Published in Biochemistry on September 07, 2004
Single-molecule analysis of dynein processivity and stepping behavior. Cell (2006) 5.63
Regulators of the cytoplasmic dynein motor. Nat Rev Mol Cell Biol (2009) 4.05
Force-induced bidirectional stepping of cytoplasmic dynein. Cell (2007) 3.31
LIS1 and NudE induce a persistent dynein force-producing state. Cell (2010) 2.88
Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein. Proc Natl Acad Sci U S A (2006) 2.87
Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold. Science (2012) 2.78
AAA+ Ring and linker swing mechanism in the dynein motor. Cell (2009) 2.63
Crystal structure of the dynein motor domain. Science (2011) 2.57
Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell (2012) 2.48
Cargo transport: molecular motors navigate a complex cytoskeleton. Curr Opin Cell Biol (2008) 2.39
Genetic analysis of the cytoplasmic dynein subunit families. PLoS Genet (2006) 2.35
Dynein achieves processive motion using both stochastic and coordinated stepping. Nat Struct Mol Biol (2012) 1.98
Walking the walk: how kinesin and dynein coordinate their steps. Curr Opin Cell Biol (2009) 1.94
Dyneins across eukaryotes: a comparative genomic analysis. Traffic (2007) 1.81
The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk. J Biol Chem (2005) 1.79
ATP-driven remodeling of the linker domain in the dynein motor. Structure (2012) 1.74
Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. Proc Natl Acad Sci U S A (2007) 1.71
Kinesin and dynein-dynactin at intersecting microtubules: motor density affects dynein function. Biophys J (2008) 1.70
The 2.8 Å crystal structure of the dynein motor domain. Nature (2012) 1.65
Cytoplasmic dynein moves through uncoordinated stepping of the AAA+ ring domains. Science (2011) 1.63
Helix sliding in the stalk coiled coil of dynein couples ATPase and microtubule binding. Nat Struct Mol Biol (2009) 1.61
Multiple modes of cytoplasmic dynein regulation. Nat Cell Biol (2012) 1.59
Functions and mechanics of dynein motor proteins. Nat Rev Mol Cell Biol (2013) 1.56
Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation. J Biol Chem (2008) 1.55
Insights into dynein motor domain function from a 3.3-Å crystal structure. Nat Struct Mol Biol (2012) 1.51
The coordination of cyclic microtubule association/dissociation and tail swing of cytoplasmic dynein. Proc Natl Acad Sci U S A (2007) 1.46
Structural basis for microtubule binding and release by dynein. Science (2012) 1.45
Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell (2016) 1.41
Direct role of dynein motor in stable kinetochore-microtubule attachment, orientation, and alignment. J Cell Biol (2008) 1.41
Exome sequencing identifies DYNC2H1 mutations as a common cause of asphyxiating thoracic dystrophy (Jeune syndrome) without major polydactyly, renal or retinal involvement. J Med Genet (2013) 1.39
Three-dimensional structure of cytoplasmic dynein bound to microtubules. Proc Natl Acad Sci U S A (2007) 1.23
Dynamic allostery of protein alpha helical coiled-coils. J R Soc Interface (2006) 1.17
The microtubule plus-end localization of Aspergillus dynein is important for dynein-early-endosome interaction but not for dynein ATPase activation. J Cell Sci (2010) 1.17
Reconstitution of the human cytoplasmic dynein complex. Proc Natl Acad Sci U S A (2012) 1.13
Two modes of microtubule sliding driven by cytoplasmic dynein. Proc Natl Acad Sci U S A (2006) 1.13
Monte Carlo modeling of single-molecule cytoplasmic dynein. Proc Natl Acad Sci U S A (2005) 1.05
Two independent switches regulate cytoplasmic dynein's processivity and directionality. Proc Natl Acad Sci U S A (2012) 1.02
Mechanism and Regulation of Cytoplasmic Dynein. Annu Rev Cell Dev Biol (2015) 1.00
A structural model reveals energy transduction in dynein. Proc Natl Acad Sci U S A (2006) 0.98
Control of cytoplasmic dynein force production and processivity by its C-terminal domain. Nat Commun (2015) 0.98
Structure of human cytoplasmic dynein-2 primed for its power stroke. Nature (2014) 0.97
Lis1 regulates dynein by sterically blocking its mechanochemical cycle. Elife (2014) 0.96
Point mutations in the stem region and the fourth AAA domain of cytoplasmic dynein heavy chain partially suppress the phenotype of NUDF/LIS1 loss in Aspergillus nidulans. Genetics (2007) 0.95
Kinetic models for the coordinated stepping of cytoplasmic dynein. J Chem Phys (2009) 0.94
The mechanism of dynein motility: insight from crystal structures of the motor domain. Biochim Biophys Acta (2011) 0.93
Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains. Proc Natl Acad Sci U S A (2015) 0.93
A simple theoretical model explains dynein's response to load. Biophys J (2005) 0.93
