PubRank

Kazuo Shin-ya

Author PubWeight™ 86.10‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol 2008 2.88
2 Effect on tumor cells of blocking survival response to glucose deprivation. J Natl Cancer Inst 2004 2.30
3 The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer Res 2006 1.62
4 Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth Biol 2013 1.40
5 Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. Mol Carcinog 2009 1.24
6 FANCJ couples replication past natural fork barriers with maintenance of chromatin structure. J Cell Biol 2013 1.21
7 Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb. Clin Cancer Res 2012 1.17
8 Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides. J Am Chem Soc 2015 1.13
9 The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells. PLoS One 2009 1.00
10 Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem 2013 0.99
11 Thioviridamide, a novel apoptosis inducer in transformed cells from Streptomyces olivoviridis. J Antibiot (Tokyo) 2006 0.98
12 Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest 2013 0.98
13 Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage. J Neurosci 2007 0.98
14 Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry. Chem Commun (Camb) 2003 0.97
15 A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis. Nat Chem Biol 2012 0.97
16 Structure of thioviridamide, a novel apoptosis inducer from Streptomyces olivoviridis. J Antibiot (Tokyo) 2006 0.96
17 Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products. Environ Microbiol 2010 0.95
18 Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A. Biochem Pharmacol 2008 0.94
19 Sponge-derived Streptomyces producing isoprenoids via the mevalonate pathway. J Nat Prod 2010 0.94
20 Total synthesis of (R)-telomestatin. Org Lett 2006 0.94
21 Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines. J Antibiot (Tokyo) 2012 0.93
22 Three eremophilane derivatives, MBJ-0011, MBJ-0012 and MBJ-0013, from an endophytic fungus Apiognomonia sp. f24023. J Antibiot (Tokyo) 2013 0.93
23 Total synthesis of spiruchostatin B aided by an automated synthesizer. Org Biomol Chem 2011 0.93
24 Anti-influenza virus compound from Streptomyces sp. RI18. Org Lett 2010 0.92
25 Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. J Cell Physiol 2010 0.91
26 Cytotoxic sesquiterpenoids MBJ-0009 and MBJ-0010 from a saprobic fungus Nectria sp. f26111. J Antibiot (Tokyo) 2013 0.91
27 Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration. J Biol Chem 2003 0.90
28 JBIR-137 and JBIR-138, new secondary metabolites from Aspergillus sp. fA75. J Antibiot (Tokyo) 2012 0.90
29 Molecular determinants of microbial resistance to thiopeptide antibiotics. J Am Chem Soc 2010 0.90
30 Novel GRP78 molecular chaperone expression down-regulators JBIR-04 and -05 isolated from Streptomyces violaceoniger. J Antibiot (Tokyo) 2007 0.90
31 Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp. J Antibiot (Tokyo) 2005 0.90
32 Isolation of 2 new naphthablin analogs, JBIR-79 and JBIR-80, from Streptomyces sp. RI24. J Antibiot (Tokyo) 2010 0.89
33 Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin. Cancer Sci 2009 0.89
34 Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2. ACS Chem Biol 2013 0.89
35 Naphthoquinone-like polyketide isolated from Streptomyces sp. RI-77 and its predicted biosynthetic pathway. J Nat Prod 2011 0.88
36 A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559. J Antibiot (Tokyo) 2007 0.88
37 Aminocaprophenone- and pyrrolidine-type alkaloids from the leaves of Ficus septica. J Nat Prod 2009 0.87
38 New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6. Org Biomol Chem 2009 0.87
39 Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD. Mol Cancer Ther 2010 0.87
40 New angucycline C-glycosides from Streptomyces sp. RI33. J Antibiot (Tokyo) 2011 0.87
41 Affinity and selectivity of G4 ligands measured by FRET. Nucleic Acids Symp Ser (Oxf) 2005 0.86
42 Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One 2012 0.85
43 New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1. J Antibiot (Tokyo) 2009 0.84
44 Combinatorial synthesis of deoxyhexasaccharides related to the landomycin A sugar moiety, based on an orthogonal deprotection strategy. Chem Asian J 2010 0.83
