Published in Blood on September 14, 2004
Microenvironmental regulation of tumor progression and metastasis. Nat Med (2013) 8.37
Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell (2011) 6.21
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics. Cancer Cell (2015) 4.30
Contribution of platelets to tumour metastasis. Nat Rev Cancer (2011) 4.16
The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat Rev Cancer (2011) 3.42
Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater (2012) 2.15
Immune cell promotion of metastasis. Nat Rev Immunol (2015) 2.15
Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol (2011) 2.14
Role of tissue factor in cancer. J Clin Oncol (2009) 1.91
Platelet glycoprotein Ib alpha supports experimental lung metastasis. Proc Natl Acad Sci U S A (2007) 1.68
Deadly allies: the fatal interplay between platelets and metastasizing cancer cells. Blood (2010) 1.67
High D-dimer levels are associated with poor prognosis in cancer patients. Haematologica (2012) 1.62
Tissue factor expressed by circulating cancer cell-derived microparticles drastically increases the incidence of deep vein thrombosis in mice. J Thromb Haemost (2015) 1.46
Impact of venous thromboembolism and anticoagulation on cancer and cancer survival. J Clin Oncol (2009) 1.45
The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov (2012) 1.40
Platelets: linking hemostasis and cancer. Arterioscler Thromb Vasc Biol (2010) 1.29
Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion. Cancer Res (2010) 1.23
Venous thromboembolism prophylaxis and treatment in cancer: a consensus statement of major guidelines panels and call to action. J Clin Oncol (2009) 1.21
Tissue factor and cell signalling in cancer progression and thrombosis. J Thromb Haemost (2011) 1.20
Hyperfibrinogenemia is associated with lymphatic as well as hematogenous metastasis and worse clinical outcome in T2 gastric cancer. BMC Cancer (2006) 1.18
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice. J Cell Biochem (2008) 1.18
Chemical Tumor Biology of Heparan Sulfate Proteoglycans. Curr Chem Biol (2010) 1.17
The prognostic value of plasma fibrinogen levels in patients with endometrial cancer: a multi-centre trial. Br J Cancer (2010) 1.14
Targeting tumor-stromal interactions in bone metastasis. Pharmacol Ther (2013) 1.12
New insights into cancer-associated thrombosis. Arterioscler Thromb Vasc Biol (2009) 1.11
Platelets at the interface of thrombosis, inflammation, and cancer. Blood (2015) 1.11
Integrin αvβ3 and fibronectin upregulate Slug in cancer cells to promote clot invasion and metastasis. Cancer Res (2013) 1.10
Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success. Cancer Cell (2012) 1.10
PAR-1 contributes to the innate immune response during viral infection. J Clin Invest (2013) 1.09
Integrins and bone metastasis: integrating tumor cell and stromal cell interactions. Bone (2010) 1.09
The tumor cell-host organ interface in the early onset of metastatic organ colonisation. Clin Exp Metastasis (2007) 1.04
Preoperative platelet count associates with survival and distant metastasis in surgically resected colorectal cancer patients. J Gastrointest Cancer (2013) 1.03
Paraneoplastic thrombocytosis: the secrets of tumor self-promotion. Blood (2014) 1.02
Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood (2011) 1.00
High preoperative plasma fibrinogen is an independent predictor of distant metastasis and poor prognosis in renal cell carcinoma. Int J Clin Oncol (2012) 0.98
Biomolecular characterization of CD44-fibrin(ogen) binding: distinct molecular requirements mediate binding of standard and variant isoforms of CD44 to immobilized fibrin(ogen). J Biol Chem (2008) 0.98
Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer. J Cell Sci (2011) 0.96
Differential changes in platelet VEGF, Tsp, CXCL12, and CXCL4 in patients with metastatic cancer. Clin Exp Metastasis (2010) 0.95
The roles of platelet GPIIb/IIIa and alphavbeta3 integrins during HeLa cells adhesion, migration, and invasion to monolayer endothelium under static and dynamic shear flow. J Biomed Biotechnol (2009) 0.95
Tissue factor and cancer. Thromb Res (2012) 0.95
Emerging Biological Principles of Metastasis. Cell (2017) 0.94
Important molecular genetic markers of colorectal cancer. Oncotarget (2016) 0.94
Activated platelets enhance ovarian cancer cell invasion in a cellular model of metastasis. Clin Exp Metastasis (2009) 0.94
Activation of blood coagulation in cancer: implications for tumour progression. Biosci Rep (2013) 0.94
Thrombocytosis is a significant indictor of hypercoagulability, prognosis and recurrence in gastric cancer. Exp Ther Med (2014) 0.94
Prognostic significance of preoperative fibrinogen in patients with colon cancer. World J Gastroenterol (2014) 0.92
Elucidation of flow-mediated tumour cell-induced platelet aggregation using an ultrasound standing wave trap. Br J Pharmacol (2011) 0.92
Colorectal cancer and hypercoagulability. Surg Today (2013) 0.92
Do circulating tumor cells play a role in coagulation and thrombosis? Front Oncol (2012) 0.92