Molecular motors: not quite like clockwork. Cell Mol Life Sci (2008) 0.90
Tension on the linker gates the ATP-dependent release of dynein from microtubules. Nat Commun (2014) 0.90
Allosteric communication in the dynein motor domain. Cell (2014) 0.88
The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization. Mol Biol Cell (2013) 0.88
Communication between the AAA+ ring and microtubule-binding domain of dynein. Biochem Cell Biol (2010) 0.87
The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release. Nat Struct Mol Biol (2014) 0.87
Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules. Nat Commun (2015) 0.86
Function and regulation of dynein in mitotic chromosome segregation. Chromosoma (2014) 0.84
Cytoplasmic dynein and early endosome transport. Cell Mol Life Sci (2015) 0.83
Analyses of dynein heavy chain mutations reveal complex interactions between dynein motor domains and cellular dynein functions. Genetics (2012) 0.82
Review: Structure and mechanism of the dynein motor ATPase. Biopolymers (2016) 0.82
A microscopy-based screen employing multiplex genome sequencing identifies cargo-specific requirements for dynein velocity. Mol Biol Cell (2014) 0.81
Insights into the mechanism of ADP action on flagellar motility derived from studies on bull sperm. Biophys J (2008) 0.80
The dynein stalk head, the microtubule binding-domain of dynein: NMR assignment and ligand binding. J Biomol NMR (2008) 0.80
Cytoplasmic dynein transports cargos via load-sharing between the heads. Nat Commun (2014) 0.80
Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements. Nat Struct Mol Biol (2017) 0.79
Microtubule- and dynein-dependent nuclear trafficking of rhesus rhadinovirus in rhesus fibroblasts. J Virol (2011) 0.79
A structural analysis of the AAA+ domains in Saccharomyces cerevisiae cytoplasmic dynein. J Struct Biol (2014) 0.79
Tug-of-war of microtubule filaments at the boundary of a kinesin- and dynein-patterned surface. Sci Rep (2014) 0.78
Cytoplasmic dynein: tension generation on microtubules and the nucleus. Cell Mol Bioeng (2013) 0.78
Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi's Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus. Pathogens (2012) 0.78
Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity. ACS Chem Biol (2015) 0.77
Microtubule Motors Drive Hedgehog Signaling in Primary Cilia. Trends Cell Biol (2016) 0.76
Elastic properties of dynein motor domain obtained from all-atom molecular dynamics simulations. Protein Eng Des Sel (2016) 0.75
Chemical structure-guided design of dynapyrazoles, potent cell-permeable dynein inhibitors with a unique mode of action. Elife (2017) 0.75
The winch model can explain both coordinated and uncoordinated stepping of cytoplasmic dynein. Biophys J (2014) 0.75
Combining Structure-Function and Single-Molecule Studies on Cytoplasmic Dynein. Methods Mol Biol (2018) 0.75
Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell (2017) 0.75
Allosteric conformational change cascade in cytoplasmic dynein revealed by structure-based molecular simulations. PLoS Comput Biol (2017) 0.75
Peptides mediating DNA Transport on microtubules and their impact on non-viral gene transfer efficiency. Biosci Rep (2017) 0.75
AAA+ Ring and linker swing mechanism in the dynein motor. Cell (2009) 2.63
ATP hydrolysis cycle-dependent tail motions in cytoplasmic dynein. Nat Struct Mol Biol (2005) 2.15
ATP-driven remodeling of the linker domain in the dynein motor. Structure (2012) 1.74
LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein. EMBO J (2008) 1.72
NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol (2006) 1.69
The 2.8 Å crystal structure of the dynein motor domain. Nature (2012) 1.65
Helix sliding in the stalk coiled coil of dynein couples ATPase and microtubule binding. Nat Struct Mol Biol (2009) 1.61
Dynein and kinesin share an overlapping microtubule-binding site. EMBO J (2004) 1.57
Functions and mechanics of dynein motor proteins. Nat Rev Mol Cell Biol (2013) 1.56
The coordination of cyclic microtubule association/dissociation and tail swing of cytoplasmic dynein. Proc Natl Acad Sci U S A (2007) 1.46
Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. Hum Mol Genet (2005) 1.45
A single-headed recombinant fragment of Dictyostelium cytoplasmic dynein can drive the robust sliding of microtubules. J Biol Chem (2004) 1.41
X-ray structure of a functional full-length dynein motor domain. Nat Struct Mol Biol (2011) 1.37
Multiple ATP-hydrolyzing sites that potentially function in cytoplasmic dynein. Proc Natl Acad Sci U S A (2004) 1.32
Head-head coordination is required for the processive motion of cytoplasmic dynein, an AAA+ molecular motor. J Struct Biol (2006) 1.24
