Published in Exp Cell Res on October 15, 2004
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. Eur Cell Mater (2011) 1.84
Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J Bone Miner Res (2009) 1.31
The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription. BMC Mol Biol (2006) 1.18
Differential in vivo effects of whole cigarette smoke exposure versus cigarette smoke extract on mouse ciliated tracheal epithelium. Exp Lung Res (2006) 1.11
Developmental mechanisms in articular cartilage degradation in osteoarthritis. Arthritis (2010) 1.10
C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways. BMC Dev Biol (2007) 1.03
Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors. Hum Mol Genet (2010) 1.02
Spatial and temporal regulation of gene expression in the mammalian growth plate. Bone (2010) 1.01
A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis. Biomaterials (2011) 0.99
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy. Arthritis Res Ther (2007) 0.96
GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation. J Biol Chem (2012) 0.91
Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation. J Orthop Res (2009) 0.88
NSAID therapy effects on healing of bone, tendon, and the enthesis. J Appl Physiol (1985) (2013) 0.85
EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair. J Bone Miner Res (2011) 0.84
The Essentiality of Arachidonic Acid in Infant Development. Nutrients (2016) 0.82
Local administration of AAV-DJ pseudoserotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice. Gene Ther (2015) 0.82
Role of G-proteins in the differentiation of epiphyseal chondrocytes. J Mol Endocrinol (2014) 0.80
Immunohistochemical localization of key arachidonic acid metabolism enzymes during fracture healing in mice. PLoS One (2014) 0.78
Prostacyclin regulates bone growth via the Epac/Rap1 pathway. Endocrinology (2014) 0.76
BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway. Osteoarthritis Cartilage (2014) 0.76
Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength. Bone (2014) 0.75
Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res (2009) 3.61
Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest (2002) 3.29
Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest (2003) 3.14
Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis Rheum (2009) 2.64
Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions. Bone (2005) 2.26
NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem (2007) 2.22
Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene. Gene (2006) 2.16
American Board of Orthopaedic Surgery Practice of the Orthopaedic Surgeon: Part-II, certification examination case mix. J Bone Joint Surg Am (2006) 2.11
Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med (2005) 2.10
Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. J Bone Miner Res (2005) 2.04
Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis (2007) 2.01
Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem (2001) 1.99
Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice. Arthritis Rheum (2011) 1.98
Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. J Biol Chem (2005) 1.96
Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice. Arthritis Rheum (2004) 1.94
Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy. J Immunol (2010) 1.94
The biology of the growth plate. J Bone Joint Surg Am (2003) 1.89
COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res (2002) 1.84
RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis. J Bone Miner Res (2004) 1.83
Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum (2008) 1.77
Willingness to pay for social health insurance among informal sector workers in Wuhan, China: a contingent valuation study. BMC Health Serv Res (2007) 1.74
Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression. J Biol Chem (2006) 1.73
RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development (2010) 1.72
Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography. Arthritis Rheum (2007) 1.68
Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum (2012) 1.67
Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. J Cell Sci (2008) 1.67
ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res (2003) 1.66
The impact of the National Essential Medicines Policy on prescribing behaviours in primary care facilities in Hubei province of China. Health Policy Plan (2012) 1.63
High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury. Arthritis Res Ther (2011) 1.62
Osteoclast precursors, RANKL/RANK, and immunology. Immunol Rev (2005) 1.57
Increased lymphangiogenesis in joints of mice with inflammatory arthritis. Arthritis Res Ther (2007) 1.57
A perspective: engineering periosteum for structural bone graft healing. Clin Orthop Relat Res (2008) 1.57
Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation. J Cell Biochem (2003) 1.56
Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis. Arthritis Rheum (2009) 1.54
Regulation of chondrogenesis and chondrocyte differentiation by stress. J Clin Invest (2008) 1.53
Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2. J Bone Miner Res (2008) 1.53
Biological effects of rAAV-caAlk2 coating on structural allograft healing. Mol Ther (2005) 1.49
Effects of pharmacological inhibition of cathepsin K on fracture repair in mice. Bone (2013) 1.47
Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. J Cell Physiol (2006) 1.46
Cyclin D1-cdk4 induce runx2 ubiquitination and degradation. J Biol Chem (2006) 1.45
The TNF-alpha transgenic mouse model of inflammatory arthritis. Springer Semin Immunopathol (2003) 1.44
BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci (2011) 1.44
A novel murine segmental femoral graft model. J Orthop Res (2004) 1.43
Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins. J Biol Chem (2008) 1.41
MRI and quantification of draining lymph node function in inflammatory arthritis. Ann N Y Acad Sci (2007) 1.41
NOTCH signaling in skeletal progenitors is critical for fracture repair. J Clin Invest (2016) 1.41
Prices, availability and affordability of essential medicines in rural areas of Hubei Province, China. Health Policy Plan (2009) 1.41
Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. Tissue Eng (2007) 1.41
Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. J Bone Miner Res (2005) 1.39
The orthopaedic genome: what does the future hold and are we ready? J Bone Joint Surg Am (2002) 1.39
Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. Arthritis Rheum (2008) 1.31
Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J Bone Miner Res (2009) 1.31
TNF-alpha and pathologic bone resorption. Keio J Med (2005) 1.31
NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone. Clin Orthop Relat Res (2003) 1.30
Near-infrared lymphatic imaging demonstrates the dynamics of lymph flow and lymphangiogenesis during the acute versus chronic phases of arthritis in mice. Arthritis Rheum (2010) 1.30