Published in J Antibiot (Tokyo) on January 22, 2010
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol (2008) 2.88
Effect on tumor cells of blocking survival response to glucose deprivation. J Natl Cancer Inst (2004) 2.30
Subcellular localization of Aft1 transcription factor responds to iron status in Saccharomyces cerevisiae. J Biol Chem (2002) 1.71
Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. J Biol Chem (2002) 1.63
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer Res (2006) 1.62
Identification of cell-active lysine specific demethylase 1-selective inhibitors. J Am Chem Soc (2009) 1.56
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. J Biol Chem (2002) 1.46
Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe. J Biol Chem (2002) 1.42
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth Biol (2013) 1.40
Hypermagnesemia induced by massive cathartic ingestion in an elderly woman without pre-existing renal dysfunction. Intern Med (2005) 1.37
Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product. ACS Chem Biol (2011) 1.34
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. J Med Chem (2010) 1.31
GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression. J Antibiot (Tokyo) (2002) 1.27
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. Mol Carcinog (2009) 1.24
Induction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicase. Cancer Sci (2007) 1.23
FANCJ couples replication past natural fork barriers with maintenance of chromatin structure. J Cell Biol (2013) 1.21
Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb. Clin Cancer Res (2012) 1.17
Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides. J Am Chem Soc (2015) 1.13
Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs. Carcinogenesis (2002) 1.12
GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. I. Taxonomy, production, isolation, physicochemical properties and biological activities. J Antibiot (Tokyo) (2002) 1.12
Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life. J Control Release (2007) 1.11
Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. Biosci Biotechnol Biochem (2008) 1.08
Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice. Biomaterials (2006) 1.07
The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1. Oncotarget (2014) 1.06
Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models. Cancer Sci (2008) 1.06
The Schizosaccharomyces pombe corepressor Tup11 interacts with the iron-responsive transcription factor Fep1. J Biol Chem (2003) 1.04
The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells. PLoS One (2009) 1.00
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem (2013) 0.99
Thioviridamide, a novel apoptosis inducer in transformed cells from Streptomyces olivoviridis. J Antibiot (Tokyo) (2006) 0.98
Halohydrin and oxime derivatives of radicicol: synthesis and antitumor activities. Bioorg Med Chem (2002) 0.98
Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage. J Neurosci (2007) 0.98
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest (2013) 0.98
Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries. J Med Chem (2012) 0.98
Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry. Chem Commun (Camb) (2003) 0.97
A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis. Nat Chem Biol (2012) 0.97
Structure of thioviridamide, a novel apoptosis inducer from Streptomyces olivoviridis. J Antibiot (Tokyo) (2006) 0.96
Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products. Environ Microbiol (2010) 0.95
A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae. Biochem J (2008) 0.94
Sponge-derived Streptomyces producing isoprenoids via the mevalonate pathway. J Nat Prod (2010) 0.94
Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A. Biochem Pharmacol (2008) 0.94
Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes. ChemMedChem (2007) 0.94
Total synthesis of (R)-telomestatin. Org Lett (2006) 0.94
Novel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format. J Biomol Screen (2009) 0.94
Total synthesis of spiruchostatin B aided by an automated synthesizer. Org Biomol Chem (2011) 0.93
Three eremophilane derivatives, MBJ-0011, MBJ-0012 and MBJ-0013, from an endophytic fungus Apiognomonia sp. f24023. J Antibiot (Tokyo) (2013) 0.93
Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines. J Antibiot (Tokyo) (2012) 0.93
Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants. Aging Cell (2010) 0.93
Phthalate esters enhance quinolinate production by inhibiting alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan pathway. Toxicol Sci (2004) 0.92
Anti-influenza virus compound from Streptomyces sp. RI18. Org Lett (2010) 0.92
Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Acta Crystallogr D Biol Crystallogr (2002) 0.92
Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. J Cell Physiol (2010) 0.91
Cytotoxic sesquiterpenoids MBJ-0009 and MBJ-0010 from a saprobic fungus Nectria sp. f26111. J Antibiot (Tokyo) (2013) 0.91
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem (2013) 0.91
[Action site of bisphenol A as metabolic disruptor lies in the tryptophan-nicotinamide conversion pathway]. Shokuhin Eiseigaku Zasshi (2004) 0.90
Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration. J Biol Chem (2003) 0.90
Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp. J Antibiot (Tokyo) (2005) 0.90
Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase. Biol Pharm Bull (2007) 0.90
JBIR-137 and JBIR-138, new secondary metabolites from Aspergillus sp. fA75. J Antibiot (Tokyo) (2012) 0.90
Streptomyces tateyamensis sp. nov., Streptomyces marinus sp. nov. and Streptomyces haliclonae sp. nov., isolated from the marine sponge Haliclona sp. Int J Syst Evol Microbiol (2010) 0.90
Novel GRP78 molecular chaperone expression down-regulators JBIR-04 and -05 isolated from Streptomyces violaceoniger. J Antibiot (Tokyo) (2007) 0.90
Molecular determinants of microbial resistance to thiopeptide antibiotics. J Am Chem Soc (2010) 0.90
A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis. Yeast (2002) 0.89
Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria. FEMS Microbiol Lett (2009) 0.89
Isolation of 2 new naphthablin analogs, JBIR-79 and JBIR-80, from Streptomyces sp. RI24. J Antibiot (Tokyo) (2010) 0.89
Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin. Cancer Sci (2009) 0.89
Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2. ACS Chem Biol (2013) 0.89
A novel amphibian hypothalamic neuropeptide: isolation, localization, and biological activity. Endocrinology (2002) 0.88
A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559. J Antibiot (Tokyo) (2007) 0.88
Naphthoquinone-like polyketide isolated from Streptomyces sp. RI-77 and its predicted biosynthetic pathway. J Nat Prod (2011) 0.88
Aminocaprophenone- and pyrrolidine-type alkaloids from the leaves of Ficus septica. J Nat Prod (2009) 0.87
New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6. Org Biomol Chem (2009) 0.87
An anti-HIV-1 compound that increases steady-state expression of apoplipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G. Int J Mol Med (2011) 0.87
New angucycline C-glycosides from Streptomyces sp. RI33. J Antibiot (Tokyo) (2011) 0.87
Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD. Mol Cancer Ther (2010) 0.87
Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor. Bioorg Med Chem (2010) 0.87
Crystal structure of the N-terminal domain of the yeast general corepressor Tup1p and its functional implications. J Biol Chem (2012) 0.87
Tetracenoquinocin and 5-iminoaranciamycin from a sponge-derived Streptomyces sp. Sp080513GE-26. J Nat Prod (2010) 0.86
JBIR-31, a new teleocidin analog, produced by salt-requiring Streptomyces sp. NBRC 105896 isolated from a marine sponge. J Antibiot (Tokyo) (2009) 0.86