Published in Mol Biol Cell on April 03, 2013
SCF(Slmb) E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila. Cell Res (2014) 0.82
Robustness of cell cycle control and flexible orders of signaling events. Sci Rep (2015) 0.78
Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication. Development (2015) 0.75
Principles of CDK regulation. Nature (1995) 13.09
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol (1999) 9.92
Coordination of growth and cell division in the Drosophila wing. Cell (1998) 5.93
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol (1999) 5.40
The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif (2003) 4.68
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol (2001) 3.87
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell (2003) 3.87
Skp2 regulates Myc protein stability and activity. Mol Cell (2003) 3.85
Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol Cell Biol (1996) 3.50
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science (2006) 3.41
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J Clin Invest (2002) 3.36
Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell (2004) 3.27
Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc Natl Acad Sci U S A (1998) 3.26
Skp2 is oncogenic and overexpressed in human cancers. Proc Natl Acad Sci U S A (2001) 2.98
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell (2005) 2.75
A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell (1996) 2.71
Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell (1996) 2.69
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol Cell (2001) 2.61
Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis. Genes Dev (1995) 2.36
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem (2003) 2.36
The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). Genes Dev (2002) 2.33
Control of Drosophila endocycles by E2F and CRL4(CDT2). Nature (2011) 1.89
SnapShot: F Box Proteins II. Cell (2009) 1.88
Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. Genes Dev (2004) 1.88
Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila Cdc2 kinase. Development (1997) 1.83
The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol (2004) 1.80
Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2. Development (2004) 1.52
Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. Cell Cycle (2006) 1.51
Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome. Mol Cell Biol (2001) 1.40
Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis. Mol Cell (2004) 1.34
Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2. Mol Cell Biol (1999) 1.32
A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SK-UT. Oncogene (2001) 1.27
SnapShot: F box proteins I. Cell (2009) 1.27
Downregulation of the KIP family members p27(KIP1) and p57(KIP2) by SKP2 and the role of methylation in p57(KIP2) inactivation in nonsmall cell lung cancer. Int J Cancer (2006) 1.21
Skp2: a novel potential therapeutic target for prostate cancer. Biochim Biophys Acta (2011) 1.21
A Skp2 autoinduction loop and restriction point control. J Cell Biol (2007) 1.18
SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells. Oncogene (2003) 1.17
Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. J Biol Chem (2006) 1.12
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation. Cardiovasc Res (2005) 1.09
The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila. Development (2007) 1.04
Expression of the cyclin-dependent kinase inhibitor Dacapo is regulated by cyclin E. Mech Dev (2000) 1.02
Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos. Nat Cell Biol (2010) 1.02
Kip1 meets SKP2: new links in cell-cycle control. Nat Cell Biol (1999) 1.01
Scaling of the Bicoid morphogen gradient by a volume-dependent production rate. Development (2011) 0.99
Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer. J Urol (2003) 0.99
Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress. J Cell Sci (2005) 0.98
The F-box protein SKP2 binds to the phosphorylated threonine 380 in cyclin E and regulates ubiquitin-dependent degradation of cyclin E. Biochem Biophys Res Commun (2001) 0.97
Cdks and the Drosophila cell cycle. Curr Opin Genet Dev (1997) 0.96
Mutual rescues between two dominant negative mutations in cardiac troponin I and cardiac troponin T. J Biol Chem (2010) 0.93
dRecQ4 is required for DNA synthesis and essential for cell proliferation in Drosophila. PLoS One (2009) 0.92
A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1. J Biol Chem (2003) 0.92
Skp2 knockout reduces cell proliferation and mouse body size: and prevents cancer? Cell Res (2010) 0.91
Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus. Development (2011) 0.88
Drosophila sbo regulates lifespan through its function in the synthesis of coenzyme Q in vivo. J Genet Genomics (2011) 0.88
Molecular and biochemical characterization of the Skp2-Cks1 binding interface. J Biol Chem (2004) 0.88
Overexpression of SKP2 promotes the radiation resistance of esophageal squamous cell carcinoma. Radiat Res (2011) 0.87
Cell cycle-dependent phosphorylation of p27 cyclin-dependent kinase (Cdk) inhibitor by cyclin E/Cdk2. Biochem Biophys Res Commun (1997) 0.87
Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry. J Mol Biol (2006) 0.86
