Published in J Clin Invest on January 01, 2007
Exploring the full spectrum of macrophage activation. Nat Rev Immunol (2008) 26.08
Macrophage plasticity and polarization: in vivo veritas. J Clin Invest (2012) 13.44
Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol (2011) 12.21
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med (2007) 11.51
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med (2009) 11.28
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 9.59
Adipokines in inflammation and metabolic disease. Nat Rev Immunol (2011) 8.92
Type 2 diabetes as an inflammatory disease. Nat Rev Immunol (2011) 8.30
Macrophage biology in development, homeostasis and disease. Nature (2013) 8.28
Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med (2009) 8.15
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med (2011) 8.00
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med (2007) 7.87
Mechanisms underlying inflammation in neurodegeneration. Cell (2010) 7.66
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science (2011) 6.83
Inflammasomes in health and disease. Nature (2012) 6.75
Inflammatory links between obesity and metabolic disease. J Clin Invest (2011) 6.73
Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest (2008) 6.60
Adipose tissue remodeling and obesity. J Clin Invest (2011) 6.12
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab (2008) 5.83
The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med (2012) 5.63
Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab (2008) 5.53
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med (2011) 5.16
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab (2008) 5.10
Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol (2011) 4.68
Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes (2008) 4.56
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest (2010) 4.56
CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl Acad Sci U S A (2007) 4.24
What we talk about when we talk about fat. Cell (2014) 4.12
NF-κB, inflammation, and metabolic disease. Cell Metab (2011) 4.00
The protein kinase IKKepsilon regulates energy balance in obese mice. Cell (2009) 3.93
Molecular mechanisms of cancer development in obesity. Nat Rev Cancer (2011) 3.65
Alternative macrophage activation and metabolism. Annu Rev Pathol (2011) 3.59
Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res (2008) 3.47
Inflammation and insulin resistance. FEBS Lett (2007) 3.34
Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes (2009) 3.27
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med (2013) 3.15
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol (2014) 3.12
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12
Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab (2008) 3.11
Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol (2009) 3.09
Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab (2013) 3.00
Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab (2012) 2.96
Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol (2011) 2.92
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science (2013) 2.85
Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity (2012) 2.80
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J Clin Invest (2008) 2.78
The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol (2011) 2.77
Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet--induced obesity in mice. Diabetes (2010) 2.76
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature (2013) 2.74
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest (2007) 2.73
Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab (2011) 2.73
Inflammatory mechanisms in the regulation of insulin resistance. Mol Med (2008) 2.71
Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem (2009) 2.69
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet (2013) 2.66
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J Immunol (2010) 2.66
High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One (2010) 2.60
Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation (2011) 2.52
Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol (2013) 2.47
Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages. Mol Cell Biol (2010) 2.47
Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest (2009) 2.39
TNF-alpha and adipocyte biology. FEBS Lett (2007) 2.37
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes (2010) 2.35
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest (2011) 2.34
Control of macrophage activation and function by PPARs. Circ Res (2010) 2.34
Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol (2010) 2.32
Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes (2011) 2.28
Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity. Cell (2011) 2.26
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 2.25
Mechanisms of macrophage activation in obesity-induced insulin resistance. Nat Clin Pract Endocrinol Metab (2008) 2.24
Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab (2013) 2.23
Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol (2008) 2.22
The adipocyte as an endocrine cell. Endocrinol Metab Clin North Am (2008) 2.20
Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann N Y Acad Sci (2010) 2.16
A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Cardiovasc Res (2010) 2.16
Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol (2012) 2.16
Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP. Blood (2008) 2.16
HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells. Proc Natl Acad Sci U S A (2011) 2.16
Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem (2010) 2.14
The pathophysiology of hypertension in patients with obesity. Nat Rev Endocrinol (2014) 2.13
Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. J Biol Chem (2009) 2.11
Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Diabetes (2009) 2.11
Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity. Endocrinology (2009) 2.10
Immunological complications of obesity. Nat Immunol (2012) 2.09
T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice. Obesity (Silver Spring) (2010) 2.09
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nat Immunol (2017) 2.05
Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci (2014) 2.03
The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev (2012) 2.01
Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes (2009) 2.00
Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab (2009) 2.00
The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol (2008) 2.00
Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice. Gut (2012) 1.99
Increased macrophage migration into adipose tissue in obese mice. Diabetes (2011) 1.98
Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab (2014) 1.96
Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes (2012) 1.95
Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation. Am J Physiol Endocrinol Metab (2010) 1.94
Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity. PLoS Med (2008) 1.94
Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages. Endocrinology (2011) 1.94
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Alternative activation of macrophages. Nat Rev Immunol (2003) 27.53
Monocyte and macrophage heterogeneity. Nat Rev Immunol (2005) 24.36
Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56
The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol (2004) 19.38
Inflammation and insulin resistance. J Clin Invest (2006) 18.76
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol (2002) 17.85
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest (2006) 12.32
IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med (2005) 12.07
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol (2005) 9.27
Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol (2004) 8.65
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab (2006) 6.44
Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes (2007) 6.08
Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes (2005) 5.68
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem (2001) 5.61
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem (2006) 5.57
Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J Immunol (2005) 5.20
Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr (2006) 4.72
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes (2004) 4.37
Migratory fate and differentiation of blood monocyte subsets. Immunobiology (2006) 4.30
CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature (2000) 4.10
Functional plasticity of macrophages: reversible adaptation to changing microenvironments. J Leukoc Biol (2004) 4.05
Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J Immunol (1999) 3.68
CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int (2006) 3.53
Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem Biophys Res Commun (2004) 3.21
Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation (2004) 3.17
Inflamed fat: what starts the fire? J Clin Invest (2006) 3.11
Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes (2006) 3.06
Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab (2006) 3.04
Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding. J Biol Chem (1999) 2.79
Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab (2005) 2.77
The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proc Natl Acad Sci U S A (2005) 2.74
Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J Immunol (2004) 2.58
Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation. J Leukoc Biol (2004) 2.30
CCL17 and IL-10 as effectors that enable alternatively activated macrophages to inhibit the generation of classically activated macrophages. J Immunol (2004) 2.25
Interleukin-10 suppression of myeloid cell activation--a continuing puzzle. Immunology (2004) 1.95
A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects. J Clin Endocrinol Metab (2005) 1.87
Association of interleukin-6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity, insulin sensitivity and glucose metabolism. Exp Clin Endocrinol Diabetes (2005) 1.76
Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol (2006) 1.76
Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering. Mol Biol Cell (2006) 1.75
Expression of interleukin-6 is greater in preadipocytes than in adipocytes of 3T3-L1 cells and C57BL/6J and ob/ob mice. J Nutr (2004) 1.68
Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer. Blood (2006) 1.65
The dermal microenvironment induces the expression of the alternative activation marker CD301/mMGL in mononuclear phagocytes, independent of IL-4/IL-13 signaling. J Leukoc Biol (2006) 1.59
Adipose tissue is a regulated source of interleukin-10. Cytokine (2005) 1.52
Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects. Diabetes (2006) 1.49
IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase. J Immunol (2001) 1.33
Regulation of macrophage phenotype by long-term exposure to IL-10. Immunobiology (2005) 1.27
Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action. Am J Physiol (1999) 1.25