45 Prunustatin A, a novel GRP78 molecular chaperone down-regulator isolated from Streptomyces violaceoniger. J Antibiot (Tokyo) 2005 0.83
46 Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin. Toxicon 2009 0.83
47 JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27. Org Lett 2009 0.83
48 JBIR-15, a new aspochracin derivative, isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04. Biosci Biotechnol Biochem 2009 0.82
49 Correction of the structure of cuevaene A and its identity with MBJ-0020 from Streptomyces sp. 30503. J Antibiot (Tokyo) 2013 0.82
50 Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator. Org Lett 2007 0.82
51 JBIR-56 and JBIR-57, 2(1H)-pyrazinones from a marine sponge-derived Streptomyces sp. SpD081030SC-03. J Nat Prod 2011 0.82
52 A new cyclizidine analog-JBIR-102-from Saccharopolyspora sp. RL78 isolated from mangrove soil. J Antibiot (Tokyo) 2011 0.82
53 A caged ligand for a telomeric G-quadruplex. Chembiochem 2012 0.81
54 Solid-phase total synthesis of (-)-apratoxin A and its analogues and their biological evaluation. Chem Asian J 2011 0.81
55 A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells. Mol Cancer Ther 2010 0.81
56 G-quadruplexes as potential therapeutic targets for embryonal tumors. Molecules 2013 0.81
57 Total synthesis and stereochemistry revision of mannopeptimycin aglycone. J Am Chem Soc 2014 0.80
58 G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer: greater selectivity than monomer. Chem Commun (Camb) 2009 0.80
59 Proteomic and PROTEOMEX profiling of mammary cancer progression in a HER-2/neu oncogene-driven animal model system. Proteomics 2010 0.80
60 Novel siderophore, JBIR-16, isolated from Nocardia tenerifensis NBRC 101015. J Antibiot (Tokyo) 2009 0.80
61 Isolation of 2 new metabolites, JBIR-74 and JBIR-75, from the sponge-derived Aspergillus sp. fS14. J Antibiot (Tokyo) 2010 0.79
62 New aureothin derivative, alloaureothin, from Streptomyces sp. MM23. J Antibiot (Tokyo) 2007 0.79
63 JBIR-59, a new sorbicillinoid, from a marine-derived fungus Penicillium citrinum SpI080624G1f01. J Antibiot (Tokyo) 2010 0.79
64 JBIR-58, a new salicylamide derivative, isolated from a marine sponge-derived Streptomyces sp. SpD081030ME-02. J Antibiot (Tokyo) 2010 0.79
65 Oximidine III, a new antitumor antibiotic against transformed cells from Pseudomonas sp. II. Structure elucidation. J Antibiot (Tokyo) 2003 0.79
66 A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp. J Antibiot (Tokyo) 2010 0.79
67 Human telomerase reverse transcriptase and glucose-regulated protein 78 increase the life span of articular chondrocytes and their repair potential. BMC Musculoskelet Disord 2012 0.79
68 JBIR-94 and JBIR-125, antioxidative phenolic compounds from Streptomyces sp. R56-07. J Nat Prod 2012 0.79
69 JBIR-107, a new metabolite from the marine-sponge-derived actinomycete, Streptomyces tateyamensis NBRC 105047. Biosci Biotechnol Biochem 2013 0.78
70 Byssochlamysol, a new antitumor steroid against IGF-1-dependent cells from Byssochlamys nivea. II. Physico-chemical properties and structure elucidation. J Antibiot (Tokyo) 2003 0.78
71 Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72. J Nat Prod 2012 0.78
72 Macrocyclic hexaoxazoles as sequence- and mode-selective G-quadruplex binders. Angew Chem Int Ed Engl 2008 0.78
73 Pleiotropic control of secondary metabolism and morphological development by KsbC, a butyrolactone autoregulator receptor homologue in Kitasatospora setae. Appl Environ Microbiol 2012 0.78
74 Synthesis, structure determination, and biological evaluation of destruxin E. Org Lett 2010 0.77
75 Discovery of a pimaricin analog JBIR-13, from Streptomyces bicolor NBRC 12746 as predicted by sequence analysis of type I polyketide synthase gene. Appl Microbiol Biotechnol 2009 0.77
76 JBIR-25, a novel antioxidative agent from Hyphomycetes sp. CR28109. J Antibiot (Tokyo) 2009 0.77
77 A novel antimycin-like compound, JBIR-06, from Streptomyces sp. ML55. J Antibiot (Tokyo) 2008 0.77
78 Oximidine III, a new antitumor antibiotic against transformed cells from Pseudomonas sp. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. J Antibiot (Tokyo) 2003 0.77