Nitric oxide mediates stretch-induced Ca2+ release via activation of phosphatidylinositol 3-kinase-Akt pathway in smooth muscle. PLoS One (2008) 0.84
A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. J Genet Genomics (2012) 0.83
Cul4 and DDB1 regulate Orc2 localization, BrdU incorporation and Dup stability during gene amplification in Drosophila follicle cells. J Cell Sci (2009) 0.81
Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila. PLoS One (2012) 0.80
Association of the cell cycle regulatory proteins p45(SKP2) and CksHs1. Functional effect on CDK2 complex formation and kinase activity. J Biol Chem (2001) 0.79
Drosophila RecQ5 is required for efficient SSA repair and suppression of LOH in vivo. Protein Cell (2010) 0.79
Cks85A and Skp2 interact to maintain diploidy and promote growth in Drosophila. Dev Biol (2011) 0.78
[The group of protein kinases CKI]. Postepy Biochem (2000) 0.76
Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol Cell Proteomics (2004) 19.05
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol (2011) 18.34
Ge/Si nanowire heterostructures as high-performance field-effect transistors. Nature (2006) 8.50
Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet (2009) 8.44
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
PTC124 targets genetic disorders caused by nonsense mutations. Nature (2007) 6.67
Nanoscale memristor device as synapse in neuromorphic systems. Nano Lett (2010) 6.28
Electronic health record use and the quality of ambulatory care in the United States. Arch Intern Med (2007) 5.85
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron (2010) 4.76
Reversal of the TCR stop signal by CTLA-4. Science (2006) 4.59
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Improved synthesis of graphene oxide. ACS Nano (2010) 4.32
How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys (2010) 4.14
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
A phase 3 trial of semagacestat for treatment of Alzheimer's disease. N Engl J Med (2013) 4.11
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell (2003) 3.66
Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature (2011) 3.32
Global warming preceded by increasing carbon dioxide concentrations during the last deglaciation. Nature (2012) 3.17
Soy food intake and breast cancer survival. JAMA (2009) 3.16
Observation of conducting filament growth in nanoscale resistive memories. Nat Commun (2012) 3.02
Glycopeptide and lipoglycopeptide antibiotics. Chem Rev (2005) 3.01
Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy. J Genet Genomics (2012) 2.98
Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol (2012) 2.91
The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med (2006) 2.90
Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila. Genetics (2013) 2.87
Ice-shelf collapse from subsurface warming as a trigger for Heinrich events. Proc Natl Acad Sci U S A (2011) 2.83
Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial. Lancet Oncol (2011) 2.75
Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia. Blood (2008) 2.72
Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet (2012) 2.70
Nitrogen fixation island and rhizosphere competence traits in the genome of root-associated Pseudomonas stutzeri A1501. Proc Natl Acad Sci U S A (2008) 2.70
LTP requires a reserve pool of glutamate receptors independent of subunit type. Nature (2012) 2.59
Focused ultrasound to expel calculi from the kidney. J Urol (2011) 2.55
Novel breathing motion model for radiotherapy. Int J Radiat Oncol Biol Phys (2005) 2.51
Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: a pooled data analysis of two phase III trials. J Clin Oncol (2005) 2.49
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat Immunol (2011) 2.42
Energy doubling of 42 GeV electrons in a metre-scale plasma wakefield accelerator. Nature (2007) 2.36
In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol Cancer Ther (2008) 2.34
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
The MCART radiation physics core: the quest for radiation dosimetry standardization. Health Phys (2014) 2.23
Comparison of dynamic block randomization and minimization in randomized trials: a simulation study. Clin Trials (2011) 2.22
Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders. Cell Cycle (2011) 2.19
Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med (2010) 2.15
Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice. Biomaterials (2009) 2.13
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology (2006) 2.10
Adherence to anti-tuberculosis treatment among pulmonary tuberculosis patients: a qualitative and quantitative study. BMC Health Serv Res (2009) 2.07
A functional hybrid memristor crossbar-array/CMOS system for data storage and neuromorphic applications. Nano Lett (2011) 2.06
A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy. J Am Chem Soc (2010) 2.02
Baseline serum lactate dehydrogenase levels for patients treated with intensity-modulated radiotherapy for nasopharyngeal carcinoma: a predictor of poor prognosis and subsequent liver metastasis. Int J Radiat Oncol Biol Phys (2011) 1.99
A metagenomic approach to characterization of the vaginal microbiome signature in pregnancy. PLoS One (2012) 1.98
Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium. PLoS Genet (2010) 1.98
