Published in EMBO J on February 01, 1992
Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells. J Clin Invest (1997) 2.44
Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood (2012) 2.14
High-frequency representation of a single VH gene in the expressed human B cell repertoire. J Exp Med (1993) 1.44
A new synthesis for antibody-mediated immunity. Nat Immunol (2011) 1.24
Analysis of human monoclonal antibodies elicited by vaccination with a Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide vaccine. Infect Immun (1995) 1.21
CSF IgG heavy-chain bias in patients at the time of a clinically isolated syndrome. J Neuroimmunol (2008) 1.17
Evolutionary dynamics of the immunoglobulin heavy chain variable region genes in vertebrates. Immunogenetics (2008) 1.09
Structure-function relationships for human antibodies to pneumococcal capsular polysaccharide from transgenic mice with human immunoglobulin Loci. Infect Immun (2002) 1.09
A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels? PLoS Biol (2011) 1.07
A peptide mimotope of type 8 pneumococcal capsular polysaccharide induces a protective immune response in mice. Infect Immun (2005) 1.07
Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment. J Exp Med (1993) 1.07
Protective and nonprotective human immunoglobulin M monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan manifest different specificities and gene use profiles. Infect Immun (2004) 1.06
Revenge of the microbes. Superantigens of the T and B cell lineage. Am J Pathol (1994) 1.04
Genetic control of DH reading frame and its effect on B-cell development and antigen-specifc antibody production. Crit Rev Immunol (2010) 1.02
Immunoglobulin heavy chain diversity in Pteropid bats: evidence for a diverse and highly specific antigen binding repertoire. Immunogenetics (2010) 0.99
Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "positive" selection in appendix of normal and VH-mutant rabbits. Proc Natl Acad Sci U S A (1995) 0.98
Immunogenicity and efficacy of Cryptococcus neoformans capsular polysaccharide glucuronoxylomannan peptide mimotope-protein conjugates in human immunoglobulin transgenic mice. Infect Immun (2004) 0.97
Production of protective human antipneumococcal antibodies by transgenic mice with human immunoglobulin loci. Infect Immun (2000) 0.97
Molecular basis for immunoglobulin M specificity to epitopes in Cryptococcus neoformans polysaccharide that elicit protective and nonprotective antibodies. Infect Immun (2001) 0.93
Molecular characterization of the early B cell response to pulmonary Cryptococcus neoformans infection. J Immunol (2012) 0.90
Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids. Immunogenetics (2011) 0.89
Sequencing of modern Lepus VDJ genes shows that the usage of VHn genes has been retained in both Oryctolagus and Lepus that diverged 12 million years ago. Immunogenetics (2013) 0.88
Characterization of gene use and efficacy of mouse monoclonal antibodies to Streptococcus pneumoniae serotype 8. Clin Vaccine Immunol (2010) 0.83
Functional activities and immunoglobulin variable regions of human and murine monoclonal antibodies specific for the P1.7 PorA protein loop of Neisseria meningitidis. Infect Immun (2000) 0.82
Contribution of V(H) replacement products to the generation of anti-HIV antibodies. Clin Immunol (2012) 0.82
Developmental progression of equine immunoglobulin heavy chain variable region diversity. Dev Comp Immunol (2013) 0.80
Immunoglobulin gene repertoire in chronic lymphocytic leukemia: insight into antigen selection and microenvironmental interactions. Mediterr J Hematol Infect Dis (2012) 0.79
Antigen receptor stereotypy in chronic lymphocytic leukemia. Leukemia (2016) 0.79
V genes in primates from whole genome sequencing data. Immunogenetics (2015) 0.77
Characterization of the CDR3 region of rearranged alpha heavy chain genes in human fetal liver. Clin Exp Immunol (1998) 0.77
Diversity of immunoglobulin lambda light chain gene usage over developmental stages in the horse. Dev Comp Immunol (2014) 0.77
Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination. Cell Rep (2016) 0.76
Variable region structure and staphylococcal protein A binding specificity of a mouse monoclonal IgM anti-laminin-receptor antibody. Immunology (1997) 0.75
New nucleotide sequence data on the EMBL File Server. Nucleic Acids Res (1992) 0.75
Natural antibodies that react with V-region peptide epitopes of DNA-binding antibodies are made by mice with systemic lupus erythematosus as disease develops. Immunology (1997) 0.75
Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD-iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3. Autoimmunity (2017) 0.75
The Protein Data Bank: a computer-based archival file for macromolecular structures. J Mol Biol (1977) 90.57
Somatic generation of antibody diversity. Nature (1983) 28.06
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature (1984) 5.75
Conformations of immunoglobulin hypervariable regions. Nature (1990) 5.31
Comparison of super-secondary structures in proteins. J Mol Biol (1973) 4.85
The role of clonal selection and somatic mutation in autoimmunity. Nature (1987) 4.66
Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A. J Mol Biol (1986) 4.16
Early restriction of the human antibody repertoire. Science (1987) 3.90
Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science (1990) 3.89
Three-dimensional structure of an antibody-antigen complex. Proc Natl Acad Sci U S A (1987) 3.48
Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 A and 1.0 A resolution. J Mol Biol (1980) 3.25
Developmentally controlled expression of immunoglobulin VH genes. Science (1985) 2.96
Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences. J Exp Med (1990) 2.83
Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex. Proc Natl Acad Sci U S A (1989) 2.65
Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a. Cell (1990) 2.42
The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain. J Exp Med (1990) 2.22
Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution. J Biol Chem (1978) 2.21
Organization and evolution of variable region genes of the human immunoglobulin heavy chain. J Mol Biol (1986) 2.17
Evolutionary nucleotide replacements in DNA. Nature (1979) 2.16
Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc Natl Acad Sci U S A (1990) 1.99
The galactan-binding immunoglobulin Fab J539: an X-ray diffraction study at 2.6-A resolution. Proteins (1986) 1.96
The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. J Exp Med (1990) 1.72
Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies. J Immunol (1987) 1.67
Human IgM molecules that bind staphylococcal protein A contain VHIII H chains. J Immunol (1989) 1.59
Structure and evolution of mammalian VH families. Int Immunol (1990) 1.53
Three-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate group. Proc Natl Acad Sci U S A (1989) 1.35
Structural patterns in anti-DNA antibodies from MRL/lpr mice. Cold Spring Harb Symp Quant Biol (1989) 1.35
The expression of the Ig H chain repertoire in developing bone marrow B lineage cells. J Immunol (1991) 1.17
Conservation of an immunoglobulin variable-region gene family indicates a specific, noncoding function. Proc Natl Acad Sci U S A (1989) 1.12
Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice. J Exp Med (1991) 1.10
Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest (1998) 3.96
Aflatoxins: Environmental Factors Governing Occurrence in Spanish Peanuts. Science (1965) 3.09
Effect of corn steep liquor on mycelial growth and aflatoxin production in Aspergillus parasiticus. Appl Microbiol (1966) 2.89
Neuroendoscopic approach to intraventricular lesions. J Neurosurg (1998) 2.67
Aflatoxins: production of the toxins in vitro in relation to temperature. Appl Microbiol (1967) 1.81
Antigenically distinct conformations of CXCR4. J Virol (2001) 1.74
Inhibition of aflatoxin production and tentative identification of an aflatoxin intermediate "versiconal acetate" from treatment with dichlorvos. Appl Microbiol (1974) 1.61
IgM heavy chain complementarity-determining region 3 diversity is constrained by genetic and somatic mechanisms until two months after birth. J Immunol (1999) 1.61
Complement activation in factor D-deficient mice. Proc Natl Acad Sci U S A (2001) 1.59
Aflatoxin-producing potential of isolates of the Aspergillus flavus-oryzae group from peanuts (Arachis hypogaea). Appl Microbiol (1967) 1.47
Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos. Appl Microbiol (1975) 1.45
Five cases of coexistent primary ocular and cutaneous melanoma. Arch Dermatol (1993) 1.45
Composition of the immunoglobulin classic antigen-binding site regulates allergic airway inflammation in a murine model of experimental asthma. Clin Exp Allergy (2009) 1.43
Heterogeneity in the human Ig VH locus. J Immunol (1989) 1.41
Isolation and mapping of a polymorphic DNA sequence pH30 on chromosome 4[HGM provisional no. D4S139]. Nucleic Acids Res (1989) 1.37
Neuroendoscopic approach to intraventricular lesions. Neurosurg Focus (1999) 1.26
Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients. J Immunol (1994) 1.23