Are Platelets Cells? And if Yes, are They Immune Cells? Front Immunol (2015) 0.92
In vivo migration of labeled autologous natural killer cells to liver metastases in patients with colon carcinoma. J Transl Med (2006) 0.91
Coagulation, protease-activated receptors, and viral myocarditis. J Cardiovasc Transl Res (2013) 0.91
Circulating and disseminated tumour cells - mechanisms of immune surveillance and escape. Nat Rev Clin Oncol (2016) 0.91
Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth. PLoS One (2012) 0.90
Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond. J Mol Med (Berl) (2013) 0.90
Effect of preoperative hyperfibrinogenemia on recurrence of colorectal cancer without a systemic inflammatory response. World J Surg (2009) 0.90
The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer. Int J Colorectal Dis (2015) 0.90
Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-κB/tissue factor/Factor Xa pathway in melanoma B16F10 cells. PLoS One (2013) 0.89
Lung cancer with gastrointestinal metastasis - review of theories of metastasis with three rare case descriptions. Cancer Microenviron (2013) 0.89
The prothrombotic activity of cancer cells in the circulation. Blood Rev (2015) 0.88
Deformability of Tumor Cells versus Blood Cells. Sci Rep (2015) 0.88
Selectins as mediators of lung metastasis. Cancer Microenviron (2010) 0.88
Molecular imaging of fibrin in a breast cancer xenograft mouse model. Invest Radiol (2012) 0.88
Preoperative high level of D-dimers predicts unresectability of pancreatic head cancer. World J Gastroenterol (2014) 0.87
Glucocorticoid-induced TNFR-related (GITR) protein and its ligand in antitumor immunity: functional role and therapeutic modulation. Clin Dev Immunol (2010) 0.87
Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation. Cancer Lett (2011) 0.87
Revisiting perioperative chemotherapy: the critical importance of targeting residual cancer prior to wound healing. BMC Cancer (2009) 0.86
Smoking, fibrinogen and cancer mortality. J Natl Med Assoc (2007) 0.86
Effect of anti-fibrinolytic therapy on experimental melanoma metastasis. Clin Exp Metastasis (2008) 0.85
Negative impact of preoperative platelet-lymphocyte ratio on outcome after hepatic resection for intrahepatic cholangiocarcinoma. Medicine (Baltimore) (2015) 0.84
Thrombin-inhibiting nanoparticles rapidly constitute versatile and detectable anticlotting surfaces. Nanotechnology (2014) 0.84
Thrombin drives tumorigenesis in colitis-associated colon cancer. Cancer Res (2014) 0.84
Living in shear: platelets protect cancer cells from shear induced damage. Clin Exp Metastasis (2014) 0.82
Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen. Cancer Res (2015) 0.82
Perspective: Flicking with flow: Can microfluidics revolutionize the cancer research? Biomicrofluidics (2013) 0.81
Aspirin as a neoadjuvant agent during preoperative chemoradiation for rectal cancer. Br J Cancer (2015) 0.81
Involvement of platelet-tumor cell interaction in immune evasion. Potential role of podocalyxin-like protein 1. Front Oncol (2014) 0.81
NF-E2 p45 is important for establishing normal function of platelets. Mol Cell Biol (2013) 0.81
Platelet activation by Streptococcus pyogenes leads to entrapment in platelet aggregates, from which bacteria subsequently escape. Infect Immun (2014) 0.81
P-selectin-mediated platelet adhesion promotes tumor growth. Oncotarget (2015) 0.81
Platelet adhesion and fusion to endothelial cell facilitate the metastasis of tumor cell in hypoxia-reoxygenation condition. Clin Exp Metastasis (2011) 0.80
Clinical and Prognostic Significance of Preoperative Plasma Fibrinogen Levels in Patients with Operable Breast Cancer. PLoS One (2016) 0.80
Plasma Fibronectin Promotes Tumor Cell Survival and Invasion through Regulation of Tie2. J Cancer (2013) 0.79
Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditions. Am J Physiol Cell Physiol (2012) 0.79
A platelet-mimetic paradigm for metastasis-targeted nanomedicine platforms. Biomacromolecules (2013) 0.79
Relocation of CLIC1 promotes tumor cell invasion and colonization of fibrin. Mol Cancer Res (2014) 0.79
Elevated pretreatment plasma D-dimer levels and platelet counts predict poor prognosis in pancreatic adenocarcinoma. Onco Targets Ther (2015) 0.79
Venous thromboembolism in cancer patients: an underestimated major health problem. World J Surg Oncol (2015) 0.79
Bone specific immunity and its impact on metastasis. Bonekey Rep (2015) 0.78
1-methylnicotinamide and its structural analog 1,4-dimethylpyridine for the prevention of cancer metastasis. J Exp Clin Cancer Res (2016) 0.78
Malignant melanoma as a target malignancy for the study of the anti-metastatic properties of the heparins. Cancer Metastasis Rev (2010) 0.78
D-dimer: not just an indicator of venous thrombosis but a predictor of asymptomatic hematogenous metastasis in gastric cancer patients. PLoS One (2014) 0.78
Thrombocytes Correlate with Lymphangiogenesis in Human Esophageal Cancer and Mediate Growth of Lymphatic Endothelial Cells In Vitro. PLoS One (2013) 0.78
Platelets and tumor cells: a new form of border control. Cancer Cell (2013) 0.78