79 Actinobacteria associated with the marine sponges Cinachyra sp., Petrosia sp., and Ulosa sp. and their culturability. Microbes Environ 2011 0.77
80 Novel 24-membered macrolides, JBIR-19 and -20 isolated from Metarhizium sp. fE61. J Antibiot (Tokyo) 2009 0.77
81 Two novel benzastatin derivatives, JBIR-67 and JBIR-73, isolated from Streptomyces sp. RI18. J Antibiot (Tokyo) 2011 0.77
82 Synthesis of a potent G-quadruplex-binding macrocyclic heptaoxazole. Chembiochem 2009 0.77
83 Efrapeptin J, a new down-regulator of the molecular chaperone GRP78 from a marine Tolypocladium sp. J Antibiot (Tokyo) 2008 0.77
84 Synthesis of potent G-quadruplex binders of macrocyclic heptaoxazole and evaluation of their activities. Nucleic Acids Symp Ser (Oxf) 2009 0.76
85 JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634. J Antibiot (Tokyo) 2009 0.76
86 A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species. J Antibiot (Tokyo) 2010 0.76
87 New xanthoquinodin-like compounds, JBIR-97, -98 and -99, obtained from marine sponge-derived fungus Tritirachium sp. SpB081112MEf2. J Antibiot (Tokyo) 2010 0.76
88 Induction of tubulin polymerization and apoptosis in malignant mesothelioma cells by a new compound JBIR-23. Cancer Lett 2010 0.76
89 Studies on terpenoids produced by actinomycetes. Isolation and structural elucidation of antioxidative agents, naphterpins B and C. J Antibiot (Tokyo) 2005 0.76
90 Divergence in signaling pathways involved in promotion of cell viability mediated by bFGF, NGF, and EGF in PC12 cells. Neurochem Res 2003 0.76
91 JBIR-124: a novel antioxidative agent from a marine sponge-derived fungus Penicillium citrinum SpI080624G1f01. J Antibiot (Tokyo) 2011 0.75
92 Efficient synthesis of the deoxysugar part of versipelostatin by direct and stereoselective glycosylation and revision of the structure of the trisaccharide unit. Chem Asian J 2009 0.75
93 Isolation of two new terpeptin analogs-JBIR-81 and JBIR-82-from a seaweed-derived fungus, Aspergillus sp. SpD081030G1f1. J Antibiot (Tokyo) 2010 0.75
94 Isolation and structure elucidation of tumescenamides A and B, two peptides produced by Streptomyces tumescens YM23-260. J Antibiot (Tokyo) 2010 0.75
95 Solophenols B-D and solomonin: new prenylated polyphenols isolated from propolis collected from the Solomon Islands and their antibacterial activity. J Agric Food Chem 2012 0.75
96 (S)-stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor. Org Biomol Chem 2010 0.75
97 A new furaquinocin derivative, JBIR-136, from Streptomyces sp. 4963H2. J Antibiot (Tokyo) 2012 0.75
98 JBIR-69, a new metabolite from Streptomyces sp. OG05. J Antibiot (Tokyo) 2010 0.75
99 New pyridone alkaloids JBIR-130, JBIR-131 and JBIR-132 from Isaria sp. NBRC 104353. J Antibiot (Tokyo) 2012 0.75
100 JBIR-14, a highly oxygenated ergostane, from Isaria sp. NBRC 104353. J Antibiot (Tokyo) 2010 0.75
101 JBIR-129 and -139, cytotoxic 34-membered polyol macrolides of microbial origin. J Nat Prod 2012 0.75
102 Screening and evaluation of new inhibitors of hepatic glucose production. J Antibiot (Tokyo) 2009 0.75
103 Byssochlamysol, a new antitumor steroid against IGF-1-dependent cells from Byssochlamys nivea. I. Taxonomy, fermentation, isolation and biological activity. J Antibiot (Tokyo) 2003 0.75
104 The telomerase inhibitor telomestatin induces telomere shortening and cell death in Arabidopsis. Biochim Biophys Acta 2005 0.75
105 Tyrosyl-DNA phosphodiesterase 1 inhibitor from an anamorphic fungus. J Nat Prod 2012 0.75
106 JBIR-54, a new 4-pyridinone derivative isolated from Penicillium daleae Zaleski fE50. J Antibiot (Tokyo) 2009 0.75
107 Stawamycin analog, JBIR-11 from Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830. J Antibiot (Tokyo) 2008 0.75
108 A phenylacetylated peptide, JBIR-96, isolated from Streptomyces sp. RI051-SDHV6. J Nat Prod 2011 0.75
109 Streptomyces aomiensis sp. nov., isolated from a soil sample using the membrane-filter method. Int J Syst Evol Microbiol 2010 0.75
110 Relative configuration of JBIR-129, a cytotoxic 34-membered glycosidic polyol macrolide from Streptomyces sp. RK74. Org Lett 2012 0.75
111 Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp. Chem Commun (Camb) 2015 0.75