Published in Circulation on September 13, 2004
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull (2011) 4.27
Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care (2009) 2.83
Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin Transl Sci (2008) 2.54
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest (2011) 2.34
Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol (2012) 2.16
Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr (2010) 1.85
High glucose induces IL-1beta expression in human monocytes: mechanistic insights. Am J Physiol Endocrinol Metab (2007) 1.85
Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep (2009) 1.76
Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis. Hepatology (2008) 1.76
Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care (2010) 1.61
Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways. Diabetes (2008) 1.52
Comparison effect of atorvastatin (10 versus 80 mg) on biomarkers of inflammation and oxidative stress in subjects with metabolic syndrome. Am J Cardiol (2008) 1.51
Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front Endocrinol (Lausanne) (2013) 1.47
MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med (2009) 1.46
Nonalcoholic fatty pancreas disease. HPB (Oxford) (2007) 1.44
Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr (2010) 1.44
The impact of obesity on the immune response to infection. Proc Nutr Soc (2012) 1.41
Human C-reactive protein and the metabolic syndrome. Curr Opin Lipidol (2009) 1.40
Exenatide exerts a potent antiinflammatory effect. J Clin Endocrinol Metab (2011) 1.37
Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice. PLoS One (2011) 1.31
Weight loss in obese adults 65years and older: a review of the controversy. Exp Gerontol (2013) 1.26
Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-κB stress pathway. Diabetes (2011) 1.24
FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages. Diabetes (2009) 1.22
Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE). J Nutr (2015) 1.20
A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adults. J Nutr (2011) 1.17
Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia. Diabetes Care (2012) 1.16
Fat: a matter of disturbance for the immune system. World J Gastroenterol (2010) 1.13
Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance. Diabetes (2011) 1.11
Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. Biochim Biophys Acta (2009) 1.09
Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a Treg- and Th2-dominated phenotype. Diabetes (2012) 1.09
Increased toll-like receptor activity in patients with metabolic syndrome. Diabetes Care (2012) 1.07
Association between plasma monocyte chemoattractant protein-1 concentration and cardiovascular disease mortality in middle-aged diabetic and nondiabetic individuals. Diabetes Care (2009) 1.05
Palmitate and insulin synergistically induce IL-6 expression in human monocytes. Cardiovasc Diabetol (2010) 1.03
Nutritionally mediated oxidative stress and inflammation. Oxid Med Cell Longev (2013) 1.01
Experimental evidence of obesity as a risk factor for severe acute pancreatitis. World J Gastroenterol (2009) 1.00
Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome. J Lipid Res (2010) 0.99
Adipose tissue and inflammatory bowel disease pathogenesis. Inflamm Bowel Dis (2012) 0.98
Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women. Am J Physiol Endocrinol Metab (2011) 0.98
Diet-induced obesity increases NF-kappaB signaling in reporter mice. Genes Nutr (2009) 0.98
Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. BMC Genomics (2010) 0.97
Inflammatory mediators and insulin resistance in obesity: role of nuclear receptor signaling in macrophages. Mediators Inflamm (2010) 0.97
Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance. Exp Mol Med (2010) 0.96
Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. Nutr Metab (Lond) (2010) 0.96
Feto-placental adaptations to maternal obesity in the baboon. Placenta (2009) 0.96
Macrophage migration inhibitory factor: critical role in obesity, insulin resistance, and associated comorbidities. Mediators Inflamm (2010) 0.96
Peripheral blood mononuclear cells: a potential source of homeostatic imbalance markers associated with obesity development. Pflugers Arch (2013) 0.95
