Published in Nat Rev Neurosci on October 01, 2004
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03
Light-induced rescue of breathing after spinal cord injury. J Neurosci (2008) 1.68
Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain. Cell Mol Life Sci (2008) 1.67
Role of voltage-gated potassium channels in cancer. J Membr Biol (2005) 1.60
Functional roles of a Ca2+-activated K+ channel in atrioventricular nodes. Circ Res (2007) 1.58
Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol (2008) 1.58
Ionic mechanisms of autorhythmic firing in rat cerebellar Golgi cells. J Physiol (2006) 1.53
Expression and function of calcium-activated potassium channels in human glioma cells. Glia (2006) 1.52
Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurones. J Physiol (2005) 1.45
Hippocalcin gates the calcium activation of the slow afterhyperpolarization in hippocampal pyramidal cells. Neuron (2007) 1.43
A novel calcium-sensitive potassium conductance is coupled to P2X3 subunit containing receptors in myenteric neurons of guinea pig ileum. Neurogastroenterol Motil (2007) 1.40
Bee Venom for the Treatment of Parkinson Disease - A Randomized Controlled Clinical Trial. PLoS One (2016) 1.39
Electroreceptor neuron dynamics shape information transmission. Nat Neurosci (2005) 1.36
Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell (2013) 1.31
K+ channels in apoptosis. J Membr Biol (2006) 1.29
Homeostatic synapse-driven membrane plasticity in nucleus accumbens neurons. J Neurosci (2009) 1.27
Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection. Antioxid Redox Signal (2010) 1.27
Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels. Circ Res (2010) 1.24
Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes. Cardiovasc Res (2013) 1.23
Overexpression of KCNN3 results in sudden cardiac death. Cardiovasc Res (2013) 1.21
Spike frequency adaptation mediates looming stimulus selectivity in a collision-detecting neuron. Nat Neurosci (2009) 1.21
Computational reconstruction of pacemaking and intrinsic electroresponsiveness in cerebellar Golgi cells. Front Cell Neurosci (2007) 1.20
Vascular large conductance calcium-activated potassium channels: functional role and therapeutic potential. Naunyn Schmiedebergs Arch Pharmacol (2007) 1.19
Learning-related postburst afterhyperpolarization reduction in CA1 pyramidal neurons is mediated by protein kinase A. Proc Natl Acad Sci U S A (2009) 1.18
Purinergic neuromuscular transmission is selectively attenuated in ulcerated regions of inflamed guinea pig distal colon. J Physiol (2010) 1.12
CRF facilitates calcium release from intracellular stores in midbrain dopamine neurons. Neuron (2008) 1.10
Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-β1/Smad pathway in diabetic mice. Diabetes (2013) 1.10
Learning and aging related changes in intrinsic neuronal excitability. Front Aging Neurosci (2010) 1.08
Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels. Alcohol Clin Exp Res (2009) 1.08
Pharmacological activation of small conductance calcium-activated potassium channels with naphtho[1,2-d]thiazol-2-ylamine decreases guinea pig detrusor smooth muscle excitability and contractility. J Pharmacol Exp Ther (2011) 1.07
Ca(2+) signaling by T-type Ca(2+) channels in neurons. Pflugers Arch (2008) 1.07
Mechanically Activated Ion Channels. Neuron (2015) 1.07
Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets. J Cardiovasc Pharmacol (2013) 1.05
Excitability of paraventricular nucleus neurones that project to the rostral ventrolateral medulla is regulated by small-conductance Ca2+-activated K+ channels. J Physiol (2009) 1.04
Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol (2012) 1.04
The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus. Proc Natl Acad Sci U S A (2010) 1.03
Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1. Mol Biol Cell (2005) 1.03
The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones. J Physiol (2004) 1.03
K(Ca)3.1 channels facilitate K+ secretion or Na+ absorption depending on apical or basolateral P2Y receptor stimulation. J Physiol (2011) 1.03
Fast-reset of pacemaking and theta-frequency resonance patterns in cerebellar golgi cells: simulations of their impact in vivo. Front Cell Neurosci (2007) 1.03
Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel. J Gen Physiol (2006) 1.01
Structural determinants of the closed KCa3.1 channel pore in relation to channel gating: results from a substituted cysteine accessibility analysis. J Gen Physiol (2007) 1.01
Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel). Proc Natl Acad Sci U S A (2009) 1.01
In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning. Neuropharmacology (2009) 1.00
Small-conductance, Ca(2+) -activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder. Am J Physiol Regul Integr Comp Physiol (2008) 0.99
An amino acid outside the pore region influences apamin sensitivity in small conductance Ca2+-activated K+ channels. J Biol Chem (2006) 0.99
Allosteric block of KCa2 channels by apamin. J Biol Chem (2010) 0.99
Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons. PLoS Biol (2010) 0.99
Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation. J Neurosci (2009) 0.98
The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro. J Neuroinflammation (2010) 0.98
Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. EMBO J (2007) 0.97
Structural basis for calmodulin as a dynamic calcium sensor. Structure (2012) 0.97
NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons. Mol Pain (2009) 0.97
Calcium and small-conductance calcium-activated potassium channels in gonadotropin-releasing hormone neurons before, during, and after puberty. Endocrinology (2007) 0.97
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance. Nat Neurosci (2012) 0.96
Apamin as a template for structure-based rational design of potent peptide activators of p53. Angew Chem Int Ed Engl (2009) 0.95
Learning to learn - intrinsic plasticity as a metaplasticity mechanism for memory formation. Neurobiol Learn Mem (2013) 0.95
KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia. Cell Death Dis (2011) 0.95
SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes. Proc Natl Acad Sci U S A (2006) 0.94
Identification of the functional binding pocket for compounds targeting small-conductance Ca²⁺-activated potassium channels. Nat Commun (2012) 0.94
Orientation of palmitoylated CaVbeta2a relative to CaV2.2 is critical for slow pathway modulation of N-type Ca2+ current by tachykinin receptor activation. J Gen Physiol (2009) 0.94
Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, K(Ca)3.1, in immune function of lymphoid cells. J Biol Chem (2011) 0.93
The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum. Eur J Neurosci (2010) 0.93
The Drosophila SK channel (dSK) contributes to photoreceptor performance by mediating sensitivity control at the first visual network. J Neurosci (2011) 0.93
Potassium channels--multiplicity and challenges. Br J Pharmacol (2006) 0.93
Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels. Mol Pharmacol (2011) 0.92
Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes. PLoS One (2013) 0.91
Excitatory effects of serotonin on rat striatal cholinergic interneurones. J Physiol (2005) 0.90
Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice. J Neurophysiol (2010) 0.90
Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca²⁺-sensing and SK channel activation. Proc Natl Acad Sci U S A (2013) 0.90
Hypertension induced by angiotensin II and a high salt diet involves reduced SK current and increased excitability of RVLM projecting PVN neurons. J Neurophysiol (2010) 0.90
Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc Natl Acad Sci U S A (2014) 0.89
Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice. Sleep (2010) 0.89
Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels. Br J Pharmacol (2009) 0.89
Amiodarone inhibits apamin-sensitive potassium currents. PLoS One (2013) 0.89
Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing. Hum Genet (2011) 0.89
A proinvasive role for the Ca(2+) -activated K(+) channel KCa3.1 in malignant glioma. Glia (2014) 0.89
Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. J Biol Chem (2013) 0.88
The SK channel blocker apamin inhibits slow afterhyperpolarization currents in rat gonadotropin-releasing hormone neurones. J Physiol (2006) 0.88
Large neurological component to genetic differences underlying biased sperm use in Drosophila. Genetics (2012) 0.87
Signaling complexes of voltage-gated calcium channels. Channels (Austin) (2011) 0.87
Analytical approximations of the firing rate of an adaptive exponential integrate-and-fire neuron in the presence of synaptic noise. Front Comput Neurosci (2014) 0.87
Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex. Nat Chem Biol (2014) 0.87
Intracellular gold nanoparticles increase neuronal excitability and aggravate seizure activity in the mouse brain. PLoS One (2014) 0.86
Protective Roles for Potassium SK/K(Ca)2 Channels in Microglia and Neurons. Front Pharmacol (2012) 0.86
Synergistic roles of GABAA receptors and SK channels in regulating thalamocortical oscillations. J Neurophysiol (2009) 0.86
Calmodulin interaction with hEAG1 visualized by FRET microscopy. PLoS One (2010) 0.86
Neuronal T-type calcium channels: what's new? Iftinca: T-type channel regulation. J Med Life (2011) 0.86
Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts? ChemMedChem (2012) 0.86
Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization. Neurobiol Aging (2008) 0.86
Complex distribution patterns of voltage-gated calcium channel α-subunits in the spiral ganglion. Hear Res (2011) 0.86
Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membrane. Biochim Biophys Acta (2012) 0.86
Sodium permeability of a cloned small-conductance calcium-activated potassium channel. Biophys J (2005) 0.85
Role of spike-frequency adaptation in shaping neuronal response to dynamic stimuli. Biol Cybern (2009) 0.85
Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior. Front Physiol (2014) 0.85
Modulation of endothelial SK3 channel activity by Ca²+dependent caveolar trafficking. Am J Physiol Cell Physiol (2012) 0.84
Catecholamine secretion from rat foetal adrenal chromaffin cells and hypoxia sensitivity. Pflugers Arch (2006) 0.84
Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A (2012) 0.84
Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memory. Behav Brain Res (2012) 0.84
Cav1.3 Channels as Key Regulators of Neuron-Like Firings and Catecholamine Release in Chromaffin Cells. Curr Mol Pharmacol (2015) 0.84