Published in Development on September 01, 2004
Preventing re-replication of chromosomal DNA. Nat Rev Mol Cell Biol (2005) 5.82
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J (2006) 3.53
Replication licensing and cancer--a fatal entanglement? Nat Rev Cancer (2008) 2.86
Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev (2004) 2.36
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. EMBO J (2004) 1.84
DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol (2006) 1.84
Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision. Mol Cell (2006) 1.73
Endocycling cells do not apoptose in response to DNA rereplication genotoxic stress. Genes Dev (2008) 1.53
CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication. Mol Biol Cell (2005) 1.46
Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways. Cell Div (2007) 1.42
Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells. Cell Div (2006) 1.38
Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development (2010) 1.37
Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sites. Proc Natl Acad Sci U S A (2007) 1.33
Selective killing of cancer cells by suppression of geminin activity. Cancer Res (2009) 1.33
The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. Mol Cell Biol (2006) 1.31
The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles. EMBO J (2007) 1.30
An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication. Mol Cell Biol (2006) 1.27
Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant. Mol Biol Cell (2006) 1.23
Genomic instability in cancer. Cold Spring Harb Perspect Biol (2013) 1.23
Understanding the limitations of radiation-induced cell cycle checkpoints. Crit Rev Biochem Mol Biol (2011) 1.22
Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing. Proc Natl Acad Sci U S A (2009) 1.14
The origin recognition complex is dispensable for endoreplication in Drosophila. Proc Natl Acad Sci U S A (2008) 1.14
Developmentally regulated histone modifications in Drosophila follicle cells: initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation. Chromosoma (2007) 1.13
Cell and plastid division are coordinated through the prereplication factor AtCDT1. Proc Natl Acad Sci U S A (2005) 1.11
Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation. J Cell Sci (2012) 1.02
APC/C--the master controller of origin licensing? Cell Div (2007) 1.02
Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage. J Biol Chem (2008) 1.02
Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells. J Cell Sci (2010) 0.95
Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells. Breast Cancer Res (2011) 0.93
Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals. Development (2013) 0.90
The Cyclin-dependent kinase inhibitor Dacapo promotes genomic stability during premeiotic S phase. Mol Biol Cell (2009) 0.88
Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. Proc Natl Acad Sci U S A (2007) 0.88
SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication. J Biol Chem (2014) 0.87
Preferential re-replication of Drosophila heterochromatin in the absence of geminin. PLoS Genet (2010) 0.87
Dynamic localization of the DNA replication proteins MCM5 and MCM7 in plants. Plant Physiol (2009) 0.86
Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs. PLoS One (2012) 0.83
Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase. Mol Biol Cell (2010) 0.81
Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes. J Biol Chem (2009) 0.81
Mechanisms and regulation of DNA replication initiation in eukaryotes. Crit Rev Biochem Mol Biol (2017) 0.79
The Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation. Mol Biol Cell (2013) 0.78
Safeguarding genetic information in Drosophila. Chromosoma (2011) 0.78
Re-replication of a centromere induces chromosomal instability and aneuploidy. PLoS Genet (2015) 0.78
Knockdown of SCF(Skp2) function causes double-parked accumulation in the nucleus and DNA re-replication in Drosophila plasmatocytes. PLoS One (2013) 0.77
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
Chromatin regulates origin activity in Drosophila follicle cells. Nature (2004) 2.78
Endocycling cells do not apoptose in response to DNA rereplication genotoxic stress. Genes Dev (2008) 1.53
Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication. Mol Biol Cell (2002) 1.31
Developmental and cell cycle regulation of the Drosophila histone locus body. Mol Biol Cell (2007) 1.30
Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress. J Cell Sci (2005) 0.98
Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells. J Cell Sci (2010) 0.95
Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability. Development (2013) 0.95
The histone acetyltransferases CBP and Chameau integrate developmental and DNA replication programs in Drosophila ovarian follicle cells. Development (2012) 0.89
Adjunctive use of AndroGel (testosterone gel) with sildenafil to treat erectile dysfunction in men with acquired androgen deficiency syndrome after failure using sildenafil alone. Urology (2006) 0.87
Analysis of model replication origins in Drosophila reveals new aspects of the chromatin landscape and its relationship to origin activity and the prereplicative complex. Mol Biol Cell (2011) 0.86
humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila. Curr Biol (2005) 0.84
Duplication of the genome in normal and cancer cell cycles. Cancer Biol Ther (2002) 0.77
Serum creatinine predicts success in retrograde ureteral stent placement in patients with pelvic malignancies. Urology (2008) 0.75