Targeting the IKKβ/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer. Mol Cancer Ther (2012) 0.94
Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin. PLoS One (2012) 0.94
Enhanced lipid oxidation and maintenance of muscle insulin sensitivity despite glucose intolerance in a diet-induced obesity mouse model. PLoS One (2013) 0.93
Severely obese have greater LPS-stimulated TNF-alpha production than normal weight African-American women. Obesity (Silver Spring) (2008) 0.93
Obese reproductive-age women exhibit a proatherogenic inflammatory response during hyperglycemia. Obesity (Silver Spring) (2007) 0.93
Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. Cancer Prev Res (Phila) (2011) 0.92
Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women. J Clin Endocrinol Metab (2012) 0.91
Adipogenesis of human adipose-derived stem cells within three-dimensional hollow fiber-based bioreactors. Tissue Eng Part C Methods (2011) 0.90
Fast food fever: reviewing the impacts of the Western diet on immunity. Nutr J (2014) 0.89
Milk protein for improved metabolic health: a review of the evidence. Nutr Metab (Lond) (2013) 0.89
The association between obesity, cardiometabolic disease biomarkers, and innate immunity-related inflammation in Canadian adults. Diabetes Metab Syndr Obes (2012) 0.88
DNA methylation pattern in overweight women under an energy-restricted diet supplemented with fish oil. Biomed Res Int (2014) 0.88
Obesity and infection: two sides of one coin. Eur J Pediatr (2013) 0.87
Nuclear magnetic resonance spectroscopy-based metabolomics of the fatty pancreas: implicating fat in pancreatic pathology. Pancreatology (2009) 0.87
Acute exercise increases circulating inflammatory markers in overweight and obese compared with lean subjects. Eur J Appl Physiol (2013) 0.87
Islet-specific T-cell responses and proinflammatory monocytes define subtypes of autoantibody-negative ketosis-prone diabetes. Diabetes Care (2013) 0.87
Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome. Curr Atheroscler Rep (2010) 0.87
Functional polymorphism of IL-1 alpha and its potential role in obesity in humans and mice. PLoS One (2011) 0.85
Cardiac mTOR rescues the detrimental effects of diet-induced obesity in the heart after ischemia-reperfusion. Am J Physiol Heart Circ Physiol (2015) 0.84
Nutrigenomics, beta-cell function and type 2 diabetes. Curr Genomics (2007) 0.84
Macrophage migration inhibitory factor (MIF) knockout preserves cardiac homeostasis through alleviating Akt-mediated myocardial autophagy suppression in high-fat diet-induced obesity. Int J Obes (Lond) (2014) 0.84
High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment. Calcif Tissue Int (2015) 0.84
Impact of Obesity and Metabolic Syndrome on Immunity. Adv Nutr (2016) 0.83
Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids. Am J Obstet Gynecol (2011) 0.83
Dichotomous mechanisms of aortic stiffening in high-fat diet fed young and old B6D2F1 mice. Physiol Rep (2014) 0.83
Obesity and cytokines in childhood-onset systemic lupus erythematosus. J Immunol Res (2014) 0.83
The macrophage migration inhibitory factor protein superfamily in obesity and wound repair. Exp Mol Med (2015) 0.83
The role of obesity in gastrointestinal cancer: evidence and opinion. Therap Adv Gastroenterol (2014) 0.82
Impaired alternative macrophage differentiation of peripheral blood mononuclear cells from obese subjects. Diab Vasc Dis Res (2011) 0.82
Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies. Front Immunol (2015) 0.82
MiRNA-194 Regulates Palmitic Acid-Induced Toll-Like Receptor 4 Inflammatory Responses in THP-1 Cells. Nutrients (2015) 0.81
Short-term exercise training improves insulin sensitivity but does not inhibit inflammatory pathways in immune cells from insulin-resistant subjects. J Diabetes Res (2013) 0.81
Chronic subclinical bowel inflammation may explain increased risk of colorectal cancer in obese people. Gut (2007) 0.80
Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes. Int J Obes (Lond) (2011) 0.80
Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity. PLoS One (2013) 0.79
Adipose inflammation: cause or consequence of obesity-related insulin resistance. Diabetes Metab Syndr Obes (2008) 0.79
