Published in J Biol Chem on September 16, 2004
Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors. Cancer Cell (2014) 1.84
Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (2010) 1.83
Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. Nat Immunol (2009) 1.70
Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J Immunol (2009) 1.52
Coordination between RAB GTPase and phosphoinositide regulation and functions. Nat Rev Mol Cell Biol (2012) 1.35
The regulation of class IA PI 3-kinases by inter-subunit interactions. Curr Top Microbiol Immunol (2010) 1.16
Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation. Mol Cell (2013) 1.11
Caspase 8 promotes peripheral localization and activation of Rab5. J Biol Chem (2008) 1.09
Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation. J Biol Chem (2008) 1.08
Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia. Blood (2009) 1.07
Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains. Proc Natl Acad Sci U S A (2011) 1.06
Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. PLoS One (2012) 1.00
T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood (2007) 1.00
Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases. Nat Rev Rheumatol (2015) 0.96
Endogenous retroviral pathogenesis in lupus. Curr Opin Rheumatol (2010) 0.95
Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE. Autoimmunity (2008) 0.93
Identification of components of the host type IA phosphoinositide 3-kinase pathway that promote internalization of Listeria monocytogenes. Infect Immun (2011) 0.91
Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion. J Cell Sci (2014) 0.90
Coordination of the Rab5 cycle on macropinosomes. Traffic (2011) 0.88
Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Mol Biol Cell (2012) 0.87
Caspase-8 as a regulator of tumor cell motility. Curr Mol Med (2014) 0.85
The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells. Autoimmunity (2009) 0.83
Phosphoinositide 3-kinase at the crossroad between endocytosis and signaling of cytokine receptors. Commun Integr Biol (2013) 0.82
Class IA phosphatidylinositol 3-kinase p110α regulates phagosome maturation. PLoS One (2012) 0.81
GTPase activating protein function of p85 facilitates uptake and recycling of the beta1 integrin. Biochem Biophys Res Commun (2009) 0.81
The structural basis of PI3K cancer mutations: from mechanism to therapy. Cancer Res (2014) 0.81
Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis. PLoS One (2010) 0.80
Phosphoinositides: Key modulators of energy metabolism. Biochim Biophys Acta (2014) 0.79
Phosphatidylinositol 3-kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming growth factor-β1. J Biol Chem (2012) 0.79
Ether-linked diglycerides inhibit vascular smooth muscle cell growth via decreased MAPK and PI3K/Akt signaling. Am J Physiol Heart Circ Physiol (2008) 0.77
Identification of mutations in distinct regions of p85 alpha in urothelial cancer. PLoS One (2013) 0.77
Role of Host Type IA Phosphoinositide 3-Kinase Pathway Components in Invasin-Mediated Internalization of Yersinia enterocolitica. Infect Immun (2016) 0.76
Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium. Elife (2015) 0.76
Signal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55α and p50α regulate autophagy in vivo. FEBS J (2014) 0.76
PI3King the right partner: unique interactions and signaling by p110β. Postdoc J (2015) 0.76
Role of p85α in neutrophil extra- and intracellular reactive oxygen species generation. Oncotarget (2016) 0.75
Study of vaccinia and cowpox viruses' replication in Rac1-N17 dominant-negative cells. Mem Inst Oswaldo Cruz (2013) 0.75
A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion. Commun Integr Biol (2014) 0.75
Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (2010) 1.83
SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation. J Virol (2007) 1.47
Caspase 8 promotes peripheral localization and activation of Rab5. J Biol Chem (2008) 1.09
Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation. J Biol Chem (2008) 1.08
Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking. Biochem J (2012) 1.00
Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity. J Biol Chem (2008) 0.99
Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking. Cell Signal (2010) 0.93
Haloperidol induces the nuclear translocation of phosphatidylinositol 3'-kinase to disrupt Akt phosphorylation in PC12 cells. J Psychiatry Neurosci (2007) 0.92
Genetically engineered, biarsenically labeled influenza virus allows visualization of viral NS1 protein in living cells. J Virol (2010) 0.92
Measurement of the interaction of the p85alpha subunit of phosphatidylinositol 3-kinase with Rab5. Methods Enzymol (2005) 0.87
CREB3L1 is a metastasis suppressor that represses expression of genes regulating metastasis, invasion, and angiogenesis. Mol Cell Biol (2013) 0.85
A-Raf associates with and regulates platelet-derived growth factor receptor signalling. Cell Signal (2004) 0.85
The signalling factor PI3K is a specific regulator of the clathrin-independent dynamin-dependent endocytosis of IL-2 receptors. J Cell Sci (2013) 0.85
p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN. Cell Cycle (2010) 0.83
Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation. Int J Biochem Cell Biol (2012) 0.80
Assay and stimulation of the Rab5 GTPase by the p85 alpha subunit of phosphatidylinositol 3-kinase. Methods Enzymol (2005) 0.80
The smaller isoforms of ankyrin 3 bind to the p85 subunit of phosphatidylinositol 3'-kinase and enhance platelet-derived growth factor receptor down-regulation. J Biol Chem (2005) 0.80
Identification of key residues in the A-Raf kinase important for phosphoinositide lipid binding specificity. Biochemistry (2005) 0.79
Molecular cloning of bovine cardiac muscle heat-shock protein 70 kDa and its phosphorylation by cAMP-dependent protein kinase in vitro. Biochemistry (2004) 0.79
In vitro proteolytic degradation of bovine brain calcineurin by m-calpain. Neurochem Res (2004) 0.77
Molecular cloning, expression, purification and characterization of calcineurin from bovine cardiac muscle. Biochimie (2005) 0.77
Two phosphorylation-independent sites on the p85 SH2 domains bind A-Raf kinase. Biochem Biophys Res Commun (2002) 0.75