Three-dimensional structure of cytoplasmic dynein bound to microtubules. Proc Natl Acad Sci U S A (2007) 1.23
Direct long-term observation of kinesin processivity at low load. Curr Biol (2002) 1.22
Measuring collective transport by defined numbers of processive and nonprocessive kinesin motors. Proc Natl Acad Sci U S A (2012) 1.18
The human chromokinesin Kid is a plus end-directed microtubule-based motor. EMBO J (2003) 1.17
Two modes of microtubule sliding driven by cytoplasmic dynein. Proc Natl Acad Sci U S A (2006) 1.13
Dictyostelium myosin II mutations that uncouple the converter swing and ATP hydrolysis cycle. Biochemistry (2003) 1.09
Diffusion and directed movement: in vitro motile properties of fission yeast kinesin-14 Pkl1. J Biol Chem (2008) 1.04
Fission yeast synaptobrevin is involved in cytokinesis and cell elongation. Biochem Biophys Res Commun (2003) 1.04
Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes. EMBO J (2003) 1.03
A high-speed atomic force microscope for studying biological macromolecules in action. Chemphyschem (2003) 1.03
Kinetic characterization of tail swing steps in the ATPase cycle of Dictyostelium cytoplasmic dynein. J Biol Chem (2007) 1.03
C-sequence of the Dictyostelium cytoplasmic dynein participates in processivity modulation. FEBS Lett (2011) 1.02
The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site. Biochemistry (2005) 1.01
CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity. J Neurochem (2009) 1.00
Molecular mechanism of force generation by dynein, a molecular motor belonging to the AAA+ family. Biochem Soc Trans (2008) 0.99
BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking. Genes Cells (2008) 0.99
Requirement of domain-domain interaction for conformational change and functional ATP hydrolysis in myosin. J Biol Chem (2003) 0.98
Nucleotide-dependent behavior of single molecules of cytoplasmic dynein on microtubules in vitro. FEBS Lett (2010) 0.97
Microtubule-binding properties of dynactin p150 expedient for dynein motility. Biochem Biophys Res Commun (2005) 0.96
A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5. Chem Biol (2003) 0.96
The second microtubule-binding site of monomeric kid enhances the microtubule affinity. J Biol Chem (2003) 0.96
Keratocyte-like locomotion in amiB-null Dictyostelium cells. Cell Motil Cytoskeleton (2004) 0.95
Functional dissection of LIS1 and NDEL1 towards understanding the molecular mechanisms of cytoplasmic dynein regulation. J Biol Chem (2010) 0.94
A novel actin-bundling kinesin-related protein from Dictyostelium discoideum. J Biol Chem (2003) 0.94
Functional characterization of the N-terminal region of myosin-2. J Biol Chem (2006) 0.88
HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth. Biochem Biophys Res Commun (2007) 0.87
Dictyostelium myosin II as a model to study the actin-myosin interactions during force generation. J Muscle Res Cell Motil (2002) 0.83
A Rho GDP-dissociation inhibitor is involved in cytokinesis of Dictyostelium. Biochem Biophys Res Commun (2002) 0.83
Protein engineering approaches to study the dynein mechanism using a Dictyostelium expression system. Methods Cell Biol (2009) 0.81
Properties of the full-length heavy chains of Tetrahymena ciliary outer arm dynein separated by urea treatment. Cell Motil Cytoskeleton (2004) 0.81
Imaging of the fluorescence spectrum of a single fluorescent molecule by prism-based spectroscopy. FEBS Lett (2002) 0.81
Biomolecular-motor-based nano- or microscale particle translocations on DNA microarrays. Nano Lett (2009) 0.80
MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway. Biochem Biophys Res Commun (2006) 0.79
A single protofilament is sufficient to support unidirectional walking of dynein and kinesin. PLoS One (2012) 0.78
Removal of tightly bound ADP induces distinct structural changes of the two tryptophan-containing regions of the ncd motor domain. J Biochem (2005) 0.78
Biomolecular-motor-based autonomous delivery of lipid vesicles as nano- or microscale reactors on a chip. Lab Chip (2010) 0.78
Sea lily muscle lacks a troponin-regulatory system, while it contains paramyosin. Zoolog Sci (2014) 0.77
Autonomous loading, transport, and unloading of specified cargoes by using DNA hybridization and biological motor-based motility. Small (2008) 0.76
The alanine-scanning mutagenesis of Dictyostelium myosin II at the ionic interface with actin. Results Probl Cell Differ (2002) 0.75
[Evolution and mechanical models of the myosin superfamily]. Tanpakushitsu Kakusan Koso (2006) 0.75
[Cooperative activation of motor proteins revealed by bioimaging and a high-speed optical tweezer]. Seikagaku (2014) 0.75