E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation. Stem Cells (2010) 1.97
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. Proc Natl Acad Sci U S A (2009) 1.94
A multimodal location and routing model for hazardous materials transportation. J Hazard Mater (2012) 1.93
Inhibiting the regeneration of N-nitrosodimethylamine in drinking water by UV photolysis combined with ozonation. J Hazard Mater (2009) 1.92
Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. PLoS Genet (2012) 1.91
Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVa. J Immunol (2008) 1.90
Novel ultrasound method to reposition kidney stones. Urol Res (2010) 1.90
Amnioinfusion for the prevention of the meconium aspiration syndrome. N Engl J Med (2005) 1.89
Evaluation of breast cancer susceptibility loci in Chinese women. Cancer Epidemiol Biomarkers Prev (2010) 1.87
Tracking lung tissue motion and expansion/compression with inverse consistent image registration and spirometry. Med Phys (2007) 1.86
Impact of clinical trial results on national trends in alpha-blocker prescribing, 1996-2002. JAMA (2004) 1.85
Long-term and short-term changes in antihypertensive prescribing by office-based physicians in the United States. Hypertension (2006) 1.82
Short-term memory to long-term memory transition in a nanoscale memristor. ACS Nano (2011) 1.81
Time trends and characteristics of childhood cancer among children age 0-14 in Shanghai. Pediatr Blood Cancer (2009) 1.78
P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes. Biol Reprod (2010) 1.77
Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression. Epigenetics (2011) 1.76
Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry (2007) 1.74
118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects. BMC Med Genet (2009) 1.74
Is primary tumor volume still a prognostic factor in intensity modulated radiation therapy for nasopharyngeal carcinoma? Radiother Oncol (2012) 1.72
Preliminary results of a prospective randomized trial comparing concurrent chemoradiotherapy plus adjuvant chemotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma in endemic regions of china. Int J Radiat Oncol Biol Phys (2008) 1.71
A blood-based biomarker panel for stratifying current risk for colorectal cancer. Int J Cancer (2010) 1.70
Trends in blood pressure and body mass index among Chinese children and adolescents from 2005 to 2010. Am J Hypertens (2013) 1.70
Focused ultrasonic propulsion of kidney stones: review and update of preclinical technology. J Endourol (2013) 1.69
Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study. J Am Geriatr Soc (2008) 1.68
Relationships between indices of obesity and its cardiovascular comorbidities in a Chinese population. Circ J (2008) 1.68
Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain. Cell Res (2011) 1.67
Global climate evolution during the last deglaciation. Proc Natl Acad Sci U S A (2012) 1.67
Single-crystal metallic nanowires and metal/semiconductor nanowire heterostructures. Nature (2004) 1.67
A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell (2008) 1.66
In vivo Cerenkov luminescence imaging: a new tool for molecular imaging. Philos Trans A Math Phys Eng Sci (2011) 1.64
Respiratory viral infection in obliterative airway disease after orthotopic tracheal transplantation. Ann Thorac Surg (2006) 1.63
The seventh edition of the UICC/AJCC staging system for nasopharyngeal carcinoma is prognostically useful for patients treated with intensity-modulated radiotherapy from an endemic area in China. Radiother Oncol (2011) 1.60
Obesity and weight change in relation to breast cancer survival. Breast Cancer Res Treat (2010) 1.60
Bmi-1 is essential for the tumorigenicity of neuroblastoma cells. Am J Pathol (2007) 1.59
Replication and functional genomic analyses of the breast cancer susceptibility locus at 6q25.1 generalize its importance in women of chinese, Japanese, and European ancestry. Cancer Res (2011) 1.59
Extended transsternal thymectomy for the treatment of ocular myasthenia gravis. Ann Thorac Surg (2011) 1.58
The biological meaning of anti-HBC positive result in blood donors: relation to HBV-DNA and to other serological markers. Rev Inst Med Trop Sao Paulo (2003) 1.56
Trends in childhood cancer incidence and mortality in urban Shanghai, 1973-2005. Pediatr Blood Cancer (2010) 1.56
Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium. Hum Mol Genet (2011) 1.55
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function. Proc Natl Acad Sci U S A (2005) 1.51
Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p. PLoS Biol (2010) 1.51
High-density crossbar arrays based on a Si memristive system. Nano Lett (2009) 1.51
The association of weight with the detection of airflow obstruction and inhaled treatment among patients with a clinical diagnosis of COPD. Chest (2014) 1.51
The use of complementary and alternative medicine among Chinese women with breast cancer. J Altern Complement Med (2008) 1.51
Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women. J Natl Cancer Inst (2010) 1.51
4D-CT motion estimation using deformable image registration and 5D respiratory motion modeling. Med Phys (2008) 1.49
High-responsivity graphene/InAs nanowire heterojunction near-infrared photodetectors with distinct photocurrent on/off ratios. Small (2014) 1.49