Egg intake during carbohydrate restriction alters peripheral blood mononuclear cell inflammation and cholesterol homeostasis in metabolic syndrome. Nutrients (2014) 0.79
Octanoylated Ghrelin Inhibits the Activation of the Palmitic Acid-Induced TLR4/NF-κB Signaling Pathway in THP-1 Macrophages. ISRN Endocrinol (2012) 0.79
Sunflower oil supplementation has proinflammatory effects and does not reverse insulin resistance in obesity induced by high-fat diet in C57BL/6 mice. J Biomed Biotechnol (2012) 0.79
Effects of berberine and red yeast on proinflammatory cytokines IL-6 and TNF-α in peripheral blood mononuclear cells (PBMCs) of human subjects. Front Pharmacol (2014) 0.78
Neutrophil functions in morbidly obese subjects. Clin Exp Immunol (2015) 0.78
Evidence of mononuclear cell preactivation in the fasting state in polycystic ovary syndrome. Am J Obstet Gynecol (2014) 0.78
MIF deficiency does not alter glucose homeostasis or adipose tissue inflammatory cell infiltrates during diet-induced obesity. Obesity (Silver Spring) (2013) 0.78
Hyperandrogenism induces a proinflammatory TNFα response to glucose ingestion in a receptor-dependent fashion. J Clin Endocrinol Metab (2014) 0.78
Steatocholecystitis: the influence of obesity and dietary carbohydrates. J Surg Res (2007) 0.78
Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells. Oncotarget (2015) 0.77
Is there an estrogenic component in the metabolic syndrome? Genes Nutr (2006) 0.77
The altered mononuclear cell-derived cytokine response to glucose ingestion is not regulated by excess adiposity in polycystic ovary syndrome. J Clin Endocrinol Metab (2014) 0.77
Validation of the circulating monocyte being representative of the cholesterol-loaded macrophage: biomediator activity. Arch Pathol Lab Med (2008) 0.77
Bariatric surgery rapidly improves mitochondrial respiration in morbidly obese patients. Surg Endosc (2013) 0.77
Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR: LA-cp rats. Nutrients (2010) 0.77
Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol (2004) 6.78
Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation (2005) 4.17
Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes (2003) 3.00
Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. J Clin Endocrinol Metab (2004) 2.93
Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care (2009) 2.83
Evidence for a potent antiinflammatory effect of rosiglitazone. J Clin Endocrinol Metab (2004) 2.36
Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy. Stroke (2005) 2.24
Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr (2010) 1.85
Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care (2010) 1.61
Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care (2010) 1.60
Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. Am J Clin Nutr (2004) 1.57
Sitagliptin exerts an antinflammatory action. J Clin Endocrinol Metab (2012) 1.55
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THE ASSOCIATION OF TESTOSTERONE AND CARDIOVASCULAR RISK. Endocr Pract (2015) 1.52
The potential therapeutic role of insulin in acute myocardial infarction in patients admitted to intensive care and in those with unspecified hyperglycemia. Diabetes Care (2003) 1.50
An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab (2010) 1.48
Acute modulation of toll-like receptors by insulin. Diabetes Care (2008) 1.46
Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction. Circulation (2004) 1.46
Orange juice or fructose intake does not induce oxidative and inflammatory response. Diabetes Care (2007) 1.46
Insulin as an anti-inflammatory and antiatherogenic modulator. J Am Coll Cardiol (2009) 1.43
Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese. J Clin Endocrinol Metab (2007) 1.38
Exenatide exerts a potent antiinflammatory effect. J Clin Endocrinol Metab (2011) 1.37
Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. J Clin Endocrinol Metab (2002) 1.35
Exenatide therapy in obese patients with type 2 diabetes mellitus treated with insulin. Endocr Pract (2007) 1.35
A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J Clin Endocrinol Metab (2011) 1.35
A comparison of the effects of rosiglitazone and glyburide on cardiovascular function and glycemic control in patients with type 2 diabetes. Diabetes Care (2002) 1.35
Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin. J Clin Endocrinol Metab (2004) 1.34
Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action. J Clin Endocrinol Metab (2003) 1.25
Proinflammatory effects of glucose and anti-inflammatory effect of insulin: relevance to cardiovascular disease. Am J Cardiol (2006) 1.23
Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells. Am J Clin Nutr (2002) 1.19
Contrasting testosterone concentrations in type 1 and type 2 diabetes. Diabetes Care (2006) 1.18
Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-kappaB in mononuclear cells. Metabolism (2004) 1.17
Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9. Diabetes Care (2003) 1.16
Liraglutide as additional treatment for type 1 diabetes. Eur J Endocrinol (2011) 1.15
Efficacy of glyburide/metformin tablets compared with initial monotherapy in type 2 diabetes. J Clin Endocrinol Metab (2003) 1.13
Testosterone concentration in young patients with diabetes. Diabetes Care (2008) 1.11
Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes. Diabetes Care (2006) 1.11
Insulin infusion in acute illness. J Clin Invest (2005) 1.10
Anti-inflammatory effects of insulin. Curr Opin Clin Nutr Metab Care (2007) 1.10
The potential influence of inflammation and insulin resistance on the pathogenesis and treatment of atherosclerosis-related complications in type 2 diabetes. J Clin Endocrinol Metab (2003) 1.08
Low-dose rosiglitazone exerts an antiinflammatory effect with an increase in adiponectin independently of free fatty acid fall and insulin sensitization in obese type 2 diabetics. J Clin Endocrinol Metab (2006) 1.04
Suppressive effect of insulin infusion on chemokines and chemokine receptors. Diabetes Care (2010) 1.03
Endothelial dysfunction, inflammation and diabetes. Rev Endocr Metab Disord (2004) 1.03
Durability of effects of exenatide treatment on glycemic control, body weight, systolic blood pressure, C-reactive protein, and triglyceride concentrations. Endocr Pract (2011) 1.01
Comparative evaluation of adjunctive oral irrigation in diabetics. J Clin Periodontol (2002) 1.00
Prediction of adverse outcomes by blood glucose level after endovascular therapy for acute ischemic stroke. J Neurosurg (2011) 1.00
Hypogonadotrophic hypogonadism in type 2 diabetes, obesity and the metabolic syndrome. Curr Mol Med (2008) 1.00
Reduction in inflammation and the expression of amyloid precursor protein and other proteins related to Alzheimer's disease following gastric bypass surgery. J Clin Endocrinol Metab (2012) 0.99
A high-carbohydrate diet in the immediate postnatal life of rats induces adaptations predisposing to adult-onset obesity. J Endocrinol (2008) 0.98
Tumor necrosis factor-alpha inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells. Metabolism (2002) 0.95
Cardiovascular benefits of exogenous insulin. J Clin Endocrinol Metab (2012) 0.95
Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury. Arterioscler Thromb Vasc Biol (2009) 0.95
Tetraiodothyroacetic acid, a small molecule integrin ligand, blocks angiogenesis induced by vascular endothelial growth factor and basic fibroblast growth factor. Angiogenesis (2007) 0.95
Testosterone concentrations in young pubertal and post-pubertal obese males. Clin Endocrinol (Oxf) (2013) 0.94
Pharmacokinetics and pharmacodynamics of oral heparin solid dosage form in healthy human subjects. J Clin Pharmacol (2007) 0.94
Control of postprandial plasma glucose by an oral insulin product (HIM2) in patients with type 2 diabetes. Diabetes Care (2003) 0.93
Liraglutide as additional treatment to insulin in obese patients with type 1 diabetes mellitus. Endocr Pract (2013) 0.93
Low estradiol concentrations in men with subnormal testosterone concentrations and type 2 diabetes. Diabetes Care (2011) 0.93
The effects of hypogonadism on body composition and bone mineral density in type 2 diabetic patients. Diabetes Care (2007) 0.91
Proinflammatory and prothrombotic effects of hypoglycemia. Diabetes Care (2010) 0.91
Insulin resistance as a proinflammatory state: mechanisms, mediators, and therapeutic interventions. Curr Drug Targets (2003) 0.90
Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism. Atherosclerosis (2012) 0.89
Endothelial dysfunction and hypertension in diabetes mellitus. Med Clin North Am (2004) 0.89