Major histocompatibility complex class III genes and susceptibility to immunoglobulin A deficiency and common variable immunodeficiency. J Clin Invest (1992) 1.22
An immune defect causing dominant chronic mucocutaneous candidiasis and thyroid disease maps to chromosome 2p in a single family. Am J Hum Genet (2001) 1.18
Zearalenol and 8'-hydroxyzearalenone from Fusarium roseum. Mycopathologia (1975) 1.18
Antibody structure and the evolution of immunoglobulin V gene segments. Semin Immunol (1994) 1.17
Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals. J Clin Invest (1995) 1.16
The treatment of chilblains with nifedipine: the results of a pilot study, a double-blind placebo-controlled randomized study and a long-term open trial. Br J Dermatol (1989) 1.16
Influence of fungicides and irrigation practice on aflatoxin in peantus before digging. Appl Microbiol (1971) 1.16
Correction of a developmental defect in neutrophil activation and movement. Am J Pathol (1987) 1.13
Tremorgenic mycotoxins from Aspergillus caespitosus. Appl Microbiol (1975) 1.11
Experiences with cranial neuronavigation in pediatric neurosurgery. Pediatr Neurosurg (1999) 1.07
Accumulation of only aflatoxin B 2 by a strain of Aspergillus flavus. Appl Microbiol (1973) 1.06
The immunoglobulin kappa light chain repertoire expressed in the synovium of a patient with rheumatoid arthritis. Arthritis Rheum (1992) 1.06
Membranous glomerulopathy in an adult patient with X-linked agammaglobulinemia receiving intravenous gammaglobulin. J Investig Allergol Clin Immunol (2011) 1.05
The human cord blood antibody repertoire. Frequent usage of the VH7 gene family. Eur J Immunol (1992) 1.05
Age-related changes in serum immunoglobulins in patients with familial IgA deficiency and common variable immunodeficiency (CVID). Clin Exp Immunol (1997) 1.04
Human cord blood antibody repertoire. Mixed population of VH gene segments and CDR3 distribution in the expressed C alpha and C gamma repertoires. J Immunol (1993) 1.04
The hand and foot malformations in fibrodysplasia ossificans progressiva. Johns Hopkins Med J (1980) 1.03
Natural occurrence of alternariols in discolored pecans. J Agric Food Chem (1977) 1.02
Production of aflatoxin by Aspergillus wentii Wehmer. Can J Microbiol (1969) 1.01
Developmental regulation of the human antibody repertoire. Ann N Y Acad Sci (1995) 1.01
Muir-Torre syndrome: a variant of the cancer family syndrome. J Med Genet (1994) 0.97
Developmental regulation of D beta reading frame and junctional diversity in T cell receptor-beta transcripts from human thymus. J Immunol (1992) 0.97
Evidence of antigen receptor-influenced oligoclonal B lymphocyte expansion in the synovium of a patient with longstanding rheumatoid arthritis. J Clin Invest (1994) 0.96
Quantification of active caspase 3 in apoptotic cells. Anal Biochem (2000) 0.95
VHDJH gene sequences and antigen reactivity of monoclonal antibodies produced by human B-1 cells: evidence for somatic selection. J Immunol (1997) 0.95
The human immunoglobulin VH7 gene family consists of a small, polymorphic group of six to eight gene segments dispersed throughout the VH locus. Eur J Immunol (1993) 0.94
Leucocytoclastic vasculitis and angio-oedema associated with inflammatory bowel disease. Clin Exp Dermatol (1984) 0.94
Ribosome binding site analysis of ovalbumin messenger ribonucleic acid. Biochemistry (1979) 0.94
Potato plants genetically modified to produce N-acylhomoserine lactones increase susceptibility to soft rot erwiniae. Mol Plant Microbe Interact (2004) 0.92
Effect of diurnal temperature cycles on the production of aflatoxin. Appl Microbiol (1968) 0.92
A rheumatoid factor from a normal individual encoded by VH2 and V kappa II gene segments. Arthritis Rheum (1992) 0.92
Aflatoxin production of species and strains of the Aspergillus flavus group isolated from field crops. Appl Microbiol (1973) 0.91
Analysis of immunoglobulin gamma heavy chain expression in synovial tissue of a patient with rheumatoid arthritis. Arthritis Rheum (1993) 0.90
The treatment of multiple angiokeratomata with the argon laser. Clin Exp Dermatol (1987) 0.90
Melanoma and skin cancer: evaluation of a health education programme for secondary schools. Br J Dermatol (1993) 0.89
Familial primary cutaneous amyloidosis. Br J Dermatol (1985) 0.88
Structure-function studies of human monoclonal antibodies to pneumococcus type 3 polysaccharide. Ann N Y Acad Sci (1995) 0.88
Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following focal cerebral ischemia. Neurosurg Rev (2000) 0.87
Plasma mercury during prolonged acute renal failure after mercuric chloride ingestion. Hum Toxicol (1983) 0.87
