cell ATP-sensitive potassium channels. Am J Physiol Cell Physiol (2011) 0.83
Syntaxin requirement for Ca2+-triggered exocytosis in neurons and endocrine cells demonstrated with an engineered neurotoxin. Biochemistry (2011) 0.83
KATP Channels in the Cardiovascular System. Physiol Rev (2016) 0.82
Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25. Biochem J (2006) 0.80
ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic beta-cell KATP channels. J Biol Chem (2010) 0.80
Syntaxin 1A mediates isoflurane but not hypoxia preconditioning-induced alleviation of hypoxia-reoxygenation injury in rat cardiomyocytes. Am J Transl Res (2015) 0.80
Current understanding of K ATP channels in neonatal diseases: focus on insulin secretion disorders. Acta Pharmacol Sin (2011) 0.77
Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells. PLoS One (2016) 0.76
Phosphatidylinositol 4,5-biphosphate (PIP2) modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic β-cell ATP-sensitive potassium channels. J Biol Chem (2014) 0.76
Comparative proteomic analysis of the ATP-sensitive K+ channel complex in different tissue types. Proteomics (2013) 0.76
Silencing vascular smooth muscle ATP-sensitive K+ channels with caveolin-1. J Physiol (2010) 0.75
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation (2007) 3.33
Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production. Nature (2008) 3.31
2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest (2013) 2.15
The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. Diabetes (2002) 1.96
Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients. Diabetes (2006) 1.89
Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis. J Biol Chem (2004) 1.66
Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1. Circulation (2009) 1.62
Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility. Hypertension (2010) 1.59
Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt. J Biol Chem (2008) 1.52
Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell. Diabetologia (2013) 1.51
Cloning and characterization of a family C orphan G-protein coupled receptor. J Neurochem (2005) 1.44
Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. J Exp Med (2010) 1.44
Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans. Clin Chem (2011) 1.42
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res (2007) 1.40
Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion. J Biol Chem (2002) 1.37
SDF-1alpha up-regulates interleukin-6 through CXCR4, PI3K/Akt, ERK, and NF-kappaB-dependent pathway in microglia. Eur J Pharmacol (2009) 1.35
Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. J Mol Cell Cardiol (2006) 1.30
Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Mol Cell Biol (2005) 1.26
Munc18-1 is critical for plasma membrane localization of syntaxin1 but not of SNAP-25 in PC12 cells. Mol Biol Cell (2007) 1.26
SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins. Endocr Rev (2007) 1.25
Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells. Mol Biol Cell (2009) 1.24
VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis. J Clin Invest (2008) 1.23
Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel. Diabetes (2009) 1.22
Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes (2006) 1.22
Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking. J Biol Chem (2003) 1.19
Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes? Diabetes (2003) 1.18
Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for ω-3 fatty acids. Neuropsychopharmacology (2010) 1.14
Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C alpha phosphorylation of Munc18c. J Biol Chem (2007) 1.13
Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Mol Cell Biol (2011) 1.13
UCP2 regulates the glucagon response to fasting and starvation. Diabetes (2013) 1.13
Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus. Mol Endocrinol (2002) 1.13
Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules. Diabetes (2011) 1.12
Glucagon-like peptide 1 regulates sequential and compound exocytosis in pancreatic islet beta-cells. Diabetes (2005) 1.12
Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse. Endocrinology (2005) 1.12
The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J (2003) 1.10
Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes. Hum Genet (2004) 1.10
Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology (2008) 1.10
SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. Diabetes (2011) 1.09
Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neurons. J Neurosci (2003) 1.09
Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment. Endocrinology (2002) 1.07
Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion. J Biol Chem (2011) 1.07
Hypothalamic protein kinase C regulates glucose production. Diabetes (2008) 1.07
Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition. Endocrinology (2006) 1.05
Transgenic mouse overexpressing syntaxin-1A as a diabetes model. Diabetes (2005) 1.05
Pharmacological activation of plasma-membrane KATP channels reduces reoxygenation-induced Ca(2+) overload in cardiac myocytes via modulation of the diastolic membrane potential. Br J Pharmacol (2004) 1.04
Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth. Cell Metab (2012) 1.03
Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circ Res (2008) 1.02
Ca2+-dependent activator protein for secretion 1 is critical for constitutive and regulated exocytosis but not for loading of transmitters into dense core vesicles. J Biol Chem (2007) 1.02
Saturated and cis/trans unsaturated acyl CoA esters differentially regulate wild-type and polymorphic beta-cell ATP-sensitive K+ channels. Diabetes (2005) 1.02
The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J Biol Chem (2006) 1.01
Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis. Gastroenterology (2007) 1.00
Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance. Diabetes (2010) 1.00
Regulation of insulin exocytosis by Munc13-1. J Biol Chem (2003) 1.00
The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor. J Biol Chem (2008) 1.00
Alcohol redirects CCK-mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis. Traffic (2007) 0.99
Modulation of L-type Ca(2+) channels by distinct domains within SNAP-25. Diabetes (2002) 0.99
Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells. Diabetes (2007) 0.98
Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells. Endocrinology (2006) 0.98
Direct interaction of target SNAREs with the Kv2.1 channel. Modal regulation of channel activation and inactivation gating. J Biol Chem (2003) 0.98
Unperturbed islet α-cell function examined in mouse pancreas tissue slices. J Physiol (2010) 0.97
H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2. J Biol Chem (2004) 0.97
High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice. Am J Physiol Endocrinol Metab (2009) 0.96
Syntaxin-1A binds the nucleotide-binding folds of sulphonylurea receptor 1 to regulate the KATP channel. J Biol Chem (2003) 0.96
Dynamin is functionally coupled to insulin granule exocytosis. J Biol Chem (2007) 0.96
Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells. Am J Physiol Endocrinol Metab (2009) 0.96
Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets. J Biol Chem (2009) 0.96
Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet β- and MIN6 cells. J Endocrinol (2011) 0.96
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways. J Biol Chem (2003) 0.95
Hypoxia-induced matrix metalloproteinase-13 expression in astrocytes enhances permeability of brain endothelial cells. J Cell Physiol (2009) 0.94
Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy. J Physiol (2006) 0.94
Bradykinin-induced cell migration and COX-2 production mediated by the bradykinin B1 receptor in glioma cells. J Cell Biochem (2010) 0.94
Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAs. EMBO J (2006) 0.94
In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking. Diabetes (2012) 0.94
A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Mol Biol Cell (2007) 0.93