Published in Nat Rev Genet on September 01, 2004
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
Molecular targeted therapies in hepatocellular carcinoma. Hepatology (2008) 6.16
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell (2008) 5.93
Regulation of bone mass by Wnt signaling. J Clin Invest (2006) 5.59
The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96
Wnt/beta-catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol (2008) 3.87
The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev (2006) 3.85
New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol (2009) 3.83
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell (2009) 3.76
FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell (2011) 3.58
Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol (2009) 3.42
WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest (2009) 3.33
CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature (2014) 3.28
Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circ Res (2009) 3.25
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A (2007) 3.24
Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. Cold Spring Harb Perspect Biol (2010) 3.02
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS One (2008) 2.94
A Wnt survival guide: from flies to human disease. J Invest Dermatol (2009) 2.91
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell (2009) 2.74
Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity (2007) 2.71
Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A (2010) 2.66
Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11. Proc Natl Acad Sci U S A (2009) 2.56
The tuberous sclerosis complex. Ann N Y Acad Sci (2010) 2.51
EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell (2009) 2.50
Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci U S A (2009) 2.41
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol (2010) 2.37
R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell (2008) 2.37
Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. Gastroenterology (2011) 2.33
Blockade of Wnt/β-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol (2010) 2.21
Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol (2008) 2.21
Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A (2011) 2.12
Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway. Mol Cell Biol (2009) 2.06
GSK-3: Functional Insights from Cell Biology and Animal Models. Front Mol Neurosci (2011) 1.99
Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol (2006) 1.96
Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. J Mol Cell Cardiol (2011) 1.93
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A (2011) 1.92
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes (2009) 1.90
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell (2012) 1.89
β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin. Am J Respir Crit Care Med (2013) 1.89
Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Nature (2014) 1.86
Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet (2006) 1.86
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A (2007) 1.84
Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem (2008) 1.83
Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell (2009) 1.83
Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities. Nat Rev Rheumatol (2011) 1.82
Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science (2008) 1.81
A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling. EMBO J (2012) 1.81
Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease. J Neurosci (2009) 1.72
Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response. Dev Biol (2010) 1.68
Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Hum Mol Genet (2008) 1.62
Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci (2007) 1.61
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A (2007) 1.58
The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry (2009) 1.58
Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. Cancer Res (2011) 1.58
Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress. J Biol Chem (2011) 1.58
A deep investigation into the adipogenesis mechanism: profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/beta-catenin signaling pathway. BMC Genomics (2010) 1.56
Wnt signalling in lung development and diseases. Respir Res (2006) 1.55
Crystal structure of a full-length beta-catenin. Structure (2008) 1.55
Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation. Dev Biol (2006) 1.54
Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem Biol (2011) 1.52
A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers. Curr Oncol Rep (2010) 1.52
Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity. J Cell Biol (2008) 1.51
Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem (2011) 1.51
Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res (2011) 1.50
Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer. Cell Mol Life Sci (2009) 1.50
MicroRNA-26a promotes cholangiocarcinoma growth by activating β-catenin. Gastroenterology (2012) 1.48
Wnt signaling in bone metabolism. J Bone Miner Metab (2009) 1.48
The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS One (2009) 1.47
Merlin is a potent inhibitor of glioma growth. Cancer Res (2008) 1.47
Retracted Regulation of Wnt/beta-catenin pathway by cPLA2alpha and PPARdelta. J Cell Biochem (2008) 1.47
Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Fertil Steril (2014) 1.45
Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol (2011) 1.44
Constitutively active beta-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors. Immunity (2005) 1.42
Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol (2008) 1.41
Beta-catenin is required for memory consolidation. Nat Neurosci (2008) 1.40
Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor. Mol Cell Biol (2007) 1.40
The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth. J Biol Chem (2010) 1.38
Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo. Neoplasia (2010) 1.35
Oncogenic miRNA-182-5p targets Smad4 and RECK in human bladder cancer. PLoS One (2012) 1.35
Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem (2008) 1.35
WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther (2009) 1.34
Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J Biol Chem (2009) 1.34
Wnt signaling in liver cancer. Curr Drug Targets (2008) 1.34
Impaired neural development caused by inducible expression of Axin in transgenic mice. Mech Dev (2006) 1.32
Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2. Mol Cancer Ther (2009) 1.31
Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5. J Biol Chem (2007) 1.29
Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res (2011) 1.29
Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia (2008) 1.28
Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to interferon-alpha/5-fluorouracil combination therapy for hepatocellular carcinoma. Br J Cancer (2009) 1.28
Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity. Adv Pharmacol (2011) 1.27
A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis. Cell Res (2011) 1.27
Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway. Mol Cell Biol (2011) 1.27
Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation. Eur J Pharmacol (2008) 1.26
A novel role for Wnt/Ca2+ signaling in actin cytoskeleton remodeling and cell motility in prostate cancer. PLoS One (2010) 1.26
β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. PLoS One (2011) 1.25
Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma. J Gastroenterol (2008) 1.25
Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling. J Cell Biol (2011) 1.25
Resveratrol and cancer: focus on in vivo evidence. Endocr Relat Cancer (2014) 1.24
N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis. EMBO Mol Med (2012) 1.24
CK1epsilon is required for breast cancers dependent on beta-catenin activity. PLoS One (2010) 1.22
Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol (2003) 6.60
Functional genomic analysis of the Wnt-wingless signaling pathway. Science (2005) 4.73
Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.90
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nat Genet (2002) 2.90
Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. Blood (2007) 1.79
Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells. PLoS One (2011) 1.08
High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration. Endocrinology (2007) 1.04
Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res (2009) 1.03
Canonical Wnt3a modulates intracellular calcium and enhances excitatory neurotransmission in hippocampal neurons. J Biol Chem (2010) 1.00
The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation. Stem Cells (2007) 0.99
Wnt signaling involvement in beta-amyloid-dependent neurodegeneration. Neurochem Int (2002) 0.91
Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. PLoS One (2009) 0.89
Biphasic effects of copper on neurotransmission in rat hippocampal neurons. J Neurochem (2011) 0.89
Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms. J Endocrinol (2007) 0.86
Improving reliability and absolute quantification of human brain microarray data by filtering and scaling probes using RNA-Seq. BMC Genomics (2014) 0.83
Capecitabine therapy for refractory metastatic thyroid carcinoma: a case series. Thyroid (2006) 0.80
A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer's disease. Neurobiol Aging (2012) 0.79
Wnt/β-catenin signaling in Alzheimer's disease. CNS Neurol Disord Drug Targets (2014) 0.78
Acetylcholinesterase induces the expression of the beta-amyloid precursor protein in glia and activates glial cells in culture. Neurobiol Dis (2003) 0.78
Lentiviral-mediated transgene expression can potentiate intestinal mesenchymal-epithelial signaling. Biol Proced Online (2009) 0.77
Enhanced CRAd activity using enhancer motifs driven by a nucleosome positioning sequence. Mol Ther (2013) 0.76