Use of paromomycin for the treatment of cryptosporidiosis in patients with AIDS. Clin Infect Dis (1993) 0.86
Clonally-related immunoglobulin VH domains and nonrandom use of DH gene segments in rheumatoid arthritis synovium. Mol Med (1998) 0.86
Marriage, divorce, and promiscuity in human B cells. Nat Immunol (2000) 0.85
p53 protein detected by immunohistochemical staining is not always mutant. Dis Markers (1993) 0.85
What is the CLL B-lymphocyte? Leuk Lymphoma (1996) 0.84
Malignant angiosarcoma of the scalp: a case report with immunohistochemical studies. Br J Dermatol (1985) 0.84
Rapp-Hodgkin ectodermal dysplasia. J Pediatr (1987) 0.83
Weekly fluconazole for the suppression of recurrent thrush in HIV-seropositive patients: impact on the incidence of disseminated cryptococcal infection. AIDS (1995) 0.83
TH1 cytokine response of CD57+ T-cell subsets in healthy controls and patients with alcoholic liver disease. Alcohol (2001) 0.83
Cutis laxa associated with amyloidosis. Clin Exp Dermatol (1986) 0.83
Early expression of iepsilon, CD23 (FcepsilonRII), IL-4Ralpha, and IgE in the human fetus. J Allergy Clin Immunol (2000) 0.83
Most women with acne have polycystic ovaries. Br J Dermatol (1989) 0.83
Analysis of immunoglobulin gamma heavy chains from rheumatoid arthritis synovium. Evidence of antigen-driven selection. Ann N Y Acad Sci (1995) 0.83
Intravenous gamma globulin administration to common variable immunodeficient women during pregnancy: case report and review of the literature. J Perinatol (1994) 0.83
Genetic control of the B cell response to LPS: opposing effects in peritoneal versus splenic B cell populations. Immunogenetics (2009) 0.83
Wegener's granulomatosis presenting as pyoderma gangrenosum. Clin Exp Dermatol (1992) 0.83
Immunoregulatory activity of human bone marrow. Identification of suppressor cells possessing OKM1, SSEA-1, and HNK-1 antigens. J Immunol (1986) 0.82
The J chain gene is transcribed during B and T lymphopoiesis in humans. J Immunol (1996) 0.82
Blue naevus associated with trichoepithelioma: a report of two cases. J Cutan Pathol (1984) 0.82
CDR3 fingerprinting of immunoglobulin kappa light chains expressed in rheumatoid arthritis. Evidence of antigenic selection or dysregulation of gene rearrangement in B cells. Ann N Y Acad Sci (1997) 0.82
Wound infection due to Aeromonas sobria. Clin Infect Dis (1993) 0.82
Ig D(H) gene segment transcription and rearrangement before surface expression of the pan-B-cell marker CD19 in normal human bone marrow. Blood (1997) 0.81
Smoking and risk of cryptococcosis in patients with AIDS. JAMA (1997) 0.81
Aspiration pneumonia caused by Mycobacterium smegmatis. Mayo Clin Proc (1994) 0.81
Cranial neuronavigation in neurosurgery: assessment of usefulness in relation to type and site of pathology in 284 patients. Minim Invasive Neurosurg (2000) 0.81
VH gene usage by family members affected with chronic lymphocytic leukaemia. Br J Haematol (1999) 0.81
Familial malignant atrophic papulosis. Clin Exp Dermatol (1984) 0.80
Screening tests for Sezary cells in cutaneous T-cell lymphomas. Clin Lab Haematol (1986) 0.80
Recombination aneusomy of chromosome 5 associated with multiple severe congenital malformations. Clin Genet (1986) 0.80
SAW: a graphical user interface for the analysis of immunoglobulin variable domain sequences. Biotechniques (1993) 0.80
Factor(s) secreted by AFT024 fetal liver cells following stimulation with human cytokines are important for human LTC-IC growth. Leukemia (1999) 0.79
The hormonal profile of women with acne and polycystic ovaries. Clin Exp Dermatol (1991) 0.79
A rapid and quantitative method for the evaluation of V gene usage, specificities and the clonal size of B cell repertoires. J Immunol Methods (2011) 0.79
Immunoglobulin variable heavy chain cDNA sequence from a patient with X-linked agammaglobulinemia. Nucleic Acids Res (1991) 0.79
Eosinophilic cellulitis (Well's syndrome) with florid histological changes. Clin Exp Dermatol (1988) 0.78
Three cases of primary acquired melanosis of the conjunctiva as a manifestation of the atypical mole syndrome. Br J Dermatol (1993) 0.78
Infrared-based neuronavigation and cortical motor stimulation in the management of central-region tumors. Stereotact Funct Neurosurg (1997) 0.78
Study of psoriatic epidermal cell kinetics and cell death after oral methotrexate. Dermatologica (1985) 0.78
Acropustulosis of infancy. Br J Dermatol (1986) 0.78
Nucleotide sequence of the intron of the germline human kappa immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer. Nucleic Acids Res (1992) 0.78