Role of coagulation in the recruitment of colon adenocarcinoma cells to thrombus under shear. Am J Physiol Cell Physiol (2013) 0.78
Immunological Consequences of Epithelial-Mesenchymal Transition in Tumor Progression. J Immunol (2016) 0.78
Retracted Platelets and their role in cancer evolution and immune system. Transl Lung Cancer Res (2015) 0.78
A universal tumor cell isolation method enabled by fibrin-coated microchannels. Analyst (2016) 0.77
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18
Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo. J Clin Invest (2004) 2.57
The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med (2007) 2.16
The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med (2003) 1.98
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun (2012) 1.82
Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci (2010) 1.82
Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression. Blood (2009) 1.79
IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells. J Immunol (2009) 1.77
Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway. Genes Dev (2008) 1.73
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood (2011) 1.71
Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis. Kidney Int (2011) 1.70
Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice. Cancer Res (2002) 1.64
Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif. J Clin Invest (2007) 1.52
Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals. J Am Soc Nephrol (2007) 1.25
Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen. Cancer Res (2010) 1.21
Fibrin(ogen)-alpha M beta 2 interactions regulate leukocyte function and innate immunity in vivo. Exp Biol Med (Maywood) (2004) 1.20
Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload. Blood (2011) 1.20
Factor XIII activity mediates red blood cell retention in venous thrombi. J Clin Invest (2014) 1.18
Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets. Blood (2003) 1.18
Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood (2010) 1.12
Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Blood (2008) 1.11
Reduced thrombin generation increases host susceptibility to group A streptococcal infection. Blood (2008) 1.10
Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia. Blood (2013) 1.03
Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia. Am J Pathol (2008) 1.01
Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood (2011) 1.00
Binding of Efb from Staphylococcus aureus to fibrinogen blocks neutrophil adherence. J Biol Chem (2011) 0.99
Plasminogen supports tumor growth through a fibrinogen-dependent mechanism linked to vascular patency. Blood (2003) 0.97
Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain. Blood (2003) 0.97
Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32). BMC Biochem (2011) 0.95
Fibrin but not adsorbed fibrinogen supports fibronectin assembly by spread platelets. Effects of the interaction of alphaIIb beta3 with the C terminus of the fibrinogen gamma-chain. J Biol Chem (2005) 0.93
Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor. BMC Gastroenterol (2006) 0.91
Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification. J Clin Invest (2015) 0.91
Plasminogen directs the pleiotropic effects of uPA in liver injury and repair. Am J Physiol Gastrointest Liver Physiol (2002) 0.90
Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice. Int J Hematol (2007) 0.90
Psoriasis patients exhibit impairment of the high potency CCR5(+) T regulatory cell subset. Clin Immunol (2013) 0.89
Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury. Am J Pathol (2012) 0.89
Mechanisms coupling the hemostatic system to colitis-associated cancer. Thromb Res (2010) 0.89
Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor. Hum Mol Genet (2012) 0.89
Mechanisms linking tumor cell-associated procoagulant function to tumor metastasis. Thromb Res (2007) 0.89
Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice. Neurosci Lett (2004) 0.88
Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair. J Biol Chem (2009) 0.88
Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy. Blood (2003) 0.87
Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol (2014) 0.87
Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice. Proc Natl Acad Sci U S A (2005) 0.85
Saposin C coupled lipid nanovesicles specifically target arthritic mouse joints for optical imaging of disease severity. PLoS One (2012) 0.83
Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII. Thromb Haemost (2008) 0.82
Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice. Arthritis Rheumatol (2014) 0.82
Targeting the coagulation factor fibrinogen for arthritis therapy. Curr Pharm Biotechnol (2011) 0.81
Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice. Arthritis Rheumatol (2014) 0.81
Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression. J Biol Chem (2002) 0.79
Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice. Am J Hematol (2007) 0.79
Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification. J Clin Invest (2015) 0.76