Adipose tissue metabolism and CD11b expression on monocytes in obese hypertensives. Hypertension (2005) 1.19
Inflammatory links between obesity and metabolic disease. J Clin Invest (2011) 6.73
Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes (2007) 6.08
Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes (2008) 4.56
The protein kinase IKKepsilon regulates energy balance in obese mice. Cell (2009) 3.93
A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell (2006) 3.90
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med (2013) 3.15
Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab (2006) 3.04
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. Nature (2003) 2.89
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett (2008) 2.28
Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol (2012) 2.18
Insulin signaling and the regulation of glucose transport. Mol Med (2006) 1.99
Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med (2007) 1.91
Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev Cell (2007) 1.88
Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering. Mol Biol Cell (2006) 1.75
T-ing up inflammation in fat. Nat Med (2009) 1.66
APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Mol Cell Biol (2002) 1.52
Changes in integrin expression during adipocyte differentiation. Cell Metab (2005) 1.51
MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med (2009) 1.46
RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis. J Biol Chem (2006) 1.45
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A (2012) 1.39
Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell (2003) 1.38
Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metab (2007) 1.35
A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev (2007) 1.32
PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance. J Clin Invest (2003) 1.27
Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis. Mol Biol Cell (2009) 1.27
Lipid phosphatases as drug discovery targets for type 2 diabetes. Nat Rev Drug Discov (2006) 1.26
Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes. Mol Biol Cell (2002) 1.19
The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes. J Biol Chem (2005) 1.18
Inhibition of AMPK catabolic action by GSK3. Mol Cell (2013) 1.18
Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. Mol Biol Cell (2012) 1.17
CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility. EMBO J (2006) 1.14
Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest. Circulation (2004) 1.13
A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol Biol Cell (2010) 1.13
The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes. Proc Natl Acad Sci U S A (2002) 1.12
The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1. J Biol Chem (2002) 1.11
Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. J Cell Biol (2004) 1.10
The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. J Biol Chem (2003) 1.08
Exocyst function is regulated by effector phosphorylation. Nat Cell Biol (2011) 1.08
TC10alpha is required for insulin-stimulated glucose uptake in adipocytes. Endocrinology (2006) 1.06
Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport. J Biol Chem (2002) 1.03
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Mol Biol Cell (2008) 1.03
Rab5 proteins regulate activation and localization of target of rapamycin complex 1. J Biol Chem (2012) 1.02
GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. Dev Cell (2006) 1.00
Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5. J Biol Chem (2006) 0.98
p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A (2012) 0.96
TC10 and insulin-stimulated glucose transport. Methods Enzymol (2006) 0.95
Distinct mutations in the glycogen debranching enzyme found in glycogen storage disease type III lead to impairment in diverse cellular functions. Hum Mol Genet (2009) 0.94
Roles for PI(3,5)P2 in nutrient sensing through TORC1. Mol Biol Cell (2014) 0.93
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1. Elife (2013) 0.93
TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J (2003) 0.93
The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes. Mol Cell Biol (2003) 0.91
Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells. Endocrinology (2006) 0.87
Identification of CAP as a costameric protein that interacts with filamin C. Mol Biol Cell (2007) 0.86
Cloning and characterization of Cbl-associated protein splicing isoforms. Mol Med (2003) 0.86
Circadian metabolic regulation through crosstalk between casein kinase 1δ and transcriptional coactivator PGC-1α. Mol Endocrinol (2011) 0.84
More TORC for the gluconeogenic engine. Bioessays (2006) 0.83
Staying in SHIP shape. Nat Med (2005) 0.81
Ral's engagement with the exocyst: breaking up is hard to do. Cell Cycle (2011) 0.81
Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation. Diabetes (2013) 0.81
TIRFing out studies on Glut4 trafficking. Dev Cell (2007) 0.81
Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest (2017) 0.79
TC10 is regulated by caveolin in 3T3-L1 adipocytes. PLoS One (2012) 0.79
Phosphoinositides in insulin action and diabetes. Curr Top Microbiol Immunol (2012) 0.78
Holding the line on hepatic fat. Cell Metab (2005) 0.78
Autophagy works out. Cell Metab (2012) 0.77
Negative regulation of the RalGAP complex by 14-3-3. J Biol Chem (2013) 0.77
Insulin htts on autophagy. Autophagy (2006) 0.76
Von Gierke's disease adopts an orphan (and its partner). Sci Signal (2009) 0.75
A TUG on glucose transport. Nat Med (2003) 0.75